FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6325, 435 aa 1>>>pF1KE6325 435 - 435 aa - 435 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2289+/-0.000456; mu= 8.1502+/- 0.028 mean_var=139.3049+/-27.293, 0's: 0 Z-trim(112.7): 41 B-trim: 38 in 1/54 Lambda= 0.108665 statistics sampled from 21670 (21707) to 21670 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.618), E-opt: 0.2 (0.255), width: 16 Scan time: 6.570 The best scores are: opt bits E(85289) NP_005438 (OMIM: 610383) ras association domain-co ( 435) 2841 457.6 2.9e-128 XP_011537290 (OMIM: 610383) PREDICTED: ras associa ( 414) 2697 435.0 1.8e-121 NP_001073990 (OMIM: 614713) ras association domain ( 507) 352 67.4 9.6e-11 >>NP_005438 (OMIM: 610383) ras association domain-contai (435 aa) initn: 2841 init1: 2841 opt: 2841 Z-score: 2423.6 bits: 457.6 E(85289): 2.9e-128 Smith-Waterman score: 2841; 100.0% identity (100.0% similar) in 435 aa overlap (1-435:1-435) 10 20 30 40 50 60 pF1KE6 MAPFGRNLLKTRHKNRSPTKDMDSEEKEIVVWVCQEEKLVCGLTKRTTSADVIQALLEEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MAPFGRNLLKTRHKNRSPTKDMDSEEKEIVVWVCQEEKLVCGLTKRTTSADVIQALLEEH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 EATFGEKRFLLGKPSDYCIIEKWRGSERVLPPLTRILKLWKAWGDEQPNMQFVLVKADAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EATFGEKRFLLGKPSDYCIIEKWRGSERVLPPLTRILKLWKAWGDEQPNMQFVLVKADAF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 LPVPLWRTAEAKLVQNTEKLWELSPANYMKTLPPDKQKRIVRKTFRKLAKIKQDTVSHDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LPVPLWRTAEAKLVQNTEKLWELSPANYMKTLPPDKQKRIVRKTFRKLAKIKQDTVSHDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 DNMETLVHLIISQDHTIHQQVKRMKELDLEIEKCEAKFHLDRVENDGENYVQDAYLMPSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DNMETLVHLIISQDHTIHQQVKRMKELDLEIEKCEAKFHLDRVENDGENYVQDAYLMPSF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 SEVEQNLDLQYEENQTLEDLSESDGIEQLEERLKYYRILIDKLSAEIEKEVKSVCIDINE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SEVEQNLDLQYEENQTLEDLSESDGIEQLEERLKYYRILIDKLSAEIEKEVKSVCIDINE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 DAEGEAASELESSNLESVKCDLEKSMKAGLKIHSHLSGIQKEIKYSDSLLQMKAKEYELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DAEGEAASELESSNLESVKCDLEKSMKAGLKIHSHLSGIQKEIKYSDSLLQMKAKEYELL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 AKEFNSLHISNKDGCQLKENRAKESEVPSSNGEIPPFTQRVFSNYTNDTDSDTGISSNHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AKEFNSLHISNKDGCQLKENRAKESEVPSSNGEIPPFTQRVFSNYTNDTDSDTGISSNHS 370 380 390 400 410 420 430 pF1KE6 QDSETTVGDVVLLST ::::::::::::::: NP_005 QDSETTVGDVVLLST 430 >>XP_011537290 (OMIM: 610383) PREDICTED: ras association (414 aa) initn: 2697 init1: 2697 opt: 2697 Z-score: 2301.9 bits: 435.0 E(85289): 1.8e-121 Smith-Waterman score: 2697; 100.0% identity (100.0% similar) in 414 aa overlap (22-435:1-414) 10 20 30 40 50 60 pF1KE6 MAPFGRNLLKTRHKNRSPTKDMDSEEKEIVVWVCQEEKLVCGLTKRTTSADVIQALLEEH ::::::::::::::::::::::::::::::::::::::: XP_011 MDSEEKEIVVWVCQEEKLVCGLTKRTTSADVIQALLEEH 10 20 30 70 80 90 100 110 120 pF1KE6 EATFGEKRFLLGKPSDYCIIEKWRGSERVLPPLTRILKLWKAWGDEQPNMQFVLVKADAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EATFGEKRFLLGKPSDYCIIEKWRGSERVLPPLTRILKLWKAWGDEQPNMQFVLVKADAF 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE6 LPVPLWRTAEAKLVQNTEKLWELSPANYMKTLPPDKQKRIVRKTFRKLAKIKQDTVSHDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPVPLWRTAEAKLVQNTEKLWELSPANYMKTLPPDKQKRIVRKTFRKLAKIKQDTVSHDR 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE6 DNMETLVHLIISQDHTIHQQVKRMKELDLEIEKCEAKFHLDRVENDGENYVQDAYLMPSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DNMETLVHLIISQDHTIHQQVKRMKELDLEIEKCEAKFHLDRVENDGENYVQDAYLMPSF 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE6 SEVEQNLDLQYEENQTLEDLSESDGIEQLEERLKYYRILIDKLSAEIEKEVKSVCIDINE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEVEQNLDLQYEENQTLEDLSESDGIEQLEERLKYYRILIDKLSAEIEKEVKSVCIDINE 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE6 DAEGEAASELESSNLESVKCDLEKSMKAGLKIHSHLSGIQKEIKYSDSLLQMKAKEYELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAEGEAASELESSNLESVKCDLEKSMKAGLKIHSHLSGIQKEIKYSDSLLQMKAKEYELL 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE6 AKEFNSLHISNKDGCQLKENRAKESEVPSSNGEIPPFTQRVFSNYTNDTDSDTGISSNHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKEFNSLHISNKDGCQLKENRAKESEVPSSNGEIPPFTQRVFSNYTNDTDSDTGISSNHS 340 350 360 370 380 390 430 pF1KE6 QDSETTVGDVVLLST ::::::::::::::: XP_011 QDSETTVGDVVLLST 400 410 >>NP_001073990 (OMIM: 614713) ras association domain-con (507 aa) initn: 896 init1: 282 opt: 352 Z-score: 313.9 bits: 67.4 E(85289): 9.6e-11 Smith-Waterman score: 695; 34.5% identity (57.3% similar) in 447 aa overlap (22-374:1-447) 10 20 30 40 50 60 pF1KE6 MAPFGRNLLKTRHKNRSPTKDMDSEEKEIVVWVCQEEKLVCGLTKRTTSADVIQALLEEH :: ::.: ::.::::::: ::..::: .::...:::. NP_001 MDPSEKKISVWICQEEKLVSGLSRRTTCSDVVRVLLEDG 10 20 30 70 80 pF1KE6 EATFGEKR-----------------------------------FLLGKPSDYCIIEKWRG ..: .: : :. :::.::::: NP_001 CRRRRRQRRSRRLGSAGDPHGPGELPEPPNEDDEDDDEALPQGMLCGPPQCYCIVEKWRG 40 50 60 70 80 90 90 100 110 120 130 140 pF1KE6 SERVLPPLTRILKLWKAWGDEQPNMQFVLVKADAFLPVPLWRTAEAKLVQNTEKL--WEL ::.:: ::::.:: :::.:: :..::::...: :: :.:::..: . :. . NP_001 FERILPNKTRILRLWAAWGEEQENVRFVLVRSEASLPNAGPRSAEARVVLSRERPCPARG 100 110 120 130 140 150 150 160 170 180 pF1KE6 SPANYMKTLPPDKQKRIVRKTFRKLAKI----KQDTVS-------------------HDR .:: .. .::.:.:::.::::::. .:.: : :. NP_001 APARPSLAMTQEKQRRVVRKAFRKLAKLNRRRQQQTPSSCSSTSSSTASSCSSSPRTHES 160 170 180 190 200 210 190 200 210 220 230 pF1KE6 ---DNMETLVHLIISQDHTIHQQVKRMKELDLEIEKCEAKFHLDRVENDGENYVQDAYLM . :::::::..::::::.:::.:..::: ::.. ::: ::::.. : :::::.::. NP_001 ASVERMETLVHLVLSQDHTIRQQVQRLHELDREIDHYEAKVHLDRMRRHGVNYVQDTYLV 220 230 240 250 260 270 240 250 260 270 pF1KE6 PSFSEVE--------QNLDLQYEENQTLEDLSESDGIEQLEE---------RLKYYRI-- . :.. ... . :: . :. ::: ::. :. NP_001 GAGIELDGSRPGEEPEEVAAEAEEAAAAPPLAGEAQAAALEELARRCDDLLRLQEQRVQQ 280 290 300 310 320 330 280 290 300 310 320 pF1KE6 --LIDKLSAEIEKEVKSVCIDINEDAEGEAASELESSN---------LESVKCDLEKSMK :...:::::..:... . .. . :: .. : :. .: :. NP_001 EELLERLSAEIQEELNQRWMRRRQEELAAREEPLEPDGGPDGELLLEQERVRTQLSTSLY 340 350 360 370 380 390 330 340 350 360 370 380 pF1KE6 AGLKIHSHLSGIQKEIKYSDSLLQMKAKEYELLAKEFNSLHIS-NKDGCQLKENRAKESE ::.... : ...... ::.. . : .: . : . ...:... :: NP_001 IGLRLNTDLEAVKSDLDYSQQQWDSKKRELQGLLQTLHTLELTVAPDGAPGSGSPSREPG 400 410 420 430 440 450 390 400 410 420 430 pF1KE6 VPSSNGEIPPFTQRVFSNYTNDTDSDTGISSNHSQDSETTVGDVVLLST NP_001 PQACADMWVDQARGLAKSGPGNDEDSDTGLSSMHSQDSDSLPMCESLV 460 470 480 490 500 435 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 12:07:20 2016 done: Tue Nov 8 12:07:21 2016 Total Scan time: 6.570 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]