Result of FASTA (omim) for pFN21AB5307
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5307, 412 aa
  1>>>pF1KB5307 412 - 412 aa - 412 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.9923+/-0.000403; mu= 19.0439+/- 0.025
 mean_var=69.7236+/-14.198, 0's: 0 Z-trim(112.8): 32  B-trim: 403 in 1/50
 Lambda= 0.153598
 statistics sampled from 21851 (21880) to 21851 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.633), E-opt: 0.2 (0.257), width:  16
 Scan time:  8.620

The best scores are:                                      opt bits E(85289)
NP_005872 (OMIM: 614901,614923) [3-methyl-2-oxobut ( 412) 2751 618.9 7.2e-177
XP_016878348 (OMIM: 614901,614923) PREDICTED: 3-me ( 410) 2443 550.6 2.5e-156
NP_001116429 (OMIM: 614901,614923) [3-methyl-2-oxo ( 365) 2442 550.4 2.7e-156
NP_001258855 (OMIM: 614901,614923) [3-methyl-2-oxo ( 335) 1881 426.0 6.6e-119
XP_011509647 (OMIM: 602524) PREDICTED: pyruvate de ( 360)  289 73.3 1.1e-12
NP_002601 (OMIM: 602524) [Pyruvate dehydrogenase ( ( 436)  289 73.3 1.3e-12
NP_002602 (OMIM: 602525) pyruvate dehydrogenase ki ( 407)  288 73.1 1.4e-12
NP_002603 (OMIM: 602527) pyruvate dehydrogenase ki ( 411)  279 71.1 5.7e-12
NP_005382 (OMIM: 300906) pyruvate dehydrogenase ki ( 406)  245 63.6   1e-09
NP_001135858 (OMIM: 300906) pyruvate dehydrogenase ( 415)  245 63.6 1.1e-09
NP_001186827 (OMIM: 602525) pyruvate dehydrogenase ( 343)  233 60.9 5.8e-09
NP_001186828 (OMIM: 602525) pyruvate dehydrogenase ( 343)  233 60.9 5.8e-09
NP_001186829 (OMIM: 602525) pyruvate dehydrogenase ( 199)  207 54.9 2.1e-07
XP_011509645 (OMIM: 602524) PREDICTED: pyruvate de ( 380)  188 50.9 6.3e-06
XP_011509646 (OMIM: 602524) PREDICTED: pyruvate de ( 380)  188 50.9 6.3e-06
XP_011509649 (OMIM: 602524) PREDICTED: pyruvate de ( 380)  188 50.9 6.3e-06
NP_001265478 (OMIM: 602524) [Pyruvate dehydrogenas ( 456)  188 51.0 7.2e-06
XP_006712658 (OMIM: 602524) PREDICTED: pyruvate de ( 244)  158 44.1 0.00045


>>NP_005872 (OMIM: 614901,614923) [3-methyl-2-oxobutanoa  (412 aa)
 initn: 2751 init1: 2751 opt: 2751  Z-score: 3296.4  bits: 618.9 E(85289): 7.2e-177
Smith-Waterman score: 2751; 100.0% identity (100.0% similar) in 412 aa overlap (1-412:1-412)

               10        20        30        40        50        60
pF1KB5 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAID
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 AAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 TIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQS
              310       320       330       340       350       360

              370       380       390       400       410  
pF1KB5 GPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI
              370       380       390       400       410  

>>XP_016878348 (OMIM: 614901,614923) PREDICTED: 3-methyl  (410 aa)
 initn: 2443 init1: 2443 opt: 2443  Z-score: 2927.6  bits: 550.6 E(85289): 2.5e-156
Smith-Waterman score: 2443; 99.7% identity (100.0% similar) in 366 aa overlap (1-366:1-366)

               10        20        30        40        50        60
pF1KB5 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAID
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 AAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 TIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQS
              310       320       330       340       350       360

              370       380       390       400       410  
pF1KB5 GPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI
       :::::.                                              
XP_016 GPMHGLQPQVRTENQELQDCRTLNIQLAGPRGRPQKPIGSCYITDPALKP  
              370       380       390       400       410  

>>NP_001116429 (OMIM: 614901,614923) [3-methyl-2-oxobuta  (365 aa)
 initn: 2442 init1: 2442 opt: 2442  Z-score: 2927.1  bits: 550.4 E(85289): 2.7e-156
Smith-Waterman score: 2442; 100.0% identity (100.0% similar) in 365 aa overlap (1-365:1-365)

               10        20        30        40        50        60
pF1KB5 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAID
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 AAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 TIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQS
              310       320       330       340       350       360

              370       380       390       400       410  
pF1KB5 GPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI
       :::::                                               
NP_001 GPMHG                                               
                                                           

>>NP_001258855 (OMIM: 614901,614923) [3-methyl-2-oxobuta  (335 aa)
 initn: 1881 init1: 1881 opt: 1881  Z-score: 2255.7  bits: 426.0 E(85289): 6.6e-119
Smith-Waterman score: 2181; 91.8% identity (91.8% similar) in 365 aa overlap (1-365:1-335)

               10        20        30        40        50        60
pF1KB5 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAID
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 AAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVI
       ::::::::::::::::::::::::::::::::::::::::::                  
NP_001 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMR------------------
              250       260       270       280                    

              310       320       330       340       350       360
pF1KB5 TIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQS
                   ::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ------------ISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQS
                        290       300       310       320       330

              370       380       390       400       410  
pF1KB5 GPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI
       :::::                                               
NP_001 GPMHG                                               
                                                           

>>XP_011509647 (OMIM: 602524) PREDICTED: pyruvate dehydr  (360 aa)
 initn: 516 init1: 146 opt: 289  Z-score: 348.7  bits: 73.3 E(85289): 1.1e-12
Smith-Waterman score: 552; 32.9% identity (61.2% similar) in 340 aa overlap (93-407:2-322)

             70        80        90       100       110       120  
pF1KB5 AEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTI
                                     .:.::::::.:. .: .  ::  .  .:..
XP_011                              MFLRQELPVRLANIMKEISLLPDNLLRTPSV
                                            10        20        30 

            130       140        150           160       170       
pF1KB5 LHVHELYIRAFQKLTDFPPIKDQ-ADEAQ----YCQLVRQLLDDHKDVVTLLAEGLRESR
         :.  ::...:.: ::   ::. :..:.    . . : .. . :.::.  .:.:. : .
XP_011 QLVQSWYIQSLQELLDF---KDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYK
              40           50        60        70        80        

       180           190       200       210              220      
pF1KB5 KHIEDEKL----VRYFLDKTLTSRLGIRMLATHHLALHEDK----PDF---VGIICTRLS
       . .  . .    :.::::.   ::..:::: ..:  :   :    :.    .: :    .
XP_011 ESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCN
       90       100       110       120       130       140        

        230       240       250       260              270         
pF1KB5 PKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFP-------FIPMPLDYILPELLKN
         ..:.   . :::::.  : :.:..... .. :. :       ..:  : ... ::.::
XP_011 VLEVIKDGYENARRLCDLYYINSPELELE-ELNAKSPGQPIQVVYVPSHLYHMVFELFKN
      150       160       170        180       190       200       

     280       290       300       310       320       330         
pF1KB5 AMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEAS
       ::::::: : .     : . . .. .. :: ...::::::.  . .::...: ..::   
XP_011 AMRATMEHHANRGV-YPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPR-
       210       220        230       240       250       260      

     340       350       360       370       380       390         
pF1KB5 TQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTD--VY
          ::.            ... :. :::.::: :: ::.:. :.:.: ::.: :::  .:
XP_011 ---PRVET----------SRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIY
            270                 280       290       300       310  

       400       410                                   
pF1KB5 LRLRHIDGREESFRI                                 
       ..    :. :                                      
XP_011 IKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA
            320       330       340       350       360

>>NP_002601 (OMIM: 602524) [Pyruvate dehydrogenase (acet  (436 aa)
 initn: 540 init1: 146 opt: 289  Z-score: 347.6  bits: 73.3 E(85289): 1.3e-12
Smith-Waterman score: 552; 32.9% identity (61.2% similar) in 340 aa overlap (93-407:78-398)

             70        80        90       100       110       120  
pF1KB5 AEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTI
                                     .:.::::::.:. .: .  ::  .  .:..
NP_002 FYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSV
        50        60        70        80        90       100       

            130       140        150           160       170       
pF1KB5 LHVHELYIRAFQKLTDFPPIKDQ-ADEAQ----YCQLVRQLLDDHKDVVTLLAEGLRESR
         :.  ::...:.: ::   ::. :..:.    . . : .. . :.::.  .:.:. : .
NP_002 QLVQSWYIQSLQELLDF---KDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYK
       110       120          130       140       150       160    

       180           190       200       210              220      
pF1KB5 KHIEDEKL----VRYFLDKTLTSRLGIRMLATHHLALHEDK----PDF---VGIICTRLS
       . .  . .    :.::::.   ::..:::: ..:  :   :    :.    .: :    .
NP_002 ESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCN
          170       180       190       200       210       220    

        230       240       250       260              270         
pF1KB5 PKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFP-------FIPMPLDYILPELLKN
         ..:.   . :::::.  : :.:..... .. :. :       ..:  : ... ::.::
NP_002 VLEVIKDGYENARRLCDLYYINSPELELE-ELNAKSPGQPIQVVYVPSHLYHMVFELFKN
          230       240       250        260       270       280   

     280       290       300       310       320       330         
pF1KB5 AMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEAS
       ::::::: : .     : . . .. .. :: ...::::::.  . .::...: ..::   
NP_002 AMRATMEHHANRGV-YPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPR-
           290        300       310       320       330       340  

     340       350       360       370       380       390         
pF1KB5 TQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTD--VY
          ::.            ... :. :::.::: :: ::.:. :.:.: ::.: :::  .:
NP_002 ---PRVET----------SRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIY
                          350       360       370       380        

       400       410                                   
pF1KB5 LRLRHIDGREESFRI                                 
       ..    :. :                                      
NP_002 IKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA
      390       400       410       420       430      

>>NP_002602 (OMIM: 602525) pyruvate dehydrogenase kinase  (407 aa)
 initn: 448 init1: 149 opt: 288  Z-score: 346.8  bits: 73.1 E(85289): 1.4e-12
Smith-Waterman score: 565; 32.8% identity (60.7% similar) in 338 aa overlap (90-407:49-369)

      60        70        80        90       100       110         
pF1KB5 DAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCN
                                     :  .:.::::::.:. .: .  ::  .  .
NP_002 YIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLST
       20        30        40        50        60        70        

     120       130       140       150          160       170      
pF1KB5 PTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLL---DDHKDVVTLLAEGLRES
       :..  :.  :....  . .:   ::  :.    :..  :.   . :.:::  .:.:. : 
NP_002 PSVQLVQSWYVQSLLDIMEFLD-KDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEY
       80        90       100        110       120       130       

        180           190       200       210            220       
pF1KB5 RKHIEDEKL----VRYFLDKTLTSRLGIRMLATHHLALHEDK-----PDFVGIICTRLSP
       .    :. .    ..::::.   ::..:::: ..:  . . .     :  .: :    . 
NP_002 KDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNV
       140       150       160       170       180       190       

       230       240       250       260             270       280 
pF1KB5 KKIIEKWVDFARRLCEHKYGNAPRVRINGHVAA--RFP----FIPMPLDYILPELLKNAM
       .....   :.:. ::.. :  .: ..:.   ::  . :    ..:  : ..: ::.::::
NP_002 SEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAM
       200       210       220       230       240       250       

             290       300       310       320       330       340 
pF1KB5 RATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQ
       :::.::: ..   .: . . .: .. :: :..::::::.  . ..:...: ..::     
NP_002 RATVESH-ESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTA-----
       260        270       280       290       300       310      

             350       360       370       380       390           
pF1KB5 DPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTD--VYLR
        :  .:         :. . :. :::.::: :: ::.:. :.::: :..:.:::  .::.
NP_002 -PTPQP---------GTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK
                       320       330       340       350       360 

     400       410                                   
pF1KB5 LRHIDGREESFRI                                 
           :. :                                      
NP_002 ALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
             370       380       390       400       

>>NP_002603 (OMIM: 602527) pyruvate dehydrogenase kinase  (411 aa)
 initn: 462 init1: 144 opt: 279  Z-score: 335.9  bits: 71.1 E(85289): 5.7e-12
Smith-Waterman score: 534; 31.1% identity (63.4% similar) in 328 aa overlap (93-401:56-365)

             70        80        90       100       110       120  
pF1KB5 AEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTI
                                     .:.::::::.:. .: .  ::  .  . ..
NP_002 HFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPTQLVNTSSV
          30        40        50        60        70        80     

            130          140       150       160       170         
pF1KB5 LHVHELYIRAFQKLTDF---PPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKH
         :.  ::.... :..:    :  ::   ... . . .. . :..::  .:.:. : .  
NP_002 QLVKSWYIQSLMDLVEFHEKSP-DDQKALSDFVDTLIKVRNRHHNVVPTMAQGIIEYKDA
          90       100        110       120       130       140    

          180       190       200       210           220       230
pF1KB5 -----IEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDK----PDFVGIICTRLSPKKI
            . ...: .::::.   .:.. ::: ..:. .  :.    :. .: :    .   .
NP_002 CTVDPVTNQNL-QYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSHIGSIDPNCDVVAV
          150        160       170       180       190       200   

              240       250       260              270       280   
pF1KB5 IEKWVDFARRLCEHKYGNAPRVRINGHVAARFP-------FIPMPLDYILPELLKNAMRA
       ..   . .: ::.. : ..:..... .: ..::       ..:  : ..: ::.::::::
NP_002 VQDAFECSRMLCDQYYLSSPELKLT-QVNGKFPDQPIHIVYVPSHLHHMLFELFKNAMRA
           210       220        230       240       250       260  

           290       300       310       320       330       340   
pF1KB5 TMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDP
       :.: . . :  .:  ::.. ... :: :.:::::::.  . .::...: ..:: . ..: 
NP_002 TVEHQENQPSLTPIEVIVVLGKE-DLTIKISDRGGGVPLRIIDRLFSYTYSTAPTPVMD-
            270       280        290       300       310       320 

           350       360       370       380       390       400   
pF1KB5 RISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHI
                    .....:. :::.::: :: ::.:. :.:.: ::.: :::. . :.  
NP_002 -------------NSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKAL
                           330       340       350       360       

           410                                     
pF1KB5 DGREESFRI                                   
                                                   
NP_002 SSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM
       370       380       390       400       410 

>>NP_005382 (OMIM: 300906) pyruvate dehydrogenase kinase  (406 aa)
 initn: 449 init1: 170 opt: 245  Z-score: 295.3  bits: 63.6 E(85289): 1e-09
Smith-Waterman score: 524; 29.2% identity (60.2% similar) in 359 aa overlap (70-410:27-366)

      40        50        60        70        80        90         
pF1KB5 VEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELP
                                     :.  ..:  ::  :..    :  .:..:::
NP_005     MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGR--DNACEKTSYMFLRKELP
                   10        20        30          40        50    

     100       110       120       130       140         150       
pF1KB5 VRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEA--QYCQLVRQ
       ::.:. ..    ::  .   :..  :.  :...: .: ..   . .  ..  .. :.. .
NP_005 VRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIK
           60        70        80        90       100       110    

       160       170       180           190       200       210   
pF1KB5 LLDDHKDVVTLLAEGLRESRKHIEDEKLV----RYFLDKTLTSRLGIRMLATHHLAL---
       . . :.:::  .:.:. : ....  . ..    .::::.  :.:...::: ..:  :   
NP_005 VRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGG
          120       130       140       150       160       170    

                220       230       240       250       260        
pF1KB5 --HEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFP-----
         .  .:  .: :    .   ...   . :. :::. :  ::..... .  :. :     
NP_005 DTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVE-EFNAKAPDKPIQ
          180       190       200       210       220        230   

             270       280       290       300       310       320 
pF1KB5 --FIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIA
         ..:  : ..: ::.::.::::.: . :   . : :   .. .  :: :.::: :::. 
NP_005 VVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVP
           240       250       260       270       280       290   

             330       340       350       360       370       380 
pF1KB5 HKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLG
        . .::...: ..::   . .:              ....:. :::.::: :: ::.:. 
NP_005 LRKIDRLFNYMYSTAPRPSLEP--------------TRAAPLAGFGYGLPISRLYARYFQ
           300       310                     320       330         

             390       400       410                               
pF1KB5 GSLQLQSLQGIGTDVYLRLRHIDGREESFRI                             
       :.:.: :..:.:::. . :. ...  :::                               
NP_005 GDLKLYSMEGVGTDAVIYLKALSS--ESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPR
     340       350       360         370       380       390       

>>NP_001135858 (OMIM: 300906) pyruvate dehydrogenase kin  (415 aa)
 initn: 449 init1: 170 opt: 245  Z-score: 295.2  bits: 63.6 E(85289): 1.1e-09
Smith-Waterman score: 524; 29.2% identity (60.2% similar) in 359 aa overlap (70-410:27-366)

      40        50        60        70        80        90         
pF1KB5 VEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELP
                                     :.  ..:  ::  :..    :  .:..:::
NP_001     MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGR--DNACEKTSYMFLRKELP
                   10        20        30          40        50    

     100       110       120       130       140         150       
pF1KB5 VRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEA--QYCQLVRQ
       ::.:. ..    ::  .   :..  :.  :...: .: ..   . .  ..  .. :.. .
NP_001 VRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIK
           60        70        80        90       100       110    

       160       170       180           190       200       210   
pF1KB5 LLDDHKDVVTLLAEGLRESRKHIEDEKLV----RYFLDKTLTSRLGIRMLATHHLAL---
       . . :.:::  .:.:. : ....  . ..    .::::.  :.:...::: ..:  :   
NP_001 VRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGG
          120       130       140       150       160       170    

                220       230       240       250       260        
pF1KB5 --HEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFP-----
         .  .:  .: :    .   ...   . :. :::. :  ::..... .  :. :     
NP_001 DTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVE-EFNAKAPDKPIQ
          180       190       200       210       220        230   

             270       280       290       300       310       320 
pF1KB5 --FIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIA
         ..:  : ..: ::.::.::::.: . :   . : :   .. .  :: :.::: :::. 
NP_001 VVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVP
           240       250       260       270       280       290   

             330       340       350       360       370       380 
pF1KB5 HKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLG
        . .::...: ..::   . .:              ....:. :::.::: :: ::.:. 
NP_001 LRKIDRLFNYMYSTAPRPSLEP--------------TRAAPLAGFGYGLPISRLYARYFQ
           300       310                     320       330         

             390       400       410                               
pF1KB5 GSLQLQSLQGIGTDVYLRLRHIDGREESFRI                             
       :.:.: :..:.:::. . :. ...  :::                               
NP_001 GDLKLYSMEGVGTDAVIYLKALSS--ESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPR
     340       350       360         370       380       390       




412 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 12:27:41 2016 done: Sat Nov  5 12:27:42 2016
 Total Scan time:  8.620 Total Display time:  0.050

Function used was FASTA [36.3.4 Apr, 2011]
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