FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3586, 205 aa 1>>>pF1KE3586 205 - 205 aa - 205 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2608+/-0.000313; mu= 13.9040+/- 0.019 mean_var=64.5085+/-13.390, 0's: 0 Z-trim(116.2): 20 B-trim: 76 in 1/50 Lambda= 0.159686 statistics sampled from 27239 (27259) to 27239 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.715), E-opt: 0.2 (0.32), width: 16 Scan time: 6.040 The best scores are: opt bits E(85289) NP_004419 (OMIM: 191164) ephrin-A1 isoform a precu ( 205) 1420 335.3 4.1e-92 NP_872626 (OMIM: 191164) ephrin-A1 isoform b precu ( 183) 941 224.9 6.2e-59 XP_006714628 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 201) 509 125.4 6.1e-29 NP_001953 (OMIM: 601535) ephrin-A5 precursor [Homo ( 228) 503 124.1 1.8e-28 NP_004943 (OMIM: 601381) ephrin-A3 precursor [Homo ( 238) 502 123.9 2.1e-28 NP_001396 (OMIM: 602756) ephrin-A2 precursor [Homo ( 213) 457 113.5 2.6e-25 NP_005218 (OMIM: 601380) ephrin-A4 isoform a precu ( 201) 435 108.4 8.2e-24 NP_872632 (OMIM: 601380) ephrin-A4 isoform c precu ( 193) 434 108.2 9.4e-24 NP_872631 (OMIM: 601380) ephrin-A4 isoform b precu ( 207) 421 105.2 7.9e-23 XP_011541552 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 210) 413 103.3 2.9e-22 XP_016881939 (OMIM: 602756) PREDICTED: ephrin-A2 i ( 202) 394 98.9 5.8e-21 XP_016881938 (OMIM: 602756) PREDICTED: ephrin-A2 i ( 298) 394 99.0 8e-21 XP_016864694 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 148) 268 69.8 2.4e-12 XP_011541553 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 148) 268 69.8 2.4e-12 NP_004420 (OMIM: 300035,304110) ephrin-B1 precurso ( 346) 244 64.5 2.3e-10 NP_004084 (OMIM: 600527) ephrin-B2 precursor [Homo ( 333) 233 62.0 1.3e-09 NP_001397 (OMIM: 602297) ephrin-B3 precursor [Homo ( 340) 232 61.7 1.5e-09 XP_016875895 (OMIM: 600527) PREDICTED: ephrin-B2 i ( 335) 178 49.3 8.4e-06 >>NP_004419 (OMIM: 191164) ephrin-A1 isoform a precursor (205 aa) initn: 1420 init1: 1420 opt: 1420 Z-score: 1774.7 bits: 335.3 E(85289): 4.1e-92 Smith-Waterman score: 1420; 99.0% identity (99.5% similar) in 205 aa overlap (1-205:1-205) 10 20 30 40 50 60 pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGKEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGKEF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHVNPQEKRLAADDPEVRVLHSIA :::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::. NP_004 KEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHDNPQEKRLAADDPEVRVLHSIG 130 140 150 160 170 180 190 200 pF1KE3 HSAAPRLFPLAWTVLLLPLLLLQTP ::::::::::::::::::::::::: NP_004 HSAAPRLFPLAWTVLLLPLLLLQTP 190 200 >>NP_872626 (OMIM: 191164) ephrin-A1 isoform b precursor (183 aa) initn: 939 init1: 939 opt: 941 Z-score: 1179.1 bits: 224.9 E(85289): 6.2e-59 Smith-Waterman score: 1217; 88.3% identity (88.8% similar) in 205 aa overlap (1-205:1-183) 10 20 30 40 50 60 pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGKEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 DAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGKEF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHVNPQEKRLAADDPEVRVLHSIA :::::::::: :::::: ::::::::::::::::::::. NP_872 KEGHSYYYIS----------------------HSPQAHDNPQEKRLAADDPEVRVLHSIG 130 140 150 190 200 pF1KE3 HSAAPRLFPLAWTVLLLPLLLLQTP ::::::::::::::::::::::::: NP_872 HSAAPRLFPLAWTVLLLPLLLLQTP 160 170 180 >>XP_006714628 (OMIM: 601535) PREDICTED: ephrin-A5 isofo (201 aa) initn: 311 init1: 277 opt: 509 Z-score: 640.6 bits: 125.4 E(85289): 6.1e-29 Smith-Waterman score: 509; 47.8% identity (73.3% similar) in 161 aa overlap (14-173:25-183) 10 20 30 40 pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDI : :.:::..:.::::::.:. :: : : .:::.:. XP_006 MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 ICPHYEDHSVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQ .:::::: :: . :.:.::.:. . :. :. :: ::.:::: . .:: :.::::: XP_006 FCPHYED-SVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQ 70 80 90 100 110 110 120 130 140 150 160 pF1KE3 RFTPFTLGKEFKEGHSYYYISKPIHQHEDR-CLRLKVTVSGKITHSPQAHVNPQEKRLAA ::::.:: ::. :. :.:::. : .. : ::.::: : . . . ..:.. . :: XP_006 LFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVR-PTNDTVHESAEPSRGENAA 120 130 140 150 160 170 170 180 190 200 pF1KE3 DDPEVRVLHSIAHSAAPRLFPLAWTVLLLPLLLLQTP . :.. XP_006 QTPRIPSRLLAILLFLLAMLLTL 180 190 200 >>NP_001953 (OMIM: 601535) ephrin-A5 precursor [Homo sap (228 aa) initn: 504 init1: 275 opt: 503 Z-score: 632.3 bits: 124.1 E(85289): 1.8e-28 Smith-Waterman score: 503; 48.1% identity (74.1% similar) in 158 aa overlap (14-170:25-179) 10 20 30 40 pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDI : :.:::..:.::::::.:. :: : : .:::.:. NP_001 MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 ICPHYEDHSVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQ .:::::: :: . :.:.::.:. . :. :. :: ::.:::: . .:: :.::::: NP_001 FCPHYED-SVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQ 70 80 90 100 110 110 120 130 140 150 160 pF1KE3 RFTPFTLGKEFKEGHSYYYISKPIHQHEDR-CLRLKVTVSGKITHSPQAHVNPQEKRLAA ::::.:: ::. :. :.:::. : .. : ::.::: : . :.: . .. ... . . NP_001 LFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFV--RPTNSCMKTIGVHDRVFDV 120 130 140 150 160 170 170 180 190 200 pF1KE3 DDPEVRVLHSIAHSAAPRLFPLAWTVLLLPLLLLQTP .: NP_001 NDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL 180 190 200 210 220 >>NP_004943 (OMIM: 601381) ephrin-A3 precursor [Homo sap (238 aa) initn: 503 init1: 271 opt: 502 Z-score: 630.8 bits: 123.9 E(85289): 2.1e-28 Smith-Waterman score: 510; 39.4% identity (66.5% similar) in 221 aa overlap (7-204:19-238) 10 20 30 40 pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVD :::. . : ..::.:.::::: ..: : ::..:..:::.: NP_004 MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLD 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 IICPHYEDHSVADAA-------MEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGP : ::::.. .:. .: :::.::.: .. :. :. :. ::.:::: : :.: NP_004 IYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNA-SQGFKRWECNRPHAPHSP 70 80 90 100 110 110 120 130 140 150 pF1KE3 EKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHEDRCLRLKVTVS-GKITHS------ :.::::::.. :.:: ::. :: ::::: : :. . .:::.:: : .. .:: NP_004 IKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVP 120 130 140 150 160 170 160 170 180 190 200 pF1KE3 --PQAHVNPQEK-----RLAADDPEVRVLHSIAHSAAPRL--FPLAWTVLLLPLLLLQTP :: ..:. : . ...:.: :.. ...:. .::: . .. . .: . NP_004 TLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFLAS 180 190 200 210 220 230 >>NP_001396 (OMIM: 602756) ephrin-A2 precursor [Homo sap (213 aa) initn: 470 init1: 362 opt: 457 Z-score: 575.5 bits: 113.5 E(85289): 2.6e-25 Smith-Waterman score: 467; 42.7% identity (62.5% similar) in 192 aa overlap (16-195:32-211) 10 20 30 pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFR---NED---YTI : .::..:.:: :::.:. ..: ::. NP_001 APAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYTV 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 HVQLNDYVDIICPHYEDHSVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKH .:..:::.:: :::: ::.:.::.:. : . :. ... ::.::::.: NP_001 EVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPG 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 GPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHEDR-CLRLKVTVSGKITHSPQAH :: :.::::: ::::.:: ::. :: ::::: . :: :::::: . NP_001 GPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKV------------Y 130 140 150 160 160 170 180 190 200 pF1KE3 VNPQEKRL-AADDPEVRVLHSIAHSAAPRLF----PLAWTVLLLPLLLLQTP : : .. : : .: .: . .. ::: :. ::.: NP_001 VRPTNETLYEAPEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS 170 180 190 200 210 >>NP_005218 (OMIM: 601380) ephrin-A4 isoform a precursor (201 aa) initn: 427 init1: 196 opt: 435 Z-score: 548.4 bits: 108.4 E(85289): 8.2e-24 Smith-Waterman score: 435; 43.6% identity (67.3% similar) in 156 aa overlap (4-158:11-162) 10 20 30 40 50 pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPH ::: .:: ... ::.:.::::::.. : .... ::::.::.::: NP_005 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 YEDHSVADAAMEQYILYLVEHEEYQLCQPQS-KDQVRWQCNRPSAKHGPEKLSEKFQRFT :: . .. : . ::.:. :. :: .. . :: :. : : ..:::.:::: NP_005 YEGPGPPEGP-ETFALYMVDWPGYESCQAEGPRAYKRWVCSLP---FGHVQFSEKIQRFT 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 PFTLGKEFKEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHVNPQEKRLAADDPE ::.:: :: :..::::: : . .::::.:.: : .: .:: NP_005 PFSLGFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERKSESAHPVGSPGESGTSGWR 120 130 140 150 160 170 180 190 200 pF1KE3 VRVLHSIAHSAAPRLFPLAWTVLLLPLLLLQTP NP_005 GGDTPSPLCLLLLLLLLILRLLRIL 180 190 200 >>NP_872632 (OMIM: 601380) ephrin-A4 isoform c precursor (193 aa) initn: 389 init1: 196 opt: 434 Z-score: 547.5 bits: 108.2 E(85289): 9.4e-24 Smith-Waterman score: 434; 42.0% identity (66.9% similar) in 169 aa overlap (4-171:11-171) 10 20 30 40 50 pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPH ::: .:: ... ::.:.::::::.. : .... ::::.::.::: NP_872 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 YEDHSVADAAMEQYILYLVEHEEYQLCQPQS-KDQVRWQCNRPSAKHGPEKLSEKFQRFT :: . .. : . ::.:. :. :: .. . :: :. : : ..:::.:::: NP_872 YEGPGPPEGP-ETFALYMVDWPGYESCQAEGPRAYKRWVCSLP---FGHVQFSEKIQRFT 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 PFTLGKEFKEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHVNPQEKRLAADDPE ::.:: :: :..::::: : . .::::.:.: : . : .: :.: . ...:: NP_872 PFSLGFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERNLP-SH--PKEPE-SSQDPL 120 130 140 150 160 170 180 190 200 pF1KE3 VRVLHSIAHSAAPRLFPLAWTVLLLPLLLLQTP NP_872 EEEGSLLPALGVPIQTDKMEH 180 190 >>NP_872631 (OMIM: 601380) ephrin-A4 isoform b precursor (207 aa) initn: 389 init1: 196 opt: 421 Z-score: 530.8 bits: 105.2 E(85289): 7.9e-23 Smith-Waterman score: 421; 43.9% identity (67.6% similar) in 148 aa overlap (4-150:11-154) 10 20 30 40 50 pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPH ::: .:: ... ::.:.::::::.. : .... ::::.::.::: NP_872 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 YEDHSVADAAMEQYILYLVEHEEYQLCQPQS-KDQVRWQCNRPSAKHGPEKLSEKFQRFT :: . .. : . ::.:. :. :: .. . :: :. : : ..:::.:::: NP_872 YEGPGPPEGP-ETFALYMVDWPGYESCQAEGPRAYKRWVCSLP---FGHVQFSEKIQRFT 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 PFTLGKEFKEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHVNPQEKRLAADDPE ::.:: :: :..::::: : . .::::.:.: : NP_872 PFSLGFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERRARVLPRSPGGGGIPAACTG 120 130 140 150 160 170 180 190 200 pF1KE3 VRVLHSIAHSAAPRLFPLAWTVLLLPLLLLQTP NP_872 GANSDRQDGALMGEIRGSEVTLAGACPLITG 180 190 200 >>XP_011541552 (OMIM: 601535) PREDICTED: ephrin-A5 isofo (210 aa) initn: 414 init1: 275 opt: 413 Z-score: 520.8 bits: 103.3 E(85289): 2.9e-22 Smith-Waterman score: 413; 45.7% identity (71.4% similar) in 140 aa overlap (32-170:25-161) 10 20 30 40 50 60 pF1KE3 EFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVAD :. :: : : .:::.:..:::::: :: . XP_011 MQTLEPACFRFSLHTNTNKQCTLGFQRGDYHIDVCINDYLDVFCPHYED-SVPE 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 AAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGKEFK :.:.::.:. . :. :. :: ::.:::: . .:: :.::::: ::::.:: ::. XP_011 DKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFR 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 EGHSYYYISKPIHQHEDR-CLRLKVTVSGKITHSPQAHVNPQEKRLAADDPEVRVLHSIA :. :.:::. : .. : ::.::: : . :.: . .. ... . ..: XP_011 PGREYFYISSAIPDNGRRSCLKLKVFV--RPTNSCMKTIGVHDRVFDVNDKVENSLEPAD 120 130 140 150 160 170 190 200 pF1KE3 HSAAPRLFPLAWTVLLLPLLLLQTP XP_011 DTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL 180 190 200 210 205 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:57:03 2016 done: Sun Nov 6 01:57:04 2016 Total Scan time: 6.040 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]