Result of FASTA (omim) for
pFN21AB0937
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB0937, 160 aa
1>>>pF1KB0937 160 - 160 aa - 160 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.6728+/-0.000287; mu= 7.0711+/- 0.018
mean_var=117.2497+/-23.875, 0's: 0 Z-trim(121.0): 73 B-trim: 1966 in 1/50
Lambda= 0.118445
statistics sampled from 36882 (37033) to 36882 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.779), E-opt: 0.2 (0.434), width: 16
Scan time: 5.510
The best scores are: opt bits E(85289)
NP_001258822 (OMIM: 200110,209885,227260,607556) t ( 160) 1038 187.1 1.1e-47
NP_476527 (OMIM: 200110,209885,227260,607556) twis ( 160) 1038 187.1 1.1e-47
XP_011513798 (OMIM: 101400,123100,180750,601622) P ( 202) 655 121.7 6.5e-28
NP_000465 (OMIM: 101400,123100,180750,601622) twis ( 202) 655 121.7 6.5e-28
XP_006716679 (OMIM: 609067) PREDICTED: basic helix ( 201) 230 49.1 4.7e-06
NP_001073983 (OMIM: 609067) basic helix-loop-helix ( 201) 230 49.1 4.7e-06
NP_005089 (OMIM: 603628) musculin [Homo sapiens] ( 206) 226 48.4 7.7e-06
NP_835455 (OMIM: 607194,609069,615935) pancreas tr ( 328) 227 48.7 9.8e-06
NP_004600 (OMIM: 601010) transcription factor 15 [ ( 199) 213 46.1 3.5e-05
NP_005412 (OMIM: 186855,613065) T-cell acute lymph ( 108) 207 44.9 4.4e-05
NP_003197 (OMIM: 603306) transcription factor 21 [ ( 179) 210 45.6 4.6e-05
NP_938206 (OMIM: 603306) transcription factor 21 [ ( 179) 210 45.6 4.6e-05
NP_068808 (OMIM: 602407) heart- and neural crest d ( 217) 205 44.8 9.6e-05
NP_001277335 (OMIM: 187040,613065) T-cell acute ly ( 172) 196 43.2 0.00023
XP_016857682 (OMIM: 187040,613065) PREDICTED: T-ce ( 172) 196 43.2 0.00023
NP_005589 (OMIM: 162360) helix-loop-helix protein ( 133) 190 42.1 0.00039
XP_016857678 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 196 43.4 0.00039
NP_001277332 (OMIM: 187040,613065) T-cell acute ly ( 331) 196 43.4 0.00039
XP_016857676 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 196 43.4 0.00039
XP_016857680 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 196 43.4 0.00039
NP_001274276 (OMIM: 187040,613065) T-cell acute ly ( 331) 196 43.4 0.00039
NP_001277333 (OMIM: 187040,613065) T-cell acute ly ( 331) 196 43.4 0.00039
NP_003180 (OMIM: 187040,613065) T-cell acute lymph ( 331) 196 43.4 0.00039
XP_005271217 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 196 43.4 0.00039
XP_016857679 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 196 43.4 0.00039
XP_016857677 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 196 43.4 0.00039
NP_001277334 (OMIM: 187040,613065) T-cell acute ly ( 331) 196 43.4 0.00039
NP_002491 (OMIM: 125853,601724,606394) neurogenic ( 356) 196 43.4 0.00041
NP_067014 (OMIM: 611635) neurogenic differentiatio ( 331) 194 43.1 0.00049
NP_073565 (OMIM: 611513) neurogenic differentiatio ( 337) 190 42.4 0.0008
XP_005259969 (OMIM: 151440) PREDICTED: protein lyl ( 206) 186 41.5 0.00088
NP_005163 (OMIM: 601461) protein atonal homolog 1 ( 354) 189 42.2 0.00094
NP_005574 (OMIM: 151440) protein lyl-1 [Homo sapie ( 280) 186 41.6 0.0011
NP_803238 (OMIM: 608606) class A basic helix-loop- ( 189) 183 41.0 0.0012
XP_016882306 (OMIM: 151440) PREDICTED: protein lyl ( 302) 186 41.7 0.0012
NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapien ( 272) 185 41.5 0.0012
XP_005268588 (OMIM: 602406) PREDICTED: heart- and ( 214) 183 41.0 0.0013
NP_004812 (OMIM: 602406) heart- and neural crest d ( 215) 183 41.0 0.0013
XP_016882305 (OMIM: 151440) PREDICTED: protein lyl ( 351) 186 41.7 0.0013
NP_006151 (OMIM: 601725) neurogenic differentiatio ( 382) 184 41.4 0.0018
XP_016871769 (OMIM: 604882,610370) PREDICTED: neur ( 214) 179 40.4 0.0021
NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo ( 214) 179 40.4 0.0021
NP_005590 (OMIM: 162361) helix-loop-helix protein ( 135) 168 38.3 0.0053
NP_001104531 (OMIM: 162361) helix-loop-helix prote ( 135) 168 38.3 0.0053
NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapien ( 237) 171 39.0 0.0058
NP_660161 (OMIM: 609875) protein atonal homolog 7 ( 152) 166 38.0 0.0074
NP_620450 (OMIM: 606385) oligodendrocyte transcrip ( 271) 169 38.7 0.0082
>>NP_001258822 (OMIM: 200110,209885,227260,607556) twist (160 aa)
initn: 1038 init1: 1038 opt: 1038 Z-score: 977.3 bits: 187.1 E(85289): 1.1e-47
Smith-Waterman score: 1038; 100.0% identity (100.0% similar) in 160 aa overlap (1-160:1-160)
10 20 30 40 50 60
pF1KB0 MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSAQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSAQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 FEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQV
70 80 90 100 110 120
130 140 150 160
pF1KB0 LQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH
::::::::::::::::::::::::::::::::::::::::
NP_001 LQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH
130 140 150 160
>>NP_476527 (OMIM: 200110,209885,227260,607556) twist-re (160 aa)
initn: 1038 init1: 1038 opt: 1038 Z-score: 977.3 bits: 187.1 E(85289): 1.1e-47
Smith-Waterman score: 1038; 100.0% identity (100.0% similar) in 160 aa overlap (1-160:1-160)
10 20 30 40 50 60
pF1KB0 MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSAQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_476 MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSAQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 FEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_476 FEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQV
70 80 90 100 110 120
130 140 150 160
pF1KB0 LQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH
::::::::::::::::::::::::::::::::::::::::
NP_476 LQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH
130 140 150 160
>>XP_011513798 (OMIM: 101400,123100,180750,601622) PREDI (202 aa)
initn: 794 init1: 640 opt: 655 Z-score: 622.2 bits: 121.7 E(85289): 6.5e-28
Smith-Waterman score: 713; 66.7% identity (75.0% similar) in 192 aa overlap (10-160:11-202)
10 20 30 40
pF1KB0 MEEGSSSPVSPVD-SLGTSEEELERQ-P---KRFGRKRRYSKKSS--------------
::.: ::..:::: .:: : :: ::::: :..:.
XP_011 MMQDVSSSPVSPADDSLSNSEEEPDRQQPPSGKRGGRKRRSSRRSAGGGAGPGGAAGGGV
10 20 30 40 50 60
50 60 70
pF1KB0 ----EDGSPTPGKRGKK------------------GSPSAQSFEELQSQRILANVRERQR
: :::. :::::: :. : ::.::::.::..::::::::
XP_011 GGGDEPGSPAQGKRGKKSAGCGGGGGAGGGGGSSSGGGSPQSYEELQTQRVMANVRERQR
70 80 90 100 110 120
80 90 100 110 120 130
pF1KB0 TQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAH
:::::::::::::::::::::::::::::::::::::::::::::::.:.::.:::::::
XP_011 TQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDELDSKMASCSYVAH
130 140 150 160 170 180
140 150 160
pF1KB0 ERLSYAFSVWRMEGAWSMSASH
::::::::::::::::::::::
XP_011 ERLSYAFSVWRMEGAWSMSASH
190 200
>>NP_000465 (OMIM: 101400,123100,180750,601622) twist-re (202 aa)
initn: 794 init1: 640 opt: 655 Z-score: 622.2 bits: 121.7 E(85289): 6.5e-28
Smith-Waterman score: 713; 66.7% identity (75.0% similar) in 192 aa overlap (10-160:11-202)
10 20 30 40
pF1KB0 MEEGSSSPVSPVD-SLGTSEEELERQ-P---KRFGRKRRYSKKSS--------------
::.: ::..:::: .:: : :: ::::: :..:.
NP_000 MMQDVSSSPVSPADDSLSNSEEEPDRQQPPSGKRGGRKRRSSRRSAGGGAGPGGAAGGGV
10 20 30 40 50 60
50 60 70
pF1KB0 ----EDGSPTPGKRGKK------------------GSPSAQSFEELQSQRILANVRERQR
: :::. :::::: :. : ::.::::.::..::::::::
NP_000 GGGDEPGSPAQGKRGKKSAGCGGGGGAGGGGGSSSGGGSPQSYEELQTQRVMANVRERQR
70 80 90 100 110 120
80 90 100 110 120 130
pF1KB0 TQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAH
:::::::::::::::::::::::::::::::::::::::::::::::.:.::.:::::::
NP_000 TQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDELDSKMASCSYVAH
130 140 150 160 170 180
140 150 160
pF1KB0 ERLSYAFSVWRMEGAWSMSASH
::::::::::::::::::::::
NP_000 ERLSYAFSVWRMEGAWSMSASH
190 200
>>XP_006716679 (OMIM: 609067) PREDICTED: basic helix-loo (201 aa)
initn: 201 init1: 135 opt: 230 Z-score: 229.7 bits: 49.1 E(85289): 4.7e-06
Smith-Waterman score: 230; 38.3% identity (64.8% similar) in 128 aa overlap (7-133:20-143)
10 20 30 40
pF1KB0 MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTP
::.: .. :.. ...: : : . . . ..
XP_006 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSSGSDEKPCRVHAARCGLQGARRRAG---
10 20 30 40 50
50 60 70 80 90 100
pF1KB0 GKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQT
:.:. :.:... .: :: ::.:::.::.:.: ::.::: .::: :.: :::::.:
XP_006 GRRAGGGGPGGRPGRE-PRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIET
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB0 LKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH
:.::. ::. : .:: . : . :
XP_006 LRLASSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPPPPPPPPARDGENTQPK
120 130 140 150 160 170
>>NP_001073983 (OMIM: 609067) basic helix-loop-helix tra (201 aa)
initn: 201 init1: 135 opt: 230 Z-score: 229.7 bits: 49.1 E(85289): 4.7e-06
Smith-Waterman score: 230; 38.3% identity (64.8% similar) in 128 aa overlap (7-133:20-143)
10 20 30 40
pF1KB0 MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTP
::.: .. :.. ...: : : . . . ..
NP_001 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSSGSDEKPCRVHAARCGLQGARRRAG---
10 20 30 40 50
50 60 70 80 90 100
pF1KB0 GKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQT
:.:. :.:... .: :: ::.:::.::.:.: ::.::: .::: :.: :::::.:
NP_001 GRRAGGGGPGGRPGRE-PRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIET
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB0 LKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH
:.::. ::. : .:: . : . :
NP_001 LRLASSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPPPPPPPPARDGENTQPK
120 130 140 150 160 170
>>NP_005089 (OMIM: 603628) musculin [Homo sapiens] (206 aa)
initn: 217 init1: 116 opt: 226 Z-score: 225.9 bits: 48.4 E(85289): 7.7e-06
Smith-Waterman score: 234; 36.6% identity (58.8% similar) in 153 aa overlap (7-147:37-184)
10 20
pF1KB0 MEEGSSSPVSPVDSLGTSEEELERQPKRF-------
: .:: :. .. ::. . . .:
NP_005 SDPEEMELRGLQREYPVPASKRPPLRGVERSYASPSDNSSAEEEDPDGEEERCALGTAGS
10 20 30 40 50 60
30 40 50 60 70 80
pF1KB0 --GRKRRYSKKSSEDGSP-TPGKRGKKGSPSAQSFEEL-QSQRILANVRERQRTQSLNEA
: ::. . .. :. . : ::: :. : : :::: ::.::: : . :..:
NP_005 AEGCKRKRPRVAGGGGAGGSAGGGGKKPLPAKGSAAECKQSQRNAANARERARMRVLSKA
70 80 90 100 110 120
90 100 110 120 130 140
pF1KB0 FAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYA
:. :. .: .: : ::::..::.::. :: : :.:: :...: .:: :..
NP_005 FSRLKTSLPWVPPDTKLSKLDTLRLASSYIAHLRQLLQEDRYEN-----GYVHPVNLTWP
130 140 150 160 170 180
150 160
pF1KB0 FSVWRMEGAWSMSASH
: :
NP_005 FVVSGRPDSDTKEVSAANRLCGTTA
190 200
>>NP_835455 (OMIM: 607194,609069,615935) pancreas transc (328 aa)
initn: 235 init1: 146 opt: 227 Z-score: 223.9 bits: 48.7 E(85289): 9.8e-06
Smith-Waterman score: 227; 48.9% identity (70.0% similar) in 90 aa overlap (44-124:133-222)
20 30 40 50 60
pF1KB0 SLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSA--------QSFEELQ
:: :: .:. .: .: :::
NP_835 ETGAPPGGFPYSPGSPPSCLAYPCAGAAVLSPGARLRGLSGAAAAAARRRRRVRSEAELQ
110 120 130 140 150 160
70 80 90 100 110 120
pF1KB0 SQRILANVRERQRTQSLNEAFAALRKIIPTLPSDK-LSKIQTLKLAARYIDFLYQVLQSD
. : ::::::.: ::.:.:: .::. ::::: .: :::..::.:: ::.:: ...:.:
NP_835 QLRQAANVRERRRMQSINDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLSELVQAD
170 180 190 200 210 220
130 140 150 160
pF1KB0 EMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH
NP_835 LPLRGGGAGGCGGPGGGGRLGGDSPGSQAQKVIICHRGTRSPSPSDPDYGLPPLAGHSLS
230 240 250 260 270 280
>>NP_004600 (OMIM: 601010) transcription factor 15 [Homo (199 aa)
initn: 222 init1: 143 opt: 213 Z-score: 214.1 bits: 46.1 E(85289): 3.5e-05
Smith-Waterman score: 213; 48.8% identity (68.6% similar) in 86 aa overlap (45-128:51-136)
20 30 40 50 60 70
pF1KB0 LGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSAQSFEELQSQRILANVR
: :: . :. .. . . :: ::.:
NP_004 LSEDEENRSESDASDQSFGCCEGPEAARRGPGPGGGRRAGGGGGAGPVVVVRQRQAANAR
30 40 50 60 70 80
80 90 100 110 120 130
pF1KB0 ERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQ-SDEMDNKMTS
::.::::.: ::.::: .::: : : :::::.::.::. :: : .:: .: :.
NP_004 ERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSYIAHLANVLLLGDSADDGQPC
90 100 110 120 130 140
140 150 160
pF1KB0 CSYVAHERLSYAFSVWRMEGAWSMSASH
NP_004 FRAAGSAKGAVPAAADGGRQPRSICTFCLSNQRKGGGRRDLGGSCLKVRGVAPLRGPRR
150 160 170 180 190
>>NP_005412 (OMIM: 186855,613065) T-cell acute lymphocyt (108 aa)
initn: 136 init1: 136 opt: 207 Z-score: 212.3 bits: 44.9 E(85289): 4.4e-05
Smith-Waterman score: 207; 59.6% identity (82.5% similar) in 57 aa overlap (66-121:2-58)
40 50 60 70 80 90
pF1KB0 SKKSSEDGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPT
...:..:.::: : :..: ::: :::.:::
NP_005 MTRKIFTNTRERWRQQNVNSAFAKLRKLIPT
10 20 30
100 110 120 130 140 150
pF1KB0 LPSDK-LSKIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAW
: :: ::: .::.:: :::.:: .::
NP_005 HPPDKKLSKNETLRLAMRYINFLVKVLGEQSLQQTGVAAQGNILGLFPQGPHLPGLEDRT
40 50 60 70 80 90
160 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 17:20:50 2016 done: Sat Nov 5 17:20:51 2016
Total Scan time: 5.510 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]