Result of FASTA (omim) for
pFN21AB5019
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5019, 505 aa
1>>>pF1KB5019 505 - 505 aa - 505 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5742+/-0.000393; mu= 16.8718+/- 0.025
mean_var=76.0123+/-14.463, 0's: 0 Z-trim(112.1): 43 B-trim: 42 in 1/54
Lambda= 0.147107
statistics sampled from 20886 (20929) to 20886 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.608), E-opt: 0.2 (0.245), width: 16
Scan time: 8.140
The best scores are: opt bits E(85289)
NP_005304 (OMIM: 602046) protein disulfide-isomera ( 505) 3347 720.2 3.4e-207
NP_006840 (OMIM: 608012) protein disulfide-isomera ( 525) 722 163.1 1.8e-39
NP_000909 (OMIM: 112240,176790) protein disulfide- ( 508) 643 146.3 1.9e-34
NP_001269635 (OMIM: 611099) protein disulfide-isom ( 445) 312 76.1 2.4e-13
NP_001269634 (OMIM: 611099) protein disulfide-isom ( 488) 312 76.1 2.6e-13
NP_001269633 (OMIM: 611099) protein disulfide-isom ( 492) 312 76.1 2.6e-13
XP_011508610 (OMIM: 611099) PREDICTED: protein dis ( 402) 310 75.6 3e-13
NP_005733 (OMIM: 611099) protein disulfide-isomera ( 440) 310 75.6 3.2e-13
NP_001269636 (OMIM: 611099) protein disulfide-isom ( 437) 308 75.2 4.3e-13
XP_011524337 (OMIM: 616102) PREDICTED: protein dis ( 229) 297 72.7 1.3e-12
XP_011524336 (OMIM: 616102) PREDICTED: protein dis ( 231) 297 72.7 1.3e-12
NP_061895 (OMIM: 616102) protein disulfide-isomera ( 454) 299 73.3 1.7e-12
NP_110437 (OMIM: 616412) thioredoxin domain-contai ( 432) 281 69.5 2.3e-11
NP_006801 (OMIM: 616942) protein disulfide-isomera ( 519) 257 64.4 9e-10
NP_055866 (OMIM: 609170) endoplasmic reticulum res ( 406) 254 63.7 1.1e-09
NP_001258510 (OMIM: 607987) dnaJ homolog subfamily ( 747) 230 58.8 6.5e-08
NP_061854 (OMIM: 607987) dnaJ homolog subfamily C ( 793) 230 58.8 6.8e-08
NP_110382 (OMIM: 610527) thioredoxin-related trans ( 280) 214 55.1 3e-07
XP_006724289 (OMIM: 609063,616811) PREDICTED: thio ( 166) 204 52.9 8.6e-07
NP_036605 (OMIM: 609063,616811) thioredoxin, mitoc ( 166) 204 52.9 8.6e-07
XP_005261565 (OMIM: 609063,616811) PREDICTED: thio ( 197) 204 52.9 9.9e-07
NP_001004128 (OMIM: 603120) sulfhydryl oxidase 1 i ( 604) 209 54.3 1.2e-06
NP_002817 (OMIM: 603120) sulfhydryl oxidase 1 isof ( 747) 209 54.3 1.4e-06
NP_001139021 (OMIM: 616412) thioredoxin domain-con ( 324) 182 48.4 3.8e-05
NP_859052 (OMIM: 612860) sulfhydryl oxidase 2 prec ( 698) 179 47.9 0.00011
NP_003320 (OMIM: 187700) thioredoxin isoform 1 [Ho ( 105) 155 42.4 0.0008
>>NP_005304 (OMIM: 602046) protein disulfide-isomerase A (505 aa)
initn: 3347 init1: 3347 opt: 3347 Z-score: 3840.8 bits: 720.2 E(85289): 3.4e-207
Smith-Waterman score: 3347; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505)
10 20 30 40 50 60
pF1KB5 MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 KRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 ADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 NYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 FGICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FGICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 VASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 EKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYL
430 440 450 460 470 480
490 500
pF1KB5 QREATNPPVIQEEKPKKKKKAQEDL
:::::::::::::::::::::::::
NP_005 QREATNPPVIQEEKPKKKKKAQEDL
490 500
>>NP_006840 (OMIM: 608012) protein disulfide-isomerase A (525 aa)
initn: 643 init1: 244 opt: 722 Z-score: 829.7 bits: 163.1 E(85289): 1.8e-39
Smith-Waterman score: 722; 30.1% identity (61.7% similar) in 465 aa overlap (48-501:62-508)
20 30 40 50 60 70
pF1KB5 AARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKG-
.::::.:::::::. ::::: ::. : .
NP_006 EPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAE
40 50 60 70 80 90
80 90 100 110 120 130
pF1KB5 --IVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGA--YDGPRTADGIVSHLKKQA
.: ::::: :. . ...::. :::::.::.:... : ::: :.::. :....
NP_006 SMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRV
100 110 120 130 140 150
140 150 160 170 180 190
pF1KB5 GPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESL
::... :. : . .:. .: ..:::.: .: . :: :.. : . :. :. :
NP_006 GPSAMRLEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDALD-MTFGLTDRPRL
160 170 180 190 200 210
200 210 220 230 240
pF1KB5 VNEYDDNGEGIILFRPSHLTNKFEDKTVAYT---EQKMTSGKIKKF-IQENIFGICPHMT
... . . ..::. ::.. . . : . : ...: . ... . .
NP_006 FQQFGLTKDTVVLFK------KFDEGRADFPVDEELGLDLGDLSRFLVTHSMRLVTEFNS
220 230 240 250 260
250 260 270 280 290 300
pF1KB5 EDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFS
. . .. .. .. . . ... . .: .: :. : .:
NP_006 QTSAKIFAAR--ILNHLLLFVNQTLAAHRELLAGFGEAAPRF--RGQVLFVVVDVAADNE
270 280 290 300 310 320
310 320 330 340 350 360
pF1KB5 HELSDFGLESTAGE-IPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKS
: :. :::.. :. . .: ..:.: :.. . . .. : . ..:..: :: :
NP_006 HVLQYFGLKAEAAPTLRLVNLETTK--KYAPVDGGPVTAASITAFCHAVLNGQVKPYLLS
330 340 350 360 370
370 380 390 400 410 420
pF1KB5 EPIPESNDG-PVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKD
. :: . : :::..:..::.... .:.:.:...:::::: :::.. : .. :.:: .
NP_006 QEIPPDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDH
380 390 400 410 420 430
430 440 450 460 470 480
pF1KB5 PNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREATN
.:.::..:::::.. . . :.::::. . ::. . .:.. :.: : ..:. :
NP_006 EDIIIAELDATANELDA-FAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFLD----N
440 450 460 470 480 490
490 500
pF1KB5 PPVIQEEKPKKKKKAQEDL
:. :.: .. :
NP_006 GGVLPTEEPPEEPAAPFPEPPANSTMGSKEEL
500 510 520
>>NP_000909 (OMIM: 112240,176790) protein disulfide-isom (508 aa)
initn: 675 init1: 280 opt: 643 Z-score: 739.3 bits: 146.3 E(85289): 1.9e-34
Smith-Waterman score: 853; 34.7% identity (63.5% similar) in 498 aa overlap (3-481:2-471)
10 20 30 40 50 60
pF1KB5 MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHC
::: : .:: :. : . :: : .:: .. . .::::.:::::::
NP_000 MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALA---AHKYLLVEFYAPWCGHC
10 20 30 40 50
70 80 90 100 110
pF1KB5 KRLAPEYEAAATRLKGI---VPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGA--Y
: ::::: :: .::. . ::::: : ... ..::: ::::.:.::.:. :. :
NP_000 KALAPEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEY
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 DGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAA
. : :: ::. :::..:::.. : .... .......::: : :.. ..::.::
NP_000 TAGREADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 SNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKF
. :. :. :. .. ..:. . .:..::. ::.. . : ..:. .. :
NP_000 EAI-DDIPFGITSNSDVFSKYQLDKDGVVLFK------KFDEGRNNF-EGEVTKENLLDF
180 190 200 210 220
240 250 260 270 280
pF1KB5 IQENIFGICPHMTEDNKDLIQGKD-----LLIAYYDV-DYEKNAKGSNY------WRNRV
:..: . . ..::.. : : . ::. .: :: ..: ::. .....
NP_000 IKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDY--DGKLSNFKTAAESFKGKI
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB5 MMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFS
... :.:. : : . : :::.. : :.: . : . : .. :
NP_000 LFI---FIDSDHTDNQRI---------LEFFGLKKE--ECPAVRLITLEEEMTKYKPESE
290 300 310 320 330
350 360 370 380 390 400
pF1KB5 R-DGKALERFLQDYFDGNLKRYLKSEPIPESNDG-PVKVVVAENFDEIVNNENKDVLIEF
. .. . .: . ...:..: .: :. .::. : ::::.:..::.... .:.:.:..::
NP_000 ELTAERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEF
340 350 360 370 380 390
410 420 430 440 450 460
pF1KB5 YAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKK
:::::::::.: : . .::: . ::::::::.:::.: . .:..:::. : ::.
NP_000 YAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEA-VKVHSFPTLKFFPASAD
400 410 420 430 440 450
470 480 490 500
pF1KB5 LNPKKYEGGRELSDFISYLQREATNPPVIQEEKPKKKKKAQEDL
. :.: : :. : ..:.
NP_000 RTVIDYNGERTLDGFKKFLESGGQDGAGDDDDLEDLEEAEEPDMEEDDDQKAVKDEL
460 470 480 490 500
>>NP_001269635 (OMIM: 611099) protein disulfide-isomeras (445 aa)
initn: 423 init1: 249 opt: 312 Z-score: 360.5 bits: 76.1 E(85289): 2.4e-13
Smith-Waterman score: 355; 36.8% identity (64.9% similar) in 174 aa overlap (22-183:162-333)
10 20 30 40 50
pF1KB5 MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVE
.. .::.:::::.:.. . : : . .::
NP_001 ALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLD--SEDVWMVE
140 150 160 170 180
60 70 80 90 100
pF1KB5 FFAPWCGHCKRLAPEYEAAATRLK----GIVPLAKVDCTANTNTCNKYGVSGYPTLKIFR
:.:::::::: : ::. :::...: : : :: :: :.: ..::. :.::.:::.
NP_001 FYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQ
190 200 210 220 230 240
110 120 130 140 150 160
pF1KB5 DGEEAGAYDGPRTADGIVSH----LKKQAGPASV-PLRTEEEFKKFISDKDASIVGFFD-
:: ::: :: . :::. .. .: : . . .:. :. ... .:. .
NP_001 KGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPH
250 260 270 280 290 300
170 180 190 200 210
pF1KB5 --DSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKT
:. . ... .:.. .: :.:.
NP_001 ILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINA
310 320 330 340 350 360
>--
initn: 278 init1: 249 opt: 312 Z-score: 360.5 bits: 76.1 E(85289): 2.4e-13
Smith-Waterman score: 312; 43.2% identity (73.6% similar) in 125 aa overlap (6-125:7-129)
10 20 30 40 50
pF1KB5 MRLRRLALFPGVA---LLLAAARLAAASD-VLELTDDNFESRISDTGSAGLMLVEFFAP
.: ::.. ..::. : ..:: :.::: .::. .. .. : : ::::.::
NP_001 MYPSTTMANAPGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDS--LWLVEFYAP
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 WCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGA-
:::::.::.::.. ::: :: .: .. :: . . ..:::.:.::.::: ....
NP_001 WCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPED
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 YDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKA
:.: ::...::
NP_001 YQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKN
120 130 140 150 160 170
>>NP_001269634 (OMIM: 611099) protein disulfide-isomeras (488 aa)
initn: 423 init1: 249 opt: 312 Z-score: 359.9 bits: 76.1 E(85289): 2.6e-13
Smith-Waterman score: 355; 36.8% identity (64.9% similar) in 174 aa overlap (22-183:205-376)
10 20 30 40 50
pF1KB5 MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVE
.. .::.:::::.:.. . : : . .::
NP_001 ALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLD--SEDVWMVE
180 190 200 210 220 230
60 70 80 90 100
pF1KB5 FFAPWCGHCKRLAPEYEAAATRLK----GIVPLAKVDCTANTNTCNKYGVSGYPTLKIFR
:.:::::::: : ::. :::...: : : :: :: :.: ..::. :.::.:::.
NP_001 FYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQ
240 250 260 270 280 290
110 120 130 140 150 160
pF1KB5 DGEEAGAYDGPRTADGIVSH----LKKQAGPASV-PLRTEEEFKKFISDKDASIVGFFD-
:: ::: :: . :::. .. .: : . . .:. :. ... .:. .
NP_001 KGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPH
300 310 320 330 340 350
170 180 190 200 210
pF1KB5 --DSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKT
:. . ... .:.. .: :.:.
NP_001 ILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINA
360 370 380 390 400 410
>--
initn: 254 init1: 249 opt: 312 Z-score: 359.9 bits: 76.1 E(85289): 2.6e-13
Smith-Waterman score: 312; 43.2% identity (73.6% similar) in 125 aa overlap (6-125:50-172)
10 20 30
pF1KB5 MRLRRLALFPGVA---LLLAAARLAAASD-VLELT
.: ::.. ..::. : ..:: :.:::
NP_001 ILARRSDRGSPTSPAHSLSRKSPIMYPSTTMANAPGLVSCTFFLAVNGLYSSSDDVIELT
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB5 DDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNT
.::. .. .. : : ::::.:::::::.::.::.. ::: :: .: .. :: . .
NP_001 PSNFNREVIQSDS--LWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KB5 CNKYGVSGYPTLKIFRDGEEAGA-YDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFIS
..:::.:.::.::: .... :.: ::...::
NP_001 GGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSG
140 150 160 170 180 190
160 170 180 190 200 210
pF1KB5 DKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSH
NP_001 KQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKE
200 210 220 230 240 250
>>NP_001269633 (OMIM: 611099) protein disulfide-isomeras (492 aa)
initn: 423 init1: 249 opt: 312 Z-score: 359.8 bits: 76.1 E(85289): 2.6e-13
Smith-Waterman score: 355; 36.8% identity (64.9% similar) in 174 aa overlap (22-183:209-380)
10 20 30 40 50
pF1KB5 MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVE
.. .::.:::::.:.. . : : . .::
NP_001 ALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLD--SEDVWMVE
180 190 200 210 220 230
60 70 80 90 100
pF1KB5 FFAPWCGHCKRLAPEYEAAATRLK----GIVPLAKVDCTANTNTCNKYGVSGYPTLKIFR
:.:::::::: : ::. :::...: : : :: :: :.: ..::. :.::.:::.
NP_001 FYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQ
240 250 260 270 280 290
110 120 130 140 150 160
pF1KB5 DGEEAGAYDGPRTADGIVSH----LKKQAGPASV-PLRTEEEFKKFISDKDASIVGFFD-
:: ::: :: . :::. .. .: : . . .:. :. ... .:. .
NP_001 KGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPH
300 310 320 330 340 350
170 180 190 200 210
pF1KB5 --DSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKT
:. . ... .:.. .: :.:.
NP_001 ILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINA
360 370 380 390 400 410
>--
initn: 249 init1: 249 opt: 312 Z-score: 359.8 bits: 76.1 E(85289): 2.6e-13
Smith-Waterman score: 312; 43.2% identity (73.6% similar) in 125 aa overlap (6-125:54-176)
10 20 30
pF1KB5 MRLRRLALFPGVA---LLLAAARLAAASD-VLELT
.: ::.. ..::. : ..:: :.:::
NP_001 NISSDFQPCSPTSPAHSLSRKSPIMYPSTTMANAPGLVSCTFFLAVNGLYSSSDDVIELT
30 40 50 60 70 80
40 50 60 70 80 90
pF1KB5 DDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNT
.::. .. .. : : ::::.:::::::.::.::.. ::: :: .: .. :: . .
NP_001 PSNFNREVIQSDS--LWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSL
90 100 110 120 130 140
100 110 120 130 140 150
pF1KB5 CNKYGVSGYPTLKIFRDGEEAGA-YDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFIS
..:::.:.::.::: .... :.: ::...::
NP_001 GGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSG
150 160 170 180 190 200
160 170 180 190 200 210
pF1KB5 DKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSH
NP_001 KQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKE
210 220 230 240 250 260
>>XP_011508610 (OMIM: 611099) PREDICTED: protein disulfi (402 aa)
initn: 423 init1: 249 opt: 310 Z-score: 358.8 bits: 75.6 E(85289): 3e-13
Smith-Waterman score: 355; 36.8% identity (64.9% similar) in 174 aa overlap (22-183:157-328)
10 20 30 40 50
pF1KB5 MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVE
.. .::.:::::.:.. . : : . .::
XP_011 ALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLD--SEDVWMVE
130 140 150 160 170 180
60 70 80 90 100
pF1KB5 FFAPWCGHCKRLAPEYEAAATRLK----GIVPLAKVDCTANTNTCNKYGVSGYPTLKIFR
:.:::::::: : ::. :::...: : : :: :: :.: ..::. :.::.:::.
XP_011 FYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQ
190 200 210 220 230 240
110 120 130 140 150 160
pF1KB5 DGEEAGAYDGPRTADGIVSH----LKKQAGPASV-PLRTEEEFKKFISDKDASIVGFFD-
:: ::: :: . :::. .. .: : . . .:. :. ... .:. .
XP_011 KGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPH
250 260 270 280 290 300
170 180 190 200 210
pF1KB5 --DSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKT
:. . ... .:.. .: :.:.
XP_011 ILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINA
310 320 330 340 350 360
>--
initn: 258 init1: 249 opt: 310 Z-score: 358.8 bits: 75.6 E(85289): 3e-13
Smith-Waterman score: 310; 41.3% identity (72.2% similar) in 126 aa overlap (1-125:1-124)
10 20 30 40 50 60
pF1KB5 MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHC
: : :.: . .: . . ....::.::: .::. .. .. : : ::::.:::::::
XP_011 MALLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDS--LWLVEFYAPWCGHC
10 20 30 40 50
70 80 90 100 110
pF1KB5 KRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGA-YDGPR
.::.::.. ::: :: .: .. :: . . ..:::.:.::.::: .... :.: :
XP_011 QRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 TADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLR
:...::
XP_011 TGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSE
120 130 140 150 160 170
>>NP_005733 (OMIM: 611099) protein disulfide-isomerase A (440 aa)
initn: 423 init1: 249 opt: 310 Z-score: 358.3 bits: 75.6 E(85289): 3.2e-13
Smith-Waterman score: 355; 36.8% identity (64.9% similar) in 174 aa overlap (22-183:157-328)
10 20 30 40 50
pF1KB5 MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVE
.. .::.:::::.:.. . : : . .::
NP_005 ALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLD--SEDVWMVE
130 140 150 160 170 180
60 70 80 90 100
pF1KB5 FFAPWCGHCKRLAPEYEAAATRLK----GIVPLAKVDCTANTNTCNKYGVSGYPTLKIFR
:.:::::::: : ::. :::...: : : :: :: :.: ..::. :.::.:::.
NP_005 FYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQ
190 200 210 220 230 240
110 120 130 140 150 160
pF1KB5 DGEEAGAYDGPRTADGIVSH----LKKQAGPASV-PLRTEEEFKKFISDKDASIVGFFD-
:: ::: :: . :::. .. .: : . . .:. :. ... .:. .
NP_005 KGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPH
250 260 270 280 290 300
170 180 190 200 210
pF1KB5 --DSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKT
:. . ... .:.. .: :.:.
NP_005 ILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINA
310 320 330 340 350 360
>--
initn: 258 init1: 249 opt: 310 Z-score: 358.3 bits: 75.6 E(85289): 3.2e-13
Smith-Waterman score: 310; 41.3% identity (72.2% similar) in 126 aa overlap (1-125:1-124)
10 20 30 40 50 60
pF1KB5 MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHC
: : :.: . .: . . ....::.::: .::. .. .. : : ::::.:::::::
NP_005 MALLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDS--LWLVEFYAPWCGHC
10 20 30 40 50
70 80 90 100 110
pF1KB5 KRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGA-YDGPR
.::.::.. ::: :: .: .. :: . . ..:::.:.::.::: .... :.: :
NP_005 QRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 TADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLR
:...::
NP_005 TGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSE
120 130 140 150 160 170
>>NP_001269636 (OMIM: 611099) protein disulfide-isomeras (437 aa)
initn: 423 init1: 249 opt: 308 Z-score: 356.0 bits: 75.2 E(85289): 4.3e-13
Smith-Waterman score: 355; 36.8% identity (64.9% similar) in 174 aa overlap (22-183:154-325)
10 20 30 40 50
pF1KB5 MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVE
.. .::.:::::.:.. . : : . .::
NP_001 ALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLD--SEDVWMVE
130 140 150 160 170 180
60 70 80 90 100
pF1KB5 FFAPWCGHCKRLAPEYEAAATRLK----GIVPLAKVDCTANTNTCNKYGVSGYPTLKIFR
:.:::::::: : ::. :::...: : : :: :: :.: ..::. :.::.:::.
NP_001 FYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQ
190 200 210 220 230 240
110 120 130 140 150 160
pF1KB5 DGEEAGAYDGPRTADGIVSH----LKKQAGPASV-PLRTEEEFKKFISDKDASIVGFFD-
:: ::: :: . :::. .. .: : . . .:. :. ... .:. .
NP_001 KGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPH
250 260 270 280 290 300
170 180 190 200 210
pF1KB5 --DSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKT
:. . ... .:.. .: :.:.
NP_001 ILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINA
310 320 330 340 350 360
>--
initn: 278 init1: 249 opt: 308 Z-score: 356.0 bits: 75.2 E(85289): 4.3e-13
Smith-Waterman score: 308; 44.7% identity (75.4% similar) in 114 aa overlap (14-125:10-121)
10 20 30 40 50
pF1KB5 MRLRRLALFPGVALLLAAARLAAASD-VLELTDDNFESRISDTGSAGLMLVEFFAPWCGH
..::. : ..:: :.::: .::. .. .. : : ::::.::::::
NP_001 MILGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDS--LWLVEFYAPWCGH
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 CKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGA-YDGP
:.::.::.. ::: :: .: .. :: . . ..:::.:.::.::: .... :.:
NP_001 CQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 RTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNL
::...::
NP_001 RTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDS
120 130 140 150 160 170
>>XP_011524337 (OMIM: 616102) PREDICTED: protein disulfi (229 aa)
initn: 251 init1: 134 opt: 297 Z-score: 347.5 bits: 72.7 E(85289): 1.3e-12
Smith-Waterman score: 297; 32.4% identity (62.4% similar) in 173 aa overlap (28-196:28-191)
10 20 30 40 50
pF1KB5 MRLRRLALFPGVALLLAAARLAAASDVLELTDDNF-ESRISDTGSAGLMLVEFFAPWCGH
.: :..: :.: .: . ::.:.::::::
XP_011 MAAWKSWTALRLCATVVVLDMVVCKGFVEDLDESFKENRNDD-----IWLVDFYAPWCGH
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 CKRLAPEYEAAATRLKGI---VPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYD
::.: : .. .. ..:.: : ..:.: :. .. ...:: ::::.:... :. : :
XP_011 CKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYSSIASEFGVRGYPTIKLLK-GDLAYNYR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 GPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAAS
:::: : :. .. .: :: ... :... .: . . . : . ... :::
XP_011 GPRTKDDIIEFAHRVSGALIRPLPSQQMFEHM--QKRHRVFFVYVGGESPLKEKYIDAAS
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 NLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFI
.: : . . : .: ::
XP_011 ELI-VYTYFFSASEEVVPEYVTLKEMPAVLVFKDETYFVYDDNNYTLMLSYKRYYLHT
180 190 200 210 220
505 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 22:43:17 2016 done: Fri Nov 4 22:43:18 2016
Total Scan time: 8.140 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]