Result of FASTA (omim) for
pFN21AB5715
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5715, 787 aa
1>>>pF1KB5715 787 - 787 aa - 787 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.3135+/-0.000345; mu= 7.8695+/- 0.022
mean_var=183.3291+/-36.780, 0's: 0 Z-trim(121.2): 37 B-trim: 0 in 0/55
Lambda= 0.094724
statistics sampled from 37465 (37509) to 37465 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.748), E-opt: 0.2 (0.44), width: 16
Scan time: 13.760
The best scores are: opt bits E(85289)
NP_005622 (OMIM: 601500,601707,605462) smoothened ( 787) 5464 759.3 1.4e-218
XP_011514824 (OMIM: 601500,601707,605462) PREDICTE ( 657) 4563 636.1 1.4e-181
NP_003496 (OMIM: 603408) frizzled-1 [Homo sapiens] ( 647) 604 95.1 1e-18
NP_009128 (OMIM: 606147) frizzled-10 precursor [Ho ( 581) 545 87.0 2.5e-16
NP_003498 (OMIM: 603410) frizzled-7 precursor [Hom ( 574) 536 85.8 5.9e-16
NP_003459 (OMIM: 601723) frizzled-5 precursor [Hom ( 585) 535 85.6 6.6e-16
NP_001457 (OMIM: 600667) frizzled-2 precursor [Hom ( 565) 522 83.8 2.2e-15
NP_001158088 (OMIM: 603409,614157) frizzled-6 isof ( 674) 512 82.5 6.5e-15
NP_003497 (OMIM: 603409,614157) frizzled-6 isoform ( 706) 512 82.5 6.7e-15
NP_001158087 (OMIM: 603409,614157) frizzled-6 isof ( 706) 512 82.5 6.7e-15
NP_003499 (OMIM: 601766) frizzled-9 precursor [Hom ( 591) 489 79.3 5.2e-14
XP_016869330 (OMIM: 606143) PREDICTED: frizzled-3 ( 599) 479 78.0 1.3e-13
NP_665873 (OMIM: 606143) frizzled-3 precursor [Hom ( 666) 479 78.0 1.5e-13
NP_059108 (OMIM: 606143) frizzled-3 precursor [Hom ( 666) 479 78.0 1.5e-13
XP_016869333 (OMIM: 606143) PREDICTED: frizzled-3 ( 470) 467 76.3 3.5e-13
XP_016869332 (OMIM: 606143) PREDICTED: frizzled-3 ( 491) 467 76.3 3.6e-13
XP_016869331 (OMIM: 606143) PREDICTED: frizzled-3 ( 502) 467 76.3 3.7e-13
NP_036325 (OMIM: 133780,604579) frizzled-4 precurs ( 537) 463 75.8 5.6e-13
NP_114072 (OMIM: 606146) frizzled-8 precursor [Hom ( 694) 419 69.8 4.4e-11
NP_001304725 (OMIM: 603409,614157) frizzled-6 isof ( 401) 275 50.0 2.4e-05
>>NP_005622 (OMIM: 601500,601707,605462) smoothened homo (787 aa)
initn: 5464 init1: 5464 opt: 5464 Z-score: 4045.1 bits: 759.3 E(85289): 1.4e-218
Smith-Waterman score: 5464; 100.0% identity (100.0% similar) in 787 aa overlap (1-787:1-787)
10 20 30 40 50 60
pF1KB5 MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB5 AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL
730 740 750 760 770 780
pF1KB5 MDADSDF
:::::::
NP_005 MDADSDF
>>XP_011514824 (OMIM: 601500,601707,605462) PREDICTED: s (657 aa)
initn: 4563 init1: 4563 opt: 4563 Z-score: 3380.8 bits: 636.1 E(85289): 1.4e-181
Smith-Waterman score: 4563; 100.0% identity (100.0% similar) in 657 aa overlap (131-787:1-657)
110 120 130 140 150 160
pF1KB5 EAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERE
::::::::::::::::::::::::::::::
XP_011 MPKCENDRVELPSRTLCQATRGPCAIVERE
10 20 30
170 180 190 200 210 220
pF1KB5 RGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNP
40 50 60 70 80 90
230 240 250 260 270 280
pF1KB5 LFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIG
100 110 120 130 140 150
290 300 310 320 330 340
pF1KB5 WLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWH
160 170 180 190 200 210
350 360 370 380 390 400
pF1KB5 TSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYR
220 230 240 250 260 270
410 420 430 440 450 460
pF1KB5 AGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAF
280 290 300 310 320 330
470 480 490 500 510 520
pF1KB5 GFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKI
340 350 360 370 380 390
530 540 550 560 570 580
pF1KB5 NLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELL
400 410 420 430 440 450
590 600 610 620 630 640
pF1KB5 QNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVT
460 470 480 490 500 510
650 660 670 680 690 700
pF1KB5 PVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPST
520 530 540 550 560 570
710 720 730 740 750 760
pF1KB5 IPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAH
580 590 600 610 620 630
770 780
pF1KB5 GRRQGLGPIHSRTNLMDTELMDADSDF
:::::::::::::::::::::::::::
XP_011 GRRQGLGPIHSRTNLMDTELMDADSDF
640 650
>>NP_003496 (OMIM: 603408) frizzled-1 [Homo sapiens] (647 aa)
initn: 422 init1: 258 opt: 604 Z-score: 456.9 bits: 95.1 E(85289): 1e-18
Smith-Waterman score: 715; 27.4% identity (54.7% similar) in 623 aa overlap (17-559:56-644)
10 20 30 40
pF1KB5 MAAARPARGPELPLLGLLLLLLLGDP---GRGAASSGNATGPGPRS
:::: :: : : : ..:.. : ::
NP_003 LSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLWLLEAPLLLGVRAQAAGQGPGQGP--
30 40 50 60 70 80
50 60 70 80 90
pF1KB5 AGGSARRSAAVTGPPPPLSHC---------GRAAP----CEPLRYNVCLGSVLPYGATST
: ... :::: .. : ..: :.:. .: . .
NP_003 --GPGQQP-----PPPPQQQQSGQQYNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPN
90 100 110 120 130
100 110 120 130 140
pF1KB5 LLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPS-RTLCQA
:: : .. ::.: .. . : .. .: : .. .::..: : : . :: :.::.
NP_003 LL-GHTN-QEDAGLEVHQFYPLVKV-QCSAELKFFLCSMYAPVCTVLEQALPPCRSLCER
140 150 160 170 180 190
150 160 170 180 190 200
pF1KB5 TRGPCAIVERERG--WPDFLRCTPDRFP-----EGCTNEVQNIKFNSSGQCEVPLVRTDN
.: : . . : ::: :.: ..:: : :... . : .. .: :.:
NP_003 ARQGCEALMNKFGFQWPDTLKC--EKFPVHGAGELCVGQNTSDK-GTPTPSLLPEFWTSN
200 210 220 230 240 250
210 220
pF1KB5 PK-------------------------------SW----YEDVEGCGIQCQNP------L
:. :. . . :: :.
NP_003 PQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMY
260 270 280 290 300 310
230 240 250 260 270 280
pF1KB5 FTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGW
: : . ...:. .... ::::. :...: : . :: ......:. . ....
NP_003 FGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFS-YPERPIIFLSGCYTAVAVAY
320 330 340 350 360
290 300 310 320 330
pF1KB5 LAQFMDGARREIVCR----ADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTY
.: :. : .:: ::. ... :..: .:.:.:...:. ::. .:.:.:.
NP_003 IAGFLLEDR--VVCNDKFAEDGARTVAQGTKKE--GCTILFMMLYFFSMASSIWWVILSL
370 380 390 400 410 420
340 350 360 370 380 390
pF1KB5 AWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYK
.: : : : . . . ....:::: .:..: . :..:::..::::: .::.:::: .
NP_003 TW---FLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLN
430 440 450 460 470 480
400 410 420 430 440 450
pF1KB5 NYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKS--NHPGLLSEKAASKINETMLRLG
: ::::::. . :..: ::. : ..:: :.. .: : .:: ... :.:.:
NP_003 NVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEK----LEKLMVRIG
490 500 510 520 530
460 470 480 490 500
pF1KB5 IFGFLAFGFVLITFSCHFYDFFNQAEWERSF-----RDYVL-C-QANVTIGLPTKQPIPD
.:. : . :...:.::. . .::::. ..:.. : . .. : : . :.
NP_003 VFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPMS-
540 550 560 570 580 590
510 520 530 540 550 560
pF1KB5 CEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKS
:.. : :. . . .::. . :.:. :: ::. . :::.... :
NP_003 ------PDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV
600 610 620 630 640
570 580 590 600 610 620
pF1KB5 KMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMV
>>NP_009128 (OMIM: 606147) frizzled-10 precursor [Homo s (581 aa)
initn: 404 init1: 228 opt: 545 Z-score: 414.0 bits: 87.0 E(85289): 2.5e-16
Smith-Waterman score: 632; 26.7% identity (54.2% similar) in 581 aa overlap (39-571:4-558)
10 20 30 40 50 60
pF1KB5 GPELPLLGLLLLLLLGDPGRGAASSGNATGPGPR-----SAGGSARRSAAVTGPPPPLSH
:::: .. :: ::...
NP_009 MQRPGPRLWLVLQVMGS---CAAISSMDMERPG
10 20 30
70 80 90 100 110 120
pF1KB5 CGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQ
:. :.:.. .: . :. : ..:.:: .: .. : . : . ..
NP_009 DGK---CQPIEIPMCKD--IGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYG-CHGHLR
40 50 60 70 80
130 140 150 160 170
pF1KB5 PLLCAVYMPKC-ENDRVELPS-RTLCQATRGPCAIVERERG--WPDFLRCT--PDRF-PE
.::..: : : :. . .:. :..:. .: :. . .. . ::: : : :.. :.
NP_009 FFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPN
90 100 110 120 130 140
180 190 200 210 220
pF1KB5 GCTNEVQNIKFN----SSGQCEVPLVRTDNPKSWYEDV-----EGCGIQCQNP-LFTEAE
:. : . .:: :: : . :.: : : : :.:: : ..:
NP_009 YLCMEAPNNGSDEPTRGSGLFP-PLFRPQRPHSAQEHPLKDGGPGRG-GCDNPGKFHHVE
150 160 170 180 190 200
230 240 250 260
pF1KB5 H------------------QDMHSYIAAFGAVTGLC---TLFTLATFVADWRNSNRYPAV
. .: . .. .. . :: . ::. ::. : :::
NP_009 KSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLID-PARFRYPER
210 220 230 240 250 260
270 280 290 300 310 320
pF1KB5 ILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYAL
..... :. : :.:.: ... ::. :.: :. . . :. .:...:...::
NP_009 PIIFLSMCYCVYSVGYLIRLFAGAES-IACDRDSGQLYVIQEGLESTGCTLVFLVLYYFG
270 280 290 300 310 320
330 340 350 360 370 380
pF1KB5 MAGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDG
::. .:.:::: .: : : : . . . ...::::: .:..: : :. ::.. .: :
NP_009 MASSLWWVVLTLTW---FLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAG
330 340 350 360 370
390 400 410 420 430 440
pF1KB5 DSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAAS
: ..:.:.:: . .:::: :.. :..: :.. : ..:: :. . . ..
NP_009 DELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMK--TGGENTD
380 390 400 410 420 430
450 460 470 480 490 500
pF1KB5 KINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQP
:... :.:.:.:. : . ...:.::. .:. : . . :. : ..
NP_009 KLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYW-KILAAQHKCKMN------NQTK
440 450 460 470 480
510 520 530 540 550 560
pF1KB5 IPDCEIKNR-PSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWC--RLTGQSDDEP
:: . :.. . ...: .. .::. . :.::. :: :... : :: .: .:
NP_009 TLDCLMAASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQV-CSRRLKKKSRRKP
490 500 510 520 530 540
570 580 590 600 610 620
pF1KB5 KRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQ
. : : :
NP_009 ASVITSGGIYKKAQHPQKTHHGKYEIPAQSPTCV
550 560 570 580
>>NP_003498 (OMIM: 603410) frizzled-7 precursor [Homo sa (574 aa)
initn: 367 init1: 248 opt: 536 Z-score: 407.5 bits: 85.8 E(85289): 5.9e-16
Smith-Waterman score: 685; 27.9% identity (55.0% similar) in 567 aa overlap (52-559:27-571)
30 40 50 60 70
pF1KB5 LLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAP----CEPLRYNV
.: .: : .. : ..: :.:. .
NP_003 MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPL
10 20 30 40 50
80 90 100 110 120 130
pF1KB5 CLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCEN-
: . .:: : .. ::.: .. . : .. .: .. .::..: : :
NP_003 CTDIAYNQTILPNLL-GHTN-QEDAGLEVHQFYPLVKV-QCSPELRFFLCSMYAPVCTVL
60 70 80 90 100 110
140 150 160 170 180 190
pF1KB5 DRVELPSRTLCQATRGPCAIVERERG--WPDFLRCTPDRFPEGCTNEV---QNIKFNSSG
:.. : :.::. .: : . . : ::. ::: . :: ..:. :: . .:.:
NP_003 DQAIPPCRSLCERARQGCEALMNKFGFQWPERLRC--ENFPVHGAGEICVGQNTSDGSGG
120 130 140 150 160 170
200 210
pF1KB5 QCEVPLVRTDNP----------KSWYEDVEG---------------------------CG
: . : : .: ::
NP_003 PGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCG
180 190 200 210 220 230
220 230 240 250 260
pF1KB5 IQCQ----NPL--FTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILF
:. : : : : :.. . ........ ::::. :...: : . :: ..
NP_003 APCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFS-YPERPII
240 250 260 270 280 290
270 280 290 300 310 320
pF1KB5 YVNACFFVGSIGWLAQFMDGARREIVCR--ADGTMRLGEPTSNETLSCVIIFVIVYYALM
....:.:. ... .: :. : : : :: ... :..: .:.:.:...:. :
NP_003 FLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKE--GCTILFMVLYFFGM
300 310 320 330 340
330 340 350 360 370 380
pF1KB5 AGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGD
:. .:.:.:. .: : : : . . . ....:::: .:..: : :..:::..:::::
NP_003 ASSIWWVILSLTW---FLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGD
350 360 370 380 390 400
390 400 410 420 430 440
pF1KB5 SVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKS--NHPGLLSEKAA
.::.:.:: .. ::::::. . :..: ::. : ..:: :.. .: : .:
NP_003 LLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTE---
410 420 430 440 450 460
450 460 470 480 490 500
pF1KB5 SKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQ
:... :.:.:.:. : . :...:.::. . .:::.. : :. . ..:
NP_003 -KLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTW----LLQTCKSYAVPC--
470 480 490 500 510
510 520 530 540 550 560
pF1KB5 PIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKR
: : :.. : :. . . .::. . :.:. :: ::: . ::. .: :
NP_003 P-PGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV
520 530 540 550 560 570
570 580 590 600 610 620
pF1KB5 IKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHV
>>NP_003459 (OMIM: 601723) frizzled-5 precursor [Homo sa (585 aa)
initn: 345 init1: 247 opt: 535 Z-score: 406.6 bits: 85.6 E(85289): 6.6e-16
Smith-Waterman score: 684; 27.6% identity (55.2% similar) in 554 aa overlap (66-566:29-547)
40 50 60 70 80 90
pF1KB5 ATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGD
.: :. . .: : . :. : .
NP_003 MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRG--IGYNLTHMPNQFN
10 20 30 40 50
100 110 120 130 140 150
pF1KB5 SDSQEEAHGKLV--LWSGLRNAPRCWAVIQPLLCAVYMPKCEND--RVELPSRTLCQATR
:.:.:: : : .: .. .: .. .::..: : : : . : :..:. ..
NP_003 HDTQDEA-GLEVHQFWPLVE--IQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAK
60 70 80 90 100 110
160 170 180
pF1KB5 GPCAIVERERG--WPDFLRCTPDRFPE-GCTNEVQNIKFN--------------------
. :. . :. : ::. . : ::.: : :: . .:
NP_003 AGCSPLMRQYGFAWPERMSC--DRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLPG
120 130 140 150 160 170
190 200 210 220
pF1KB5 ------SSGQCE-------------VPLVRTDNP---KSWYEDVEGCGIQCQNPLFTEAE
:.:.: ::... ..: : .: .:.. : .: :. :
NP_003 PPGAPASGGECPAGGPFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSADE
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB5 HQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFM
. .:. .... . : :.:::. : . ::: .....::.. :.:.:....
NP_003 RTFATFWIGLWSVLCFISTSTTVATFLIDMERF-RYPERPIIFLSACYLCVSLGFLVRLV
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB5 DGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKAL
: . ..: . . .. :.. .: :.:.:..::. ::. .:.:.:. .: : :
NP_003 VG-HASVACSREHN-HIHYETTGPAL-CTIVFLLVYFFGMASSIWWVILSLTW---FLAA
300 310 320 330 340
350 360 370 380 390 400
pF1KB5 GTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFV
: . . ..: ..:::: .: .: : ... ::...:::: :.:::.:: .: :::
NP_003 GMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFV
350 360 370 380 390 400
410 420 430 440 450 460
pF1KB5 LAPIGLVLIVGGYFLIRGVMTLFSIKS--NHPGLLSEKAASKINETMLRLGIFGFLAFGF
:.:. : :.:: ::. : ..:: :.: .. : ..: ... :.:.::: .:
NP_003 LGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDK----LEKLMIRIGIFTLLYTVP
410 420 430 440 450 460
470 480 490 500 510 520
pF1KB5 VLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINL
. :. .:..:. . :: . . : . : : :: . .: : ..
NP_003 ASIVVACYLYEQHYRESWEAA----LTC---ACPGHDTGQP------RAKPEYWVLMLKY
470 480 490 500
530 540 550 560 570 580
pF1KB5 FAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQN
: . .::. ..:.:. :. :: :.:.. .:.: .::
NP_003 FMCLVVGITSGVWIWSGKTVESWR----RFTSRCCCRPRRGHKSGGAMAAGDYPEASAAL
510 520 530 540 550 560
590 600 610 620 630 640
pF1KB5 PGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPV
NP_003 TGRTGPPGPAATYHKQVSLSHV
570 580
>>NP_001457 (OMIM: 600667) frizzled-2 precursor [Homo sa (565 aa)
initn: 393 init1: 250 opt: 522 Z-score: 397.2 bits: 83.8 E(85289): 2.2e-15
Smith-Waterman score: 638; 26.1% identity (54.9% similar) in 567 aa overlap (56-559:21-562)
30 40 50 60 70 80
pF1KB5 PGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAP----CEPLRYNVCLGS
:: .. : . : :.:. .:
NP_001 MRPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDI
10 20 30 40 50
90 100 110 120 130 140
pF1KB5 VLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCEN-DRVE
. .:: : .. ::.: .. . : .. .: .. .::..: : : ...
NP_001 AYNQTIMPNLL-GHTN-QEDAGLEVHQFYPLVKV-QCSPELRFFLCSMYAPVCTVLEQAI
60 70 80 90 100
150 160 170 180 190
pF1KB5 LPSRTLCQATRGPCAIVERERG--WPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLV
: :..:. .: : . . : ::. ::: ..::. .... . : : . :.
NP_001 PPCRSICERARQGCEALMNKFGFQWPERLRC--EHFPRHGAEQI-CVGQNHSEDGAPALL
110 120 130 140 150 160
200 210
pF1KB5 RTDNPKSWYEDVEG------------------------------------------CGIQ
: : . . : :.
NP_001 TTAPPPGLQPGAGGTPGGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAP
170 180 190 200 210 220
220 230 240 250 260 270
pF1KB5 CQ--NP----LFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYV
:. : .:.. : . . .: ..... :.::..:...: . ::: ....
NP_001 CEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRF-RYPERPIIFL
230 240 250 260 270 280
280 290 300 310 320
pF1KB5 NACFFVGSIGWLAQFMDGARREIVCRA----DGTMRLGEPTSNETLSCVIIFVIVYYALM
..:. . :....: :. : .:: :: . . :..: .:.:.:...:. :
NP_001 SGCYTMVSVAYIAGFVLQER--VVCNERFSEDGYRTVVQGTKKE--GCTILFMMLYFFSM
290 300 310 320 330
330 340 350 360 370 380
pF1KB5 AGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGD
:. .:.:.:. .: : : : . . . ....:::: .:..: : :..:::..:.:::
NP_001 ASSIWWVILSLTW---FLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGD
340 350 360 370 380 390
390 400 410 420 430 440
pF1KB5 SVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKS--NHPGLLSEKAA
.::.:::: .. ::::::. . :..: ::. : ..:: :.. .: : .::
NP_001 LLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEK--
400 410 420 430 440 450
450 460 470 480 490 500
pF1KB5 SKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQ
... :.:.:.:. : . :...:.::. . .::::. . :.. ..: :..
NP_001 --LERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQ-HCKS-LAIPCPAHY
460 470 480 490 500 510
510 520 530 540 550 560
pF1KB5 PIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKR
: . :.. : :. . . .::. . :.:. :: ::. . :::.. :
NP_001 T-P----RMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNSRHGETTV
520 530 540 550 560
570 580 590 600 610 620
pF1KB5 IKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHV
>>NP_001158088 (OMIM: 603409,614157) frizzled-6 isoform (674 aa)
initn: 335 init1: 203 opt: 512 Z-score: 388.7 bits: 82.5 E(85289): 6.5e-15
Smith-Waterman score: 619; 27.8% identity (56.2% similar) in 454 aa overlap (118-545:37-471)
90 100 110 120 130 140
pF1KB5 TSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKC-ENDRVELPSRTL
: :. .:: ...: : :. .: : : :
NP_001 MTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVPTCIEQIHVVPPCRKL
10 20 30 40 50 60
150 160 170 180 190
pF1KB5 CQATRGPCAIVERERG--WPDFLRC---------TPDRF-PE----GCTNEVQNIKFNSS
:. . . : . : ::. :.: .: : :. : ....... . .
NP_001 CEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIG
70 80 90 100 110 120
200 210 220 230 240
pF1KB5 GQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLC-TLFTL
: : . . . .. :. : : : : . .:.:.. .. :: ::::.
NP_001 FWCPRHLKTSGGQGYKFLGIDQCAPPCPNMYFKSDELEFAKSFIGTV-SIFCLCATLFTF
130 140 150 160 170 180
250 260 270 280 290 300
pF1KB5 ATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVC-RADGTMRLGEPT-
::. : : ::: ..: ..:. . :. .. :. : .: .:: ..::. .
NP_001 LTFLIDVRRF-RYPERPIIYYSVCYSIVSLMYFIGFLLGDST--ACNKADEKLELGDTVV
190 200 210 220 230 240
310 320 330 340 350 360
pF1KB5 -SNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLT
.... .:...:...:. :::.::.:.:: .: : : : . . . :. .:: ..
NP_001 LGSQNKACTVLFMLLYFFTMAGTVWWVILTITW---FLAAGRKWSCEAIEQKAVWFHAVA
250 260 270 280 290
370 380 390 400 410 420
pF1KB5 WSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVM
:. : ::: .::. .:.::..::.:::: . ::: :. : ..:: .:. :..
NP_001 WGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGII
300 310 320 330 340 350
430 440 450 460 470 480
pF1KB5 TLFSIKS--NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWER
.: ... .: : . :... :.:.:.:. : . .. ..:. :. :. ::
NP_001 SLNHVRQVIQHDG----RNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEI
360 370 380 390 400 410
490 500 510 520 530 540
pF1KB5 SFRDYVLCQANVTIGLPTKQPIP-DCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKAT
.. . : .. : : . . : :: : . :. . . .::. :: .: :
NP_001 TWVSDHCRQYHI--------PCPYQAKAKARPELALFMIKYLMTLIVGISAVFWVGSKKT
420 430 440 450 460
550 560 570 580 590 600
pF1KB5 LLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVA
:
NP_001 CTEWAGFFKRNRKRDPISESRRVLQESCEFFLKHNSKVKHKKKHYKPSSHKLKVISKSMG
470 480 490 500 510 520
>>NP_003497 (OMIM: 603409,614157) frizzled-6 isoform a p (706 aa)
initn: 335 init1: 203 opt: 512 Z-score: 388.5 bits: 82.5 E(85289): 6.7e-15
Smith-Waterman score: 633; 27.7% identity (54.7% similar) in 505 aa overlap (70-545:24-503)
40 50 60 70 80 90
pF1KB5 GPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATS-TLLAGDSDS
:::. :. . :. : : : :
NP_003 MEMFTFLLTCIFLPLLRGHSLFTCEPITVPRCMK--MAYNMTFFPNLMGHYD-
10 20 30 40 50
100 110 120 130 140 150
pF1KB5 QEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKC-ENDRVELPSRTLCQATRGPCAIV
: : .. . : : .: :. .:: ...: : :. .: : : ::. . . : .
NP_003 QSIAAVEMEHFLPLANL-ECSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKL
60 70 80 90 100
160 170 180 190 200
pF1KB5 ERERG--WPDFLRC---------TPDRF-PE----GCTNEVQNIKFNSSGQCEVPLVRTD
: ::. :.: .: : :. : ....... . . : : .
NP_003 IDTFGIRWPEELECDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSG
110 120 130 140 150 160
210 220 230 240 250
pF1KB5 NPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLC---TLFTLATFVADWRN
. . .. :. : : : : . .:.: :.:. .: ::::. ::. : :
NP_003 GQGYKFLGIDQCAPPCPNMYFKSDELEFAKSFI---GTVSIFCLCATLFTFLTFLIDVRR
170 180 190 200 210 220
260 270 280 290 300 310
pF1KB5 SNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVC-RADGTMRLGEPT--SNETLSCV
::: ..: ..:. . :. .. :. : .: .:: ..::. . .... .:.
NP_003 F-RYPERPIIYYSVCYSIVSLMYFIGFLLGDS--TACNKADEKLELGDTVVLGSQNKACT
230 240 250 260 270 280
320 330 340 350 360 370
pF1KB5 IIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTV
..:...:. :::.::.:.:: .: : : : . . . :. .:: ..:. : :::
NP_003 VLFMLLYFFTMAGTVWWVILTITW---FLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTV
290 300 310 320 330 340
380 390 400 410 420 430
pF1KB5 AILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKS--
.::. .:.::..::.:::: . ::: :. : ..:: .:. :...: ...
NP_003 MLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVI
350 360 370 380 390 400
440 450 460 470 480 490
pF1KB5 NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQ
.: : . :... :.:.:.:. : . .. ..:. :. :. :: .. . :
NP_003 QHDG----RNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQ
410 420 430 440 450
500 510 520 530 540 550
pF1KB5 ANVTIGLPTKQPIP-DCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWC
.. : : . . : :: : . :. . . .::. :: .: : :
NP_003 YHI--------PCPYQAKAKARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFK
460 470 480 490 500
560 570 580 590 600 610
pF1KB5 RLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEP
NP_003 RNRKRDPISESRRVLQESCEFFLKHNSKVKHKKKHYKPSSHKLKVISKSMGTSTGATANH
510 520 530 540 550 560
>>NP_001158087 (OMIM: 603409,614157) frizzled-6 isoform (706 aa)
initn: 335 init1: 203 opt: 512 Z-score: 388.5 bits: 82.5 E(85289): 6.7e-15
Smith-Waterman score: 633; 27.7% identity (54.7% similar) in 505 aa overlap (70-545:24-503)
40 50 60 70 80 90
pF1KB5 GPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATS-TLLAGDSDS
:::. :. . :. : : : :
NP_001 MEMFTFLLTCIFLPLLRGHSLFTCEPITVPRCMK--MAYNMTFFPNLMGHYD-
10 20 30 40 50
100 110 120 130 140 150
pF1KB5 QEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKC-ENDRVELPSRTLCQATRGPCAIV
: : .. . : : .: :. .:: ...: : :. .: : : ::. . . : .
NP_001 QSIAAVEMEHFLPLANL-ECSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKL
60 70 80 90 100
160 170 180 190 200
pF1KB5 ERERG--WPDFLRC---------TPDRF-PE----GCTNEVQNIKFNSSGQCEVPLVRTD
: ::. :.: .: : :. : ....... . . : : .
NP_001 IDTFGIRWPEELECDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSG
110 120 130 140 150 160
210 220 230 240 250
pF1KB5 NPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLC---TLFTLATFVADWRN
. . .. :. : : : : . .:.: :.:. .: ::::. ::. : :
NP_001 GQGYKFLGIDQCAPPCPNMYFKSDELEFAKSFI---GTVSIFCLCATLFTFLTFLIDVRR
170 180 190 200 210 220
260 270 280 290 300 310
pF1KB5 SNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVC-RADGTMRLGEPT--SNETLSCV
::: ..: ..:. . :. .. :. : .: .:: ..::. . .... .:.
NP_001 F-RYPERPIIYYSVCYSIVSLMYFIGFLLGDS--TACNKADEKLELGDTVVLGSQNKACT
230 240 250 260 270 280
320 330 340 350 360 370
pF1KB5 IIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTV
..:...:. :::.::.:.:: .: : : : . . . :. .:: ..:. : :::
NP_001 VLFMLLYFFTMAGTVWWVILTITW---FLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTV
290 300 310 320 330 340
380 390 400 410 420 430
pF1KB5 AILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKS--
.::. .:.::..::.:::: . ::: :. : ..:: .:. :...: ...
NP_001 MLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVI
350 360 370 380 390 400
440 450 460 470 480 490
pF1KB5 NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQ
.: : . :... :.:.:.:. : . .. ..:. :. :. :: .. . :
NP_001 QHDG----RNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQ
410 420 430 440 450
500 510 520 530 540 550
pF1KB5 ANVTIGLPTKQPIP-DCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWC
.. : : . . : :: : . :. . . .::. :: .: : :
NP_001 YHI--------PCPYQAKAKARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFK
460 470 480 490 500
560 570 580 590 600 610
pF1KB5 RLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEP
NP_001 RNRKRDPISESRRVLQESCEFFLKHNSKVKHKKKHYKPSSHKLKVISKSMGTSTGATANH
510 520 530 540 550 560
787 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 20:35:37 2016 done: Sat Nov 5 20:35:39 2016
Total Scan time: 13.760 Total Display time: 0.160
Function used was FASTA [36.3.4 Apr, 2011]