FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2412, 176 aa 1>>>pF1KE2412 176 - 176 aa - 176 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3138+/-0.000267; mu= 10.2342+/- 0.017 mean_var=109.0495+/-22.141, 0's: 0 Z-trim(122.3): 11 B-trim: 363 in 1/60 Lambda= 0.122818 statistics sampled from 40228 (40240) to 40228 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.789), E-opt: 0.2 (0.472), width: 16 Scan time: 6.290 The best scores are: opt bits E(85289) NP_443118 (OMIM: 609684) protein MAL2 [Homo sapien ( 176) 1206 222.9 2.1e-58 XP_011515109 (OMIM: 609684) PREDICTED: protein MAL ( 119) 514 100.2 1.2e-21 NP_002362 (OMIM: 188860) myelin and lymphocyte pro ( 153) 293 61.1 9.2e-10 NP_005425 (OMIM: 602022) MAL-like protein [Homo sa ( 153) 293 61.1 9.2e-10 XP_011510111 (OMIM: 602022) PREDICTED: MAL-like pr ( 149) 240 51.7 6.1e-07 NP_071883 (OMIM: 188860) myelin and lymphocyte pro ( 111) 237 51.1 7e-07 NP_849199 (OMIM: 607891) CKLF-like MARVEL transmem ( 173) 182 41.5 0.00085 NP_057077 (OMIM: 600340) plasmolipin [Homo sapiens ( 182) 177 40.6 0.0016 >>NP_443118 (OMIM: 609684) protein MAL2 [Homo sapiens] (176 aa) initn: 1206 init1: 1206 opt: 1206 Z-score: 1169.7 bits: 222.9 E(85289): 2.1e-58 Smith-Waterman score: 1206; 100.0% identity (100.0% similar) in 176 aa overlap (1-176:1-176) 10 20 30 40 50 60 pF1KE2 MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEILFGGLVWILVASSNVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEILFGGLVWILVASSNVP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 LPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 LPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLE 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 AAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 AAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP 130 140 150 160 170 >>XP_011515109 (OMIM: 609684) PREDICTED: protein MAL2 is (119 aa) initn: 536 init1: 514 opt: 514 Z-score: 509.4 bits: 100.2 E(85289): 1.2e-21 Smith-Waterman score: 699; 67.6% identity (67.6% similar) in 176 aa overlap (1-176:1-119) 10 20 30 40 50 60 pF1KE2 MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEILFGGLVWILVASSNVP :::::::::::::::::::::::::::::::::::::::::::: XP_011 MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEI---------------- 10 20 30 40 70 80 90 100 110 120 pF1KE2 LPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLE ::::::::::::::::::: XP_011 -----------------------------------------DFAYHFTVFVFYFGAFLLE 50 60 130 140 150 160 170 pF1KE2 AAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP 70 80 90 100 110 >>NP_002362 (OMIM: 188860) myelin and lymphocyte protein (153 aa) initn: 342 init1: 210 opt: 293 Z-score: 296.2 bits: 61.1 E(85289): 9.2e-10 Smith-Waterman score: 338; 40.1% identity (64.5% similar) in 152 aa overlap (24-175:11-151) 10 20 30 40 50 60 pF1KE2 MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEILFGGLVWILVASSNVP :::.: ... : . .:..:::::::::::: :: NP_002 MAPAAATGGSTLPSGFSVFTTLPDLLFIFEFIFGGLVWILVASSLVP 10 20 30 40 70 80 90 100 110 120 pF1KE2 LPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLE ::.::::::::: : . .. ... : . ...: :: ::: :. .::..: .:: NP_002 WPLVQGWVMFVSVFCFVATTTLIILYIIGAHGG-ETSWVTLDAAYHCTAALFYLSASVLE 50 60 70 80 90 100 130 140 150 160 170 pF1KE2 AAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP : :: :: : .. .:. :.:: .:....: : ..: ::. NP_002 ALAT----------ITMQDGFTYRHYHENIAAVVFSYIATLLYVVHAVFSLIRWKSS 110 120 130 140 150 >>NP_005425 (OMIM: 602022) MAL-like protein [Homo sapien (153 aa) initn: 262 init1: 197 opt: 293 Z-score: 296.2 bits: 61.1 E(85289): 9.2e-10 Smith-Waterman score: 337; 40.5% identity (66.0% similar) in 153 aa overlap (11-163:4-143) 10 20 30 40 50 60 pF1KE2 MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEILFGGLVWILVASSNVP : ::.:. : : :.: .. : :: :..:: ::: .::.... NP_005 MASPDPPATSYAPSDV--PSGVALFLTIPFAFFLPELIFGFLVWTMVAATHIV 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 LPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLE ::::::::.::.:.:..::.:: .: :. .... : :: :: :. ..:..: .:. NP_005 YPLLQGWVMYVSLTSFLISLMFLLSYLFGFYKRFES-WRVLDSLYHGTTGILYMSAAVLQ 60 70 80 90 100 110 130 140 150 160 170 pF1KE2 AAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP . :: :... ::. : :: :::.:::..: : NP_005 VHAT----------IVSEKLLDPRIYYINSAASFFAFIATLLYILHAFSIYYH 120 130 140 150 >>XP_011510111 (OMIM: 602022) PREDICTED: MAL-like protei (149 aa) initn: 250 init1: 185 opt: 240 Z-score: 245.6 bits: 51.7 E(85289): 6.1e-07 Smith-Waterman score: 284; 41.7% identity (70.0% similar) in 120 aa overlap (44-163:31-139) 20 30 40 50 60 70 pF1KE2 PAVSFPPPRVTLPAGPDILRTYSGAFVCLEILFGGLVWILVASSNVPLPLLQGWVMFVSV ..:: ::: .::.... ::::::::.::. XP_011 MEKLTEDSRKKKKGAGIFGKETRIQNTTKLLIFGFLVWTMVAATHIVYPLLQGWVMYVSL 10 20 30 40 50 60 80 90 100 110 120 130 pF1KE2 TAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLEAAATSLHDLHCNT :.:..::.:: .: :. .... : :: :: :. ..:..: .:.. : XP_011 TSFLISLMFLLSYLFGFYKRFES-WRVLDSLYHGTTGILYMSAAVLQVHA---------- 70 80 90 100 140 150 160 170 pF1KE2 TITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP ::... ::. : :: :::.:::..: : XP_011 TIVSEKLLDPRIYYINSAASFFAFIATLLYILHAFSIYYH 110 120 130 140 >>NP_071883 (OMIM: 188860) myelin and lymphocyte protein (111 aa) initn: 233 init1: 210 opt: 237 Z-score: 244.5 bits: 51.1 E(85289): 7e-07 Smith-Waterman score: 237; 41.7% identity (66.7% similar) in 96 aa overlap (24-119:11-105) 10 20 30 40 50 60 pF1KE2 MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEILFGGLVWILVASSNVP :::.: ... : . .:..:::::::::::: :: NP_071 MAPAAATGGSTLPSGFSVFTTLPDLLFIFEFIFGGLVWILVASSLVP 10 20 30 40 70 80 90 100 110 120 pF1KE2 LPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLE ::.::::::::: : . .. ... : . ...: : :.: :.. ..: : NP_071 WPLVQGWVMFVSVFCFVATTTLIILYIIGAHGG-ETSWVTLVFSYIATLLYVVHAVFSLI 50 60 70 80 90 100 130 140 150 160 170 pF1KE2 AAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP NP_071 RWKSS 110 >>NP_849199 (OMIM: 607891) CKLF-like MARVEL transmembran (173 aa) initn: 205 init1: 132 opt: 182 Z-score: 189.2 bits: 41.5 E(85289): 0.00085 Smith-Waterman score: 228; 27.0% identity (63.8% similar) in 163 aa overlap (15-175:20-168) 10 20 30 40 50 pF1KE2 MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEILFGGLVWILVA : .: .. ..::: : .. ::..: ::: :.: NP_849 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLPGFLIVAEIVLGLLVWTLIA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 SSNV-PLPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQI-DANWNFLDFAYHFTVFVFY ... .: . ::::::.: . ....:: .... ..: .. :. . . .. ..::.: NP_849 GTEYFRVPAF-GWVMFVAVFYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLY 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 FGAFLLEAAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRR ..: ...:...: : .....: .:.:.:::..: ::. . ... NP_849 LSAAVVDASSVS-------------PERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIA 120 130 140 150 160 pF1KE2 WRP :: NP_849 WRSRTIQ 170 >>NP_057077 (OMIM: 600340) plasmolipin [Homo sapiens] (182 aa) initn: 193 init1: 134 opt: 177 Z-score: 184.1 bits: 40.6 E(85289): 0.0016 Smith-Waterman score: 217; 28.7% identity (62.0% similar) in 150 aa overlap (29-175:28-166) 10 20 30 40 50 pF1KE2 MSAGGASVPPPPNPAVSFPPPRVTLPAGPDI--LRTYSGAFVCLEILFGGLVWILVASSN ::. .:. ::.. :....: ::: :.:.. NP_057 MAEFPSKVSTRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIADTP 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 VPLPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQID-ANWNFLDFAYHFTVFVFYFGAF : ::::::.: .. ........: . .. . : .. . ..... :.:. :: NP_057 YHLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYITAF 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 LLEAAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP . .::..: :.. : :: .:::.:: .. :: : .. . :: NP_057 IACSAAVDL------TSLRGT-----RPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGV 120 130 140 150 160 NP_057 GSNAATSQMAGGYA 170 180 176 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 19:20:48 2016 done: Sat Nov 5 19:20:48 2016 Total Scan time: 6.290 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]