FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3593, 153 aa 1>>>pF1KE3593 153 - 153 aa - 153 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2974+/-0.000262; mu= 12.5004+/- 0.017 mean_var=70.7032+/-14.301, 0's: 0 Z-trim(121.2): 112 B-trim: 1463 in 2/54 Lambda= 0.152530 statistics sampled from 37254 (37382) to 37254 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.808), E-opt: 0.2 (0.438), width: 16 Scan time: 5.640 The best scores are: opt bits E(85289) NP_004214 (OMIM: 603890) ubiquitin/ISG15-conjugati ( 153) 1057 240.5 7.9e-64 NP_937826 (OMIM: 603890) ubiquitin/ISG15-conjugati ( 87) 592 138.0 3.2e-33 NP_003338 (OMIM: 603721) ubiquitin-conjugating enz ( 154) 594 138.6 3.7e-33 NP_001243284 (OMIM: 603721) ubiquitin-conjugating ( 212) 566 132.6 3.4e-31 NP_001243285 (OMIM: 603721) ubiquitin-conjugating ( 122) 478 113.0 1.5e-25 XP_016884424 (OMIM: 603721) PREDICTED: ubiquitin-c ( 121) 457 108.4 3.6e-24 NP_003329 (OMIM: 602961) ubiquitin-conjugating enz ( 147) 375 90.4 1.1e-18 NP_003330 (OMIM: 602962) ubiquitin-conjugating enz ( 147) 359 86.9 1.3e-17 NP_871621 (OMIM: 602963) ubiquitin-conjugating enz ( 148) 353 85.6 3.3e-17 NP_871618 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 351 85.2 4.5e-17 NP_871620 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 351 85.2 4.5e-17 NP_871617 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 351 85.2 4.5e-17 NP_871619 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 351 85.2 4.5e-17 NP_871615 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 351 85.2 4.5e-17 NP_871616 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 351 85.2 4.5e-17 NP_003331 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 351 85.2 4.5e-17 XP_016865309 (OMIM: 602962) PREDICTED: ubiquitin-c ( 173) 339 82.6 3.2e-16 NP_871622 (OMIM: 602963) ubiquitin-conjugating enz ( 149) 337 82.1 3.8e-16 NP_003327 (OMIM: 300860,312180) ubiquitin-conjugat ( 152) 314 77.0 1.3e-14 NP_054895 (OMIM: 610538,616435) ubiquitin-conjugat ( 197) 315 77.3 1.4e-14 NP_862821 (OMIM: 602962) ubiquitin-conjugating enz ( 118) 312 76.5 1.4e-14 NP_001191809 (OMIM: 602961) ubiquitin-conjugating ( 109) 304 74.7 4.6e-14 XP_016872098 (OMIM: 602961) PREDICTED: ubiquitin-c ( 110) 304 74.7 4.6e-14 XP_016864073 (OMIM: 602963) PREDICTED: ubiquitin-c ( 118) 304 74.7 4.9e-14 NP_001287724 (OMIM: 602963) ubiquitin-conjugating ( 118) 304 74.7 4.9e-14 NP_003328 (OMIM: 179095) ubiquitin-conjugating enz ( 152) 301 74.2 9.4e-14 NP_003339 (OMIM: 603679) ubiquitin-conjugating enz ( 152) 297 73.3 1.7e-13 NP_001189405 (OMIM: 602916) ubiquitin-conjugating ( 160) 293 72.4 3.3e-13 NP_003332 (OMIM: 602916) ubiquitin-conjugating enz ( 193) 293 72.5 3.9e-13 XP_005265489 (OMIM: 602163) PREDICTED: ubiquitin-c ( 201) 283 70.3 1.8e-12 NP_689866 (OMIM: 602163) ubiquitin-conjugating enz ( 201) 283 70.3 1.8e-12 NP_001297255 (OMIM: 610538,616435) ubiquitin-conju ( 167) 279 69.3 2.9e-12 NP_001265484 (OMIM: 604151) ubiquitin-conjugating ( 207) 271 67.6 1.2e-11 NP_001265483 (OMIM: 604151) ubiquitin-conjugating ( 207) 271 67.6 1.2e-11 NP_872619 (OMIM: 604151) ubiquitin-conjugating enz ( 207) 271 67.6 1.2e-11 XP_005246301 (OMIM: 604151) PREDICTED: ubiquitin-c ( 207) 271 67.6 1.2e-11 NP_006348 (OMIM: 604151) ubiquitin-conjugating enz ( 207) 271 67.6 1.2e-11 NP_003960 (OMIM: 603173) NEDD8-conjugating enzyme ( 183) 270 67.4 1.2e-11 XP_005265488 (OMIM: 602916) PREDICTED: ubiquitin-c ( 167) 267 66.7 1.8e-11 NP_001269090 (OMIM: 300860,312180) ubiquitin-conju ( 119) 265 66.2 1.9e-11 XP_005265490 (OMIM: 602163) PREDICTED: ubiquitin-c ( 189) 257 64.5 9.2e-11 NP_872607 (OMIM: 602916) ubiquitin-conjugating enz ( 176) 250 63.0 2.5e-10 NP_003335 (OMIM: 601082) ubiquitin-conjugating enz ( 183) 250 63.0 2.6e-10 NP_005330 (OMIM: 602846) ubiquitin-conjugating enz ( 200) 240 60.8 1.3e-09 NP_919236 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 232 59.0 3.6e-09 XP_016879129 (OMIM: 601661) PREDICTED: SUMO-conjug ( 158) 232 59.0 3.6e-09 NP_003336 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 232 59.0 3.6e-09 NP_919237 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 232 59.0 3.6e-09 NP_919235 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 232 59.0 3.6e-09 NP_861517 (OMIM: 605574) ubiquitin-conjugating enz ( 140) 231 58.7 3.8e-09 >>NP_004214 (OMIM: 603890) ubiquitin/ISG15-conjugating e (153 aa) initn: 1057 init1: 1057 opt: 1057 Z-score: 1266.9 bits: 240.5 E(85289): 7.9e-64 Smith-Waterman score: 1057; 100.0% identity (100.0% similar) in 153 aa overlap (1-153:1-153) 10 20 30 40 50 60 pF1KE3 MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 YPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 YPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREP 70 80 90 100 110 120 130 140 150 pF1KE3 LRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS ::::::::::::::::::::::::::::::::: NP_004 LRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS 130 140 150 >>NP_937826 (OMIM: 603890) ubiquitin/ISG15-conjugating e (87 aa) initn: 592 init1: 592 opt: 592 Z-score: 717.5 bits: 138.0 E(85289): 3.2e-33 Smith-Waterman score: 592; 100.0% identity (100.0% similar) in 87 aa overlap (67-153:1-87) 40 50 60 70 80 90 pF1KE3 ALLLPDQPPYHLKAFNLRISFPPEYPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWK :::::::::::::::::::::::::::::: NP_937 MIKFTTKIYHPNVDENGQICLPIISSENWK 10 20 30 100 110 120 130 140 150 pF1KE3 PCTKTCQVLEALNVLVNRPNIREPLRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_937 PCTKTCQVLEALNVLVNRPNIREPLRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS 40 50 60 70 80 >>NP_003338 (OMIM: 603721) ubiquitin-conjugating enzyme (154 aa) initn: 594 init1: 594 opt: 594 Z-score: 716.3 bits: 138.6 E(85289): 3.7e-33 Smith-Waterman score: 594; 55.3% identity (80.3% similar) in 152 aa overlap (1-152:1-152) 10 20 30 40 50 60 pF1KE3 MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPE : :: :..::::...: .::.. :.::.:.:..:..::.::: :: ..:.:: : NP_003 MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 YPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREP :::::: : : :::::::.::.::.:::.::.::::: ::: ::...: .::: :. ..: NP_003 YPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHP 70 80 90 100 110 120 130 140 150 pF1KE3 LRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS :: :::. ... . : ::::::: ..: :: NP_003 LRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD 130 140 150 >>NP_001243284 (OMIM: 603721) ubiquitin-conjugating enzy (212 aa) initn: 566 init1: 566 opt: 566 Z-score: 680.9 bits: 132.6 E(85289): 3.4e-31 Smith-Waterman score: 566; 54.9% identity (80.6% similar) in 144 aa overlap (9-152:67-210) 10 20 30 pF1KE3 MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHAL .:::...: .::.. :.::.:.:..: NP_001 RQVPSALAGKDLAQLQAGATLAGYRRAHGPEELEEIRKCGMKNFRNIQVDEANLLTWQGL 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE3 LLPDQPPYHLKAFNLRISFPPEYPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPC ..::.::: :: ..:.:: ::::::: : : :::::::.::.::.:::.::.::::: NP_001 IVPDNPPYDKGAFRIEINFPAEYPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPA 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE3 TKTCQVLEALNVLVNRPNIREPLRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS ::: ::...: .::: :. ..::: :::. ... . : ::::::: ..: :: NP_001 TKTDQVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD 160 170 180 190 200 210 >>NP_001243285 (OMIM: 603721) ubiquitin-conjugating enzy (122 aa) initn: 478 init1: 478 opt: 478 Z-score: 579.8 bits: 113.0 E(85289): 1.5e-25 Smith-Waterman score: 478; 58.8% identity (79.8% similar) in 114 aa overlap (39-152:7-120) 10 20 30 40 50 60 pF1KE3 KELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPEYPFKPPMI :. :.::: :: ..:.:: ::::::: : NP_001 MAASRRLMKDNPPYDKGAFRIEINFPAEYPFKPPKI 10 20 30 70 80 90 100 110 120 pF1KE3 KFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREPLRMDLADL : :::::::.::.::.:::.::.::::: ::: ::...: .::: :. ..::: :::. NP_001 TFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEE 40 50 60 70 80 90 130 140 150 pF1KE3 LTQNPELFRKNAEEFTLRFGVDRPS ... . : ::::::: ..: :: NP_001 YSKDRKKFCKNAEEFTKKYGEKRPVD 100 110 120 >>XP_016884424 (OMIM: 603721) PREDICTED: ubiquitin-conju (121 aa) initn: 477 init1: 444 opt: 457 Z-score: 554.8 bits: 108.4 E(85289): 3.6e-24 Smith-Waterman score: 457; 54.9% identity (80.5% similar) in 113 aa overlap (1-113:1-113) 10 20 30 40 50 60 pF1KE3 MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPE : :: :..::::...: .::.. :.::.:.:..:..::.::: :: ..:.:: : XP_016 MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 YPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREP :::::: : : :::::::.::.::.:::.::.::::: ::: : :. .... XP_016 YPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQETSAFPIMASLRSSLEV 70 80 90 100 110 120 130 140 150 pF1KE3 LRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS XP_016 L >>NP_003329 (OMIM: 602961) ubiquitin-conjugating enzyme (147 aa) initn: 326 init1: 268 opt: 375 Z-score: 456.1 bits: 90.4 E(85289): 1.1e-18 Smith-Waterman score: 375; 38.9% identity (65.8% similar) in 149 aa overlap (2-149:1-147) 10 20 30 40 50 pF1KE3 MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLL-PDQPPYHLKAFNLRISFPP :: :. ::: :::. :: . : ... :.: .. : . :. .: : . :: NP_003 MALKRIQKELSDLQRDPPAHCSAGPVGD-DLFHWQATIMGPPDSAYQGGVFFLTVHFPT 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 EYPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIRE .:::::: : :::::::::.. ::.::: :. :. :.: . .:: .. :. :: . NP_003 DYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQ-WSPALTVSKVLLSICSLLCDPNPDD 60 70 80 90 100 110 120 130 140 150 pF1KE3 PLRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS :: :.:.. .. : . ..:.:.: .... NP_003 PLVPDIAQIYKSDKEKYNRHAREWTQKYAM 120 130 140 >>NP_003330 (OMIM: 602962) ubiquitin-conjugating enzyme (147 aa) initn: 324 init1: 270 opt: 359 Z-score: 437.1 bits: 86.9 E(85289): 1.3e-17 Smith-Waterman score: 359; 37.6% identity (63.8% similar) in 149 aa overlap (2-149:1-147) 10 20 30 40 50 pF1KE3 MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLL-PDQPPYHLKAFNLRISFPP :: :. :::.:: . :: : ... :.: .. :.. ::. .: : : :: NP_003 MALKRIHKELNDLARDPPAQCSAGPVGD-DMFHWQATIMGPNDSPYQGGVFFLTIHFPT 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 EYPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIRE .:::::: . :::.:::::.. ::.::: :. :. :.: .:: .. :. :: . NP_003 DYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQ-WSPALTISKVLLSICSLLCDPNPDD 60 70 80 90 100 110 120 130 140 150 pF1KE3 PLRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS :: ..: . . : . . :.:.: .... NP_003 PLVPEIARIYKTDREKYNRIAREWTQKYAM 120 130 140 >>NP_871621 (OMIM: 602963) ubiquitin-conjugating enzyme (148 aa) initn: 324 init1: 270 opt: 353 Z-score: 429.9 bits: 85.6 E(85289): 3.3e-17 Smith-Waterman score: 353; 36.9% identity (63.1% similar) in 149 aa overlap (2-149:1-147) 10 20 30 40 50 pF1KE3 MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLL-PDQPPYHLKAFNLRISFPP :: :. ::: :: . :: : ... :.: .. :.. ::. .: : : :: NP_871 MALKRINKELSDLARDPPAQCSAGPVGD-DMFHWQATIMGPNDSPYQGGVFFLTIHFPT 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 EYPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIRE .:::::: . :::.:::::.. ::.::: :. :. :.: .:: .. :. :: . NP_871 DYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQ-WSPALTISKVLLSICSLLCDPNPDD 60 70 80 90 100 110 120 130 140 150 pF1KE3 PLRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS :: ..: . . . . . :.:.: .... NP_871 PLVPEIARIYKTDRDKYNRLAREWTEKYAML 120 130 140 >>NP_871618 (OMIM: 602963) ubiquitin-conjugating enzyme (147 aa) initn: 324 init1: 270 opt: 351 Z-score: 427.6 bits: 85.2 E(85289): 4.5e-17 Smith-Waterman score: 351; 36.2% identity (63.1% similar) in 149 aa overlap (2-149:1-147) 10 20 30 40 50 pF1KE3 MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLL-PDQPPYHLKAFNLRISFPP :: :. ::: :: . :: : ... :.: .. :.. ::. .: : : :: NP_871 MALKRINKELSDLARDPPAQCSAGPVGD-DMFHWQATIMGPNDSPYQGGVFFLTIHFPT 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 EYPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIRE .:::::: . :::.:::::.. ::.::: :. :. :.: .:: .. :. :: . NP_871 DYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQ-WSPALTISKVLLSICSLLCDPNPDD 60 70 80 90 100 110 120 130 140 150 pF1KE3 PLRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS :: ..: . . . . . ..:.: .... NP_871 PLVPEIARIYKTDRDKYNRISREWTQKYAM 120 130 140 153 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 22:23:15 2016 done: Sun Nov 6 22:23:15 2016 Total Scan time: 5.640 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]