FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1431, 764 aa 1>>>pF1KE1431 764 - 764 aa - 764 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5458+/-0.000443; mu= 19.7426+/- 0.028 mean_var=113.0657+/-23.060, 0's: 0 Z-trim(112.8): 292 B-trim: 649 in 1/49 Lambda= 0.120617 statistics sampled from 21466 (21877) to 21466 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.625), E-opt: 0.2 (0.257), width: 16 Scan time: 11.860 The best scores are: opt bits E(85289) NP_001701 (OMIM: 138470,612924,615489,615561) comp ( 764) 5255 926.6 0 NP_000054 (OMIM: 217000,613927,615489) complement ( 752) 1846 333.3 2.2e-90 NP_001269387 (OMIM: 217000,613927,615489) compleme ( 723) 1694 306.9 2e-82 NP_001139375 (OMIM: 217000,613927,615489) compleme ( 620) 1434 261.5 7.5e-69 NP_001269386 (OMIM: 217000,613927,615489) compleme ( 506) 1099 203.2 2.3e-51 NP_001269388 (OMIM: 217000,613927,615489) compleme ( 328) 752 142.6 2.6e-33 XP_016855679 (OMIM: 608398) PREDICTED: CUB and sus (3362) 307 66.2 2.5e-09 NP_443128 (OMIM: 608398) CUB and sushi domain-cont (3487) 307 66.3 2.6e-09 XP_016855678 (OMIM: 608398) PREDICTED: CUB and sus (3506) 307 66.3 2.6e-09 XP_016855683 (OMIM: 608398) PREDICTED: CUB and sus (3566) 307 66.3 2.6e-09 XP_016855677 (OMIM: 608398) PREDICTED: CUB and sus (3567) 307 66.3 2.6e-09 XP_016855676 (OMIM: 608398) PREDICTED: CUB and sus (3606) 307 66.3 2.6e-09 XP_016855674 (OMIM: 608398) PREDICTED: CUB and sus (3607) 307 66.3 2.6e-09 XP_016855675 (OMIM: 608398) PREDICTED: CUB and sus (3607) 307 66.3 2.6e-09 NP_001268885 (OMIM: 608398) CUB and sushi domain-c (3631) 307 66.3 2.6e-09 NP_001017366 (OMIM: 120831) C4b-binding protein be ( 251) 292 62.4 2.7e-09 NP_001017364 (OMIM: 120831) C4b-binding protein be ( 251) 292 62.4 2.7e-09 XP_005273311 (OMIM: 120831) PREDICTED: C4b-binding ( 252) 292 62.4 2.7e-09 NP_000707 (OMIM: 120831) C4b-binding protein beta ( 252) 292 62.4 2.7e-09 NP_001017367 (OMIM: 120831) C4b-binding protein be ( 252) 292 62.4 2.7e-09 NP_001017365 (OMIM: 120831) C4b-binding protein be ( 252) 292 62.4 2.7e-09 XP_011528291 (OMIM: 206200,609862) PREDICTED: tran ( 680) 296 63.6 3.3e-09 NP_001275929 (OMIM: 206200,609862) transmembrane p ( 824) 296 63.7 3.7e-09 XP_011533056 (OMIM: 608397) PREDICTED: CUB and sus (2238) 282 61.7 3.9e-08 XP_011533055 (OMIM: 608397) PREDICTED: CUB and sus (2595) 282 61.8 4.3e-08 XP_016869220 (OMIM: 608397) PREDICTED: CUB and sus (3327) 282 61.9 5.1e-08 XP_011533054 (OMIM: 608397) PREDICTED: CUB and sus (3549) 282 61.9 5.3e-08 NP_150094 (OMIM: 608397) CUB and sushi domain-cont (3564) 282 61.9 5.3e-08 NP_001171534 (OMIM: 217000,613927,615489) compleme ( 538) 267 58.4 9.2e-08 XP_005245497 (OMIM: 147050,173610) PREDICTED: P-se ( 768) 268 58.7 1e-07 XP_005245496 (OMIM: 147050,173610) PREDICTED: P-se ( 790) 268 58.8 1.1e-07 XP_005245495 (OMIM: 147050,173610) PREDICTED: P-se ( 790) 268 58.8 1.1e-07 XP_005245492 (OMIM: 147050,173610) PREDICTED: P-se ( 830) 268 58.8 1.1e-07 XP_005245493 (OMIM: 147050,173610) PREDICTED: P-se ( 830) 268 58.8 1.1e-07 NP_002996 (OMIM: 147050,173610) P-selectin precurs ( 830) 268 58.8 1.1e-07 XP_011515117 (OMIM: 608399) PREDICTED: CUB and sus (2173) 258 57.5 6.9e-07 XP_016868501 (OMIM: 608399) PREDICTED: CUB and sus (3463) 258 57.7 9.5e-07 XP_016868500 (OMIM: 608399) PREDICTED: CUB and sus (3507) 258 57.7 9.5e-07 NP_699197 (OMIM: 611691) sushi, von Willebrand fac (3571) 258 57.7 9.7e-07 XP_016868499 (OMIM: 608399) PREDICTED: CUB and sus (3577) 258 57.7 9.7e-07 XP_011515118 (OMIM: 608399) PREDICTED: CUB and sus (3603) 258 57.7 9.7e-07 XP_016868498 (OMIM: 608399) PREDICTED: CUB and sus (3637) 258 57.7 9.8e-07 NP_937757 (OMIM: 608399) CUB and sushi domain-cont (3667) 258 57.8 9.8e-07 XP_016868497 (OMIM: 608399) PREDICTED: CUB and sus (3681) 258 57.8 9.9e-07 NP_937756 (OMIM: 608399) CUB and sushi domain-cont (3707) 258 57.8 9.9e-07 NP_443132 (OMIM: 608399) CUB and sushi domain-cont (3538) 256 57.4 1.2e-06 XP_016855680 (OMIM: 608398) PREDICTED: CUB and sus (2973) 255 57.1 1.2e-06 XP_011507588 (OMIM: 134580,613235) PREDICTED: coag ( 628) 226 51.3 1.4e-05 NP_001985 (OMIM: 134580,613235) coagulation factor ( 661) 226 51.4 1.5e-05 XP_011507585 (OMIM: 134580,613235) PREDICTED: coag ( 676) 226 51.4 1.5e-05 >>NP_001701 (OMIM: 138470,612924,615489,615561) compleme (764 aa) initn: 5255 init1: 5255 opt: 5255 Z-score: 4949.5 bits: 926.6 E(85289): 0 Smith-Waterman score: 5255; 99.9% identity (99.9% similar) in 764 aa overlap (1-764:1-764) 10 20 30 40 50 60 pF1KE1 MGSNLSPQLCLMPFILGLLSGGVTTTPWSLAWPQGSCSLEGVEIKGGSFRLLQEGQALEY ::::::::::::::::::::::::::::::: :::::::::::::::::::::::::::: NP_001 MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 YNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 YRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 TIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 ASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 AVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 DYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 VWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 EGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG 670 680 690 700 710 720 730 740 750 760 pF1KE1 VVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL :::::::::::::::::::::::::::::::::::::::::::: NP_001 VVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL 730 740 750 760 >>NP_000054 (OMIM: 217000,613927,615489) complement C2 i (752 aa) initn: 1524 init1: 548 opt: 1846 Z-score: 1743.6 bits: 333.3 E(85289): 2.2e-90 Smith-Waterman score: 1846; 39.8% identity (69.6% similar) in 757 aa overlap (30-764:17-750) 10 20 30 40 50 pF1KE1 MGSNLSPQLCLMPFILGLLSGGVTTTPWSLAWPQGSCSLEGVEIKGGSFRLLQ---EGQA :: :: ..:.:.::.: : . :. NP_000 MGPLMVLFCLLFLYPGLADSAPSCP-QNVNISGGTFTLSHGWAPGSL 10 20 30 40 60 70 80 90 100 110 pF1KE1 LEYVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPR : : ::.:.:: :. .: :.:.:.:.: ... :: :. ..:: : .:::: : :: NP_000 LTYSCPQGLYPSPA-SRLCKSSGQWQT--PGATRSLSKAVCKPVRCPAPVSFENGIYTPR 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 SPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKV : :. ..::.: ::. :::: : :. :: :.:.::.::::::.: :::: .:. .. NP_000 LGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRT 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 GSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSS : .. :.: :.:: .:.: ::..: :: .: :::::: :.. . :: :..:: :. .: NP_000 GFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTS 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 LTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLI ... . ... . :. ::: .. :: .:.::.:: :.:.. ..: :. .. NP_000 FSHMLGATNPT--QKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMV 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE1 EKVASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKK ... :. .. ...:.:. ::. ..: . .: . : ..:.. ::.::. .:::: NP_000 DRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYA 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE1 ALQAVYSMMSWPD---DVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKD ::..:: ::. . .:.. ::.:::.::: ::::.: :..:.::..: :.. NP_000 ALNSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQK 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE1 RKNPREDYLDVYVFGVGPL-VNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQ : .::::.:..::: : :. ..: :.::::.:.:.: ..: . :..:: .:.: :. NP_000 R----NDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSK 410 420 430 440 450 480 490 500 510 520 530 pF1KE1 -SLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDD . ..::. ...: .. ::.. .:.: :..:.: ::..:. .:::::::: : NP_000 LTDTICGVGNMSANASDQERTPWHV---TIKP-KSQETCRGALISDQWVLTAAHCFR-DG 460 470 480 490 500 510 540 550 560 570 580 pF1KE1 KEHSI-KVSVGGEK----RDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLK ..::. .:.:: : ... :: ... :.... .::. :: ::: :.::.:: .:.: NP_000 NDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVK 520 530 540 550 560 570 590 600 610 620 630 640 pF1KE1 YGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYI .. :::::::: .. ::: : .::.....::: :.. : ::. . .:: .. . NP_000 MSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKL---NINL 580 590 600 610 620 650 660 670 680 690 700 pF1KE1 KNGDKKGSC-ERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVH : : . :: : .: . .. :. :::: .:::.: : . :.:.::: .... NP_000 KMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSG---TQEDESPCKGESGGAVFLE 630 640 650 660 670 680 710 720 730 740 750 pF1KE1 KRSRFIQVGVISWGVVDVC-----KNQKRQ---KQVPAHARDFHINLFQVLPWLKEKLQD .: ::.:::..:::. . : ::.... ..:: ::::::::.. :::...: : NP_000 RRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPP-PRDFHINLFRMQPWLRQHLGD 690 700 710 720 730 740 760 pF1KE1 EDLGFL :.:: NP_000 V-LNFLPL 750 >>NP_001269387 (OMIM: 217000,613927,615489) complement C (723 aa) initn: 1502 init1: 526 opt: 1694 Z-score: 1600.8 bits: 306.9 E(85289): 2e-82 Smith-Waterman score: 1694; 40.0% identity (70.4% similar) in 685 aa overlap (99-764:56-721) 70 80 90 100 110 120 pF1KE1 YPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEIS .:..:: : .:::: : :: : :. ..: NP_001 ARAADSGRPQEPPGLCLRRSANVRLPVGFAQAVRCPAPVSFENGIYTPRLGSYPVGGNVS 30 40 50 60 70 80 130 140 150 160 170 180 pF1KE1 FHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVT :.: ::. :::: : :. :: :.:.::.::::::.: :::: .:. ..: .. :.: NP_001 FECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVR 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE1 YHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAE :.:: .:.: ::..: :: .: :::::: :.. . :: :..:: :. .:... . ... NP_001 YRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPT 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE1 DGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPR . :. ::: .. :: .:.::.:: :.:.. ..: :. ..... :. .. NP_001 --QKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVS 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE1 YGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSW ...:.:. ::. ..: . .: . : ..:.. ::.::. .:::: ::..:: ::. NP_001 VAIITFASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNN 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE1 PD---DVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDV . .:.. ::.:::.::: ::::.: :..:.::..: :.. :. ::::. NP_001 QMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRN----DYLDI 330 340 350 360 370 430 440 450 460 470 480 pF1KE1 YVFGVGPL-VNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQ-SLSLCGMVWE :..::: : :. ..: :.::::.:.:.: ..: . :..:: .:.: :. . ..::. NP_001 YAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNM 380 390 400 410 420 430 490 500 510 520 530 540 pF1KE1 HRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSI-KVSVG ...: .. ::.. .:.: :..:.: ::..:. .:::::::: : ..::. .:.:: NP_001 SANASDQERTPWHV---TIKP-KSQETCRGALISDQWVLTAAHCFR-DGNDHSLWRVNVG 440 450 460 470 480 490 550 560 570 580 590 pF1KE1 GEK----RDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLP : ... :: ... :.... .::. :: ::: :.::.:: .:.:.. :::::: NP_001 DPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLP 500 510 520 530 540 550 600 610 620 630 640 650 pF1KE1 CTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSC-E :: .. ::: : .::.....::: :.. : ::. . .:: .. .: : . :: : NP_001 CTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKL---NINLKMGVEWTSCAE 560 570 580 590 600 610 660 670 680 690 700 710 pF1KE1 RDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVI .: . .. :. :::: .:::.: : . :.:.::: .....: ::.:::.. NP_001 VVSQEKTMFPNLTDVREVVTDQFLCSG---TQEDESPCKGESGGAVFLERRFRFFQVGLV 620 630 640 650 660 720 730 740 750 760 pF1KE1 SWGVVDVC-----KNQKRQ---KQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL :::. . : ::.... ..:: ::::::::.. :::...: : :.:: NP_001 SWGLYNPCLGSADKNSRKRAPRSKVPP-PRDFHINLFRMQPWLRQHLGDV-LNFLPL 670 680 690 700 710 720 >>NP_001139375 (OMIM: 217000,613927,615489) complement C (620 aa) initn: 1351 init1: 266 opt: 1434 Z-score: 1357.1 bits: 261.5 E(85289): 7.5e-69 Smith-Waterman score: 1434; 38.6% identity (69.9% similar) in 622 aa overlap (162-764:16-618) 140 150 160 170 180 190 pF1KE1 YDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHC ::.: :::: .:. ..: .. :.: :.: NP_001 MGPLMVLFCLLFLYPAGHCPNPGISLGAVRTGFRFGHGDKVRYRC 10 20 30 40 200 210 220 230 240 250 pF1KE1 SRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGH : .:.: ::..: :: .: :::::: :.. . :: :..:: :. .:... . ... . NP_001 SSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPT--Q 50 60 70 80 90 100 260 270 280 290 300 310 pF1KE1 GPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGL :. ::: .. :: .:.::.:: :.:.. ..: :. ..... :. .. .. NP_001 KTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAI 110 120 130 140 150 160 320 330 340 350 360 370 pF1KE1 VTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPD- .:.:. ::. ..: . .: . : ..:.. ::.::. .:::: ::..:: ::. NP_001 ITFASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMR 170 180 190 200 210 220 380 390 400 410 420 pF1KE1 --DVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDVYVF . .:.. ::.:::.::: ::::.: :..:.::..: :.. : .::::.:.. NP_001 LLGMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKR----NDYLDIYAI 230 240 250 260 270 430 440 450 460 470 480 pF1KE1 GVGPL-VNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQ-SLSLCGMVWEHRK ::: : :. ..: :.::::.:.:.: ..: . :..:: .:.: :. . ..::. . NP_001 GVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSAN 280 290 300 310 320 330 490 500 510 520 530 540 pF1KE1 GTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSI-KVSVGGEK ..: .. ::.. .:.: :..:.: ::..:. .:::::::: : ..::. .:.:: : NP_001 ASDQERTPWHV---TIKP-KSQETCRGALISDQWVLTAAHCFR-DGNDHSLWRVNVGDPK 340 350 360 370 380 390 550 560 570 580 590 600 pF1KE1 ----RDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTE ... :: ... :.... .::. :: ::: :.::.:: .:.:.. :::::::: NP_001 SQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTM 400 410 420 430 440 450 610 620 630 640 650 660 pF1KE1 GTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSC-ERDA .. ::: : .::.....::: :.. : ::. . .::. . .: : . :: : . NP_001 EANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLN---INLKMGVEWTSCAEVVS 460 470 480 490 500 510 670 680 690 700 710 720 pF1KE1 QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG : . .. :. :::: .:::.: : . :.:.::: .....: ::.:::..::: NP_001 QEKTMFPNLTDVREVVTDQFLCSG---TQEDESPCKGESGGAVFLERRFRFFQVGLVSWG 520 530 540 550 560 730 740 750 760 pF1KE1 VVDVC-----KNQKRQ---KQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL . . : ::.... ..:: ::::::::.. :::...: : :.:: NP_001 LYNPCLGSADKNSRKRAPRSKVPP-PRDFHINLFRMQPWLRQHLGDV-LNFLPL 570 580 590 600 610 620 >>NP_001269386 (OMIM: 217000,613927,615489) complement C (506 aa) initn: 894 init1: 256 opt: 1099 Z-score: 1043.1 bits: 203.2 E(85289): 2.3e-51 Smith-Waterman score: 1099; 39.0% identity (70.0% similar) in 484 aa overlap (300-764:38-504) 270 280 290 300 310 320 pF1KE1 NIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKIWVKVSEADS . :. .. ...:.:. ::. ..: . .: NP_001 AAPRILCSRGLRSGSARATGSGVERSPSAAIFSFEINVSVAIITFASEPKVLMSVLNDNS 10 20 30 40 50 60 330 340 350 360 370 380 pF1KE1 SNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPD---DVPPEGWNRTRHVIIL . : ..:.. ::.::. .:::: ::..:: ::. . .:.. ::.::: NP_001 RDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHAIIL 70 80 90 100 110 120 390 400 410 420 430 440 pF1KE1 MTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDVYVFGVGPL-VNQVNINALASK .::: ::::.: :..:.::..: :.. :. ::::.:..::: : :. ..: :.:: NP_001 LTDGKSNMGGSPKTAVDHIREILNINQKRN----DYLDIYAIGVGKLDVDWRELNELGSK 130 140 150 160 170 180 450 460 470 480 490 500 pF1KE1 KDNEQHVFKVKDMENLEDVFYQMIDESQ-SLSLCGMVWEHRKGTDYHKQPWQAKISVIRP ::.:.:.: ..: . :..:: .:.: :. . ..::. ...: .. ::.. .:.: NP_001 KDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHV---TIKP 190 200 210 220 230 240 510 520 530 540 550 pF1KE1 SKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSI-KVSVGGEK----RDLEIEVVLFHPNY :..:.: ::..:. .:::::::: : ..::. .:.:: : ... :: ... :.. NP_001 -KSQETCRGALISDQWVLTAAHCFR-DGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGF 250 260 270 280 290 560 570 580 590 600 610 pF1KE1 NINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQK .. .::. :: ::: :.::.:: .:.:.. :::::::: .. ::: : .::.... NP_001 DVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHE 300 310 320 330 340 350 620 630 640 650 660 670 pF1KE1 EELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSC-ERDAQYAPGYDKVKDISEVVTP .::: :.. : ::. . .:: .. .: : . :: : .: . .. :. :::: NP_001 NELLNKQSVPAHFVALNGSKL---NINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTD 360 370 380 390 400 410 680 690 700 710 720 730 pF1KE1 RFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVC-----KNQKRQ-- .:::.: : . :.:.::: .....: ::.:::..:::. . : ::.... NP_001 QFLCSG---TQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAP 420 430 440 450 460 470 740 750 760 pF1KE1 -KQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL ..:: ::::::::.. :::...: : :.:: NP_001 RSKVPP-PRDFHINLFRMQPWLRQHLGDV-LNFLPL 480 490 500 >>NP_001269388 (OMIM: 217000,613927,615489) complement C (328 aa) initn: 840 init1: 543 opt: 752 Z-score: 719.0 bits: 142.6 E(85289): 2.6e-33 Smith-Waterman score: 752; 41.2% identity (69.0% similar) in 274 aa overlap (30-300:17-284) 10 20 30 40 50 pF1KE1 MGSNLSPQLCLMPFILGLLSGGVTTTPWSLAWPQGSCSLEGVEIKGGSFRLLQ---EGQA :: :: ..:.:.::.: : . :. NP_001 MGPLMVLFCLLFLYPGLADSAPSCP-QNVNISGGTFTLSHGWAPGSL 10 20 30 40 60 70 80 90 100 110 pF1KE1 LEYVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPR : : ::.:.:: :. .: :.:.:.:.: ... :: :. ..:: : .:::: : :: NP_001 LTYSCPQGLYPSPA-SRLCKSSGQWQT--PGATRSLSKAVCKPVRCPAPVSFENGIYTPR 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 SPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKV : :. ..::.: ::. :::: : :. :: :.:.::.::::::.: :::: .:. .. NP_001 LGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRT 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 GSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSS : .. :.: :.:: .:.: ::..: :: .: :::::: :.. . :: :..:: :. .: NP_001 GFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTS 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 LTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLI ... . ... . :. ::: .. :: .:.::.:: :.:.. ..: :. .. NP_001 FSHMLGATNPT--QKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMV 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE1 EKVASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKK ..: NP_001 DRVRNQESACSRGLPVLTISLCLLPLLRTPLTAHLLQEVFSDYTHAM 290 300 310 320 >>XP_016855679 (OMIM: 608398) PREDICTED: CUB and sushi d (3362 aa) initn: 598 init1: 178 opt: 307 Z-score: 288.4 bits: 66.2 E(85289): 2.5e-09 Smith-Waterman score: 337; 28.7% identity (54.2% similar) in 216 aa overlap (14-220:2799-2999) 10 20 30 pF1KE1 MGSNLSPQLCLMPFILGLLSGGVTTT-PWSLAWPQG---SCSL . :::: ... :. . :. .:. XP_016 NPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGD 2770 2780 2790 2800 2810 2820 40 50 60 70 80 90 pF1KE1 EGVEIKGGSFRL---LQEGQALEYVCPSGFY--PYPVQTRTCRSTGSWSTLKTQDQKTVR :. .: .:: .. .... : : :.. . :.. .: . .:. : XP_016 PGIPANG--LRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPV------ 2830 2840 2850 2860 2870 2880 100 110 120 130 140 150 pF1KE1 KAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQ :.:. : : . ::. . ... : ... : .:: : : ::. :: :.:. XP_016 ---CKALMCKPPPLIPNGKVVGSDFMWGSS--VTYACLEGYQLSLPAVFTCEGNGSWTGE 2890 2900 2910 2920 2930 160 170 180 190 200 210 pF1KE1 TAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGT : .:..::.: :. . ..::.. : :.: :: :: :: :.:::: XP_016 LPQC--FPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGT 2940 2950 2960 2970 2980 2990 220 230 240 250 260 270 pF1KE1 EPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLV .::: : XP_016 QPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWS 3000 3010 3020 3030 3040 3050 >-- initn: 330 init1: 175 opt: 255 Z-score: 239.5 bits: 57.2 E(85289): 1.3e-06 Smith-Waterman score: 340; 30.3% identity (59.4% similar) in 165 aa overlap (55-218:2609-2762) 30 40 50 60 70 80 pF1KE1 TTPWSLAWPQGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWST : .. : : ::: . . .:.. :.:. XP_016 TCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTPVLSCQGDGTWDR 2580 2590 2600 2610 2620 2630 90 100 110 120 130 140 pF1KE1 LKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRT . : : . : .: . .... : :.:. . . : :: :...: XP_016 PRPQ---------CLLVSCGHPGSPPHSQMSGDS--YTVGAVVRYSCIGKRTLVGNSTRM 2640 2650 2660 2670 2680 150 160 170 180 190 200 pF1KE1 CQVNGRWSGQTAICDN-GAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRR : ..:.:.:. :.. ..: :..:::: ..:... . . : : .::::..: XP_016 CGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSER 2690 2700 2710 2720 2730 2740 210 220 230 240 250 260 pF1KE1 TCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVL ::: .:::::..: : XP_016 TCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRH 2750 2760 2770 2780 2790 2800 >-- initn: 311 init1: 175 opt: 255 Z-score: 239.5 bits: 57.2 E(85289): 1.3e-06 Smith-Waterman score: 314; 31.2% identity (54.0% similar) in 189 aa overlap (36-218:2345-2522) 10 20 30 40 50 pF1KE1 SPQLCLMPFILGLLSGGVTTTPWSLAWPQGSC-SLEGVEIKGGSFRLLQEGQ-----ALE .: .. .. .. : .::. : : : XP_016 HLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLM 2320 2330 2340 2350 2360 2370 60 70 80 90 100 110 pF1KE1 YVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSP .: :.: .. :...:.:: :. . :: : : . ::. XP_016 LICDPGYYYTGQRVIRCQANGKWSL---GDSTPT----CRIISCGELPIPPNGHRIGTLS 2380 2390 2400 2410 2420 120 130 140 150 160 170 pF1KE1 YYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGS :... : : .:::: :: : :..:: :::. . : ::.:..: .. . : XP_016 VYGAT--AIFSCNSGYTLVGSRVRECMANGLWSGSEVRC--LAGHCGTPEPIVNGHINGE 2430 2440 2450 2460 2470 2480 180 190 200 210 220 230 pF1KE1 QYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLT .: . ::.:.:. :. : : . : ::. ::: : : XP_016 NYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQF 2490 2500 2510 2520 2530 2540 240 250 260 270 280 290 pF1KE1 ETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEK XP_016 NLNDVVKFVCNPGYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGP 2550 2560 2570 2580 2590 2600 >-- initn: 169 init1: 123 opt: 233 Z-score: 218.8 bits: 53.4 E(85289): 1.9e-05 Smith-Waterman score: 233; 36.5% identity (60.6% similar) in 104 aa overlap (118-218:3019-3119) 90 100 110 120 130 140 pF1KE1 QDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQV : :.:.. . :.: :: :.::..::: XP_016 TWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLP 2990 3000 3010 3020 3030 3040 150 160 170 180 190 200 pF1KE1 NGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQY--RLEDSVTYHCSRGLTLRG-SQRRT : ::: : .: .: : . .::. . .. : :..:..:.: :..:: XP_016 NLTWSGTPPDC--VPHHCRQPETPTHA-NVGALDLPSMGYTLIYSCQEGFSLKGGSEHRT 3050 3060 3070 3080 3090 3100 210 220 230 240 250 260 pF1KE1 CQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLD :. :::.: : : XP_016 CKADGSWTGKPPICLAEVRPSGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKKQ 3110 3120 3130 3140 3150 3160 >>NP_443128 (OMIM: 608398) CUB and sushi domain-containi (3487 aa) initn: 682 init1: 197 opt: 307 Z-score: 288.2 bits: 66.3 E(85289): 2.6e-09 Smith-Waterman score: 337; 28.7% identity (54.2% similar) in 216 aa overlap (14-220:2925-3125) 10 20 30 pF1KE1 MGSNLSPQLCLMPFILGLLSGGVTTT-PWSLAWPQG---SCSL . :::: ... :. . :. .:. NP_443 NPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGD 2900 2910 2920 2930 2940 2950 40 50 60 70 80 90 pF1KE1 EGVEIKGGSFRL---LQEGQALEYVCPSGFY--PYPVQTRTCRSTGSWSTLKTQDQKTVR :. .: .:: .. .... : : :.. . :.. .: . .:. : NP_443 PGIPANG--LRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPV------ 2960 2970 2980 2990 3000 100 110 120 130 140 150 pF1KE1 KAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQ :.:. : : . ::. . ... : ... : .:: : : ::. :: :.:. NP_443 ---CKALMCKPPPLIPNGKVVGSDFMWGSS--VTYACLEGYQLSLPAVFTCEGNGSWTGE 3010 3020 3030 3040 3050 3060 160 170 180 190 200 210 pF1KE1 TAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGT : .:..::.: :. . ..::.. : :.: :: :: :: :.:::: NP_443 LPQC--FPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGT 3070 3080 3090 3100 3110 220 230 240 250 260 270 pF1KE1 EPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLV .::: : NP_443 QPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWS 3120 3130 3140 3150 3160 3170 >-- initn: 578 init1: 175 opt: 255 Z-score: 239.3 bits: 57.2 E(85289): 1.4e-06 Smith-Waterman score: 319; 30.0% identity (58.1% similar) in 160 aa overlap (60-218:2740-2888) 30 40 50 60 70 80 pF1KE1 LAWPQGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWSTLKTQD : : .:: ...: :.. :: NP_443 RCLAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSG----- 2710 2720 2730 2740 2750 2760 90 100 110 120 130 140 pF1KE1 QKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNG . : . : .: . .... : :.:. . . : :: :...: : ..: NP_443 ----KTPFCVLVSCGHPGSPPHSQMSGDS--YTVGAVVRYSCIGKRTLVGNSTRMCGLDG 2770 2780 2790 2800 2810 150 160 170 180 190 200 pF1KE1 RWSGQTAICDN-GAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEG .:.:. :.. ..: :..:::: ..:... . . : : .::::..:::: . NP_443 HWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQAN 2820 2830 2840 2850 2860 2870 210 220 230 240 250 260 pF1KE1 GSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGS :::::..: : NP_443 GSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNG 2880 2890 2900 2910 2920 2930 >-- initn: 481 init1: 175 opt: 255 Z-score: 239.3 bits: 57.2 E(85289): 1.4e-06 Smith-Waterman score: 255; 27.0% identity (50.4% similar) in 230 aa overlap (28-244:2519-2736) 10 20 30 40 50 pF1KE1 MGSNLSPQLCLMPFILGLLSGGVTTTPWSLAWP--QG-SCSLEGVEIKGGSF-RLLQ :: : : :. ::.: . .: : . NP_443 GSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMVFGKEYT 2490 2500 2510 2520 2530 2540 60 70 80 90 100 pF1KE1 EGQALEYVCPSGFY--PYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDF-- : : : :.. : : .:: ::. .. : : . :: .. NP_443 VGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQ-------CVPVTCPDVSSISV 2550 2560 2570 2580 2590 2600 110 120 130 140 150 160 pF1KE1 ENGEYWPRSPY---YNVSDEISFHCYDGYTLRGSANRTCQVNGRWS--GQTAICDNGAGY :.:. : : . :. . .. . : :: :. ::.::.:: .: : . NP_443 EHGR-W-RLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIIS-- 2610 2620 2630 2640 2650 170 180 190 200 210 220 pF1KE1 CSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMY :.. :: . ...:. .. . :. : :: ::. : :. .: :::.: : . NP_443 CGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHC- 2660 2670 2680 2690 2700 2710 230 240 250 260 270 280 pF1KE1 DTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGAS ::. .... ... . . .: NP_443 GTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGH 2720 2730 2740 2750 2760 2770 >-- initn: 169 init1: 123 opt: 234 Z-score: 219.6 bits: 53.6 E(85289): 1.7e-05 Smith-Waterman score: 234; 32.7% identity (57.3% similar) in 150 aa overlap (118-260:3145-3289) 90 100 110 120 130 140 pF1KE1 QDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQV : :.:.. . :.: :: :.::..::: NP_443 TWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLP 3120 3130 3140 3150 3160 3170 150 160 170 180 190 200 pF1KE1 NGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQY--RLEDSVTYHCSRGLTLRG-SQRRT : ::: : .: .: : . .::. . .. : :..:..:.: :..:: NP_443 NLTWSGTPPDCV--PHHCRQPETPTHA-NVGALDLPSMGYTLIYSCQEGFSLKGGSEHRT 3180 3190 3200 3210 3220 3230 210 220 230 240 250 260 pF1KE1 CQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTET-IEG-VDAEDG--HGPGEQQKRK :. :::.: : : . . . . . : ::.. : : : :... .: : : .: NP_443 CKADGSWTGKPPICLE--VRPSGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKK 3240 3250 3260 3270 3280 270 280 290 300 310 320 pF1KE1 IVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKI NP_443 QPAMLRVTGFQVANSKVNATMIDHSGVELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKF 3290 3300 3310 3320 3330 3340 >>XP_016855678 (OMIM: 608398) PREDICTED: CUB and sushi d (3506 aa) initn: 846 init1: 178 opt: 307 Z-score: 288.2 bits: 66.3 E(85289): 2.6e-09 Smith-Waterman score: 337; 28.7% identity (54.2% similar) in 216 aa overlap (14-220:3044-3244) 10 20 30 pF1KE1 MGSNLSPQLCLMPFILGLLSGGVTTT-PWSLAWPQG---SCSL . :::: ... :. . :. .:. XP_016 NPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGD 3020 3030 3040 3050 3060 3070 40 50 60 70 80 90 pF1KE1 EGVEIKGGSFRL---LQEGQALEYVCPSGFY--PYPVQTRTCRSTGSWSTLKTQDQKTVR :. .: .:: .. .... : : :.. . :.. .: . .:. : XP_016 PGIPANG--LRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPV------ 3080 3090 3100 3110 3120 100 110 120 130 140 150 pF1KE1 KAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQ :.:. : : . ::. . ... : ... : .:: : : ::. :: :.:. XP_016 ---CKALMCKPPPLIPNGKVVGSDFMWGSS--VTYACLEGYQLSLPAVFTCEGNGSWTGE 3130 3140 3150 3160 3170 3180 160 170 180 190 200 210 pF1KE1 TAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGT : .:..::.: :. . ..::.. : :.: :: :: :: :.:::: XP_016 LPQC--FPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGT 3190 3200 3210 3220 3230 220 230 240 250 260 270 pF1KE1 EPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLV .::: : XP_016 QPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWS 3240 3250 3260 3270 3280 3290 >-- initn: 578 init1: 175 opt: 255 Z-score: 239.3 bits: 57.2 E(85289): 1.4e-06 Smith-Waterman score: 340; 30.3% identity (59.4% similar) in 165 aa overlap (55-218:2854-3007) 30 40 50 60 70 80 pF1KE1 TTPWSLAWPQGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWST : .. : : ::: . . .:.. :.:. XP_016 TCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTPVLSCQGDGTWDR 2830 2840 2850 2860 2870 2880 90 100 110 120 130 140 pF1KE1 LKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRT . : : . : .: . .... : :.:. . . : :: :...: XP_016 PRPQ---------CLLVSCGHPGSPPHSQMSGDS--YTVGAVVRYSCIGKRTLVGNSTRM 2890 2900 2910 2920 2930 150 160 170 180 190 200 pF1KE1 CQVNGRWSGQTAICDN-GAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRR : ..:.:.:. :.. ..: :..:::: ..:... . . : : .::::..: XP_016 CGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSER 2940 2950 2960 2970 2980 2990 210 220 230 240 250 260 pF1KE1 TCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVL ::: .:::::..: : XP_016 TCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRH 3000 3010 3020 3030 3040 3050 >-- initn: 559 init1: 175 opt: 255 Z-score: 239.3 bits: 57.2 E(85289): 1.4e-06 Smith-Waterman score: 314; 31.2% identity (54.0% similar) in 189 aa overlap (36-218:2590-2767) 10 20 30 40 50 pF1KE1 SPQLCLMPFILGLLSGGVTTTPWSLAWPQGSC-SLEGVEIKGGSFRLLQEGQ-----ALE .: .. .. .. : .::. : : : XP_016 HLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLM 2560 2570 2580 2590 2600 2610 60 70 80 90 100 110 pF1KE1 YVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSP .: :.: .. :...:.:: :. . :: : : . ::. XP_016 LICDPGYYYTGQRVIRCQANGKWSL---GDSTPT----CRIISCGELPIPPNGHRIGTLS 2620 2630 2640 2650 2660 2670 120 130 140 150 160 170 pF1KE1 YYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGS :... : : .:::: :: : :..:: :::. . : ::.:..: .. . : XP_016 VYGAT--AIFSCNSGYTLVGSRVRECMANGLWSGSEVRC--LAGHCGTPEPIVNGHINGE 2680 2690 2700 2710 2720 180 190 200 210 220 230 pF1KE1 QYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLT .: . ::.:.:. :. : : . : ::. ::: : : XP_016 NYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQF 2730 2740 2750 2760 2770 2780 240 250 260 270 280 290 pF1KE1 ETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEK XP_016 NLNDVVKFVCNPGYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGP 2790 2800 2810 2820 2830 2840 >-- initn: 169 init1: 123 opt: 233 Z-score: 218.6 bits: 53.4 E(85289): 1.9e-05 Smith-Waterman score: 233; 36.5% identity (60.6% similar) in 104 aa overlap (118-218:3264-3364) 90 100 110 120 130 140 pF1KE1 QDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQV : :.:.. . :.: :: :.::..::: XP_016 TWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLP 3240 3250 3260 3270 3280 3290 150 160 170 180 190 200 pF1KE1 NGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQY--RLEDSVTYHCSRGLTLRG-SQRRT : ::: : .: .: : . .::. . .. : :..:..:.: :..:: XP_016 NLTWSGTPPDC--VPHHCRQPETPTHA-NVGALDLPSMGYTLIYSCQEGFSLKGGSEHRT 3300 3310 3320 3330 3340 3350 210 220 230 240 250 260 pF1KE1 CQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLD :. :::.: : : XP_016 CKADGSWTGKPPICLAEVRPSGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKKQ 3360 3370 3380 3390 3400 3410 >>XP_016855683 (OMIM: 608398) PREDICTED: CUB and sushi d (3566 aa) initn: 682 init1: 197 opt: 307 Z-score: 288.1 bits: 66.3 E(85289): 2.6e-09 Smith-Waterman score: 337; 28.7% identity (54.2% similar) in 216 aa overlap (14-220:3004-3204) 10 20 30 pF1KE1 MGSNLSPQLCLMPFILGLLSGGVTTT-PWSLAWPQG---SCSL . :::: ... :. . :. .:. XP_016 NPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGD 2980 2990 3000 3010 3020 3030 40 50 60 70 80 90 pF1KE1 EGVEIKGGSFRL---LQEGQALEYVCPSGFY--PYPVQTRTCRSTGSWSTLKTQDQKTVR :. .: .:: .. .... : : :.. . :.. .: . .:. : XP_016 PGIPANG--LRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPV------ 3040 3050 3060 3070 3080 100 110 120 130 140 150 pF1KE1 KAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQ :.:. : : . ::. . ... : ... : .:: : : ::. :: :.:. XP_016 ---CKALMCKPPPLIPNGKVVGSDFMWGSS--VTYACLEGYQLSLPAVFTCEGNGSWTGE 3090 3100 3110 3120 3130 3140 160 170 180 190 200 210 pF1KE1 TAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGT : .:..::.: :. . ..::.. : :.: :: :: :: :.:::: XP_016 LPQC--FPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGT 3150 3160 3170 3180 3190 220 230 240 250 260 270 pF1KE1 EPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLV .::: : XP_016 QPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWS 3200 3210 3220 3230 3240 3250 >-- initn: 578 init1: 175 opt: 255 Z-score: 239.2 bits: 57.2 E(85289): 1.4e-06 Smith-Waterman score: 340; 30.3% identity (59.4% similar) in 165 aa overlap (55-218:2814-2967) 30 40 50 60 70 80 pF1KE1 TTPWSLAWPQGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWST : .. : : ::: . . .:.. :.:. XP_016 TCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTPVLSCQGDGTWDR 2790 2800 2810 2820 2830 2840 90 100 110 120 130 140 pF1KE1 LKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRT . : : . : .: . .... : :.:. . . : :: :...: XP_016 PRPQ---------CLLVSCGHPGSPPHSQMSGDS--YTVGAVVRYSCIGKRTLVGNSTRM 2850 2860 2870 2880 2890 150 160 170 180 190 200 pF1KE1 CQVNGRWSGQTAICDN-GAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRR : ..:.:.:. :.. ..: :..:::: ..:... . . : : .::::..: XP_016 CGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSER 2900 2910 2920 2930 2940 2950 210 220 230 240 250 260 pF1KE1 TCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVL ::: .:::::..: : XP_016 TCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRH 2960 2970 2980 2990 3000 3010 >-- initn: 559 init1: 175 opt: 255 Z-score: 239.2 bits: 57.2 E(85289): 1.4e-06 Smith-Waterman score: 314; 31.2% identity (54.0% similar) in 189 aa overlap (36-218:2550-2727) 10 20 30 40 50 pF1KE1 SPQLCLMPFILGLLSGGVTTTPWSLAWPQGSC-SLEGVEIKGGSFRLLQEGQ-----ALE .: .. .. .. : .::. : : : XP_016 HLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLM 2520 2530 2540 2550 2560 2570 60 70 80 90 100 110 pF1KE1 YVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSP .: :.: .. :...:.:: :. . :: : : . ::. XP_016 LICDPGYYYTGQRVIRCQANGKWSL---GDSTPT----CRIISCGELPIPPNGHRIGTLS 2580 2590 2600 2610 2620 2630 120 130 140 150 160 170 pF1KE1 YYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGS :... : : .:::: :: : :..:: :::. . : ::.:..: .. . : XP_016 VYGAT--AIFSCNSGYTLVGSRVRECMANGLWSGSEVRC--LAGHCGTPEPIVNGHINGE 2640 2650 2660 2670 2680 180 190 200 210 220 230 pF1KE1 QYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLT .: . ::.:.:. :. : : . : ::. ::: : : XP_016 NYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQF 2690 2700 2710 2720 2730 2740 240 250 260 270 280 290 pF1KE1 ETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEK XP_016 NLNDVVKFVCNPGYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGP 2750 2760 2770 2780 2790 2800 >-- initn: 169 init1: 123 opt: 234 Z-score: 219.4 bits: 53.6 E(85289): 1.7e-05 Smith-Waterman score: 234; 32.7% identity (57.3% similar) in 150 aa overlap (118-260:3224-3368) 90 100 110 120 130 140 pF1KE1 QDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQV : :.:.. . :.: :: :.::..::: XP_016 TWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLP 3200 3210 3220 3230 3240 3250 150 160 170 180 190 200 pF1KE1 NGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQY--RLEDSVTYHCSRGLTLRG-SQRRT : ::: : .: .: : . .::. . .. : :..:..:.: :..:: XP_016 NLTWSGTPPDCV--PHHCRQPETPTHA-NVGALDLPSMGYTLIYSCQEGFSLKGGSEHRT 3260 3270 3280 3290 3300 3310 210 220 230 240 250 260 pF1KE1 CQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTET-IEG-VDAEDG--HGPGEQQKRK :. :::.: : : . . . . . : ::.. : : : :... .: : : .: XP_016 CKADGSWTGKPPICLE--VRPSGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKK 3320 3330 3340 3350 3360 270 280 290 300 310 320 pF1KE1 IVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKI XP_016 QPAMLRVTGFQVANSKVNATMIDHSGVELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKF 3370 3380 3390 3400 3410 3420 764 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 23:19:24 2016 done: Sun Nov 6 23:19:26 2016 Total Scan time: 11.860 Total Display time: 0.160 Function used was FASTA [36.3.4 Apr, 2011]