FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6444, 510 aa 1>>>pF1KE6444 510 - 510 aa - 510 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5827+/-0.000338; mu= 14.3091+/- 0.021 mean_var=191.2857+/-40.018, 0's: 0 Z-trim(120.9): 225 B-trim: 7 in 2/56 Lambda= 0.092733 statistics sampled from 36348 (36657) to 36348 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.753), E-opt: 0.2 (0.43), width: 16 Scan time: 9.380 The best scores are: opt bits E(85289) NP_112178 (OMIM: 609607,613573) nectin-4 precursor ( 510) 3411 469.0 1.5e-131 XP_011508323 (OMIM: 609607,613573) PREDICTED: nect ( 511) 3399 467.4 4.5e-131 XP_011508325 (OMIM: 609607,613573) PREDICTED: nect ( 460) 2927 404.2 4.3e-112 XP_005245565 (OMIM: 609607,613573) PREDICTED: nect ( 485) 2777 384.1 4.9e-106 XP_011508324 (OMIM: 609607,613573) PREDICTED: nect ( 486) 2765 382.5 1.5e-105 XP_016861615 (OMIM: 607147) PREDICTED: nectin-3 is ( 510) 721 109.1 3.2e-23 NP_001230217 (OMIM: 607147) nectin-3 isoform 3 [Ho ( 487) 712 107.9 7.2e-23 XP_016861612 (OMIM: 607147) PREDICTED: nectin-3 is ( 541) 697 105.9 3.1e-22 NP_056295 (OMIM: 607147) nectin-3 isoform 1 precur ( 549) 690 105.0 5.9e-22 XP_016861614 (OMIM: 607147) PREDICTED: nectin-3 is ( 526) 681 103.8 1.3e-21 NP_001230215 (OMIM: 607147) nectin-3 isoform 2 pre ( 366) 674 102.6 2e-21 XP_016861613 (OMIM: 607147) PREDICTED: nectin-3 is ( 534) 666 101.8 5.4e-21 XP_011510965 (OMIM: 607147) PREDICTED: nectin-3 is ( 580) 666 101.8 5.7e-21 NP_976030 (OMIM: 225060,600644) nectin-1 isoform 2 ( 458) 555 86.8 1.5e-16 NP_002846 (OMIM: 225060,600644) nectin-1 isoform 1 ( 517) 542 85.2 5.2e-16 NP_976031 (OMIM: 225060,600644) nectin-1 isoform 3 ( 352) 514 81.2 5.5e-15 NP_001129242 (OMIM: 173850) poliovirus receptor is ( 392) 474 75.9 2.4e-13 NP_006496 (OMIM: 173850) poliovirus receptor isofo ( 417) 474 75.9 2.5e-13 NP_001129240 (OMIM: 173850) poliovirus receptor is ( 372) 463 74.4 6.5e-13 NP_001129241 (OMIM: 173850) poliovirus receptor is ( 364) 457 73.6 1.1e-12 NP_001036189 (OMIM: 600798) nectin-2 isoform delta ( 538) 401 66.3 2.6e-10 XP_016861616 (OMIM: 607147) PREDICTED: nectin-3 is ( 337) 388 64.3 6.4e-10 XP_011525494 (OMIM: 600798) PREDICTED: nectin-2 is ( 369) 369 61.8 3.9e-09 NP_002847 (OMIM: 600798) nectin-2 isoform alpha pr ( 479) 370 62.1 4.2e-09 NP_001091987 (OMIM: 605686) cell adhesion molecule ( 414) 343 58.4 4.7e-08 NP_001120645 (OMIM: 609743) cell adhesion molecule ( 398) 314 54.5 6.8e-07 NP_067012 (OMIM: 609743) cell adhesion molecule 3 ( 432) 314 54.6 7.1e-07 XP_016872950 (OMIM: 605686) PREDICTED: cell adhesi ( 267) 288 50.8 5.9e-06 XP_016858441 (OMIM: 608869,615112) PREDICTED: leuc ( 553) 289 51.3 8.4e-06 XP_016861625 (OMIM: 608868) PREDICTED: leucine-ric ( 833) 290 51.7 9.8e-06 XP_011531881 (OMIM: 608868) PREDICTED: leucine-ric ( 833) 290 51.7 9.8e-06 XP_016861624 (OMIM: 608868) PREDICTED: leucine-ric ( 867) 290 51.7 1e-05 XP_011531880 (OMIM: 608868) PREDICTED: leucine-ric (1045) 290 51.8 1.1e-05 XP_016861623 (OMIM: 608868) PREDICTED: leucine-ric (1068) 290 51.8 1.1e-05 NP_056356 (OMIM: 608868) leucine-rich repeats and (1093) 290 51.9 1.2e-05 NP_001299615 (OMIM: 608869,615112) leucine-rich re ( 962) 289 51.7 1.2e-05 NP_055628 (OMIM: 608869,615112) leucine-rich repea (1065) 289 51.7 1.3e-05 XP_016881941 (OMIM: 609744) PREDICTED: cell adhesi ( 369) 275 49.2 2.4e-05 NP_660339 (OMIM: 609744) cell adhesion molecule 4 ( 388) 275 49.3 2.5e-05 XP_011536195 (OMIM: 608870) PREDICTED: leucine-ric (1041) 266 48.6 0.0001 NP_001129523 (OMIM: 608870) leucine-rich repeats a (1059) 266 48.6 0.00011 NP_700356 (OMIM: 608870) leucine-rich repeats and (1119) 266 48.7 0.00011 XP_005271426 (OMIM: 608869,615112) PREDICTED: leuc ( 958) 251 46.6 0.0004 NP_005520 (OMIM: 142461,224410,255800) basement me (4391) 259 48.5 0.00048 NP_001278789 (OMIM: 142461,224410,255800) basement (4392) 259 48.5 0.00048 XP_016856611 (OMIM: 142461,224410,255800) PREDICTE (4438) 259 48.5 0.00048 XP_016856610 (OMIM: 142461,224410,255800) PREDICTE (4439) 259 48.5 0.00048 XP_016856609 (OMIM: 142461,224410,255800) PREDICTE (4456) 259 48.5 0.00049 XP_011539620 (OMIM: 142461,224410,255800) PREDICTE (4574) 259 48.5 0.00049 NP_001275739 (OMIM: 614133) HEPACAM family member ( 455) 230 43.3 0.0018 >>NP_112178 (OMIM: 609607,613573) nectin-4 precursor [Ho (510 aa) initn: 3411 init1: 3411 opt: 3411 Z-score: 2482.8 bits: 469.0 E(85289): 1.5e-131 Smith-Waterman score: 3411; 100.0% identity (100.0% similar) in 510 aa overlap (1-510:1-510) 10 20 30 40 50 60 pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 FCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 FCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 EGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 EGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQ 430 440 450 460 470 480 490 500 510 pF1KE6 AMNHFVQENGTLRAKPTGNGIYINGRGHLV :::::::::::::::::::::::::::::: NP_112 AMNHFVQENGTLRAKPTGNGIYINGRGHLV 490 500 510 >>XP_011508323 (OMIM: 609607,613573) PREDICTED: nectin-4 (511 aa) initn: 2321 init1: 2321 opt: 3399 Z-score: 2474.1 bits: 467.4 E(85289): 4.5e-131 Smith-Waterman score: 3399; 99.8% identity (99.8% similar) in 511 aa overlap (1-510:1-511) 10 20 30 40 50 60 pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL 250 260 270 280 290 300 310 320 330 340 350 pF1KE6 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVL-DPQEDSGKQVDLVSASVVVVGVIAAL ::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::: XP_011 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLADPQEDSGKQVDLVSASVVVVGVIAAL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE6 LFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLR 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE6 AEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIK 430 440 450 460 470 480 480 490 500 510 pF1KE6 QAMNHFVQENGTLRAKPTGNGIYINGRGHLV ::::::::::::::::::::::::::::::: XP_011 QAMNHFVQENGTLRAKPTGNGIYINGRGHLV 490 500 510 >>XP_011508325 (OMIM: 609607,613573) PREDICTED: nectin-4 (460 aa) initn: 2979 init1: 2321 opt: 2927 Z-score: 2133.4 bits: 404.2 E(85289): 4.3e-112 Smith-Waterman score: 2927; 99.1% identity (99.3% similar) in 441 aa overlap (1-440:1-441) 10 20 30 40 50 60 pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL 250 260 270 280 290 300 310 320 330 340 350 pF1KE6 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVL-DPQEDSGKQVDLVSASVVVVGVIAAL ::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::: XP_011 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLADPQEDSGKQVDLVSASVVVVGVIAAL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE6 LFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLR 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE6 AEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIK ::::::::::::::::: . : XP_011 AEGHPDSLKDNSSCSVMVRPPAPPVSPPLSSGPCPGPRYE 430 440 450 460 >>XP_005245565 (OMIM: 609607,613573) PREDICTED: nectin-4 (485 aa) initn: 2857 init1: 2777 opt: 2777 Z-score: 2024.7 bits: 384.1 E(85289): 4.9e-106 Smith-Waterman score: 3181; 95.1% identity (95.1% similar) in 510 aa overlap (1-510:1-485) 10 20 30 40 50 60 pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 FCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRA ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQ--------- 370 380 390 400 410 430 440 450 460 470 480 pF1KE6 EGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQ :::::::::::::::::::::::::::::::::::::::::::: XP_005 ----------------SEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQ 420 430 440 450 490 500 510 pF1KE6 AMNHFVQENGTLRAKPTGNGIYINGRGHLV :::::::::::::::::::::::::::::: XP_005 AMNHFVQENGTLRAKPTGNGIYINGRGHLV 460 470 480 >>XP_011508324 (OMIM: 609607,613573) PREDICTED: nectin-4 (486 aa) initn: 2817 init1: 2321 opt: 2765 Z-score: 2016.0 bits: 382.5 E(85289): 1.5e-105 Smith-Waterman score: 3169; 94.9% identity (94.9% similar) in 511 aa overlap (1-510:1-486) 10 20 30 40 50 60 pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL 250 260 270 280 290 300 310 320 330 340 350 pF1KE6 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVL-DPQEDSGKQVDLVSASVVVVGVIAAL ::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::: XP_011 GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLADPQEDSGKQVDLVSASVVVVGVIAAL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE6 LFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLR :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQ-------- 370 380 390 400 410 420 430 440 450 460 470 pF1KE6 AEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIK ::::::::::::::::::::::::::::::::::::::::::: XP_011 -----------------SEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIK 420 430 440 450 480 490 500 510 pF1KE6 QAMNHFVQENGTLRAKPTGNGIYINGRGHLV ::::::::::::::::::::::::::::::: XP_011 QAMNHFVQENGTLRAKPTGNGIYINGRGHLV 460 470 480 >>XP_016861615 (OMIM: 607147) PREDICTED: nectin-3 isofor (510 aa) initn: 261 init1: 110 opt: 721 Z-score: 537.9 bits: 109.1 E(85289): 3.2e-23 Smith-Waterman score: 721; 34.5% identity (65.0% similar) in 371 aa overlap (12-376:36-396) 10 20 30 pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPA--GELETSDV : ::::. : :. : : : . . XP_016 RPSPLCPGGGKAQLSSASLLGAGLLLQPPTPPPLLLLLFPLLLFSRLCGALAGPIIVEPH 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE6 VTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVE ::.: :....: :. . .: . :..: .. :...: .:. : .::. :. :.::: XP_016 VTAVWGKNVSLKCLI--EVNETITQISWEKIH-GKSSQTVAVHHPQYGFSVQGEYQGRVL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE6 QPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGP-A : :... :.: .: :.: :.. ::: :. :. . ::: : :: :: . XP_016 FKNYSLN--DATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE6 LEEGQGLTLAASC-TAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMN : .: . :.:: : .: :.:. . :. .. :. . ...:.. :...: :.: XP_016 LIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFAR 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE6 GQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPP :. .::::.::.: .: : . :: ... :.:: : : : : .::.:. ::: ....:: XP_016 GRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGY-DGN-WFVGRKGVNLKCNADANPP 250 260 270 280 290 280 290 300 310 320 330 pF1KE6 PSYN-WTRLDGPLPSGVRVDGDTLGF-PPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDP : . :.:::: :.:. .. .:: : ::: ..::.:.:.:.: ...:..: .. . : XP_016 PFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDV 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE6 QEDSGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRE ::.. .... .:.:.. ::.. . :.:.: : .: XP_016 PF---KQTSSIAVAGAVIGAVLALFIIAIFVTVLLTPRKKRPSYLDKVIDLPPTHKPPPL 360 370 380 390 400 410 400 410 420 430 440 450 pF1KE6 NSIRRLHSHHTDPRSQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIE XP_016 YEERSPPLPQKDLFQPEHLPLQTQFKEREVGNLQHSNGLNSRSFDYEDENPVGEDGIQQM 420 430 440 450 460 470 >>NP_001230217 (OMIM: 607147) nectin-3 isoform 3 [Homo s (487 aa) initn: 326 init1: 110 opt: 712 Z-score: 531.6 bits: 107.9 E(85289): 7.2e-23 Smith-Waterman score: 712; 34.7% identity (65.6% similar) in 363 aa overlap (20-376:21-373) 10 20 30 40 50 pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTG--RCPAGELETSDVVTVVLGQDAKLPCFYRGD :: ::.: : :: . . ::.: :....: :. . NP_001 MAEGWRWCFVRRTPGLLRGPLLPRSFSGNPRALAGPIIVEPHVTAVWGKNVSLKCLI--E 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 SGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNA .: . :..: .. :...: .:. : .::. :. :.::: : :... :.: NP_001 VNETITQISWEKIH-GKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLN--DATITLHNI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 VQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGP-ALEEGQGLTLAASC-TAEG .: :.: :.. ::: :. :. . ::: : :: :: .: .: . :.:: : .: : NP_001 GFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 SPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQR .:. . :. .. :. . ...:.. :...: :.: :. .::::.::.: .: : NP_001 KPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE6 ITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYN-WTRLDGPLPSGVR . :: ... :.:: : : : : .::.:. ::: ....::: . :.:::: :.:. NP_001 YSFILDIQYAPEVSVTGY-DGN-WFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE6 VDGDTLGF-PPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVV .. .:: : ::: ..::.:.:.:.: ...:..: .. . : ::.. .... .:. NP_001 ASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDVPF---KQTSSIAVAGAVI 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE6 GVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPE :.. ::.. . :.:.: : .: NP_001 GAVLALFIIAIFVTVLLTPRKKRPSYLDKVIDLPPTHKPPPLYEERSPPLPQKDLFQPEH 360 370 380 390 400 410 >>XP_016861612 (OMIM: 607147) PREDICTED: nectin-3 isofor (541 aa) initn: 261 init1: 110 opt: 697 Z-score: 520.2 bits: 105.9 E(85289): 3.1e-22 Smith-Waterman score: 697; 34.3% identity (66.0% similar) in 350 aa overlap (31-376:88-427) 10 20 30 40 50 60 pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE :: . . ::.: :....: :. . .: XP_016 GDCFSCKTIDCPPFILLNKLSREDLLHCALAGPIIVEPHVTAVWGKNVSLKCLI--EVNE 60 70 80 90 100 110 70 80 90 100 110 120 pF1KE6 QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA . :..: .. :...: .:. : .::. :. :.::: : :... :.: . XP_016 TITQISWEKIH-GKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLN--DATITLHNIGFS 120 130 140 150 160 170 130 140 150 160 170 pF1KE6 DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGP-ALEEGQGLTLAASC-TAEGSPA : :.: :.. ::: :. :. . ::: : :: :: .: .: . :.:: : .: :.:. XP_016 DSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPV 180 190 200 210 220 230 180 190 200 210 220 230 pF1KE6 PSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITH . :. .. :. . ...:.. :...: :.: :. .::::.::.: .: : . XP_016 AHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSF 240 250 260 270 280 290 240 250 260 270 280 290 pF1KE6 ILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYN-WTRLDGPLPSGVRVDG :: ... :.:: : : : : .::.:. ::: ....::: . :.:::: :.:. .. XP_016 ILDIQYAPEVSVTGY-DGN-WFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASD 300 310 320 330 340 350 300 310 320 330 340 350 pF1KE6 DTLGF-PPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVI .:: : ::: ..::.:.:.:.: ...:..: .. . : ::.. .... .:.:.. XP_016 NTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDVPF---KQTSSIAVAGAVIGAV 360 370 380 390 400 360 370 380 390 400 410 pF1KE6 AALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESV ::.. . :.:.: : .: XP_016 LALFIIAIFVTVLLTPRKKRPSYLDKVIDLPPTHKPPPLYEERSPPLPQKDLFQPEHLPL 410 420 430 440 450 460 >>NP_056295 (OMIM: 607147) nectin-3 isoform 1 precursor (549 aa) initn: 153 init1: 153 opt: 690 Z-score: 515.1 bits: 105.0 E(85289): 5.9e-22 Smith-Waterman score: 692; 30.5% identity (60.1% similar) in 486 aa overlap (12-455:36-505) 10 20 30 pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTGRCPA--GELETSDV : ::::. : :. : : : . . NP_056 RPSPLCPGGGKAQLSSASLLGAGLLLQPPTPPPLLLLLFPLLLFSRLCGALAGPIIVEPH 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE6 VTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVE ::.: :....: :. . .: . :..: .. :...: .:. : .::. :. :.::: NP_056 VTAVWGKNVSLKCLI--EVNETITQISWEKIH-GKSSQTVAVHHPQYGFSVQGEYQGRVL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE6 QPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGP-A : :... :.: .: :.: :.. ::: :. :. . ::: : :: :: . NP_056 FKNYSLN--DATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE6 LEEGQGLTLAASC-TAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMN : .: . :.:: : .: :.:. . :. .. :. . ...:.. :...: :.: NP_056 LIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFAR 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE6 GQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPP :. .::::.::.: .: : . :: ... :.:: : : : : .::.:. ::: ....:: NP_056 GRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGY-DGN-WFVGRKGVNLKCNADANPP 250 260 270 280 290 280 290 300 310 320 330 pF1KE6 PSYN-WTRLDGPLPSGVRVDGDTLGF-PPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDP : . :.:::: :.:. .. .:: : ::: ..::.:.:.:.: ...:..: .. . :: NP_056 PFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDP 300 310 320 330 340 350 340 350 360 pF1KE6 QEDSGKQV------------DLVS------------ASV-------VVVGVIAALLFCLL . : ::.. :.. ....:... :: .: NP_056 PTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLSTLATIKDDTIATIIASVVGGALFIVL 360 370 380 390 400 410 370 380 390 400 410 420 pF1KE6 VVVVVLMSRYHRRKA---QQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRAE : :.. . :.::.. . ....: . .:..: :.. . : : :. :: . . NP_056 VSVLAGIFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLQQDELD--SYPD-SVKKENK 420 430 440 450 460 470 430 440 450 460 470 pF1KE6 GHPDSL--KDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIK . ..: :: . :::: ..... .. ..: NP_056 NPVNNLIRKD------YLEEPEKTQWNNVENLNRFERPMDYYEDLKMGMKFVSDEHYDEN 480 490 500 510 520 480 490 500 510 pF1KE6 QAMNHFVQENGTLRAKPTGNGIYINGRGHLV NP_056 EDDLVSHVDGSVISRREWYV 530 540 >>XP_016861614 (OMIM: 607147) PREDICTED: nectin-3 isofor (526 aa) initn: 258 init1: 153 opt: 681 Z-score: 508.8 bits: 103.8 E(85289): 1.3e-21 Smith-Waterman score: 683; 30.5% identity (60.5% similar) in 478 aa overlap (20-455:21-482) 10 20 30 40 50 pF1KE6 MPLSLGAEMWGPEAWLLLLLLLASFTG--RCPAGELETSDVVTVVLGQDAKLPCFYRGD :: ::.: : :: . . ::.: :....: :. . XP_016 MAEGWRWCFVRRTPGLLRGPLLPRSFSGNPRALAGPIIVEPHVTAVWGKNVSLKCLI--E 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 SGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNA .: . :..: .. :...: .:. : .::. :. :.::: : :... :.: XP_016 VNETITQISWEKIH-GKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLN--DATITLHNI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 VQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGP-ALEEGQGLTLAASC-TAEG .: :.: :.. ::: :. :. . ::: : :: :: .: .: . :.:: : .: : XP_016 GFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 SPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQR .:. . :. .. :. . ...:.. :...: :.: :. .::::.::.: .: : XP_016 KPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE6 ITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYN-WTRLDGPLPSGVR . :: ... :.:: : : : : .::.:. ::: ....::: . :.:::: :.:. XP_016 YSFILDIQYAPEVSVTGY-DGN-WFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLL 240 250 260 270 280 290 300 310 320 330 340 pF1KE6 VDGDTLGF-PPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQV---------- .. .:: : ::: ..::.:.:.:.: ...:..: .. . :: . : XP_016 ASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTAD 300 310 320 330 340 350 350 360 370 pF1KE6 --DLVS------------ASV-------VVVGVIAALLFCLLVVVVVLMSRYHRRKA--- ::.. :.. ....:... :: .:: :.. . :.::.. XP_016 IEDLATEPKKLPFPLSTLATIKDDTIATIIASVVGGALFIVLVSVLAGIFCYRRRRTFRG 360 370 380 390 400 410 380 390 400 410 420 430 pF1KE6 QQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRAEGHPDSL--KDNSSCSVMS . ....: . .:..: :.. . : : :. :: . .. ..: :: . XP_016 DYFAKNYIPPSDMQKESQIDVLQQDELD--SYPD-SVKKENKNPVNNLIRKD------YL 420 430 440 450 460 440 450 460 470 480 490 pF1KE6 EEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQAMNHFVQENGTLRAKPT :::: ..... .. ..: XP_016 EEPEKTQWNNVENLNRFERPMDYYEDLKMGMKFVSDEHYDENEDDLVSHVDGSVISRREW 470 480 490 500 510 520 510 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:21:52 2016 done: Tue Nov 8 13:21:54 2016 Total Scan time: 9.380 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]