FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1440, 349 aa 1>>>pF1KE1440 349 - 349 aa - 349 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6676+/-0.000366; mu= 20.6433+/- 0.023 mean_var=76.5651+/-15.483, 0's: 0 Z-trim(113.5): 69 B-trim: 59 in 1/53 Lambda= 0.146575 statistics sampled from 22831 (22902) to 22831 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.63), E-opt: 0.2 (0.269), width: 16 Scan time: 7.300 The best scores are: opt bits E(85289) NP_004616 (OMIM: 228930,276820,601570) protein Wnt ( 349) 2477 533.3 3.1e-151 XP_011532393 (OMIM: 228930,276820,601570) PREDICTE ( 282) 2031 438.9 6.5e-123 NP_478679 (OMIM: 601967) protein Wnt-7b precursor ( 349) 2026 437.9 1.6e-122 XP_011528668 (OMIM: 601967) PREDICTED: protein Wnt ( 353) 1967 425.4 9e-119 NP_078613 (OMIM: 601968) protein Wnt-2b isoform WN ( 391) 1210 265.4 1.5e-70 NP_004176 (OMIM: 601968) protein Wnt-2b isoform WN ( 372) 1209 265.2 1.7e-70 NP_110388 (OMIM: 158330,603490,611812) protein Wnt ( 351) 1173 257.5 3.1e-68 XP_011539899 (OMIM: 158330,603490,611812) PREDICTE ( 373) 1168 256.5 6.8e-68 NP_110402 (OMIM: 606361) protein Wnt-5b precursor ( 359) 1157 254.2 3.3e-67 NP_116031 (OMIM: 606361) protein Wnt-5b precursor ( 359) 1157 254.2 3.3e-67 XP_011532389 (OMIM: 164975,180700) PREDICTED: prot ( 365) 1140 250.6 4.1e-66 XP_011532388 (OMIM: 164975,180700) PREDICTED: prot ( 365) 1140 250.6 4.1e-66 XP_011532387 (OMIM: 164975,180700) PREDICTED: prot ( 365) 1140 250.6 4.1e-66 NP_001243034 (OMIM: 164975,180700) protein Wnt-5a ( 365) 1140 250.6 4.1e-66 XP_006713387 (OMIM: 164975,180700) PREDICTED: prot ( 365) 1140 250.6 4.1e-66 XP_016862617 (OMIM: 164975,180700) PREDICTED: prot ( 365) 1140 250.6 4.1e-66 XP_011532391 (OMIM: 164975,180700) PREDICTED: prot ( 365) 1140 250.6 4.1e-66 XP_011532390 (OMIM: 164975,180700) PREDICTED: prot ( 365) 1140 250.6 4.1e-66 NP_003383 (OMIM: 164975,180700) protein Wnt-5a iso ( 380) 1140 250.6 4.2e-66 XP_016862616 (OMIM: 164975,180700) PREDICTED: prot ( 394) 1140 250.6 4.3e-66 NP_110380 (OMIM: 165330,273395) proto-oncogene Wnt ( 355) 1122 246.7 5.6e-65 XP_011539900 (OMIM: 158330,603490,611812) PREDICTE ( 296) 1115 245.2 1.4e-64 NP_003382 (OMIM: 147870) protein Wnt-2 precursor [ ( 360) 1105 243.2 6.8e-64 NP_149122 (OMIM: 606359) protein Wnt-3a precursor ( 352) 1102 242.5 1e-63 XP_011542621 (OMIM: 606359) PREDICTED: protein Wnt ( 446) 1102 242.6 1.2e-63 NP_001278809 (OMIM: 601968) protein Wnt-2b isoform ( 299) 1083 238.4 1.5e-62 NP_476509 (OMIM: 606267) protein Wnt-16 isoform 1 ( 365) 1083 238.5 1.7e-62 NP_057171 (OMIM: 606267) protein Wnt-16 isoform 2 ( 355) 1082 238.3 2e-62 NP_005421 (OMIM: 164820,615220,615221) proto-oncog ( 370) 981 217.0 5.4e-56 NP_003384 (OMIM: 601396) protein Wnt-8b precursor ( 351) 891 197.9 2.8e-50 NP_004617 (OMIM: 603699) protein Wnt-11 precursor ( 354) 882 196.0 1.1e-49 XP_005274288 (OMIM: 603699) PREDICTED: protein Wnt ( 354) 882 196.0 1.1e-49 XP_011543542 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 853 189.9 7.5e-48 XP_011543540 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 853 189.9 7.5e-48 XP_011543541 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 853 189.9 7.5e-48 NP_003387 (OMIM: 602864) protein Wnt-9b isoform 1 ( 357) 822 183.3 7e-46 XP_011523480 (OMIM: 602864) PREDICTED: protein Wnt ( 363) 822 183.3 7.1e-46 NP_490645 (OMIM: 606360) protein Wnt-8a isoform 3 ( 351) 821 183.1 8e-46 NP_001287868 (OMIM: 606360) protein Wnt-8a isoform ( 369) 821 183.1 8.3e-46 XP_016865314 (OMIM: 606360) PREDICTED: protein Wnt ( 391) 821 183.1 8.6e-46 NP_001287867 (OMIM: 606360) protein Wnt-8a isoform ( 386) 810 180.8 4.3e-45 XP_016865313 (OMIM: 606360) PREDICTED: protein Wnt ( 408) 810 180.8 4.4e-45 NP_003386 (OMIM: 602863) protein Wnt-9a precursor ( 365) 794 177.4 4.3e-44 XP_011542573 (OMIM: 602863) PREDICTED: protein Wnt ( 295) 771 172.4 1.1e-42 XP_016873730 (OMIM: 603699) PREDICTED: protein Wnt ( 251) 767 171.5 1.7e-42 XP_011543543 (OMIM: 603699) PREDICTED: protein Wnt ( 251) 767 171.5 1.7e-42 XP_016875408 (OMIM: 225300,601906,617073) PREDICTE ( 267) 713 160.1 5e-39 XP_011537024 (OMIM: 225300,601906,617073) PREDICTE ( 267) 713 160.1 5e-39 NP_003385 (OMIM: 225300,601906,617073) protein Wnt ( 389) 713 160.3 6.4e-39 XP_011541927 (OMIM: 606360) PREDICTED: protein Wnt ( 337) 697 156.9 6.1e-38 >>NP_004616 (OMIM: 228930,276820,601570) protein Wnt-7a (349 aa) initn: 2477 init1: 2477 opt: 2477 Z-score: 2836.2 bits: 533.3 E(85289): 3.1e-151 Smith-Waterman score: 2477; 100.0% identity (100.0% similar) in 349 aa overlap (1-349:1-349) 10 20 30 40 50 60 pF1KE1 MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAII 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAIT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 AACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 NLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 VRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQ 250 260 270 280 290 300 310 320 330 340 pF1KE1 ASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK ::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 310 320 330 340 >>XP_011532393 (OMIM: 228930,276820,601570) PREDICTED: p (282 aa) initn: 2031 init1: 2031 opt: 2031 Z-score: 2327.7 bits: 438.9 E(85289): 6.5e-123 Smith-Waterman score: 2031; 100.0% identity (100.0% similar) in 282 aa overlap (68-349:1-282) 40 50 60 70 80 90 pF1KE1 CNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKEL :::::::::::::::::::::::::::::: XP_011 MGLDECQFQFRNGRWNCSALGERTVFGKEL 10 20 30 100 110 120 130 140 150 pF1KE1 KVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIR 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE1 YGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTT 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE1 LPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNY 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE1 CEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCN 220 230 240 250 260 270 340 pF1KE1 TCSERTEMYTCK :::::::::::: XP_011 TCSERTEMYTCK 280 >>NP_478679 (OMIM: 601967) protein Wnt-7b precursor [Hom (349 aa) initn: 2011 init1: 2011 opt: 2026 Z-score: 2320.8 bits: 437.9 E(85289): 1.6e-122 Smith-Waterman score: 2026; 77.9% identity (94.0% similar) in 349 aa overlap (1-349:1-349) 10 20 30 40 50 60 pF1KE1 MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAII :.:. :. . ..:: .:..:...:..::::::::.::::::::::::::::::::::::: NP_478 MHRNFRKWIFYVFLCFGVLYVKLGALSSVVALGANIICNKIPGLAPRQRAICQSRPDAII 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAIT :::::.:::..:::.::: ::::::::::.::::.::.:::::::::::: :::::::.: NP_478 VIGEGAQMGINECQYQFRFGRWNCSALGEKTVFGQELRVGSREAAFTYAITAAGVAHAVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 AACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLM :::.:::::.::::.:::: :.. :::::::::::.:::: :.. ::::::::.::: :: NP_478 AACSQGNLSNCGCDREKQGYYNQAEGWKWGGCSADVRYGIDFSRRFVDAREIKKNARRLM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 NLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEP ::::::::::.::. :.::::::::::::::::::::::.:::.:..::.::: ::.:: NP_478 NLHNNEAGRKVLEDRMQLECKCHGVSGSCTTKTCWTTLPKFREVGHLLKEKYNAAVQVEV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 VRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQ ::::: ..::::.::. ::.:::.:::::::::::::::: .::::::::: ::.:.: NP_478 VRASRLRQPTFLRIKQLRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRLCNRTSPG 250 260 270 280 290 300 310 320 330 340 pF1KE1 ASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK :.::: ::::::::::::..::::::::::::.:::::::::::..::: NP_478 ADGCDTMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK 310 320 330 340 >>XP_011528668 (OMIM: 601967) PREDICTED: protein Wnt-7b (353 aa) initn: 1963 init1: 1963 opt: 1967 Z-score: 2253.3 bits: 425.4 E(85289): 9e-119 Smith-Waterman score: 1967; 79.9% identity (93.2% similar) in 338 aa overlap (12-349:20-353) 10 20 30 40 50 pF1KE1 MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAIC :.:: : :: ..::::::::.::::::::::::::::: XP_011 MLLLSPRSALVSVYCPQIFLLLSSGS-YL---ALSSVVALGANIICNKIPGLAPRQRAIC 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 QSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIA :::::::::::::.:::..:::.::: ::::::::::.::::.::.:::::::::::: : XP_011 QSRPDAIIVIGEGAQMGINECQYQFRFGRWNCSALGEKTVFGQELRVGSREAAFTYAITA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 AGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREI ::::::.::::.:::::.::::.:::: :.. :::::::::::.:::: :.. ::::::: XP_011 AGVAHAVTAACSQGNLSNCGCDREKQGYYNQAEGWKWGGCSADVRYGIDFSRRFVDAREI 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 KQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKY :.::: ::::::::::::.::. :.::::::::::::::::::::::.:::.:..::.:: XP_011 KKNARRLMNLHNNEAGRKVLEDRMQLECKCHGVSGSCTTKTCWTTLPKFREVGHLLKEKY 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 NEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGR : ::.:: ::::: ..::::.::. ::.:::.:::::::::::::::: .::::::::: XP_011 NAAVQVEVVRASRLRQPTFLRIKQLRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGR 240 250 260 270 280 290 300 310 320 330 340 pF1KE1 ACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK ::.:.: :.::: ::::::::::::..::::::::::::.:::::::::::..::: XP_011 LCNRTSPGADGCDTMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK 300 310 320 330 340 350 >>NP_078613 (OMIM: 601968) protein Wnt-2b isoform WNT-2B (391 aa) initn: 1207 init1: 409 opt: 1210 Z-score: 1387.7 bits: 265.4 E(85289): 1.5e-70 Smith-Waterman score: 1210; 49.7% identity (75.7% similar) in 346 aa overlap (8-349:43-380) 10 20 30 pF1KE1 MNRKARRCLGHLFLSLGMVYLRIG-GFSSVVALGASI :: :.: : . :. .. . :::: . NP_078 LPLRRASAPVPVPSPAAPDGSRASARLGLACL--LLLLLLTLPARVDTSWWYIGALGARV 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE1 ICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALG-ERTVFGK ::..::::. ::: .:: :: . .:::.. . ::: :::. ::::..: ..::::. NP_078 ICDNIPGLVSRQRQLCQRYPDIMRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGR 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE1 ELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEG-WKWGGCSA . .::::::.::: .:::.:::: ::.::.:: :.:: .:..: ..: . ::::: NP_078 VMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYTRGRHHDQRGDFDWGGCSD 140 150 160 170 180 190 160 170 180 190 200 210 pF1KE1 DIRYGIGFAKVFVDAREIK-QNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKT .:.::. :::.::::.: . ..::.:::::::. :: ... .:::::::::::::: .: NP_078 NIHYGVRFAKAFVDAKEKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRT 200 210 220 230 240 250 220 230 240 250 260 270 pF1KE1 CWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEK :: .: .::. : :. .:. ::.: .. . : : .. .::. :::::... NP_078 CWRALSDFRRTGDYLRRRYDGAVQVMATQDGAN----FTAARQ--GYRRATRTDLVYFDN 260 270 280 290 300 280 290 300 310 320 330 pF1KE1 SPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCY ::.:: : ..::.:: ::.:.::. ..::..:::::::.: . .:: ::.::::::: NP_078 SPDYCVLDKAAGSLGTAGRVCSKTSKGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCA 310 320 330 340 350 360 340 pF1KE1 VKCNTCSERTEMYTCK :.:. : . ....::: NP_078 VRCKECRNTVDVHTCKAPKKAEWLDQT 370 380 390 >>NP_004176 (OMIM: 601968) protein Wnt-2b isoform WNT-2B (372 aa) initn: 1207 init1: 409 opt: 1209 Z-score: 1386.8 bits: 265.2 E(85289): 1.7e-70 Smith-Waterman score: 1209; 51.6% identity (77.6% similar) in 322 aa overlap (31-349:46-361) 10 20 30 40 50 60 pF1KE1 MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAII :::: .::..::::. ::: .:: :: . NP_004 QLKTEGSLRTAVPGIPTQSAFNKCLQRYIGALGARVICDNIPGLVSRQRQLCQRYPDIMR 20 30 40 50 60 70 70 80 90 100 110 pF1KE1 VIGEGSQMGLDECQFQFRNGRWNCSALG-ERTVFGKELKVGSREAAFTYAIIAAGVAHAI .:::.. . ::: :::. ::::..: ..::::. . .::::::.::: .:::.::: NP_004 SVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVHAI 80 90 100 110 120 130 120 130 140 150 160 170 pF1KE1 TAACTQGNLSDCGCDKEKQGQYHRDEG-WKWGGCSADIRYGIGFAKVFVDAREIK-QNAR : ::.::.:: :.:: .:..: ..: . ::::: .:.::. :::.::::.: . ..:: NP_004 TRACSQGELSVCSCDPYTRGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDAR 140 150 160 170 180 190 180 190 200 210 220 230 pF1KE1 TLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVH .:::::::. :: ... .:::::::::::::: .::: .: .::. : :. .:. ::. NP_004 ALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRALSDFRRTGDYLRRRYDGAVQ 200 210 220 230 240 250 240 250 260 270 280 290 pF1KE1 VEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKT : .. . : : .. .::. :::::...::.:: : ..::.:: ::.:.:: NP_004 VMATQDGAN----FTAARQ--GYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKT 260 270 280 290 300 300 310 320 330 340 pF1KE1 APQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK . ..::..:::::::.: . .:: ::.::::::: :.:. : . ....::: NP_004 SKGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCKAPKKAEWL 310 320 330 340 350 360 NP_004 DQT 370 >>NP_110388 (OMIM: 158330,603490,611812) protein Wnt-4 p (351 aa) initn: 1133 init1: 392 opt: 1173 Z-score: 1345.9 bits: 257.5 E(85289): 3.1e-68 Smith-Waterman score: 1173; 45.5% identity (72.9% similar) in 354 aa overlap (6-349:4-351) 10 20 30 40 50 pF1KE1 MNRKARRCLGHLFLSLGMVY-------LRIGGFSSVVALGASIICNKIPGLAPRQRAICQ : :: : : . :. : .. .::: ... :.:. :: :: .:. NP_110 MSPRSCLRSLRLLVFAVFSAAASNWLYLAKLSSVGSISEEETCEKLKGLIQRQVQMCK 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 SRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAA ... . .:.:....:::.:::: :::::.: :::: . :.:::::.::: .: NP_110 RNLEVMDSVRRGAQLAIEECQYQFRNRRWNCSTLDSLPVFGKVVTQGTREAAFVYAISSA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 GVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIK ::: :.: ::..:.: ::::. .: .:..:.::: .: ::..:.. :::.:: . NP_110 GVAFAVTRACSSGELEKCGCDRTVHGV--SPQGFQWSGCSDNIAYGVAFSQSFVDVRERS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 QNA---RTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKD ..: :.:::::::::::: . .:..::::::::::: .:::: ..: ::..:..::. NP_110 KGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRAVPPFRQVGHALKE 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 KYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQ :.. :..::: :.. .. . . ... : ::::.: ::..::.: .: .::. NP_110 KFDGATEVEPRRVGSSRA----LVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTR 240 250 260 270 280 290 300 310 320 330 340 pF1KE1 GRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK ::.::::. .::.:.:::::..: : . .:.:::::::.::: :.. .:..::. NP_110 GRTCNKTSKAIDGCELLCCGRGFHTAQVELAERCSCKFHWCCFVKCRQCQRLVELHTCR 300 310 320 330 340 350 >>XP_011539899 (OMIM: 158330,603490,611812) PREDICTED: p (373 aa) initn: 1133 init1: 392 opt: 1168 Z-score: 1339.9 bits: 256.5 E(85289): 6.8e-68 Smith-Waterman score: 1168; 46.1% identity (74.7% similar) in 336 aa overlap (17-349:44-373) 10 20 30 40 pF1KE1 MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAP : . .. .::: ... :.:. :: XP_011 QGSLCSTQGKRNKRLPRTLPNQRGYEGEDTGHIPRYLAKLSSVGSISEEETCEKLKGLIQ 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE1 RQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAF :: .:. ... . .:.:....:::.:::: :::::.: :::: . :.::::: XP_011 RQVQMCKRNLEVMDSVRRGAQLAIEECQYQFRNRRWNCSTLDSLPVFGKVVTQGTREAAF 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE1 TYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVF .::: .:::: :.: ::..:.: ::::. .: .:..:.::: .: ::..:.. : XP_011 VYAISSAGVAFAVTRACSSGELEKCGCDRTVHGV--SPQGFQWSGCSDNIAYGVAFSQSF 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE1 VDAREIKQNA---RTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRE ::.:: ...: :.:::::::::::: . .:..::::::::::: .:::: ..: ::. XP_011 VDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRAVPPFRQ 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE1 LGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPV .:..::.:.. :..::: :.. .. . . ... : ::::.: ::..::.: XP_011 VGHALKEKFDGATEVEPRRVGSSRA----LVPRNAQFKPHTDEDLVYLEPSPDFCEQDMR 260 270 280 290 300 290 300 310 320 330 340 pF1KE1 TGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERT .: .::.::.::::. .::.:.:::::..: : . .:.:::::::.::: :.. . XP_011 SGVLGTRGRTCNKTSKAIDGCELLCCGRGFHTAQVELAERCSCKFHWCCFVKCRQCQRLV 310 320 330 340 350 360 pF1KE1 EMYTCK :..::. XP_011 ELHTCR 370 >>NP_110402 (OMIM: 606361) protein Wnt-5b precursor [Hom (359 aa) initn: 693 init1: 693 opt: 1157 Z-score: 1327.5 bits: 254.2 E(85289): 3.3e-67 Smith-Waterman score: 1157; 47.7% identity (73.4% similar) in 327 aa overlap (32-349:42-359) 10 20 30 40 50 60 pF1KE1 NRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIV .::. .:...:::.: :: .:: . . NP_110 LLSSWAQLLTDANSWWSLALNPVQRPEMFIIGAQPVCSQLPGLSPGQRKLCQLYQEHMAY 20 30 40 50 60 70 70 80 90 100 110 120 pF1KE1 IGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITA ::::.. :. ::: :::. :::::. . .:::. ...::::.:::.:. ::::..::. NP_110 IGEGAKTGIKECQHQFRQRRWNCSTADNASVFGRVMQIGSRETAFTHAVSAAGVVNAISR 80 90 100 110 120 130 130 140 150 160 170 pF1KE1 ACTQGNLSDCGCDKEKQGQ-YHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQN----- :: .:.:: :::.. . . :: : ::::. ...:: ::: :::::: ..: NP_110 ACREGELSTCGCSRTARPKDLPRD--WLWGGCGDNVEYGYRFAKEFVDAREREKNFAKGS 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 ---ARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKY .:.::::.::::::. . . . ::::::::::. :::: : .::..: ::.:: NP_110 EEQGRVLMNLQNNEAGRRAVYKMADVACKCHGVSGSCSLKTCWLQLAEFRKVGDRLKEKY 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE1 NEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGR . :. .:..:. : ... . . .: ::::.. ::.:: .. :::.::::: NP_110 DSAA---AMRVTRKGRLELVNSR----FTQPTPEDLVYVDPSPDYCLRNESTGSLGTQGR 250 260 270 280 290 300 300 310 320 330 340 pF1KE1 ACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK ::::. .::.::::::::: . ..: .:.:::::::.:.:. :.: ...: :: NP_110 LCNKTSEGMDGCELMCCGRGYNQFKSVQVERCHCKFHWCCFVRCKKCTEIVDQYICK 310 320 330 340 350 >>NP_116031 (OMIM: 606361) protein Wnt-5b precursor [Hom (359 aa) initn: 693 init1: 693 opt: 1157 Z-score: 1327.5 bits: 254.2 E(85289): 3.3e-67 Smith-Waterman score: 1157; 47.7% identity (73.4% similar) in 327 aa overlap (32-349:42-359) 10 20 30 40 50 60 pF1KE1 NRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIV .::. .:...:::.: :: .:: . . NP_116 LLSSWAQLLTDANSWWSLALNPVQRPEMFIIGAQPVCSQLPGLSPGQRKLCQLYQEHMAY 20 30 40 50 60 70 70 80 90 100 110 120 pF1KE1 IGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITA ::::.. :. ::: :::. :::::. . .:::. ...::::.:::.:. ::::..::. NP_116 IGEGAKTGIKECQHQFRQRRWNCSTADNASVFGRVMQIGSRETAFTHAVSAAGVVNAISR 80 90 100 110 120 130 130 140 150 160 170 pF1KE1 ACTQGNLSDCGCDKEKQGQ-YHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQN----- :: .:.:: :::.. . . :: : ::::. ...:: ::: :::::: ..: NP_116 ACREGELSTCGCSRTARPKDLPRD--WLWGGCGDNVEYGYRFAKEFVDAREREKNFAKGS 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 ---ARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKY .:.::::.::::::. . . . ::::::::::. :::: : .::..: ::.:: NP_116 EEQGRVLMNLQNNEAGRRAVYKMADVACKCHGVSGSCSLKTCWLQLAEFRKVGDRLKEKY 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE1 NEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGR . :. .:..:. : ... . . .: ::::.. ::.:: .. :::.::::: NP_116 DSAA---AMRVTRKGRLELVNSR----FTQPTPEDLVYVDPSPDYCLRNESTGSLGTQGR 250 260 270 280 290 300 300 310 320 330 340 pF1KE1 ACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK ::::. .::.::::::::: . ..: .:.:::::::.:.:. :.: ...: :: NP_116 LCNKTSEGMDGCELMCCGRGYNQFKSVQVERCHCKFHWCCFVRCKKCTEIVDQYICK 310 320 330 340 350 349 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 23:09:51 2016 done: Sun Nov 6 23:09:52 2016 Total Scan time: 7.300 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]