FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2158, 207 aa 1>>>pF1KE2158 207 - 207 aa - 207 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1634+/-0.000355; mu= 14.5259+/- 0.022 mean_var=65.0103+/-13.187, 0's: 0 Z-trim(113.5): 17 B-trim: 0 in 0/49 Lambda= 0.159068 statistics sampled from 22874 (22891) to 22874 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.268), width: 16 Scan time: 5.650 The best scores are: opt bits E(85289) NP_001172085 (OMIM: 604136) interleukin-24 isoform ( 207) 1373 323.6 1.5e-88 NP_006841 (OMIM: 604136) interleukin-24 isoform 1 ( 206) 1356 319.6 2.2e-87 XP_011507403 (OMIM: 604136) PREDICTED: interleukin ( 179) 1178 278.8 3.8e-75 XP_016855610 (OMIM: 604136) PREDICTED: interleukin ( 179) 1178 278.8 3.8e-75 NP_001172086 (OMIM: 604136) interleukin-24 isoform ( 154) 705 170.2 1.6e-42 XP_005273209 (OMIM: 605619) PREDICTED: interleukin ( 261) 296 76.5 4.5e-14 NP_061194 (OMIM: 605619) interleukin-20 precursor ( 176) 292 75.4 6.1e-14 NP_715639 (OMIM: 605687) interleukin-19 isoform 1 ( 215) 247 65.2 9.2e-11 NP_037503 (OMIM: 605687) interleukin-19 isoform 2 ( 177) 243 64.2 1.5e-10 NP_000563 (OMIM: 124092,180300,609423,614395) inte ( 178) 142 41.0 0.0014 XP_011507752 (OMIM: 605687) PREDICTED: interleukin ( 207) 141 40.8 0.0019 >>NP_001172085 (OMIM: 604136) interleukin-24 isoform 3 p (207 aa) initn: 1373 init1: 1373 opt: 1373 Z-score: 1711.0 bits: 323.6 E(85289): 1.5e-88 Smith-Waterman score: 1373; 100.0% identity (100.0% similar) in 207 aa overlap (1-207:1-207) 10 20 30 40 50 60 pF1KE2 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ 130 140 150 160 170 180 190 200 pF1KE2 LDVEAALTKALGEVDILLTWMQKFYKL ::::::::::::::::::::::::::: NP_001 LDVEAALTKALGEVDILLTWMQKFYKL 190 200 >>NP_006841 (OMIM: 604136) interleukin-24 isoform 1 prec (206 aa) initn: 1274 init1: 1274 opt: 1356 Z-score: 1689.9 bits: 319.6 E(85289): 2.2e-87 Smith-Waterman score: 1356; 99.5% identity (99.5% similar) in 207 aa overlap (1-207:1-206) 10 20 30 40 50 60 pF1KE2 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::: NP_006 MNFQQRLQSLWTLA-RPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ 120 130 140 150 160 170 190 200 pF1KE2 LDVEAALTKALGEVDILLTWMQKFYKL ::::::::::::::::::::::::::: NP_006 LDVEAALTKALGEVDILLTWMQKFYKL 180 190 200 >>XP_011507403 (OMIM: 604136) PREDICTED: interleukin-24 (179 aa) initn: 1178 init1: 1178 opt: 1178 Z-score: 1470.0 bits: 278.8 E(85289): 3.8e-75 Smith-Waterman score: 1178; 100.0% identity (100.0% similar) in 179 aa overlap (29-207:1-179) 10 20 30 40 50 60 pF1KE2 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC :::::::::::::::::::::::::::::::: XP_011 MQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC 10 20 30 70 80 90 100 110 120 pF1KE2 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ 100 110 120 130 140 150 190 200 pF1KE2 LDVEAALTKALGEVDILLTWMQKFYKL ::::::::::::::::::::::::::: XP_011 LDVEAALTKALGEVDILLTWMQKFYKL 160 170 >>XP_016855610 (OMIM: 604136) PREDICTED: interleukin-24 (179 aa) initn: 1178 init1: 1178 opt: 1178 Z-score: 1470.0 bits: 278.8 E(85289): 3.8e-75 Smith-Waterman score: 1178; 100.0% identity (100.0% similar) in 179 aa overlap (29-207:1-179) 10 20 30 40 50 60 pF1KE2 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC :::::::::::::::::::::::::::::::: XP_016 MQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC 10 20 30 70 80 90 100 110 120 pF1KE2 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ 100 110 120 130 140 150 190 200 pF1KE2 LDVEAALTKALGEVDILLTWMQKFYKL ::::::::::::::::::::::::::: XP_016 LDVEAALTKALGEVDILLTWMQKFYKL 160 170 >>NP_001172086 (OMIM: 604136) interleukin-24 isoform 4 p (154 aa) initn: 705 init1: 705 opt: 705 Z-score: 884.4 bits: 170.2 E(85289): 1.6e-42 Smith-Waterman score: 923; 74.4% identity (74.4% similar) in 207 aa overlap (1-207:1-154) 10 20 30 40 50 60 pF1KE2 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKT :::::::::::::::::::::::::::::::::::::::::: NP_001 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVS------------------ 70 80 90 100 130 140 150 160 170 180 pF1KE2 VFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQ ::::::::::::::::::::::::: NP_001 -----------------------------------QENEMFSIRDSAHRRFLLFRRAFKQ 110 120 190 200 pF1KE2 LDVEAALTKALGEVDILLTWMQKFYKL ::::::::::::::::::::::::::: NP_001 LDVEAALTKALGEVDILLTWMQKFYKL 130 140 150 >>XP_005273209 (OMIM: 605619) PREDICTED: interleukin-20 (261 aa) initn: 278 init1: 149 opt: 296 Z-score: 373.7 bits: 76.5 E(85289): 4.5e-14 Smith-Waterman score: 296; 31.8% identity (64.1% similar) in 195 aa overlap (10-203:77-259) 10 20 30 pF1KE2 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGF :: : : : . ::.. . .: . XP_005 ATTCATNSHSDSELRPEIFSSREAWQFFLLLW---SPDFRPKM--KASSLAFSLLSAAFY 50 60 70 80 90 100 40 50 60 70 80 90 pF1KE2 TLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQ-EVL :::. .: . ...: : . . :.. ..: .. ..::.:. . :.:.. : : XP_005 --LLWTPSTGLK--TLNLGSCVIATNL-QEIRNGFSEIRGSVQAKDGNIDIRILRRTESL 110 120 130 140 150 100 110 120 130 140 150 pF1KE2 QNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQEN :... :. : :.. ::..:: ::::: .: . ::...:.:::.:. : ..:. . . XP_005 QDTKPANRCCLLRHLLRLYLDRVFKNY--QTPDHYTLRKISSLANSFLTIKKDLRLCHAH 160 170 180 190 200 210 160 170 180 190 200 pF1KE2 EMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL . : ... . :..:. .::..:::::.:::: ::.. XP_005 MTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEETE 220 230 240 250 260 >>NP_061194 (OMIM: 605619) interleukin-20 precursor [Hom (176 aa) initn: 251 init1: 149 opt: 292 Z-score: 371.3 bits: 75.4 E(85289): 6.1e-14 Smith-Waterman score: 292; 33.1% identity (68.1% similar) in 163 aa overlap (42-203:17-174) 20 30 40 50 60 70 pF1KE2 TLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLW :::. .: . ...: : . . :.. NP_061 MKASSLAFSLLSAAFYLLWTPSTGLK--TLNLGSCVIATNL-QEIR 10 20 30 40 80 90 100 110 120 130 pF1KE2 EAFWAVKDTMQAQDNITSARLLQQ-EVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTV ..: .. ..::.:. . :.:.. : ::... :. : :.. ::..:: ::::: .: NP_061 NGFSEIRGSVQAKDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNY--QTP 50 60 70 80 90 100 140 150 160 170 180 190 pF1KE2 EVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKA . ::...:.:::.:. : ..:. . . . : ... . :..:. .::..:: NP_061 DHYTLRKISSLANSFLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKA 110 120 130 140 150 160 200 pF1KE2 LGEVDILLTWMQKFYKL :::.:::: ::.. NP_061 LGELDILLQWMEETE 170 >>NP_715639 (OMIM: 605687) interleukin-19 isoform 1 [Hom (215 aa) initn: 216 init1: 127 opt: 247 Z-score: 314.2 bits: 65.2 E(85289): 9.2e-11 Smith-Waterman score: 247; 28.4% identity (65.8% similar) in 190 aa overlap (19-203:27-207) 10 20 30 40 pF1KE2 MNFQQRLQSLWTLASRPFCPPLL----ATASQMQMVVLPCLGFTLLLWSQVS : :.: . ..: : : :: :.:. .:. NP_715 MCTEGAFPHRSACSLPLTHVHTHIHVCVPVLWGSVPRGMKLQCVSLWLLG-TILILCSVD 10 20 30 40 50 50 60 70 80 90 100 pF1KE2 GAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQ-EVLQNVSDAESC . .: . : .. . ... :.: .: ..::.:.. .. .:. :.:: .. . : NP_715 N-HGLR----RCLISTDM-HHIEESFQEIKRAIQAKDTFPNVTILSTLETLQIIKPLDVC 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE2 YLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSA ....:: ::. :::.... . .. :...:..::.:. . . :. ::... :. : NP_715 CVTKNLLAFYVDRVFKDHQEPNPKI--LRKISSIANSFLYMQKTLRQCQEQRQCHCRQEA 120 130 140 150 160 170 170 180 190 200 pF1KE2 HRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL ... . ::.:.:: :.:::.:..:.:..: NP_715 TNATRVIHDNYDQLEVHAAAIKSLGELDVFLAWINKNHEVMFSA 180 190 200 210 >>NP_037503 (OMIM: 605687) interleukin-19 isoform 2 prec (177 aa) initn: 216 init1: 127 opt: 243 Z-score: 310.5 bits: 64.2 E(85289): 1.5e-10 Smith-Waterman score: 243; 28.8% identity (67.8% similar) in 177 aa overlap (28-203:2-169) 10 20 30 40 50 60 pF1KE2 MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPC ..: : : :: :.:. .:.. .: . : NP_037 MKLQCVSLWLLG-TILILCSVDN-HGLRR----C 10 20 70 80 90 100 110 pF1KE2 QVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQ-EVLQNVSDAESCYLVHTLLEFYLK .. . ... :.: .: ..::.:.. .. .:. :.:: .. . : ....:: ::. NP_037 LISTDM-HHIEESFQEIKRAIQAKDTFPNVTILSTLETLQIIKPLDVCCVTKNLLAFYVD 30 40 50 60 70 80 120 130 140 150 160 170 pF1KE2 TVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFK :::.... . .. :...:..::.:. . . :. ::... :. : ... . NP_037 RVFKDHQEPNPKI--LRKISSIANSFLYMQKTLRQCQEQRQCHCRQEATNATRVIHDNYD 90 100 110 120 130 140 180 190 200 pF1KE2 QLDVEAALTKALGEVDILLTWMQKFYKL ::.:.:: :.:::.:..:.:..: NP_037 QLEVHAAAIKSLGELDVFLAWINKNHEVMFSA 150 160 170 >>NP_000563 (OMIM: 124092,180300,609423,614395) interleu (178 aa) initn: 87 init1: 46 opt: 142 Z-score: 185.2 bits: 41.0 E(85289): 0.0014 Smith-Waterman score: 142; 21.9% identity (59.6% similar) in 178 aa overlap (33-207:6-174) 10 20 30 40 50 60 pF1KE2 FQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQV .: :: .:: ..: .:: . . . . NP_000 MHSSALLCCL--VLLTGVRASPGQGTQSENSCTHF 10 20 30 70 80 90 100 110 pF1KE2 KGVVP---QKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLK : .: . : .:: :: .: .:.. . ::.. .:.. . .: . ...:::. NP_000 PGNLPNMLRDLRDAFSRVKTFFQMKDQLDNL-LLKESLLEDFKGYLGCQALSEMIQFYLE 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE2 TVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFK :. . .:. .... ..:..:. . .:. .. : .. . . ::. NP_000 EVMPQAENQDPDIKA--HVNSLGENLKTLRLRLRRCHR---FLPCENKSKAVEQVKNAFN 100 110 120 130 140 180 190 200 pF1KE2 QLDVEAALTKALGEVDILLTWMQKFYKL .:. : .. ::..: ::...... .. . NP_000 KLQ-EKGIYKAMSEFDIFINYIEAYMTMKIRN 150 160 170 207 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 23:06:19 2016 done: Sun Nov 6 23:06:20 2016 Total Scan time: 5.650 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]