FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1386, 205 aa 1>>>pF1KE1386 205 - 205 aa - 205 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8889+/-0.000309; mu= 11.3724+/- 0.019 mean_var=80.8835+/-16.058, 0's: 0 Z-trim(118.1): 35 B-trim: 36 in 1/53 Lambda= 0.142608 statistics sampled from 30689 (30724) to 30689 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.36), width: 16 Scan time: 6.460 The best scores are: opt bits E(85289) XP_011512920 (OMIM: 153440,607507,608446,610988) P ( 205) 1356 287.9 7.9e-78 NP_000586 (OMIM: 153440,607507,608446,610988) lymp ( 205) 1356 287.9 7.9e-78 XP_011512918 (OMIM: 153440,607507,608446,610988) P ( 205) 1356 287.9 7.9e-78 NP_001153212 (OMIM: 153440,607507,608446,610988) l ( 205) 1356 287.9 7.9e-78 XP_011512917 (OMIM: 153440,607507,608446,610988) P ( 205) 1356 287.9 7.9e-78 XP_011512919 (OMIM: 153440,607507,608446,610988) P ( 205) 1356 287.9 7.9e-78 NP_000585 (OMIM: 157300,191160,600807,611162) tumo ( 233) 305 71.7 1.1e-12 NP_000630 (OMIM: 134638,211980,601859) tumor necro ( 281) 244 59.1 7.7e-09 NP_005109 (OMIM: 604052) tumor necrosis factor lig ( 251) 226 55.4 9.1e-08 NP_001191273 (OMIM: 604052) tumor necrosis factor ( 192) 215 53.1 3.5e-07 NP_002332 (OMIM: 600978) lymphotoxin-beta isoform ( 244) 189 47.8 1.7e-05 NP_003798 (OMIM: 604520) tumor necrosis factor lig ( 240) 170 43.9 0.00026 XP_016882906 (OMIM: 604520) PREDICTED: tumor necro ( 240) 170 43.9 0.00026 NP_742011 (OMIM: 604520) tumor necrosis factor lig ( 204) 166 43.0 0.0004 NP_003801 (OMIM: 603598) tumor necrosis factor lig ( 281) 157 41.2 0.0019 >>XP_011512920 (OMIM: 153440,607507,608446,610988) PREDI (205 aa) initn: 1356 init1: 1356 opt: 1356 Z-score: 1518.2 bits: 287.9 E(85289): 7.9e-78 Smith-Waterman score: 1356; 99.5% identity (99.5% similar) in 205 aa overlap (1-205:1-205) 10 20 30 40 50 60 pF1KE1 MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ 130 140 150 160 170 180 190 200 pF1KE1 LSTHTDGIPHLVLSPSTVFFGAFAL ::::::::::::::::::::::::: XP_011 LSTHTDGIPHLVLSPSTVFFGAFAL 190 200 >>NP_000586 (OMIM: 153440,607507,608446,610988) lymphoto (205 aa) initn: 1356 init1: 1356 opt: 1356 Z-score: 1518.2 bits: 287.9 E(85289): 7.9e-78 Smith-Waterman score: 1356; 99.5% identity (99.5% similar) in 205 aa overlap (1-205:1-205) 10 20 30 40 50 60 pF1KE1 MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ 130 140 150 160 170 180 190 200 pF1KE1 LSTHTDGIPHLVLSPSTVFFGAFAL ::::::::::::::::::::::::: NP_000 LSTHTDGIPHLVLSPSTVFFGAFAL 190 200 >>XP_011512918 (OMIM: 153440,607507,608446,610988) PREDI (205 aa) initn: 1356 init1: 1356 opt: 1356 Z-score: 1518.2 bits: 287.9 E(85289): 7.9e-78 Smith-Waterman score: 1356; 99.5% identity (99.5% similar) in 205 aa overlap (1-205:1-205) 10 20 30 40 50 60 pF1KE1 MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ 130 140 150 160 170 180 190 200 pF1KE1 LSTHTDGIPHLVLSPSTVFFGAFAL ::::::::::::::::::::::::: XP_011 LSTHTDGIPHLVLSPSTVFFGAFAL 190 200 >>NP_001153212 (OMIM: 153440,607507,608446,610988) lymph (205 aa) initn: 1356 init1: 1356 opt: 1356 Z-score: 1518.2 bits: 287.9 E(85289): 7.9e-78 Smith-Waterman score: 1356; 99.5% identity (99.5% similar) in 205 aa overlap (1-205:1-205) 10 20 30 40 50 60 pF1KE1 MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ 130 140 150 160 170 180 190 200 pF1KE1 LSTHTDGIPHLVLSPSTVFFGAFAL ::::::::::::::::::::::::: NP_001 LSTHTDGIPHLVLSPSTVFFGAFAL 190 200 >>XP_011512917 (OMIM: 153440,607507,608446,610988) PREDI (205 aa) initn: 1356 init1: 1356 opt: 1356 Z-score: 1518.2 bits: 287.9 E(85289): 7.9e-78 Smith-Waterman score: 1356; 99.5% identity (99.5% similar) in 205 aa overlap (1-205:1-205) 10 20 30 40 50 60 pF1KE1 MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ 130 140 150 160 170 180 190 200 pF1KE1 LSTHTDGIPHLVLSPSTVFFGAFAL ::::::::::::::::::::::::: XP_011 LSTHTDGIPHLVLSPSTVFFGAFAL 190 200 >>XP_011512919 (OMIM: 153440,607507,608446,610988) PREDI (205 aa) initn: 1356 init1: 1356 opt: 1356 Z-score: 1518.2 bits: 287.9 E(85289): 7.9e-78 Smith-Waterman score: 1356; 99.5% identity (99.5% similar) in 205 aa overlap (1-205:1-205) 10 20 30 40 50 60 pF1KE1 MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQ 130 140 150 160 170 180 190 200 pF1KE1 LSTHTDGIPHLVLSPSTVFFGAFAL ::::::::::::::::::::::::: XP_011 LSTHTDGIPHLVLSPSTVFFGAFAL 190 200 >>NP_000585 (OMIM: 157300,191160,600807,611162) tumor ne (233 aa) initn: 288 init1: 178 opt: 305 Z-score: 348.8 bits: 71.7 E(85289): 1.1e-12 Smith-Waterman score: 305; 32.4% identity (62.8% similar) in 207 aa overlap (8-205:38-233) 10 20 30 pF1KE1 MTPPERLFLPRVRGTTLHLLL-LGLLLVLLPGAQGLP :: . .::: :: .: :. : . .: NP_000 RDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFG---VIGPQREEFP 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 -GVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLS ..: ::..:. . . ::.::....:. ...: : :.: .: : NP_000 RDLSLISPLAQAVRSSSRT----PSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE1 NNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSS---- .:.:.::. :.:..::::.:.:.. : :. . :.: .. .. .: .: :::. NP_000 DNQLVVPSEGLYLIYSQVLFKGQG-CP---STHVLLTHTISRIAVSYQTKVNLLSAIKSP 130 140 150 160 170 160 170 180 190 200 pF1KE1 -QKMVYPGLQ-EPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPS-TVFFGAFAL :. . : . .:: . .: :..::: .::.::.. . .: .. : :.:: .:: NP_000 CQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL 180 190 200 210 220 230 >>NP_000630 (OMIM: 134638,211980,601859) tumor necrosis (281 aa) initn: 217 init1: 121 opt: 244 Z-score: 279.7 bits: 59.1 E(85289): 7.7e-09 Smith-Waterman score: 244; 29.5% identity (61.4% similar) in 166 aa overlap (43-205:123-281) 20 30 40 50 60 70 pF1KE1 RGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQ--HPKMHLAHSTLKPAAHLIGD .:.. .: ::. .. :. .::: : NP_000 ALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEKKELRKVAHLTGK 100 110 120 130 140 150 80 90 100 110 120 pF1KE1 P-SKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPL :.. : :. .: : .: . ....:.. .:.:::::.: : :. . . : NP_000 SNSRSMPLEWE-DTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQ------SCNNL 160 170 180 190 200 130 140 150 160 170 180 pF1KE1 YLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIP :.:.: . .:.:: . .. .. : : . : .: : ::.:.::..:.: .... . NP_000 PLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELS 210 220 230 240 250 260 190 200 pF1KE1 HLVLSPSTVFFGAFAL . . : .::: . : NP_000 LVNFEESQTFFGLYKL 270 280 >>NP_005109 (OMIM: 604052) tumor necrosis factor ligand (251 aa) initn: 228 init1: 122 opt: 226 Z-score: 260.4 bits: 55.4 E(85289): 9.1e-08 Smith-Waterman score: 227; 28.6% identity (53.9% similar) in 217 aa overlap (7-205:42-251) 10 20 30 pF1KE1 MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQ--G ..:: . : : .::. : .: . NP_005 TASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQA 20 30 40 50 60 70 40 50 60 70 80 pF1KE1 LPGVGLTPSAAQTAR------QHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFL : : ..:: :. ..:. ::. :. :. .. .: :. . :: NP_005 LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHF---KNQFPALHWEHELGLAFT 80 90 100 110 120 90 100 110 120 130 pF1KE1 QDGFSLSNNSLLVPTSGIYFVYSQVVFSG---------KAYSPKATSSPLYLAHEVQLFS .. .. .:. ::.: :: ::.::::.: : .: :. .: . .: . NP_005 KNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKV---T 130 140 150 160 170 180 140 150 160 170 180 190 pF1KE1 SQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHL-VLSPSTV ..:: . :: . : : . :.. .: :: :.: .::.: .... : . . . . NP_005 DSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKT 190 200 210 220 230 240 200 pF1KE1 FFGAFAL ::::: : NP_005 FFGAFLL 250 >>NP_001191273 (OMIM: 604052) tumor necrosis factor liga (192 aa) initn: 186 init1: 122 opt: 215 Z-score: 250.0 bits: 53.1 E(85289): 3.5e-07 Smith-Waterman score: 216; 29.9% identity (56.1% similar) in 164 aa overlap (52-205:36-192) 30 40 50 60 70 80 pF1KE1 LGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRA :. ::. :. :. .. .: :. NP_001 GRLHFSHPLSHTKHISPFVTDAPLRADGDKPRAHLTVVRQTPTQHF---KNQFPALHWEH 10 20 30 40 50 60 90 100 110 120 130 pF1KE1 NTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSG---------KAYSPKATSSPLYLA . :: .. .. .:. ::.: :: ::.::::.: : .: :. .: . NP_001 ELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVI 70 80 90 100 110 120 140 150 160 170 180 190 pF1KE1 HEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHL- .: ...:: . :: . : : . :.. .: :: :.: .::.: .... : . NP_001 TKV---TDSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVD 130 140 150 160 170 200 pF1KE1 VLSPSTVFFGAFAL . . .::::: : NP_001 YTKEDKTFFGAFLL 180 190 205 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 22:18:29 2016 done: Sun Nov 6 22:18:30 2016 Total Scan time: 6.460 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]