FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2543, 265 aa 1>>>pF1KE2543 265 - 265 aa - 265 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9121+/-0.00045; mu= 11.0625+/- 0.028 mean_var=65.1774+/-13.127, 0's: 0 Z-trim(109.3): 9 B-trim: 291 in 1/51 Lambda= 0.158864 statistics sampled from 17411 (17419) to 17411 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.568), E-opt: 0.2 (0.204), width: 16 Scan time: 6.160 The best scores are: opt bits E(85289) XP_006714526 (OMIM: 609022) PREDICTED: rapamycin-i (1670) 1591 373.9 1e-102 XP_011512307 (OMIM: 609022) PREDICTED: rapamycin-i (1694) 1591 373.9 1e-102 NP_689969 (OMIM: 609022) rapamycin-insensitive com (1708) 1591 373.9 1e-102 NP_001272368 (OMIM: 609022) rapamycin-insensitive (1732) 1591 373.9 1.1e-102 XP_016864801 (OMIM: 609022) PREDICTED: rapamycin-i (1692) 1392 328.3 5.6e-89 XP_016864800 (OMIM: 609022) PREDICTED: rapamycin-i (1716) 1392 328.3 5.7e-89 XP_016864802 (OMIM: 609022) PREDICTED: rapamycin-i (1679) 1253 296.5 2.2e-79 XP_011512308 (OMIM: 609022) PREDICTED: rapamycin-i (1669) 1173 278.1 7.1e-74 >>XP_006714526 (OMIM: 609022) PREDICTED: rapamycin-insen (1670 aa) initn: 1591 init1: 1591 opt: 1591 Z-score: 1965.0 bits: 373.9 E(85289): 1e-102 Smith-Waterman score: 1591; 100.0% identity (100.0% similar) in 251 aa overlap (1-251:1-251) 10 20 30 40 50 60 pF1KE2 MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKT 190 200 210 220 230 240 250 260 pF1KE2 RQYVRADVELEVGTLIFFSSFKILL ::::::::::: XP_006 RQYVRADVELERILAPYTDFHYRHSPDTAEGQLKEDREARFLASKMGIIATFRSWAGIIN 250 260 270 280 290 300 >>XP_011512307 (OMIM: 609022) PREDICTED: rapamycin-insen (1694 aa) initn: 1591 init1: 1591 opt: 1591 Z-score: 1964.9 bits: 373.9 E(85289): 1e-102 Smith-Waterman score: 1591; 100.0% identity (100.0% similar) in 251 aa overlap (1-251:1-251) 10 20 30 40 50 60 pF1KE2 MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKT 190 200 210 220 230 240 250 260 pF1KE2 RQYVRADVELEVGTLIFFSSFKILL ::::::::::: XP_011 RQYVRADVELERILAPYTDFHYRHSPDTAEGQLKEDREARFLASKMGIIATFRSWAGIIN 250 260 270 280 290 300 >>NP_689969 (OMIM: 609022) rapamycin-insensitive compani (1708 aa) initn: 1591 init1: 1591 opt: 1591 Z-score: 1964.9 bits: 373.9 E(85289): 1e-102 Smith-Waterman score: 1591; 100.0% identity (100.0% similar) in 251 aa overlap (1-251:1-251) 10 20 30 40 50 60 pF1KE2 MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 NNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 LKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 DRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKT 190 200 210 220 230 240 250 260 pF1KE2 RQYVRADVELEVGTLIFFSSFKILL ::::::::::: NP_689 RQYVRADVELERILAPYTDFHYRHSPDTAEGQLKEDREARFLASKMGIIATFRSWAGIIN 250 260 270 280 290 300 >>NP_001272368 (OMIM: 609022) rapamycin-insensitive comp (1732 aa) initn: 1591 init1: 1591 opt: 1591 Z-score: 1964.8 bits: 373.9 E(85289): 1.1e-102 Smith-Waterman score: 1591; 100.0% identity (100.0% similar) in 251 aa overlap (1-251:1-251) 10 20 30 40 50 60 pF1KE2 MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKT 190 200 210 220 230 240 250 260 pF1KE2 RQYVRADVELEVGTLIFFSSFKILL ::::::::::: NP_001 RQYVRADVELERILAPYTDFHYRHSPDTAEGQLKEDREARFLASKMGIIATFRSWAGIIN 250 260 270 280 290 300 >>XP_016864801 (OMIM: 609022) PREDICTED: rapamycin-insen (1692 aa) initn: 1392 init1: 1392 opt: 1392 Z-score: 1718.5 bits: 328.3 E(85289): 5.6e-89 Smith-Waterman score: 1442; 93.6% identity (93.6% similar) in 251 aa overlap (1-251:1-235) 10 20 30 40 50 60 pF1KE2 MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHL ::::::::::::::: ::::::::::::::::::::::::::::: XP_016 MAAIGRGRSLKNLRV----------------REPSDNLREILQNVARLQGVSNMRKLGHL 10 20 30 40 70 80 90 100 110 120 pF1KE2 NNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKV 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE2 LKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE2 DRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKT 170 180 190 200 210 220 250 260 pF1KE2 RQYVRADVELEVGTLIFFSSFKILL ::::::::::: XP_016 RQYVRADVELERILAPYTDFHYRHSPDTAEGQLKEDREARFLASKMGIIATFRSWAGIIN 230 240 250 260 270 280 >>XP_016864800 (OMIM: 609022) PREDICTED: rapamycin-insen (1716 aa) initn: 1392 init1: 1392 opt: 1392 Z-score: 1718.4 bits: 328.3 E(85289): 5.7e-89 Smith-Waterman score: 1442; 93.6% identity (93.6% similar) in 251 aa overlap (1-251:1-235) 10 20 30 40 50 60 pF1KE2 MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHL ::::::::::::::: ::::::::::::::::::::::::::::: XP_016 MAAIGRGRSLKNLRV----------------REPSDNLREILQNVARLQGVSNMRKLGHL 10 20 30 40 70 80 90 100 110 120 pF1KE2 NNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKV 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE2 LKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE2 DRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKT 170 180 190 200 210 220 250 260 pF1KE2 RQYVRADVELEVGTLIFFSSFKILL ::::::::::: XP_016 RQYVRADVELERILAPYTDFHYRHSPDTAEGQLKEDREARFLASKMGIIATFRSWAGIIN 230 240 250 260 270 280 >>XP_016864802 (OMIM: 609022) PREDICTED: rapamycin-insen (1679 aa) initn: 1253 init1: 1253 opt: 1253 Z-score: 1546.3 bits: 296.5 E(85289): 2.2e-79 Smith-Waterman score: 1253; 100.0% identity (100.0% similar) in 198 aa overlap (54-251:1-198) 30 40 50 60 70 80 pF1KE2 ENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHLNNFTKLLCDIGHSEEKLGFHYED :::::::::::::::::::::::::::::: XP_016 MRKLGHLNNFTKLLCDIGHSEEKLGFHYED 10 20 30 90 100 110 120 130 140 pF1KE2 IIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQSNEVER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQSNEVER 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE2 TQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQERDRMVRACIAIICELALQNPEVVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQERDRMVRACIAIICELALQNPEVVA 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE2 LRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKTRQYVRADVELEVGTLIFFSSFKI :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYR 160 170 180 190 200 210 pF1KE2 LL XP_016 HSPDTAEGQLKEDREARFLASKMGIIATFRSWAGIINLCKPGNSGIQSLIGVLCIPNMEI 220 230 240 250 260 270 >>XP_011512308 (OMIM: 609022) PREDICTED: rapamycin-insen (1669 aa) initn: 1173 init1: 1173 opt: 1173 Z-score: 1447.3 bits: 278.1 E(85289): 7.1e-74 Smith-Waterman score: 1173; 99.5% identity (100.0% similar) in 187 aa overlap (65-251:2-188) 40 50 60 70 80 90 pF1KE2 SDNLREILQNVARLQGVSNMRKLGHLNNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLN .::::::::::::::::::::::::::::: XP_011 MELLCDIGHSEEKLGFHYEDIIICLRLALLN 10 20 30 100 110 120 130 140 150 pF1KE2 EAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQSNEVERTQALRLVRKMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQSNEVERTQALRLVRKMI 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE2 TVNASLFPSSVTNSLIAVGNDGLQERDRMVRACIAIICELALQNPEVVALRGGLNTILKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVNASLFPSSVTNSLIAVGNDGLQERDRMVRACIAIICELALQNPEVVALRGGLNTILKN 100 110 120 130 140 150 220 230 240 250 260 pF1KE2 VIDCQLSRINEALITTILHLLNHPKTRQYVRADVELEVGTLIFFSSFKILL ::::::::::::::::::::::::::::::::::::: XP_011 VIDCQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHSPDTAEGQLK 160 170 180 190 200 210 XP_011 EDREARFLASKMGIIATFRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDI 220 230 240 250 260 270 265 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 03:46:48 2016 done: Tue Nov 8 03:46:49 2016 Total Scan time: 6.160 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]