FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0955, 483 aa 1>>>pF1KE0955 483 - 483 aa - 483 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.6265+/-0.000583; mu= -12.7936+/- 0.036 mean_var=900.3660+/-195.656, 0's: 0 Z-trim(121.6): 750 B-trim: 0 in 0/58 Lambda= 0.042743 statistics sampled from 37413 (38357) to 37413 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.749), E-opt: 0.2 (0.45), width: 16 Scan time: 11.100 The best scores are: opt bits E(85289) NP_063937 (OMIM: 606784) glycogen synthase kinase- ( 483) 3250 216.2 1.6e-55 NP_001139628 (OMIM: 605004) glycogen synthase kina ( 420) 2082 144.1 7.3e-34 XP_006713674 (OMIM: 605004) PREDICTED: glycogen sy ( 387) 1983 137.9 4.8e-32 XP_006713673 (OMIM: 605004) PREDICTED: glycogen sy ( 400) 1676 119.0 2.4e-26 NP_002084 (OMIM: 605004) glycogen synthase kinase- ( 433) 1676 119.1 2.6e-26 NP_001789 (OMIM: 116953) cyclin-dependent kinase 2 ( 298) 605 52.8 1.6e-06 NP_001249 (OMIM: 123828) cyclin-dependent kinase 3 ( 305) 594 52.1 2.6e-06 NP_001790 (OMIM: 601955) cyclin-dependent kinase 7 ( 346) 582 51.5 4.6e-06 NP_002737 (OMIM: 601795) mitogen-activated protein ( 379) 583 51.6 4.6e-06 NP_001035145 (OMIM: 601795) mitogen-activated prot ( 357) 582 51.5 4.7e-06 NP_001310218 (OMIM: 300203,300672) cyclin-dependen ( 960) 573 51.6 1.2e-05 NP_003150 (OMIM: 300203,300672) cyclin-dependent k (1030) 573 51.6 1.2e-05 NP_001032420 (OMIM: 300203,300672) cyclin-dependen (1030) 573 51.6 1.2e-05 NP_002736 (OMIM: 176948) mitogen-activated protein ( 360) 557 49.9 1.4e-05 NP_620407 (OMIM: 176948) mitogen-activated protein ( 360) 557 49.9 1.4e-05 XP_016865978 (OMIM: 612325,612651) PREDICTED: seri ( 632) 562 50.6 1.5e-05 XP_016865980 (OMIM: 612325,612651) PREDICTED: seri ( 632) 562 50.6 1.5e-05 XP_016865977 (OMIM: 612325,612651) PREDICTED: seri ( 632) 562 50.6 1.5e-05 XP_016865981 (OMIM: 612325,612651) PREDICTED: seri ( 632) 562 50.6 1.5e-05 XP_016865979 (OMIM: 612325,612651) PREDICTED: seri ( 632) 562 50.6 1.5e-05 NP_055735 (OMIM: 612325,612651) serine/threonine-p ( 632) 562 50.6 1.5e-05 NP_057597 (OMIM: 612325,612651) serine/threonine-p ( 632) 562 50.6 1.5e-05 XP_011512721 (OMIM: 612325,612651) PREDICTED: seri ( 639) 562 50.6 1.5e-05 XP_011512723 (OMIM: 612325,612651) PREDICTED: seri ( 639) 562 50.6 1.5e-05 XP_016865976 (OMIM: 612325,612651) PREDICTED: seri ( 639) 562 50.6 1.5e-05 XP_011512722 (OMIM: 612325,612651) PREDICTED: seri ( 639) 562 50.6 1.5e-05 XP_016865975 (OMIM: 612325,612651) PREDICTED: seri ( 639) 562 50.6 1.5e-05 XP_016865974 (OMIM: 612325,612651) PREDICTED: seri ( 639) 562 50.6 1.5e-05 NP_002742 (OMIM: 602898) mitogen-activated protein ( 364) 551 49.6 1.8e-05 NP_001034892 (OMIM: 610076) cyclin-dependent kinas ( 346) 550 49.5 1.8e-05 XP_016866355 (OMIM: 154235,614181) PREDICTED: seri ( 439) 553 49.8 1.8e-05 XP_016864300 (OMIM: 603442) PREDICTED: cyclin-depe ( 479) 553 49.9 1.9e-05 NP_003939 (OMIM: 603442) cyclin-dependent kinase-l ( 493) 553 49.9 1.9e-05 XP_016864299 (OMIM: 603442) PREDICTED: cyclin-depe ( 493) 553 49.9 1.9e-05 XP_006714469 (OMIM: 603442) PREDICTED: cyclin-depe ( 530) 553 50.0 2e-05 XP_016870050 (OMIM: 610076) PREDICTED: cyclin-depe ( 351) 547 49.3 2.1e-05 NP_001317653 (OMIM: 603442) cyclin-dependent kinas ( 570) 553 50.0 2.1e-05 XP_016864298 (OMIM: 603442) PREDICTED: cyclin-depe ( 570) 553 50.0 2.1e-05 NP_001229314 (OMIM: 154235,614181) serine/threonin ( 583) 553 50.0 2.1e-05 XP_011512924 (OMIM: 154235,614181) PREDICTED: seri ( 583) 553 50.0 2.1e-05 XP_016866353 (OMIM: 154235,614181) PREDICTED: seri ( 623) 553 50.1 2.2e-05 NP_005897 (OMIM: 154235,614181) serine/threonine-p ( 623) 553 50.1 2.2e-05 NP_002740 (OMIM: 602521) mitogen-activated protein ( 816) 556 50.4 2.2e-05 NP_620602 (OMIM: 602521) mitogen-activated protein ( 816) 556 50.4 2.2e-05 NP_620603 (OMIM: 602521) mitogen-activated protein ( 816) 556 50.4 2.2e-05 XP_016866352 (OMIM: 154235,614181) PREDICTED: seri ( 648) 553 50.1 2.2e-05 XP_011512922 (OMIM: 154235,614181) PREDICTED: seri ( 648) 553 50.1 2.2e-05 XP_011512921 (OMIM: 154235,614181) PREDICTED: seri ( 648) 553 50.1 2.2e-05 NP_001229886 (OMIM: 154235,614181) serine/threonin ( 648) 553 50.1 2.2e-05 NP_001777 (OMIM: 116940) cyclin-dependent kinase 1 ( 297) 540 48.8 2.5e-05 >>NP_063937 (OMIM: 606784) glycogen synthase kinase-3 al (483 aa) initn: 3250 init1: 3250 opt: 3250 Z-score: 1117.6 bits: 216.2 E(85289): 1.6e-55 Smith-Waterman score: 3250; 100.0% identity (100.0% similar) in 483 aa overlap (1-483:1-483) 10 20 30 40 50 60 pF1KE0 MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_063 MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_063 GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_063 DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_063 SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_063 CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_063 IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_063 AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_063 PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT 430 440 450 460 470 480 pF1KE0 NSS ::: NP_063 NSS >>NP_001139628 (OMIM: 605004) glycogen synthase kinase-3 (420 aa) initn: 2131 init1: 2065 opt: 2082 Z-score: 728.9 bits: 144.1 E(85289): 7.3e-34 Smith-Waterman score: 2082; 78.1% identity (90.8% similar) in 401 aa overlap (84-483:21-420) 60 70 80 90 100 110 pF1KE0 GAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPER ..: :. .:..:::::::: ::::.: NP_001 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDR 10 20 30 40 50 120 130 140 150 160 170 pF1KE0 SQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIV :::.::: ::::::::::::::.: .. ::::::::::::::::::::::::::::::: NP_001 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 60 70 80 90 100 110 180 190 200 210 220 230 pF1KE0 RLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLA :::::::::::::::.::::::.::::::::::::...:: :.:..:::.:::::::::: NP_001 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 120 130 140 150 160 170 240 250 260 270 280 290 pF1KE0 YIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG :::: :.:::::::::::.::::::::::::::::::::::::::::::::::::::::: NP_001 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG 180 190 200 210 220 230 300 310 320 330 340 350 pF1KE0 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE 240 250 260 270 280 290 360 370 380 390 400 410 pF1KE0 FKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQL :::::::::::::::. ::::::::::: ::::::..::.:::::::::::::: ...: NP_001 FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKL 300 310 320 330 340 350 420 430 440 450 460 470 pF1KE0 PNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQST ::.: : ::::.. ::: .: : .:::::: : :...: : .. : ... :.. :.. NP_001 PNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAA-SDANTGDRGQTN 360 370 380 390 400 480 pF1KE0 DA-TPTLTNSS .: . . .::. NP_001 NAASASASNST 410 420 >>XP_006713674 (OMIM: 605004) PREDICTED: glycogen syntha (387 aa) initn: 2034 init1: 1968 opt: 1983 Z-score: 696.3 bits: 137.9 E(85289): 4.8e-32 Smith-Waterman score: 1983; 85.1% identity (94.2% similar) in 343 aa overlap (84-426:21-363) 60 70 80 90 100 110 pF1KE0 GAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPER ..: :. .:..:::::::: ::::.: XP_006 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDR 10 20 30 40 50 120 130 140 150 160 170 pF1KE0 SQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIV :::.::: ::::::::::::::.: .. ::::::::::::::::::::::::::::::: XP_006 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 60 70 80 90 100 110 180 190 200 210 220 230 pF1KE0 RLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLA :::::::::::::::.::::::.::::::::::::...:: :.:..:::.:::::::::: XP_006 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 120 130 140 150 160 170 240 250 260 270 280 290 pF1KE0 YIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG :::: :.:::::::::::.::::::::::::::::::::::::::::::::::::::::: XP_006 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG 180 190 200 210 220 230 300 310 320 330 340 350 pF1KE0 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE 240 250 260 270 280 290 360 370 380 390 400 410 pF1KE0 FKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQL :::::::::::::::. ::::::::::: ::::::..::.:::::::::::::: ...: XP_006 FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKL 300 310 320 330 340 350 420 430 440 450 460 470 pF1KE0 PNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQST ::.: : ::::. XP_006 PNGRDTPALFNFTTQDANTGDRGQTNNAASASASNST 360 370 380 >>XP_006713673 (OMIM: 605004) PREDICTED: glycogen syntha (400 aa) initn: 2009 init1: 1673 opt: 1676 Z-score: 593.8 bits: 119.0 E(85289): 2.4e-26 Smith-Waterman score: 1947; 82.0% identity (90.7% similar) in 356 aa overlap (84-426:21-376) 60 70 80 90 100 110 pF1KE0 GAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPER ..: :. .:..:::::::: ::::.: XP_006 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDR 10 20 30 40 50 120 130 140 150 160 170 pF1KE0 SQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIV :::.::: ::::::::::::::.: .. ::::::::::::::::::::::::::::::: XP_006 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 60 70 80 90 100 110 180 190 200 210 220 230 pF1KE0 RLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLA :::::::::::::::.::::::.::::::::::::...:: :.:..:::.:::::::::: XP_006 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 120 130 140 150 160 170 240 250 260 270 280 290 pF1KE0 YIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG :::: :.:::::::::::.::::::::::::::::::::::::::::::::::::::::: XP_006 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG 180 190 200 210 220 230 300 310 320 330 340 350 pF1KE0 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE 240 250 260 270 280 290 360 370 380 390 400 pF1KE0 FKFPQIKAHPWTK-------------VFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAH ::::::::::::: ::. ::::::::::: ::::::..::.::::::: XP_006 FKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 300 310 320 330 340 350 410 420 430 440 450 460 pF1KE0 SFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQA ::::::: ...:::.: : ::::. XP_006 SFFDELRDPNVKLPNGRDTPALFNFTTQDANTGDRGQTNNAASASASNST 360 370 380 390 400 >>NP_002084 (OMIM: 605004) glycogen synthase kinase-3 be (433 aa) initn: 2106 init1: 1673 opt: 1676 Z-score: 593.5 bits: 119.1 E(85289): 2.6e-26 Smith-Waterman score: 2046; 75.6% identity (87.9% similar) in 414 aa overlap (84-483:21-433) 60 70 80 90 100 110 pF1KE0 GAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPER ..: :. .:..:::::::: ::::.: NP_002 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDR 10 20 30 40 50 120 130 140 150 160 170 pF1KE0 SQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIV :::.::: ::::::::::::::.: .. ::::::::::::::::::::::::::::::: NP_002 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 60 70 80 90 100 110 180 190 200 210 220 230 pF1KE0 RLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLA :::::::::::::::.::::::.::::::::::::...:: :.:..:::.:::::::::: NP_002 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 120 130 140 150 160 170 240 250 260 270 280 290 pF1KE0 YIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG :::: :.:::::::::::.::::::::::::::::::::::::::::::::::::::::: NP_002 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG 180 190 200 210 220 230 300 310 320 330 340 350 pF1KE0 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE 240 250 260 270 280 290 360 370 380 390 400 pF1KE0 FKFPQIKAHPWTK-------------VFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAH ::::::::::::: ::. ::::::::::: ::::::..::.::::::: NP_002 FKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 300 310 320 330 340 350 410 420 430 440 450 460 pF1KE0 SFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQA ::::::: ...:::.: : ::::.. ::: .: : .:::::: : :...: : .. : NP_002 SFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAA 360 370 380 390 400 410 470 480 pF1KE0 LTETPTSSDWQSTDA-TPTLTNSS ... :.. :...: . . .::. NP_002 -SDANTGDRGQTNNAASASASNST 420 430 >>NP_001789 (OMIM: 116953) cyclin-dependent kinase 2 iso (298 aa) initn: 525 init1: 362 opt: 605 Z-score: 238.1 bits: 52.8 E(85289): 1.6e-06 Smith-Waterman score: 605; 36.4% identity (67.5% similar) in 305 aa overlap (119-406:4-289) 90 100 110 120 130 140 pF1KE0 PGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIK . .. ::.:..::::.:: : :.::.: NP_001 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALK 10 20 30 150 160 170 180 190 200 pF1KE0 KVLQDKRFKN------RELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETV :. : . .. ::......:.: :::.: ... ...:: ::.:.. . . NP_001 KIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHT----ENKLY--LVFEFLHQDL 40 50 60 70 80 210 220 230 240 250 260 pF1KE0 YRVARHFTKAK-LT-IPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLK ..: :. :: ::. .: :..::...::. ::. : :::.::::::.. . :. : NP_001 ----KKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI-K 90 100 110 120 130 140 270 280 290 300 310 pF1KE0 LCDFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ : ::: :. . : : .: . . .:::::...: :....:.:: ::..::.. . NP_001 LADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRR 150 160 170 180 190 200 320 330 340 350 360 370 pF1KE0 PIFPGDSGVDQLVEIIKVLGTPTR---EQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPP .::::: .::: .:...:::: . . : :.: .::. . ..:: .:: NP_001 ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM-PDYKP-SFPKWARQDFSKV----VPP 210 220 230 240 250 380 390 400 410 420 430 pF1KE0 ---EAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELS .. .: :..:.: :..:.: : :: ::... NP_001 LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 260 270 280 290 440 450 460 470 480 pF1KE0 IQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS >>NP_001249 (OMIM: 123828) cyclin-dependent kinase 3 [Ho (305 aa) initn: 490 init1: 331 opt: 594 Z-score: 234.4 bits: 52.1 E(85289): 2.6e-06 Smith-Waterman score: 594; 35.9% identity (67.4% similar) in 301 aa overlap (119-403:4-286) 90 100 110 120 130 140 pF1KE0 PGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIK . .. ::.:..::::.:. :: .:::.: NP_001 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALK 10 20 30 150 160 170 180 190 200 pF1KE0 KVLQDKRFKN------RELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETV :. : .... ::......: : ::::: .. :.: ::: :.:.. . . NP_001 KIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHN--ERK--LYL--VFEFLSQDL 40 50 60 70 80 210 220 230 240 250 260 pF1KE0 YRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLC . ..: :. .: :..::...... ::. : :::.::::::.. . ...:: NP_001 KKYMDSTPGSEL--PLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAIKLA 90 100 110 120 130 140 270 280 290 300 310 pF1KE0 DFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPI ::: :. . : : .: . . .:::::...:. ::...:.:: ::..::.. . . NP_001 DFGLARAF--GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKAL 150 160 170 180 190 200 320 330 340 350 360 370 pF1KE0 FPGDSGVDQLVEIIKVLGTPTREQ---IREMNPNYTEFKFPQIKAHPWT-KVFKSRTP-- ::::: .::: .:...::::... . .. :.: . .::. :: : .. .: NP_001 FPGDSEIDQLFRIFRMLGTPSEDTWPGVTQL-PDY-KGSFPK-----WTRKGLEEIVPNL 210 220 230 240 250 380 390 400 410 420 430 pF1KE0 -PEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSI ::. : .::.: ::.:.. : :: .: NP_001 EPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH 260 270 280 290 300 440 450 460 470 480 pF1KE0 QPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS >>NP_001790 (OMIM: 601955) cyclin-dependent kinase 7 iso (346 aa) initn: 347 init1: 347 opt: 582 Z-score: 229.9 bits: 51.5 E(85289): 4.6e-06 Smith-Waterman score: 615; 36.6% identity (66.4% similar) in 339 aa overlap (113-433:6-328) 90 100 110 120 130 140 pF1KE0 GTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETR .:. : . .:.:.:..::.:: .: NP_001 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTN 10 20 30 150 160 170 180 190 pF1KE0 ELVAIKKVLQDKRFKN---------RELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNL ..:::::. .: . ::......:.: ::. : : :.:.. ..: NP_001 QIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAF---GHKSN---ISL 40 50 60 70 80 200 210 220 230 240 250 pF1KE0 VLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVD :.... :: .: . .:.. ..:.:: . ...: :.:.. . :::.::.:::.: NP_001 VFDFM-ETDLEVI--IKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLD 90 100 110 120 130 140 260 270 280 290 300 310 pF1KE0 PDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGATDYTSSIDVWSAGCVL ...:::: ::: ::.. : :: .: . .:.::::::.::: : ..:.:..::.: NP_001 -ENGVLKLADFGLAKSF--GSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCIL 150 160 170 180 190 200 320 330 340 350 360 pF1KE0 AELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN--PNYTEFK-FPQIKAHPWTKV ::::: :..:::: .:::..:...:::::.:: .: :.:. :: :: : : .. NP_001 AELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLH---HI 210 220 230 240 250 260 370 380 390 400 410 420 pF1KE0 FKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELR--CLGTQLPN-NRPLPPLFN : : . . . : ..:. ..: .:.. .: ..:.. : ::: : :. : . NP_001 F-SAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKE 270 280 290 300 310 430 440 450 460 470 480 pF1KE0 FSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS : :.:. NP_001 QSNPALAIKRKRTEALEQGGLPKKLIF 320 330 340 >>NP_002737 (OMIM: 601795) mitogen-activated protein kin (379 aa) initn: 464 init1: 263 opt: 583 Z-score: 229.8 bits: 51.6 E(85289): 4.6e-06 Smith-Waterman score: 583; 32.4% identity (62.6% similar) in 377 aa overlap (75-434:8-356) 50 60 70 80 90 100 pF1KE0 GTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVV ::.:: : ::: :.: : NP_002 MAAAAAQGGGGGEPRRTEGVGPGV-----PGEVEMVK 10 20 30 110 120 130 140 150 pF1KE0 AT-LGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKV--LQDKRFKNR-- . . ::. ::... ::.:..:.: .: . :::::. .. . . .: NP_002 GQPFDVGPR------YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTL 40 50 60 70 80 160 170 180 190 200 210 pF1KE0 -ELQIMRKLDHCNIVRLRYFFYSSG-EKKDELYLNLVLEYVPETVYRVARHFTKAKLTIP :.::. .. : :.. .: .. .: : ..:. : . . .:.. . . .:. NP_002 REIQILLRFRHENVIGIRDILRASTLEAMRDVYI--VQDLMETDLYKLLK---SQQLSND 90 100 110 120 130 140 220 230 240 250 260 270 pF1KE0 ILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPN- .. ..::..:.: :::: .: :::.::.:::.. : ::.:::: :. .. : . NP_002 --HICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT-TCDLKICDFGLAR-IADPEHDH 150 160 170 180 190 280 290 300 310 320 330 pF1KE0 ----VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEI . :. .:.:::::..... ::.:::.::.::.:::.: ..::::: .::: .: NP_002 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 200 210 220 230 240 250 340 350 360 370 380 pF1KE0 IKVLGTPTREQIR---EMNP-NYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTP . .::.:..:.. .:. :: . ..:. :.:.: .. .:. : . .: ..: NP_002 LGILGSPSQEDLNCIINMKARNYLQ-SLPSKTKVAWAKLFP-KSDSKALDLLDRMLTFNP 260 270 280 290 300 310 390 400 410 420 430 440 pF1KE0 SSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPL-FNFSAGELSIQPSLNAILIPPHLRS ..:.. :: :: .... :...:. :.: : ::. : NP_002 NKRITVEEALAHPYLEQY-----YDPTDEPVAEEPFTF-AMELDDLPKERLKELIFQETA 320 330 340 350 360 450 460 470 480 pF1KE0 PAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS NP_002 RFQPGVLEAP 370 >>NP_001035145 (OMIM: 601795) mitogen-activated protein (357 aa) initn: 464 init1: 263 opt: 582 Z-score: 229.7 bits: 51.5 E(85289): 4.7e-06 Smith-Waterman score: 582; 32.9% identity (64.0% similar) in 347 aa overlap (75-405:8-332) 50 60 70 80 90 100 pF1KE0 GTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVV ::.:: : ::: :.: : NP_001 MAAAAAQGGGGGEPRRTEGVGPGVP-----GEVEMVK 10 20 30 110 120 130 140 150 pF1KE0 AT-LGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKV--LQDKRFKNR-- . . ::. ::... ::.:..:.: .: . :::::. .. . . .: NP_001 GQPFDVGPR------YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTL 40 50 60 70 80 160 170 180 190 200 210 pF1KE0 -ELQIMRKLDHCNIVRLRYFFYSSG-EKKDELYLNLVLEYVPETVYRVARHFTKAKLTIP :.::. .. : :.. .: .. .: : ..:. : . . .:.. . . .:. NP_001 REIQILLRFRHENVIGIRDILRASTLEAMRDVYI--VQDLMETDLYKLLK---SQQLSND 90 100 110 120 130 140 220 230 240 250 260 270 pF1KE0 ILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPN- .. ..::..:.: :::: .: :::.::.:::.. : ::.:::: :. .. : . NP_001 --HICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT-TCDLKICDFGLAR-IADPEHDH 150 160 170 180 190 280 290 300 310 320 330 pF1KE0 ----VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEI . :. .:.:::::..... ::.:::.::.::.:::.: ..::::: .::: .: NP_001 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 200 210 220 230 240 250 340 350 360 370 380 pF1KE0 IKVLGTPTREQIR---EMNP-NYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTP . .::.:..:.. .:. :: . ..:. :.:.: .. .:. : . .: ..: NP_001 LGILGSPSQEDLNCIINMKARNYLQ-SLPSKTKVAWAKLFP-KSDSKALDLLDRMLTFNP 260 270 280 290 300 310 390 400 410 420 430 440 pF1KE0 SSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSP ..:.. :: :: .... NP_001 NKRITVEEALAHPYLEQYYDPTDEVGQSPAAVGLGAGEQGGT 320 330 340 350 483 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 06:09:29 2016 done: Sun Nov 6 06:09:30 2016 Total Scan time: 11.100 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]