Result of FASTA (omim) for
pFN21AB5035
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5035, 192 aa
1>>>pF1KB5035 192 - 192 aa - 192 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.0230+/-0.000303; mu= 6.0672+/- 0.019
mean_var=130.8119+/-26.105, 0's: 0 Z-trim(120.4): 28 B-trim: 0 in 0/54
Lambda= 0.112137
statistics sampled from 35620 (35649) to 35620 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.765), E-opt: 0.2 (0.418), width: 16
Scan time: 6.350
The best scores are: opt bits E(85289)
NP_005953 (OMIM: 176807,600020) max-interacting pr ( 228) 1240 211.0 1.2e-54
NP_569157 (OMIM: 176807,600020) max-interacting pr ( 295) 1240 211.0 1.4e-54
NP_001008541 (OMIM: 176807,600020) max-interacting ( 182) 979 168.7 5e-42
NP_002348 (OMIM: 600021) max dimerization protein ( 221) 672 119.1 5.2e-27
NP_001189442 (OMIM: 600021) max dimerization prote ( 220) 654 116.2 3.9e-26
NP_001189443 (OMIM: 600021) max dimerization prote ( 211) 602 107.7 1.3e-23
NP_112590 (OMIM: 609450) max dimerization protein ( 206) 427 79.4 4.2e-15
NP_001136407 (OMIM: 609450) max dimerization prote ( 193) 370 70.2 2.4e-12
NP_064706 (OMIM: 603039) max-binding protein MNT [ ( 582) 217 45.8 0.00016
XP_011522170 (OMIM: 603039) PREDICTED: max-binding ( 590) 217 45.8 0.00016
>>NP_005953 (OMIM: 176807,600020) max-interacting protei (228 aa)
initn: 1240 init1: 1240 opt: 1240 Z-score: 1102.3 bits: 211.0 E(85289): 1.2e-54
Smith-Waterman score: 1240; 100.0% identity (100.0% similar) in 192 aa overlap (1-192:37-228)
10 20 30
pF1KB5 MPSPRLQHSKPPRRLSRAQKHSSGSSNTST
::::::::::::::::::::::::::::::
NP_005 INVQRLLEAAEFLERRERECEHGYASSFPSMPSPRLQHSKPPRRLSRAQKHSSGSSNTST
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB5 ANRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ANRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKS
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB5 QHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEF
130 140 150 160 170 180
160 170 180 190
pF1KB5 SHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSASVKLSFTS
::::::::::::::::::::::::::::::::::::::::::
NP_005 SHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSASVKLSFTS
190 200 210 220
>>NP_569157 (OMIM: 176807,600020) max-interacting protei (295 aa)
initn: 1240 init1: 1240 opt: 1240 Z-score: 1100.7 bits: 211.0 E(85289): 1.4e-54
Smith-Waterman score: 1240; 100.0% identity (100.0% similar) in 192 aa overlap (1-192:104-295)
10 20 30
pF1KB5 MPSPRLQHSKPPRRLSRAQKHSSGSSNTST
::::::::::::::::::::::::::::::
NP_569 QILLEAASYLEQIEKENKKCEHGYASSFPSMPSPRLQHSKPPRRLSRAQKHSSGSSNTST
80 90 100 110 120 130
40 50 60 70 80 90
pF1KB5 ANRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_569 ANRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKS
140 150 160 170 180 190
100 110 120 130 140 150
pF1KB5 QHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_569 QHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEF
200 210 220 230 240 250
160 170 180 190
pF1KB5 SHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSASVKLSFTS
::::::::::::::::::::::::::::::::::::::::::
NP_569 SHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSASVKLSFTS
260 270 280 290
>>NP_001008541 (OMIM: 176807,600020) max-interacting pro (182 aa)
initn: 970 init1: 970 opt: 979 Z-score: 875.5 bits: 168.7 E(85289): 5e-42
Smith-Waterman score: 1146; 94.8% identity (94.8% similar) in 192 aa overlap (1-192:1-182)
10 20 30 40 50 60
pF1KB5 MPSPRLQHSKPPRRLSRAQKHSSGSSNTSTANRSTHNELEKNRRAHLRLCLERLKVLIPL
::::::::::::::::::::::::::::::::: :::::::::::::::::
NP_001 MPSPRLQHSKPPRRLSRAQKHSSGSSNTSTANR----------RAHLRLCLERLKVLIPL
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 GPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKWRLEQLQGPQEMERI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKWRLEQLQGPQEMERI
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB5 RMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEG
120 130 140 150 160 170
190
pF1KB5 YSSASVKLSFTS
::::::::::::
NP_001 YSSASVKLSFTS
180
>>NP_002348 (OMIM: 600021) max dimerization protein 1 is (221 aa)
initn: 646 init1: 377 opt: 672 Z-score: 605.9 bits: 119.1 E(85289): 5.2e-27
Smith-Waterman score: 672; 61.8% identity (87.6% similar) in 170 aa overlap (18-187:43-207)
10 20 30 40
pF1KB5 MPSPRLQHSKPPRRLSRAQKHSSGSSNTSTANRSTHNELEKNRRAHL
: :. . :.......::::::.::::::::
NP_002 LEAADYLERREREAEHGYASMLPYNNKDRDALKRRNKSKKNNSSSRSTHNEMEKNRRAHL
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB5 RLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKWR
:::::.:: :.::::. .:::::.::.::: ::::::. .::. ::...:.:::: :: .
NP_002 RLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRQ
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB5 LEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDID
::.: .:::::::::::.::.::::.::::.::::::.. :..: :..:.:: :
NP_002 LEKLG----IERIRMDSIGSTVSSERSDSDREEIDVDVESTDYLTGDLD-WSSSSVSDSD
140 150 160 170 180
170 180 190
pF1KB5 DHSSLPSIGSDEGYSSASVKLSFTS
...:. :.::::::::.:.:
NP_002 ERGSMQSLGSDEGYSSTSIKRIKLQDSHKACLGL
190 200 210 220
>>NP_001189442 (OMIM: 600021) max dimerization protein 1 (220 aa)
initn: 634 init1: 377 opt: 654 Z-score: 590.2 bits: 116.2 E(85289): 3.9e-26
Smith-Waterman score: 654; 61.2% identity (87.1% similar) in 170 aa overlap (18-187:43-206)
10 20 30 40
pF1KB5 MPSPRLQHSKPPRRLSRAQKHSSGSSNTSTANRSTHNELEKNRRAHL
: :. . :.......::::::.::::::::
NP_001 LEAADYLERREREAEHGYASMLPYNNKDRDALKRRNKSKKNNSSSRSTHNEMEKNRRAHL
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB5 RLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKWR
:::::.:: :.::::. .:::::.::.::: ::::::. .::. ::...:.:::: :: .
NP_001 RLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRQ
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB5 LEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDID
::.: .:::::::::::.::.::::.:: :.::::::.. :..: :..:.:: :
NP_001 LEKLG----IERIRMDSIGSTVSSERSDSDRE-IDVDVESTDYLTGDLD-WSSSSVSDSD
140 150 160 170 180
170 180 190
pF1KB5 DHSSLPSIGSDEGYSSASVKLSFTS
...:. :.::::::::.:.:
NP_001 ERGSMQSLGSDEGYSSTSIKRIKLQDSHKACLGL
190 200 210 220
>>NP_001189443 (OMIM: 600021) max dimerization protein 1 (211 aa)
initn: 606 init1: 315 opt: 602 Z-score: 545.0 bits: 107.7 E(85289): 1.3e-23
Smith-Waterman score: 602; 62.2% identity (87.2% similar) in 156 aa overlap (32-187:48-197)
10 20 30 40 50 60
pF1KB5 PSPRLQHSKPPRRLSRAQKHSSGSSNTSTANRSTHNELEKNRRAHLRLCLERLKVLIPLG
:.: .:. ..::::::::::.:: :.:::
NP_001 YLERREREAEHGYASMLPYNNKDRDALKRRNKSKKNN-SSSRRAHLRLCLEKLKGLVPLG
20 30 40 50 60 70
70 80 90 100 110 120
pF1KB5 PDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIR
:. .:::::.::.::: ::::::. .::. ::...:.:::: :: .::.: : .::::
NP_001 PESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRQLEKL-G---IERIR
80 90 100 110 120 130
130 140 150 160 170 180
pF1KB5 MDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGY
:::::::.::.::::.::::.::::::.. :..: :..:.:: :...:. :.::::::
NP_001 MDSIGSTVSSERSDSDREEIDVDVESTDYLTGDLD-WSSSSVSDSDERGSMQSLGSDEGY
140 150 160 170 180 190
190
pF1KB5 SSASVKLSFTS
::.:.:
NP_001 SSTSIKRIKLQDSHKACLGL
200 210
>>NP_112590 (OMIM: 609450) max dimerization protein 3 is (206 aa)
initn: 381 init1: 297 opt: 427 Z-score: 392.1 bits: 79.4 E(85289): 4.2e-15
Smith-Waterman score: 427; 47.7% identity (76.2% similar) in 151 aa overlap (10-156:36-185)
10 20 30
pF1KB5 MPSPRLQHSKPPRRLSRAQKHSSGSSNTSTANRSTHNEL
. : . : .:. . ... ..::.::::
NP_112 SNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNEL
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB5 EKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLER
:: :::.:. :::::: .::: ::.:.:::.:: .:. ::.:::. :..... : :.
NP_112 EKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERLRS
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB5 EQRFLKWRLEQLQG---PQEMERIRMDSIGST-ISSDRSDSEREEIEVDVESTEFSHGEV
.:. :. .::::.: : ::.: ::. :. .::.::::..::.:::::: :. ::.
NP_112 KQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQEELEVDVESLVFG-GEA
130 140 150 160 170 180
160 170 180 190
pF1KB5 DNISTTSISDIDDHSSLPSIGSDEGYSSASVKLSFTS
.
NP_112 ELLRGFVAGQEHSYSHGGGAWL
190 200
>>NP_001136407 (OMIM: 609450) max dimerization protein 3 (193 aa)
initn: 356 init1: 297 opt: 370 Z-score: 342.7 bits: 70.2 E(85289): 2.4e-12
Smith-Waterman score: 370; 45.9% identity (75.2% similar) in 133 aa overlap (10-138:36-168)
10 20 30
pF1KB5 MPSPRLQHSKPPRRLSRAQKHSSGSSNTSTANRSTHNEL
. : . : .:. . ... ..::.::::
NP_001 SNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNEL
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB5 EKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLER
:: :::.:. :::::: .::: ::.:.:::.:: .:. ::.:::. :..... : :.
NP_001 EKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERLRS
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB5 EQRFLKWRLEQLQG---PQEMERIRMDSIGST-ISSDRSDSEREEIEVDVESTEFSHGEV
.:. :. .::::.: : ::.: ::. :. .::.::::..
NP_001 KQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQVLPNENGGTPNHRPTGR
130 140 150 160 170 180
160 170 180 190
pF1KB5 DNISTTSISDIDDHSSLPSIGSDEGYSSASVKLSFTS
NP_001 GNNISSHH
190
>>NP_064706 (OMIM: 603039) max-binding protein MNT [Homo (582 aa)
initn: 120 init1: 120 opt: 217 Z-score: 202.1 bits: 45.8 E(85289): 0.00016
Smith-Waterman score: 217; 36.0% identity (59.6% similar) in 161 aa overlap (2-158:192-339)
10 20
pF1KB5 MPSPRLQHSK--PPRRL-SRAQKHSSGSSNT
: : : : : ... : ::. :. .:
NP_064 SPKPLQPLPTPVLTIAPHPGVQPQLAPQQPPPPTLGTLKLAPAEEVKSSEQKKRPGGIGT
170 180 190 200 210 220
30 40 50 60 70 80
pF1KB5 STANRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAER
: .::.:::::::::. :.: :: :: . : . ..:..: : .:..:.. :.
NP_064 ----REVHNKLEKNRRAHLKECFETLKRNIP-NVDDKKTSNLSVLRTALRYIQSLKRKEK
230 240 250 260 270
90 100 110 120 130 140
pF1KB5 KSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVEST
. .:..: : ::. . :: .:. .:. . :: .. :: . . : : ::
NP_064 EYEHEMERLAREKIATQQRLAELK--HELSQW-MD----VLEIDRVLRQTGQPEDDQAST
280 290 300 310 320
150 160 170 180 190
pF1KB5 EF-SHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSASVKLSFTS
:.:: :::
NP_064 STASEGE-DNIDEDMEEDRAGLGPPKLSHRPQPELLKSTLPPPSTTPAPLPPHPHPHPHS
330 340 350 360 370 380
>>XP_011522170 (OMIM: 603039) PREDICTED: max-binding pro (590 aa)
initn: 146 init1: 120 opt: 217 Z-score: 202.0 bits: 45.8 E(85289): 0.00016
Smith-Waterman score: 217; 36.0% identity (59.6% similar) in 161 aa overlap (2-158:200-347)
10 20
pF1KB5 MPSPRLQHSK--PPRRL-SRAQKHSSGSSNT
: : : : : ... : ::. :. .:
XP_011 SPKPLQPLPTPVLTIAPHPGVQPQLAPQQPPPPTLGTLKLAPAEEVKSSEQKKRPGGIGT
170 180 190 200 210 220
30 40 50 60 70 80
pF1KB5 STANRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAER
: .::.:::::::::. :.: :: :: . : . ..:..: : .:..:.. :.
XP_011 ----REVHNKLEKNRRAHLKECFETLKRNIP-NVDDKKTSNLSVLRTALRYIQSLKRKEK
230 240 250 260 270 280
90 100 110 120 130 140
pF1KB5 KSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVEST
. .:..: : ::. . :: .:. .:. . :: .. :: . . : : ::
XP_011 EYEHEMERLAREKIATQQRLAELK--HELSQW-MD----VLEIDRVLRQTGQPEDDQAST
290 300 310 320 330
150 160 170 180 190
pF1KB5 EF-SHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSASVKLSFTS
:.:: :::
XP_011 STASEGE-DNIDEDMEEDRAGLGPPKLSHRPQPELLKSTLPPPSTTPAPLPPHPHPHPHS
340 350 360 370 380 390
192 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 20:27:03 2016 done: Fri Nov 4 20:27:04 2016
Total Scan time: 6.350 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]