FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4463, 480 aa 1>>>pF1KE4463 480 - 480 aa - 480 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2648+/-0.000451; mu= 18.3579+/- 0.028 mean_var=69.0650+/-13.916, 0's: 0 Z-trim(111.1): 64 B-trim: 16 in 1/53 Lambda= 0.154328 statistics sampled from 19527 (19591) to 19527 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.597), E-opt: 0.2 (0.23), width: 16 Scan time: 7.660 The best scores are: opt bits E(85289) NP_001076440 (OMIM: 107930,608643) aromatic-L-amin ( 480) 3250 733.1 4.2e-211 NP_000781 (OMIM: 107930,608643) aromatic-L-amino-a ( 480) 3250 733.1 4.2e-211 XP_005271802 (OMIM: 107930,608643) PREDICTED: arom ( 442) 2516 569.6 6.2e-162 NP_001229815 (OMIM: 107930,608643) aromatic-L-amin ( 442) 2515 569.4 7.2e-162 XP_011513463 (OMIM: 107930,608643) PREDICTED: arom ( 461) 2506 567.4 3e-161 NP_001229817 (OMIM: 107930,608643) aromatic-L-amin ( 402) 2239 507.9 2.1e-143 NP_001229819 (OMIM: 107930,608643) aromatic-L-amin ( 338) 2138 485.4 1.1e-136 NP_002103 (OMIM: 137580,142704) histidine decarbox ( 662) 1825 415.9 1.8e-115 NP_001229818 (OMIM: 107930,608643) aromatic-L-amin ( 387) 1678 383.0 8.1e-106 NP_001229816 (OMIM: 107930,608643) aromatic-L-amin ( 432) 1675 382.4 1.4e-105 NP_001293075 (OMIM: 137580,142704) histidine decar ( 629) 1407 322.8 1.8e-87 XP_016877584 (OMIM: 137580,142704) PREDICTED: hist ( 664) 1215 280.1 1.4e-74 XP_016877588 (OMIM: 137580,142704) PREDICTED: hist ( 437) 1016 235.6 2.1e-61 XP_016877583 (OMIM: 137580,142704) PREDICTED: hist ( 697) 1016 235.8 3.1e-61 XP_016877587 (OMIM: 137580,142704) PREDICTED: hist ( 553) 797 186.9 1.2e-46 XP_016877586 (OMIM: 137580,142704) PREDICTED: hist ( 618) 797 187.0 1.3e-46 XP_016877585 (OMIM: 137580,142704) PREDICTED: hist ( 621) 697 164.7 6.7e-40 NP_001127838 (OMIM: 138275) glutamate decarboxylas ( 585) 456 111.0 9.1e-24 NP_000809 (OMIM: 138275) glutamate decarboxylase 2 ( 585) 456 111.0 9.1e-24 XP_011509224 (OMIM: 603513,605363) PREDICTED: glut ( 594) 453 110.4 1.5e-23 NP_000808 (OMIM: 603513,605363) glutamate decarbox ( 594) 453 110.4 1.5e-23 XP_016859245 (OMIM: 603513,605363) PREDICTED: glut ( 594) 453 110.4 1.5e-23 XP_016861786 (OMIM: 615601) PREDICTED: acidic amin ( 502) 438 107.0 1.3e-22 NP_997242 (OMIM: 615601) acidic amino acid decarbo ( 521) 438 107.0 1.3e-22 NP_001231634 (OMIM: 616569) cysteine sulfinic acid ( 493) 405 99.6 2.1e-20 XP_011536748 (OMIM: 616569) PREDICTED: cysteine su ( 520) 405 99.6 2.2e-20 NP_057073 (OMIM: 616569) cysteine sulfinic acid de ( 520) 405 99.6 2.2e-20 XP_016861787 (OMIM: 615601) PREDICTED: acidic amin ( 275) 370 91.7 2.9e-18 XP_011536753 (OMIM: 616569) PREDICTED: cysteine su ( 275) 368 91.2 3.9e-18 XP_016874907 (OMIM: 616569) PREDICTED: cysteine su ( 275) 368 91.2 3.9e-18 XP_016874906 (OMIM: 616569) PREDICTED: cysteine su ( 293) 360 89.5 1.4e-17 XP_011536751 (OMIM: 616569) PREDICTED: cysteine su ( 293) 360 89.5 1.4e-17 NP_001231635 (OMIM: 616569) cysteine sulfinic acid ( 260) 359 89.2 1.5e-17 XP_016874908 (OMIM: 616569) PREDICTED: cysteine su ( 368) 360 89.5 1.7e-17 XP_016874905 (OMIM: 616569) PREDICTED: cysteine su ( 422) 360 89.6 1.9e-17 XP_011536744 (OMIM: 616569) PREDICTED: cysteine su ( 551) 360 89.6 2.3e-17 XP_016859246 (OMIM: 603513,605363) PREDICTED: glut ( 395) 293 74.6 5.5e-13 >>NP_001076440 (OMIM: 107930,608643) aromatic-L-amino-ac (480 aa) initn: 3250 init1: 3250 opt: 3250 Z-score: 3911.0 bits: 733.1 E(85289): 4.2e-211 Smith-Waterman score: 3250; 100.0% identity (100.0% similar) in 480 aa overlap (1-480:1-480) 10 20 30 40 50 60 pF1KE4 MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE 430 440 450 460 470 480 >>NP_000781 (OMIM: 107930,608643) aromatic-L-amino-acid (480 aa) initn: 3250 init1: 3250 opt: 3250 Z-score: 3911.0 bits: 733.1 E(85289): 4.2e-211 Smith-Waterman score: 3250; 100.0% identity (100.0% similar) in 480 aa overlap (1-480:1-480) 10 20 30 40 50 60 pF1KE4 MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE 430 440 450 460 470 480 >>XP_005271802 (OMIM: 107930,608643) PREDICTED: aromatic (442 aa) initn: 2944 init1: 2506 opt: 2516 Z-score: 3028.3 bits: 569.6 E(85289): 6.2e-162 Smith-Waterman score: 2872; 91.9% identity (92.1% similar) in 480 aa overlap (1-480:1-442) 10 20 30 40 50 60 pF1KE4 MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: XP_005 MNASEFRRRGKEMVDYMANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD ::::::: ::::::::::::::: XP_005 EKIIMPG--------------------------------------AASPACTELETVMMD 70 80 130 140 150 160 170 180 pF1KE4 WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE4 EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE4 ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE4 PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE4 KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN 330 340 350 360 370 380 430 440 450 460 470 480 pF1KE4 EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE 390 400 410 420 430 440 >>NP_001229815 (OMIM: 107930,608643) aromatic-L-amino-ac (442 aa) initn: 2948 init1: 2506 opt: 2515 Z-score: 3027.1 bits: 569.4 E(85289): 7.2e-162 Smith-Waterman score: 2876; 92.1% identity (92.1% similar) in 480 aa overlap (1-480:1-442) 10 20 30 40 50 60 pF1KE4 MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD ::::::: ::::::::::::::: NP_001 EKIIMPG--------------------------------------AASPACTELETVMMD 70 80 130 140 150 160 170 180 pF1KE4 WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE4 EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE4 ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE4 PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE4 KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN 330 340 350 360 370 380 430 440 450 460 470 480 pF1KE4 EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE 390 400 410 420 430 440 >>XP_011513463 (OMIM: 107930,608643) PREDICTED: aromatic (461 aa) initn: 2506 init1: 2506 opt: 2506 Z-score: 3016.0 bits: 567.4 E(85289): 3e-161 Smith-Waterman score: 2506; 100.0% identity (100.0% similar) in 375 aa overlap (106-480:87-461) 80 90 100 110 120 130 pF1KE4 FFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPKAFLNE :::::::::::::::::::::::::::::: XP_011 IRCVQSLGAGGSLEKGLAPACKPPVPPYLEAASPACTELETVMMDWLGKMLELPKAFLNE 60 70 80 90 100 110 140 150 160 170 180 190 pF1KE4 KAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSV 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE4 ERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLL 180 190 200 210 220 230 260 270 280 290 300 310 pF1KE4 EVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMW 240 250 260 270 280 290 320 330 340 350 360 370 pF1KE4 VKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQ 300 310 320 330 340 350 380 390 400 410 420 430 pF1KE4 AYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHL 360 370 380 390 400 410 440 450 460 470 480 pF1KE4 VPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE ::::::::::::::::::::::::::::::::::::::::::::: XP_011 VPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE 420 430 440 450 460 >>NP_001229817 (OMIM: 107930,608643) aromatic-L-amino-ac (402 aa) initn: 2681 init1: 2239 opt: 2239 Z-score: 2695.6 bits: 507.9 E(85289): 2.1e-143 Smith-Waterman score: 2529; 83.8% identity (83.8% similar) in 480 aa overlap (1-480:1-402) 10 20 30 40 50 60 pF1KE4 MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD ::::::: NP_001 EKIIMPG----------------------------------------------------- 130 140 150 160 170 180 pF1KE4 WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM ::::::::::::::::::::::::::::::::::: NP_001 -------------------------GSASEATLVALLAARTKVIHRLQAASPELTQAAIM 70 80 90 100 190 200 210 220 230 240 pF1KE4 EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV 110 120 130 140 150 160 250 260 270 280 290 300 pF1KE4 ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN 170 180 190 200 210 220 310 320 330 340 350 360 pF1KE4 PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL 230 240 250 260 270 280 370 380 390 400 410 420 pF1KE4 KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN 290 300 310 320 330 340 430 440 450 460 470 480 pF1KE4 EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE 350 360 370 380 390 400 >>NP_001229819 (OMIM: 107930,608643) aromatic-L-amino-ac (338 aa) initn: 2160 init1: 2138 opt: 2138 Z-score: 2575.1 bits: 485.4 E(85289): 1.1e-136 Smith-Waterman score: 2138; 99.1% identity (99.7% similar) in 318 aa overlap (1-318:1-318) 10 20 30 40 50 60 pF1KE4 MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL ::::::::::::::: .. NP_001 PHKWLLVNFDCSAMWSRQPVRMLRLKKTCLVSAVVRRS 310 320 330 >>NP_002103 (OMIM: 137580,142704) histidine decarboxylas (662 aa) initn: 1811 init1: 814 opt: 1825 Z-score: 2194.2 bits: 415.9 E(85289): 1.8e-115 Smith-Waterman score: 1825; 52.1% identity (82.6% similar) in 476 aa overlap (1-475:2-475) 10 20 30 40 50 pF1KE4 MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIIND :. :.:.::.:::::. .:. .. :.: :::.::::: .: .::..::....:..: NP_002 MMEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 VEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMM .:.::::::.::.::.. ::.:. .:.:..:.::: ::.:.::.::.:::::::: .: NP_002 IERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVM 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 DWLGKMLELPKAFLNEK-AGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAA :::.::: ::. ::... ...::::.:...::.::.:::::: . : ..... :. .. NP_002 DWLAKMLGLPEHFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESC 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 IMEKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFF . .::::.:::::::::.::::. ::.: .: : ::..:. :::.:.:.:: ::.: : NP_002 LNARLVAYASDQAHSSVEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVF 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 MVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFN . :::::: :.:: : :.:::: .: .:::.::::::.::.::::: .:.:.:.::::. NP_002 VCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFT 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE4 FNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFR ::: ::..:.:::...::: . : .: ..: ::.:. .::. ::. ::::::.:::: NP_002 FNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHA--NSGVATDFMHWQIPLSRRFR 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 SLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNK :.:.:::.: .:::.:::..:. ..... ::::::.:: ::: .. :::: ::::: : NP_002 SVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNC 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 VNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAE ..: .:..: .: .. :.: ..::...::.. :. . . : :. :.. :. .: NP_002 LTENVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAATLILSQH 420 430 440 450 460 470 480 pF1KE4 RE NP_002 CTSQPSPRVGNLISQIRGARAWACGTSLQSVSGAGDDPVQARKIIKQPQRVGAGPMKREN 480 490 500 510 520 530 >>NP_001229818 (OMIM: 107930,608643) aromatic-L-amino-ac (387 aa) initn: 2672 init1: 1675 opt: 1678 Z-score: 2020.8 bits: 383.0 E(85289): 8.1e-106 Smith-Waterman score: 2490; 80.6% identity (80.6% similar) in 480 aa overlap (1-480:1-387) 10 20 30 40 50 60 pF1KE4 MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM ::::::::::::::::::::::::: NP_001 WLGKMLELPKAFLNEKAGEGGGVIQ----------------------------------- 130 140 190 200 210 220 230 240 pF1KE4 EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV :: NP_001 ----------------------------------------------------------MV 250 260 270 280 290 300 pF1KE4 ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN 150 160 170 180 190 200 310 320 330 340 350 360 pF1KE4 PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL 210 220 230 240 250 260 370 380 390 400 410 420 pF1KE4 KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN 270 280 290 300 310 320 430 440 450 460 470 480 pF1KE4 EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE 330 340 350 360 370 380 >>NP_001229816 (OMIM: 107930,608643) aromatic-L-amino-ac (432 aa) initn: 2933 init1: 1675 opt: 1675 Z-score: 2016.4 bits: 382.4 E(85289): 1.4e-105 Smith-Waterman score: 2841; 90.0% identity (90.0% similar) in 480 aa overlap (1-480:1-432) 10 20 30 40 50 60 pF1KE4 MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV :::::::::: :: NP_001 EKLVAYSSDQ------------------------------------------------MV 190 250 260 270 280 290 300 pF1KE4 ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN 200 210 220 230 240 250 310 320 330 340 350 360 pF1KE4 PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL 260 270 280 290 300 310 370 380 390 400 410 420 pF1KE4 KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN 320 330 340 350 360 370 430 440 450 460 470 480 pF1KE4 EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE 380 390 400 410 420 430 480 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:57:13 2016 done: Sun Nov 6 00:57:14 2016 Total Scan time: 7.660 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]