FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6443, 449 aa 1>>>pF1KE6443 449 - 449 aa - 449 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.0603+/-0.000315; mu= 5.5956+/- 0.020 mean_var=152.0895+/-30.781, 0's: 0 Z-trim(121.1): 222 B-trim: 0 in 0/58 Lambda= 0.103998 statistics sampled from 36949 (37188) to 36949 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.761), E-opt: 0.2 (0.436), width: 16 Scan time: 8.040 The best scores are: opt bits E(85289) NP_002584 (OMIM: 600270) procollagen C-endopeptida ( 449) 3096 475.9 9.2e-134 NP_037495 (OMIM: 607064) procollagen C-endopeptida ( 415) 1034 166.5 1.2e-40 NP_001019800 (OMIM: 602069) neuropilin-1 isoform c ( 609) 546 93.4 1.8e-18 NP_001019799 (OMIM: 602069) neuropilin-1 isoform b ( 644) 546 93.4 1.8e-18 NP_001316997 (OMIM: 602069) neuropilin-1 isoform f ( 906) 546 93.5 2.5e-18 NP_001231902 (OMIM: 602069) neuropilin-1 isoform e ( 916) 546 93.5 2.5e-18 NP_001231901 (OMIM: 602069) neuropilin-1 isoform d ( 917) 546 93.5 2.5e-18 NP_003864 (OMIM: 602069) neuropilin-1 isoform a pr ( 923) 546 93.5 2.5e-18 XP_011518058 (OMIM: 602069) PREDICTED: neuropilin- ( 628) 541 92.7 3e-18 XP_011518057 (OMIM: 602069) PREDICTED: neuropilin- ( 656) 541 92.7 3.2e-18 XP_006717589 (OMIM: 602069) PREDICTED: neuropilin- ( 663) 541 92.7 3.2e-18 XP_006717588 (OMIM: 602069) PREDICTED: neuropilin- ( 888) 541 92.8 4.1e-18 XP_006717587 (OMIM: 602069) PREDICTED: neuropilin- ( 889) 541 92.8 4.1e-18 XP_016872354 (OMIM: 602069) PREDICTED: neuropilin- ( 899) 541 92.8 4.1e-18 XP_006717585 (OMIM: 602069) PREDICTED: neuropilin- ( 907) 541 92.8 4.1e-18 XP_006717584 (OMIM: 602069) PREDICTED: neuropilin- ( 924) 541 92.8 4.2e-18 NP_006120 (OMIM: 112264,614856) bone morphogenetic ( 986) 532 91.4 1.1e-17 XP_011530516 (OMIM: 606742,613087) PREDICTED: toll ( 837) 504 87.2 1.8e-16 XP_016864059 (OMIM: 606742,613087) PREDICTED: toll ( 964) 504 87.2 2e-16 NP_036596 (OMIM: 606742,613087) tolloid-like prote (1013) 504 87.2 2.1e-16 XP_011518012 (OMIM: 261100,602997) PREDICTED: cubi (2277) 506 87.7 3.4e-16 XP_011518011 (OMIM: 261100,602997) PREDICTED: cubi (2285) 506 87.7 3.4e-16 XP_011518013 (OMIM: 261100,602997) PREDICTED: cubi (2237) 501 87.0 5.7e-16 NP_071317 (OMIM: 616644) CUB and zona pellucida-li ( 607) 401 71.7 6.2e-12 XP_011518010 (OMIM: 261100,602997) PREDICTED: cubi (2867) 343 63.3 9.5e-09 NP_001072 (OMIM: 261100,602997) cubilin precursor (3623) 343 63.4 1.2e-08 NP_957716 (OMIM: 602070) neuropilin-2 isoform 6 pr ( 555) 308 57.7 9.2e-08 XP_016860677 (OMIM: 602070) PREDICTED: neuropilin- ( 848) 308 57.8 1.3e-07 XP_016860676 (OMIM: 602070) PREDICTED: neuropilin- ( 853) 308 57.8 1.3e-07 NP_957719 (OMIM: 602070) neuropilin-2 isoform 5 pr ( 901) 308 57.8 1.4e-07 XP_016860675 (OMIM: 602070) PREDICTED: neuropilin- ( 901) 308 57.8 1.4e-07 NP_061004 (OMIM: 602070) neuropilin-2 isoform 4 pr ( 906) 308 57.8 1.4e-07 NP_958436 (OMIM: 602070) neuropilin-2 isoform 3 pr ( 909) 308 57.8 1.4e-07 XP_016860674 (OMIM: 602070) PREDICTED: neuropilin- ( 926) 308 57.8 1.4e-07 NP_003863 (OMIM: 602070) neuropilin-2 isoform 2 pr ( 926) 308 57.8 1.4e-07 NP_957718 (OMIM: 602070) neuropilin-2 isoform 1 pr ( 931) 308 57.8 1.4e-07 XP_005246990 (OMIM: 602070) PREDICTED: neuropilin- ( 931) 308 57.8 1.4e-07 XP_005246991 (OMIM: 602070) PREDICTED: neuropilin- ( 931) 308 57.8 1.4e-07 XP_011542919 (OMIM: 112264,614856) PREDICTED: bone ( 622) 304 57.1 1.5e-07 XP_016869227 (OMIM: 112264,614856) PREDICTED: bone ( 717) 304 57.1 1.7e-07 NP_001190 (OMIM: 112264,614856) bone morphogenetic ( 730) 304 57.2 1.7e-07 XP_006716449 (OMIM: 112264,614856) PREDICTED: bone ( 813) 304 57.2 1.9e-07 NP_036597 (OMIM: 606743) tolloid-like protein 2 pr (1015) 301 56.8 3.1e-07 NP_963840 (OMIM: 612320) CUB domain-containing pro ( 449) 294 55.5 3.3e-07 NP_113621 (OMIM: 606227,609549,611040) membrane fr ( 579) 296 55.9 3.3e-07 XP_016881511 (OMIM: 607973) PREDICTED: neuropilin ( 236) 280 53.3 8.2e-07 XP_011537717 (OMIM: 601969) PREDICTED: deleted in (1766) 290 55.3 1.6e-06 XP_011537716 (OMIM: 601969) PREDICTED: deleted in (1783) 290 55.3 1.6e-06 NP_004397 (OMIM: 601969) deleted in malignant brai (1785) 290 55.3 1.6e-06 XP_016871287 (OMIM: 601969) PREDICTED: deleted in (1990) 290 55.3 1.7e-06 >>NP_002584 (OMIM: 600270) procollagen C-endopeptidase e (449 aa) initn: 3096 init1: 3096 opt: 3096 Z-score: 2522.5 bits: 475.9 E(85289): 9.2e-134 Smith-Waterman score: 3096; 100.0% identity (100.0% similar) in 449 aa overlap (1-449:1-449) 10 20 30 40 50 60 pF1KE6 MLPAATASLLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MLPAATASLLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 KECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 VAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 PPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 PGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 QPPEKTEESPSAPDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPGEGLAVTVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QPPEKTEESPSAPDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPGEGLAVTVSL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 IGAYKTGGLDLPSPPTGASLKFYVPCKQCPPMKKGVSYLLMGQVEENRGPVLPPESFVVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IGAYKTGGLDLPSPPTGASLKFYVPCKQCPPMKKGVSYLLMGQVEENRGPVLPPESFVVL 370 380 390 400 410 420 430 440 pF1KE6 HRPNQDQILTNLSKRKCPSQPVRAAASQD ::::::::::::::::::::::::::::: NP_002 HRPNQDQILTNLSKRKCPSQPVRAAASQD 430 440 >>NP_037495 (OMIM: 607064) procollagen C-endopeptidase e (415 aa) initn: 1324 init1: 711 opt: 1034 Z-score: 851.0 bits: 166.5 E(85289): 1.2e-40 Smith-Waterman score: 1328; 44.5% identity (71.6% similar) in 436 aa overlap (7-437:4-415) 10 20 30 40 50 pF1KE6 MLPAATASLLGPL-LTACALLPFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPP :. .:: : : ... :.:. :::: ::: . ::::...:::::..::: NP_037 MRGANAWAPLCLLLAAATQLSRQQSPE--RPVFTCGGILTGESGFIGSEGFPGVYPP 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 NKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAP :..: : ::::::..: :.:: .::: :::: ..:. : . .:::.:::::::::. NP_037 NSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHA-NGQRIGRFCGTFRPGA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 LVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESD ::. ::.. ..: .: .:.: ::. .:. . :.::: :.. .:.. :::::. : NP_037 LVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRD 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 YPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDA :: :..: :::.:: .:.: : :::::.: :.::::: :.::::. .:.::.::.:::. NP_037 YPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE6 VPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPK :. : :: ::::.::.::::.::::: . : :. ::: NP_037 PPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPK-------------------KLPTT 240 250 260 270 300 310 320 330 340 350 pF1KE6 SQPPEKTEESPSAPDAPT---CPKQCRRTGTLQSNFCASSLVVTATVKSMVREPGEGLAV .. : : .. :: : ..:::::::..:.:.:..:...:: . . . : .: . NP_037 TEQPVTTTFPVTTGLKPTVALCQQKCRRTGTLEGNYCSSDFVLAGTVITTITRDG-SLHA 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE6 TVSLIGAYKTGGLDLPSPPTGASLKFYVPCKQCPPMKKGVSYLLMGQV-EENRGPVLPPE :::.:. :: :.: . . . : .. : ::::: ...:..:..:::: :..:: ..: . NP_037 TVSIINIYKEGNLAIQQAGKNMSARLTVVCKQCPLLRRGLNYIIMGQVGEDGRGKIMP-N 340 350 360 370 380 390 420 430 440 pF1KE6 SFVVLHRPNQDQILTNLSKRKCPSQPVRAAASQD ::... . .....: :....: NP_037 SFIMMFKTKNQKLLDALKNKQC 400 410 >>NP_001019800 (OMIM: 602069) neuropilin-1 isoform c pre (609 aa) initn: 313 init1: 188 opt: 546 Z-score: 452.8 bits: 93.4 E(85289): 1.8e-18 Smith-Waterman score: 546; 33.8% identity (62.9% similar) in 278 aa overlap (12-280:6-272) 10 20 30 40 50 pF1KE6 MLPAATASLLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGES-GYVASEGFPNLYPP ::: ::.: .. . . . :: .: :: ::..: :.:. : : NP_001 MERGLPLL--CAVLALVLAPAGAFRND--KCGDTIKIESPGYLTSPGYPHSYHP 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 NKECIWTITVPEG-QTVSLSFRV-FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRP ...: : : .:. : . ..: :::: . :.:: .::: : . .:. :.::: . : NP_001 SEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENENGHFRGKFCGKIAP 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 APLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPE :.:. : . .....: : : :: . : : : :. .:.. .:..:: NP_001 PPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR-GPE---CSQNYTTPSGVIKSPGFPE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 SDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDT------YCRYDSVSVFNGAVSDDSRR . :: .. :.. ..:: . : : ::.::::::. .:::: . ...: : . . NP_001 K-YPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDG-FPDVGPH 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 LGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTE .:..::. .:: : : .. : . : .: ... .::::.:..: ..... NP_001 IGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMES 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE6 PKVKLPPKSQPPEKTEESPSAPDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPG NP_001 GEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQG 290 300 310 320 330 340 >>NP_001019799 (OMIM: 602069) neuropilin-1 isoform b pre (644 aa) initn: 313 init1: 188 opt: 546 Z-score: 452.4 bits: 93.4 E(85289): 1.8e-18 Smith-Waterman score: 546; 33.8% identity (62.9% similar) in 278 aa overlap (12-280:6-272) 10 20 30 40 50 pF1KE6 MLPAATASLLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGES-GYVASEGFPNLYPP ::: ::.: .. . . . :: .: :: ::..: :.:. : : NP_001 MERGLPLL--CAVLALVLAPAGAFRND--KCGDTIKIESPGYLTSPGYPHSYHP 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 NKECIWTITVPEG-QTVSLSFRV-FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRP ...: : : .:. : . ..: :::: . :.:: .::: : . .:. :.::: . : NP_001 SEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENENGHFRGKFCGKIAP 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 APLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPE :.:. : . .....: : : :: . : : : :. .:.. .:..:: NP_001 PPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR-GPE---CSQNYTTPSGVIKSPGFPE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 SDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDT------YCRYDSVSVFNGAVSDDSRR . :: .. :.. ..:: . : : ::.::::::. .:::: . ...: : . . NP_001 K-YPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDG-FPDVGPH 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 LGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTE .:..::. .:: : : .. : . : .: ... .::::.:..: ..... NP_001 IGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMES 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE6 PKVKLPPKSQPPEKTEESPSAPDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPG NP_001 GEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQG 290 300 310 320 330 340 >>NP_001316997 (OMIM: 602069) neuropilin-1 isoform f pre (906 aa) initn: 313 init1: 188 opt: 546 Z-score: 450.2 bits: 93.5 E(85289): 2.5e-18 Smith-Waterman score: 546; 33.8% identity (62.9% similar) in 278 aa overlap (12-280:6-272) 10 20 30 40 50 pF1KE6 MLPAATASLLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGES-GYVASEGFPNLYPP ::: ::.: .. . . . :: .: :: ::..: :.:. : : NP_001 MERGLPLL--CAVLALVLAPAGAFRND--KCGDTIKIESPGYLTSPGYPHSYHP 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 NKECIWTITVPEG-QTVSLSFRV-FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRP ...: : : .:. : . ..: :::: . :.:: .::: : . .:. :.::: . : NP_001 SEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENENGHFRGKFCGKIAP 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 APLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPE :.:. : . .....: : : :: . : : : :. .:.. .:..:: NP_001 PPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR-GPE---CSQNYTTPSGVIKSPGFPE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 SDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDT------YCRYDSVSVFNGAVSDDSRR . :: .. :.. ..:: . : : ::.::::::. .:::: . ...: : . . NP_001 K-YPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDG-FPDVGPH 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 LGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTE .:..::. .:: : : .. : . : .: ... .::::.:..: ..... NP_001 IGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMES 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE6 PKVKLPPKSQPPEKTEESPSAPDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPG NP_001 GEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQG 290 300 310 320 330 340 >>NP_001231902 (OMIM: 602069) neuropilin-1 isoform e pre (916 aa) initn: 313 init1: 188 opt: 546 Z-score: 450.1 bits: 93.5 E(85289): 2.5e-18 Smith-Waterman score: 546; 33.8% identity (62.9% similar) in 278 aa overlap (12-280:6-272) 10 20 30 40 50 pF1KE6 MLPAATASLLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGES-GYVASEGFPNLYPP ::: ::.: .. . . . :: .: :: ::..: :.:. : : NP_001 MERGLPLL--CAVLALVLAPAGAFRND--KCGDTIKIESPGYLTSPGYPHSYHP 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 NKECIWTITVPEG-QTVSLSFRV-FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRP ...: : : .:. : . ..: :::: . :.:: .::: : . .:. :.::: . : NP_001 SEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENENGHFRGKFCGKIAP 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 APLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPE :.:. : . .....: : : :: . : : : :. .:.. .:..:: NP_001 PPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR-GPE---CSQNYTTPSGVIKSPGFPE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 SDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDT------YCRYDSVSVFNGAVSDDSRR . :: .. :.. ..:: . : : ::.::::::. .:::: . ...: : . . NP_001 K-YPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDG-FPDVGPH 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 LGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTE .:..::. .:: : : .. : . : .: ... .::::.:..: ..... NP_001 IGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMES 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE6 PKVKLPPKSQPPEKTEESPSAPDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPG NP_001 GEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQG 290 300 310 320 330 340 >>NP_001231901 (OMIM: 602069) neuropilin-1 isoform d pre (917 aa) initn: 313 init1: 188 opt: 546 Z-score: 450.1 bits: 93.5 E(85289): 2.5e-18 Smith-Waterman score: 546; 33.8% identity (62.9% similar) in 278 aa overlap (12-280:6-272) 10 20 30 40 50 pF1KE6 MLPAATASLLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGES-GYVASEGFPNLYPP ::: ::.: .. . . . :: .: :: ::..: :.:. : : NP_001 MERGLPLL--CAVLALVLAPAGAFRND--KCGDTIKIESPGYLTSPGYPHSYHP 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 NKECIWTITVPEG-QTVSLSFRV-FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRP ...: : : .:. : . ..: :::: . :.:: .::: : . .:. :.::: . : NP_001 SEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENENGHFRGKFCGKIAP 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 APLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPE :.:. : . .....: : : :: . : : : :. .:.. .:..:: NP_001 PPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR-GPE---CSQNYTTPSGVIKSPGFPE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 SDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDT------YCRYDSVSVFNGAVSDDSRR . :: .. :.. ..:: . : : ::.::::::. .:::: . ...: : . . NP_001 K-YPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDG-FPDVGPH 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 LGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTE .:..::. .:: : : .. : . : .: ... .::::.:..: ..... NP_001 IGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMES 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE6 PKVKLPPKSQPPEKTEESPSAPDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPG NP_001 GEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQG 290 300 310 320 330 340 >>NP_003864 (OMIM: 602069) neuropilin-1 isoform a precur (923 aa) initn: 313 init1: 188 opt: 546 Z-score: 450.0 bits: 93.5 E(85289): 2.5e-18 Smith-Waterman score: 546; 33.8% identity (62.9% similar) in 278 aa overlap (12-280:6-272) 10 20 30 40 50 pF1KE6 MLPAATASLLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGES-GYVASEGFPNLYPP ::: ::.: .. . . . :: .: :: ::..: :.:. : : NP_003 MERGLPLL--CAVLALVLAPAGAFRND--KCGDTIKIESPGYLTSPGYPHSYHP 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 NKECIWTITVPEG-QTVSLSFRV-FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRP ...: : : .:. : . ..: :::: . :.:: .::: : . .:. :.::: . : NP_003 SEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENENGHFRGKFCGKIAP 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 APLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPE :.:. : . .....: : : :: . : : : :. .:.. .:..:: NP_003 PPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR-GPE---CSQNYTTPSGVIKSPGFPE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 SDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDT------YCRYDSVSVFNGAVSDDSRR . :: .. :.. ..:: . : : ::.::::::. .:::: . ...: : . . NP_003 K-YPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDG-FPDVGPH 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 LGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTE .:..::. .:: : : .. : . : .: ... .::::.:..: ..... NP_003 IGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMES 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE6 PKVKLPPKSQPPEKTEESPSAPDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPG NP_003 GEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQG 290 300 310 320 330 340 >>XP_011518058 (OMIM: 602069) PREDICTED: neuropilin-1 is (628 aa) initn: 310 init1: 185 opt: 541 Z-score: 448.5 bits: 92.7 E(85289): 3e-18 Smith-Waterman score: 541; 33.5% identity (62.9% similar) in 278 aa overlap (12-280:6-272) 10 20 30 40 50 pF1KE6 MLPAATASLLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGES-GYVASEGFPNLYPP ::: ::.: .. . . . :: .: :: ::..: :.:. : : XP_011 MERGLPLL--CAVLALVLAPAGAFRND--KCGDTIKIESPGYLTSPGYPHSYHP 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 NKECIWTITVPEG-QTVSLSFRV-FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRP ...: : : .:. : . ..: :::: . :.:: .::: : . .:. :.::: . : XP_011 SEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENENGHFRGKFCGKIAP 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 APLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPE :.:. : . .....: : : :: . : : : :. .:.. .:..:: XP_011 PPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR-GPE---CSQNYTTPSGVIKSPGFPE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 SDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDT------YCRYDSVSVFNGAVSDDSRR . :: .. :.. ...: . : : ::.::::::. .:::: . ...: : . . XP_011 K-YPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDG-FPDVGPH 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 LGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTE .:..::. .:: : : .. : . : .: ... .::::.:..: ..... XP_011 IGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMES 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE6 PKVKLPPKSQPPEKTEESPSAPDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPG XP_011 GEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQG 290 300 310 320 330 340 >>XP_011518057 (OMIM: 602069) PREDICTED: neuropilin-1 is (656 aa) initn: 310 init1: 185 opt: 541 Z-score: 448.2 bits: 92.7 E(85289): 3.2e-18 Smith-Waterman score: 541; 33.5% identity (62.9% similar) in 278 aa overlap (12-280:6-272) 10 20 30 40 50 pF1KE6 MLPAATASLLGPLLTACALLPFAQGQTPNYTRPVFLCGGDVKGES-GYVASEGFPNLYPP ::: ::.: .. . . . :: .: :: ::..: :.:. : : XP_011 MERGLPLL--CAVLALVLAPAGAFRND--KCGDTIKIESPGYLTSPGYPHSYHP 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 NKECIWTITVPEG-QTVSLSFRV-FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRP ...: : : .:. : . ..: :::: . :.:: .::: : . .:. :.::: . : XP_011 SEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENENGHFRGKFCGKIAP 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 APLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPE :.:. : . .....: : : :: . : : : :. .:.. .:..:: XP_011 PPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR-GPE---CSQNYTTPSGVIKSPGFPE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 SDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDT------YCRYDSVSVFNGAVSDDSRR . :: .. :.. ...: . : : ::.::::::. .:::: . ...: : . . XP_011 K-YPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDG-FPDVGPH 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 LGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTE .:..::. .:: : : .. : . : .: ... .::::.:..: ..... XP_011 IGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMES 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE6 PKVKLPPKSQPPEKTEESPSAPDAPTCPKQCRRTGTLQSNFCASSLVVTATVKSMVREPG XP_011 GEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQG 290 300 310 320 330 340 449 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:21:13 2016 done: Tue Nov 8 13:21:14 2016 Total Scan time: 8.040 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]