FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1463, 150 aa 1>>>pF1KE1463 150 - 150 aa - 150 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9550+/-0.000307; mu= 12.9528+/- 0.019 mean_var=53.2126+/-10.629, 0's: 0 Z-trim(116.3): 29 B-trim: 30 in 1/52 Lambda= 0.175820 statistics sampled from 27318 (27347) to 27318 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.703), E-opt: 0.2 (0.321), width: 16 Scan time: 5.450 The best scores are: opt bits E(85289) NP_665874 (OMIM: 246530,614037) leukotriene C4 syn ( 150) 964 251.9 2.9e-67 XP_016863702 (OMIM: 601733) PREDICTED: microsomal ( 147) 408 110.8 8.1e-25 XP_016863701 (OMIM: 601733) PREDICTED: microsomal ( 147) 408 110.8 8.1e-25 NP_002404 (OMIM: 601733) microsomal glutathione S- ( 147) 408 110.8 8.1e-25 XP_016863700 (OMIM: 601733) PREDICTED: microsomal ( 147) 408 110.8 8.1e-25 NP_001191295 (OMIM: 601733) microsomal glutathione ( 147) 408 110.8 8.1e-25 NP_001620 (OMIM: 601367,603700) arachidonate 5-lip ( 161) 255 72.0 4.2e-13 NP_001191335 (OMIM: 601367,603700) arachidonate 5- ( 218) 255 72.1 5.5e-13 NP_001191297 (OMIM: 601733) microsomal glutathione ( 77) 182 53.4 8.4e-08 XP_016876011 (OMIM: 601367,603700) PREDICTED: arac ( 121) 174 51.4 5.1e-07 XP_006714284 (OMIM: 601733) PREDICTED: microsomal ( 79) 146 44.3 4.8e-05 NP_001191296 (OMIM: 601733) microsomal glutathione ( 79) 146 44.3 4.8e-05 XP_016863703 (OMIM: 601733) PREDICTED: microsomal ( 79) 146 44.3 4.8e-05 XP_011530274 (OMIM: 601733) PREDICTED: microsomal ( 79) 146 44.3 4.8e-05 XP_005245231 (OMIM: 604564) PREDICTED: microsomal ( 152) 135 41.6 0.00059 NP_004519 (OMIM: 604564) microsomal glutathione S- ( 152) 135 41.6 0.00059 >>NP_665874 (OMIM: 246530,614037) leukotriene C4 synthas (150 aa) initn: 964 init1: 964 opt: 964 Z-score: 1328.6 bits: 251.9 E(85289): 2.9e-67 Smith-Waterman score: 964; 99.3% identity (100.0% similar) in 150 aa overlap (1-150:1-150) 10 20 30 40 50 60 pF1KE1 MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 PLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVA 70 80 90 100 110 120 130 140 150 pF1KE1 LAALGLLAHFLPAALRAALLGQLRTLLPWA :::::::::::::::::::::.:::::::: NP_665 LAALGLLAHFLPAALRAALLGRLRTLLPWA 130 140 150 >>XP_016863702 (OMIM: 601733) PREDICTED: microsomal glut (147 aa) initn: 406 init1: 406 opt: 408 Z-score: 566.5 bits: 110.8 E(85289): 8.1e-25 Smith-Waterman score: 408; 45.1% identity (70.8% similar) in 144 aa overlap (1-144:1-144) 10 20 30 40 50 60 pF1KE1 MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYF : . :::::..:.. :.::.::: .:: ..:.:: .:: ::::::.::: :: :.. XP_016 MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVA :.:. :::.:: .:.. :. ::::...: :: ::...:. :.. . : : ::. XP_016 PIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTL 70 80 90 100 110 120 130 140 150 pF1KE1 LAALGLLAHFLPAALRAALLGQLRTLLPWA :.:::. :: : . .:: XP_016 LGALGIANSFLDEYLDLNIAKKLRRQF 130 140 >>XP_016863701 (OMIM: 601733) PREDICTED: microsomal glut (147 aa) initn: 406 init1: 406 opt: 408 Z-score: 566.5 bits: 110.8 E(85289): 8.1e-25 Smith-Waterman score: 408; 45.1% identity (70.8% similar) in 144 aa overlap (1-144:1-144) 10 20 30 40 50 60 pF1KE1 MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYF : . :::::..:.. :.::.::: .:: ..:.:: .:: ::::::.::: :: :.. XP_016 MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVA :.:. :::.:: .:.. :. ::::...: :: ::...:. :.. . : : ::. XP_016 PIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTL 70 80 90 100 110 120 130 140 150 pF1KE1 LAALGLLAHFLPAALRAALLGQLRTLLPWA :.:::. :: : . .:: XP_016 LGALGIANSFLDEYLDLNIAKKLRRQF 130 140 >>NP_002404 (OMIM: 601733) microsomal glutathione S-tran (147 aa) initn: 406 init1: 406 opt: 408 Z-score: 566.5 bits: 110.8 E(85289): 8.1e-25 Smith-Waterman score: 408; 45.1% identity (70.8% similar) in 144 aa overlap (1-144:1-144) 10 20 30 40 50 60 pF1KE1 MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYF : . :::::..:.. :.::.::: .:: ..:.:: .:: ::::::.::: :: :.. NP_002 MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVA :.:. :::.:: .:.. :. ::::...: :: ::...:. :.. . : : ::. NP_002 PIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTL 70 80 90 100 110 120 130 140 150 pF1KE1 LAALGLLAHFLPAALRAALLGQLRTLLPWA :.:::. :: : . .:: NP_002 LGALGIANSFLDEYLDLNIAKKLRRQF 130 140 >>XP_016863700 (OMIM: 601733) PREDICTED: microsomal glut (147 aa) initn: 406 init1: 406 opt: 408 Z-score: 566.5 bits: 110.8 E(85289): 8.1e-25 Smith-Waterman score: 408; 45.1% identity (70.8% similar) in 144 aa overlap (1-144:1-144) 10 20 30 40 50 60 pF1KE1 MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYF : . :::::..:.. :.::.::: .:: ..:.:: .:: ::::::.::: :: :.. XP_016 MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVA :.:. :::.:: .:.. :. ::::...: :: ::...:. :.. . : : ::. XP_016 PIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTL 70 80 90 100 110 120 130 140 150 pF1KE1 LAALGLLAHFLPAALRAALLGQLRTLLPWA :.:::. :: : . .:: XP_016 LGALGIANSFLDEYLDLNIAKKLRRQF 130 140 >>NP_001191295 (OMIM: 601733) microsomal glutathione S-t (147 aa) initn: 406 init1: 406 opt: 408 Z-score: 566.5 bits: 110.8 E(85289): 8.1e-25 Smith-Waterman score: 408; 45.1% identity (70.8% similar) in 144 aa overlap (1-144:1-144) 10 20 30 40 50 60 pF1KE1 MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYF : . :::::..:.. :.::.::: .:: ..:.:: .:: ::::::.::: :: :.. NP_001 MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVA :.:. :::.:: .:.. :. ::::...: :: ::...:. :.. . : : ::. NP_001 PIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTL 70 80 90 100 110 120 130 140 150 pF1KE1 LAALGLLAHFLPAALRAALLGQLRTLLPWA :.:::. :: : . .:: NP_001 LGALGIANSFLDEYLDLNIAKKLRRQF 130 140 >>NP_001620 (OMIM: 601367,603700) arachidonate 5-lipoxyg (161 aa) initn: 253 init1: 240 opt: 255 Z-score: 356.2 bits: 72.0 E(85289): 4.2e-13 Smith-Waterman score: 255; 36.7% identity (64.1% similar) in 128 aa overlap (5-131:9-135) 10 20 30 40 50 pF1KE1 MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNC :.::: :::..:. ...:. .: :. :: ::::: :. :: NP_001 MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 SEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYA-SARAL . .: :::.:: ::.. . ::. ::.:::.: .:: :: . . . .: : . : . NP_001 VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYL-GERTQSTPGYIFGKRII 70 80 90 100 110 120 130 140 150 pF1KE1 WLLVALAALGLLAHFLPAALRAALLGQLRTLLPWA .: ... :.. ..: NP_001 LFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP 120 130 140 150 160 >>NP_001191335 (OMIM: 601367,603700) arachidonate 5-lipo (218 aa) initn: 240 init1: 240 opt: 255 Z-score: 354.1 bits: 72.1 E(85289): 5.5e-13 Smith-Waterman score: 255; 36.7% identity (64.1% similar) in 128 aa overlap (5-131:66-192) 10 20 30 pF1KE1 MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFR :.::: :::..:. ...:. .: :. NP_001 HQCWAGCAAGGRAVLSGEPEANMDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQN 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE1 VSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYF :: ::::: :. :: . .: :::.:: ::.. . ::. ::.:::.: .:: NP_001 GRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYF 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE1 QGYARSAQLRLAPLYA-SARALWLLVALAALGLLAHFLPAALRAALLGQLRTLLPWA :: . . . .: : . : . .: ... :.. ..: NP_001 VGYL-GERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPL 160 170 180 190 200 210 NP_001 LLIP >>NP_001191297 (OMIM: 601733) microsomal glutathione S-t (77 aa) initn: 190 init1: 179 opt: 182 Z-score: 261.1 bits: 53.4 E(85289): 8.4e-08 Smith-Waterman score: 182; 43.2% identity (70.3% similar) in 74 aa overlap (1-74:1-71) 10 20 30 40 50 60 pF1KE1 MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYF : . :::::..:.. :.::.::: .:: ..:.:: .:: ::::::.::. : :. NP_001 MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAHF-C--YL 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 PLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVA . .: . :.. NP_001 SGSGVHIWPSPILLGIFRSC 60 70 >>XP_016876011 (OMIM: 601367,603700) PREDICTED: arachido (121 aa) initn: 172 init1: 159 opt: 174 Z-score: 247.1 bits: 51.4 E(85289): 5.1e-07 Smith-Waterman score: 174; 35.9% identity (66.7% similar) in 78 aa overlap (55-131:19-95) 30 40 50 60 70 80 pF1KE1 QVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGL :: . .: :::.:: ::.. . ::. :: XP_016 MRLQEEKNMHLILLSENQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGL 10 20 30 40 90 100 110 120 130 140 pF1KE1 VYLFARLRYFQGYARSAQLRLAPLYA-SARALWLLVALAALGLLAHFLPAALRAALLGQL .:::.: .:: :: . . . .: : . : . .: ... :.. ..: XP_016 MYLFVRQKYFVGYL-GERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYI 50 60 70 80 90 100 150 pF1KE1 RTLLPWA XP_016 KTISTTISPLLLIP 110 120 150 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 00:17:11 2016 done: Mon Nov 7 00:17:12 2016 Total Scan time: 5.450 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]