FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5612, 511 aa 1>>>pF1KE5612 511 - 511 aa - 511 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9857+/-0.000403; mu= 19.7954+/- 0.025 mean_var=61.4509+/-12.846, 0's: 0 Z-trim(111.1): 30 B-trim: 1058 in 1/50 Lambda= 0.163610 statistics sampled from 19572 (19599) to 19572 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.597), E-opt: 0.2 (0.23), width: 16 Scan time: 8.810 The best scores are: opt bits E(85289) NP_003108 (OMIM: 600930) hyaluronidase PH-20 isofo ( 511) 3499 834.8 0 NP_001167517 (OMIM: 600930) hyaluronidase PH-20 is ( 509) 3377 806.0 0 NP_001167515 (OMIM: 600930) hyaluronidase PH-20 is ( 509) 3377 806.0 0 NP_694859 (OMIM: 600930) hyaluronidase PH-20 isofo ( 509) 3377 806.0 0 NP_001167516 (OMIM: 600930) hyaluronidase PH-20 is ( 509) 3377 806.0 0 XP_016867400 (OMIM: 604510) PREDICTED: hyaluronida ( 481) 1352 328.0 3.7e-89 XP_011514292 (OMIM: 604510) PREDICTED: hyaluronida ( 481) 1352 328.0 3.7e-89 NP_036401 (OMIM: 604510) hyaluronidase-4 [Homo sap ( 481) 1352 328.0 3.7e-89 XP_005265581 (OMIM: 603551) PREDICTED: hyaluronida ( 473) 1157 282.0 2.6e-75 XP_005265582 (OMIM: 603551) PREDICTED: hyaluronida ( 473) 1157 282.0 2.6e-75 NP_003764 (OMIM: 603551) hyaluronidase-2 precursor ( 473) 1157 282.0 2.6e-75 NP_149348 (OMIM: 603551) hyaluronidase-2 precursor ( 473) 1157 282.0 2.6e-75 XP_011531969 (OMIM: 601492,607071) PREDICTED: hyal ( 435) 1130 275.6 2e-73 XP_011531971 (OMIM: 601492,607071) PREDICTED: hyal ( 435) 1130 275.6 2e-73 NP_695013 (OMIM: 601492,607071) hyaluronidase-1 is ( 435) 1130 275.6 2e-73 NP_149349 (OMIM: 601492,607071) hyaluronidase-1 is ( 435) 1130 275.6 2e-73 XP_011531970 (OMIM: 601492,607071) PREDICTED: hyal ( 435) 1130 275.6 2e-73 XP_011514293 (OMIM: 604510) PREDICTED: hyaluronida ( 451) 949 232.9 1.5e-60 NP_001186958 (OMIM: 604038) hyaluronidase-3 isofor ( 417) 920 226.0 1.6e-58 NP_003540 (OMIM: 604038) hyaluronidase-3 isoform 1 ( 417) 920 226.0 1.6e-58 NP_695014 (OMIM: 601492,607071) hyaluronidase-1 is ( 405) 772 191.1 5.3e-48 NP_695015 (OMIM: 601492,607071) hyaluronidase-1 is ( 253) 688 171.1 3.3e-42 NP_001186959 (OMIM: 604038) hyaluronidase-3 isofor ( 387) 674 168.0 4.7e-41 NP_695017 (OMIM: 601492,607071) hyaluronidase-1 is ( 176) 439 112.3 1.2e-24 NP_001186960 (OMIM: 604038) hyaluronidase-3 isofor ( 168) 356 92.7 9.3e-19 NP_001186961 (OMIM: 604038) hyaluronidase-3 isofor ( 138) 154 44.9 0.00018 >>NP_003108 (OMIM: 600930) hyaluronidase PH-20 isoform 1 (511 aa) initn: 3499 init1: 3499 opt: 3499 Z-score: 4460.1 bits: 834.8 E(85289): 0 Smith-Waterman score: 3499; 100.0% identity (100.0% similar) in 511 aa overlap (1-511:1-511) 10 20 30 40 50 60 pF1KE5 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI 430 440 450 460 470 480 490 500 510 pF1KE5 FYNASPSTLSATMFIWRLEVWDQGISRIGFF ::::::::::::::::::::::::::::::: NP_003 FYNASPSTLSATMFIWRLEVWDQGISRIGFF 490 500 510 >>NP_001167517 (OMIM: 600930) hyaluronidase PH-20 isofor (509 aa) initn: 3377 init1: 3377 opt: 3377 Z-score: 4304.5 bits: 806.0 E(85289): 0 Smith-Waterman score: 3377; 100.0% identity (100.0% similar) in 495 aa overlap (1-495:1-495) 10 20 30 40 50 60 pF1KE5 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI 430 440 450 460 470 480 490 500 510 pF1KE5 FYNASPSTLSATMFIWRLEVWDQGISRIGFF ::::::::::::::: NP_001 FYNASPSTLSATMFIVSILFLIISSVASL 490 500 >>NP_001167515 (OMIM: 600930) hyaluronidase PH-20 isofor (509 aa) initn: 3377 init1: 3377 opt: 3377 Z-score: 4304.5 bits: 806.0 E(85289): 0 Smith-Waterman score: 3377; 100.0% identity (100.0% similar) in 495 aa overlap (1-495:1-495) 10 20 30 40 50 60 pF1KE5 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI 430 440 450 460 470 480 490 500 510 pF1KE5 FYNASPSTLSATMFIWRLEVWDQGISRIGFF ::::::::::::::: NP_001 FYNASPSTLSATMFIVSILFLIISSVASL 490 500 >>NP_694859 (OMIM: 600930) hyaluronidase PH-20 isoform 2 (509 aa) initn: 3377 init1: 3377 opt: 3377 Z-score: 4304.5 bits: 806.0 E(85289): 0 Smith-Waterman score: 3377; 100.0% identity (100.0% similar) in 495 aa overlap (1-495:1-495) 10 20 30 40 50 60 pF1KE5 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI 430 440 450 460 470 480 490 500 510 pF1KE5 FYNASPSTLSATMFIWRLEVWDQGISRIGFF ::::::::::::::: NP_694 FYNASPSTLSATMFIVSILFLIISSVASL 490 500 >>NP_001167516 (OMIM: 600930) hyaluronidase PH-20 isofor (509 aa) initn: 3377 init1: 3377 opt: 3377 Z-score: 4304.5 bits: 806.0 E(85289): 0 Smith-Waterman score: 3377; 100.0% identity (100.0% similar) in 495 aa overlap (1-495:1-495) 10 20 30 40 50 60 pF1KE5 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI 430 440 450 460 470 480 490 500 510 pF1KE5 FYNASPSTLSATMFIWRLEVWDQGISRIGFF ::::::::::::::: NP_001 FYNASPSTLSATMFIVSILFLIISSVASL 490 500 >>XP_016867400 (OMIM: 604510) PREDICTED: hyaluronidase-4 (481 aa) initn: 1160 init1: 679 opt: 1352 Z-score: 1721.6 bits: 328.0 E(85289): 3.7e-89 Smith-Waterman score: 1352; 45.1% identity (72.0% similar) in 446 aa overlap (15-458:14-455) 10 20 30 40 50 60 pF1KE5 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC :. ... .. :... :. :. ::. :::::.. : XP_016 MKVLSEGQLKLCVVQPVHLTSWLLIFFILKSISCLKPARLPIYQRKPFIAAWNAPTDQC 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL : :.. :....: :::: .: ::.::::::.::::::. : :: .:::.::.::: XP_016 LIKYNLRLNLKMFPVIGSPLAKARGQNVTIFYVNRLGYYPWYTS-QGVPINGGLPQNISL 60 70 80 90 100 110 130 140 150 160 170 pF1KE5 QDHLDKAKKDITFYMPVDNL-GMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQL : ::.:: .::..:.:.... :.:::::: ::: :::::. ::::...: .:..... .. XP_016 QVHLEKADQDINYYIPAEDFSGLAVIDWEYWRPQWARNWNSKDVYRQKSRKLISDMGKNV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 SLTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCF : :. :: ::...: :. :::::: ::. ::::::.:::.:.. :.:.::: XP_016 SATDIEYLAKVTFEESAKAFMKETIKLGIKSRPKGLWGYYLYPDCHNYNVYAPNYSGSCP 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE5 NVEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATL-YVRNRVREAIRVSKIPDAKSPL . :. ::..:::::: :.:::::: . . . : . . ::.:..:.: . . : XP_016 EDEVLRNNELSWLWNSSAALYPSIGVWKSLGDSENILRFSKFRVHESMRISTMTSHDYAL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE5 PVFAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYM :::.:::. . :. : :::...:: :.::..::::.:::::: ... : .: . ... XP_016 PVFVYTRLGYRDEPLFFLSKQDLVSTIGESAALGAAGIVIWGDMNLTASKANCTKVKQFV 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE5 ETILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVR . :. :: ::: ::..:: ::...: :::: ::. .:::::: .. :. . :.:::. XP_016 SSDLGSYIANVTRAAEVCSLHLCRNNGRCIRKMWNAPSYLHLNPASYHIEASEDGEFTVK 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE5 GKPTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEP :: . :: ... : : ::. : :: .. ..: : XP_016 GKASDTDLAVMADTFSCHCYQGY---EGADCREIKTADGCSGVSPSPGSLMTLCLLLLAS 420 430 440 450 460 470 480 490 500 510 pF1KE5 QIFYNASPSTLSATMFIWRLEVWDQGISRIGFF XP_016 YRSIQL 480 >>XP_011514292 (OMIM: 604510) PREDICTED: hyaluronidase-4 (481 aa) initn: 1160 init1: 679 opt: 1352 Z-score: 1721.6 bits: 328.0 E(85289): 3.7e-89 Smith-Waterman score: 1352; 45.1% identity (72.0% similar) in 446 aa overlap (15-458:14-455) 10 20 30 40 50 60 pF1KE5 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC :. ... .. :... :. :. ::. :::::.. : XP_011 MKVLSEGQLKLCVVQPVHLTSWLLIFFILKSISCLKPARLPIYQRKPFIAAWNAPTDQC 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL : :.. :....: :::: .: ::.::::::.::::::. : :: .:::.::.::: XP_011 LIKYNLRLNLKMFPVIGSPLAKARGQNVTIFYVNRLGYYPWYTS-QGVPINGGLPQNISL 60 70 80 90 100 110 130 140 150 160 170 pF1KE5 QDHLDKAKKDITFYMPVDNL-GMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQL : ::.:: .::..:.:.... :.:::::: ::: :::::. ::::...: .:..... .. XP_011 QVHLEKADQDINYYIPAEDFSGLAVIDWEYWRPQWARNWNSKDVYRQKSRKLISDMGKNV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 SLTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCF : :. :: ::...: :. :::::: ::. ::::::.:::.:.. :.:.::: XP_011 SATDIEYLAKVTFEESAKAFMKETIKLGIKSRPKGLWGYYLYPDCHNYNVYAPNYSGSCP 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE5 NVEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATL-YVRNRVREAIRVSKIPDAKSPL . :. ::..:::::: :.:::::: . . . : . . ::.:..:.: . . : XP_011 EDEVLRNNELSWLWNSSAALYPSIGVWKSLGDSENILRFSKFRVHESMRISTMTSHDYAL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE5 PVFAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYM :::.:::. . :. : :::...:: :.::..::::.:::::: ... : .: . ... XP_011 PVFVYTRLGYRDEPLFFLSKQDLVSTIGESAALGAAGIVIWGDMNLTASKANCTKVKQFV 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE5 ETILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVR . :. :: ::: ::..:: ::...: :::: ::. .:::::: .. :. . :.:::. XP_011 SSDLGSYIANVTRAAEVCSLHLCRNNGRCIRKMWNAPSYLHLNPASYHIEASEDGEFTVK 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE5 GKPTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEP :: . :: ... : : ::. : :: .. ..: : XP_011 GKASDTDLAVMADTFSCHCYQGY---EGADCREIKTADGCSGVSPSPGSLMTLCLLLLAS 420 430 440 450 460 470 480 490 500 510 pF1KE5 QIFYNASPSTLSATMFIWRLEVWDQGISRIGFF XP_011 YRSIQL 480 >>NP_036401 (OMIM: 604510) hyaluronidase-4 [Homo sapiens (481 aa) initn: 1160 init1: 679 opt: 1352 Z-score: 1721.6 bits: 328.0 E(85289): 3.7e-89 Smith-Waterman score: 1352; 45.1% identity (72.0% similar) in 446 aa overlap (15-458:14-455) 10 20 30 40 50 60 pF1KE5 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC :. ... .. :... :. :. ::. :::::.. : NP_036 MKVLSEGQLKLCVVQPVHLTSWLLIFFILKSISCLKPARLPIYQRKPFIAAWNAPTDQC 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL : :.. :....: :::: .: ::.::::::.::::::. : :: .:::.::.::: NP_036 LIKYNLRLNLKMFPVIGSPLAKARGQNVTIFYVNRLGYYPWYTS-QGVPINGGLPQNISL 60 70 80 90 100 110 130 140 150 160 170 pF1KE5 QDHLDKAKKDITFYMPVDNL-GMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQL : ::.:: .::..:.:.... :.:::::: ::: :::::. ::::...: .:..... .. NP_036 QVHLEKADQDINYYIPAEDFSGLAVIDWEYWRPQWARNWNSKDVYRQKSRKLISDMGKNV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 SLTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCF : :. :: ::...: :. :::::: ::. ::::::.:::.:.. :.:.::: NP_036 SATDIEYLAKVTFEESAKAFMKETIKLGIKSRPKGLWGYYLYPDCHNYNVYAPNYSGSCP 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE5 NVEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATL-YVRNRVREAIRVSKIPDAKSPL . :. ::..:::::: :.:::::: . . . : . . ::.:..:.: . . : NP_036 EDEVLRNNELSWLWNSSAALYPSIGVWKSLGDSENILRFSKFRVHESMRISTMTSHDYAL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE5 PVFAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYM :::.:::. . :. : :::...:: :.::..::::.:::::: ... : .: . ... NP_036 PVFVYTRLGYRDEPLFFLSKQDLVSTIGESAALGAAGIVIWGDMNLTASKANCTKVKQFV 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE5 ETILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVR . :. :: ::: ::..:: ::...: :::: ::. .:::::: .. :. . :.:::. NP_036 SSDLGSYIANVTRAAEVCSLHLCRNNGRCIRKMWNAPSYLHLNPASYHIEASEDGEFTVK 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE5 GKPTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEP :: . :: ... : : ::. : :: .. ..: : NP_036 GKASDTDLAVMADTFSCHCYQGY---EGADCREIKTADGCSGVSPSPGSLMTLCLLLLAS 420 430 440 450 460 470 480 490 500 510 pF1KE5 QIFYNASPSTLSATMFIWRLEVWDQGISRIGFF NP_036 YRSIQL 480 >>XP_005265581 (OMIM: 603551) PREDICTED: hyaluronidase-2 (473 aa) initn: 977 init1: 531 opt: 1157 Z-score: 1473.0 bits: 282.0 E(85289): 2.6e-75 Smith-Waterman score: 1157; 40.3% identity (71.8% similar) in 412 aa overlap (34-438:21-430) 10 20 30 40 50 60 pF1KE5 LKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFCLGK . :. :::.. . ::. ::..:.. : . XP_005 MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPR 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 FDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISLQDH . :::.. :. .:: . ..:..:::: :::: :: .:: .: .:.::.::..:: : XP_005 LKVPLDLNAFDVQASPNEGFVNQNITIFYRDRLGLYPRFDS-AGRSVHGGVPQNVSLWAH 60 70 80 90 100 130 140 150 160 170 180 pF1KE5 LDKAKKDITFYMPV-DNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLSLT .: . :. . .. :.::::::.:::.:.:::. ::::. : .:: ... . XP_005 RKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPD 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE5 EATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKK--PGYNGSCFN . ...:. ::: :...:..::.. : .:: ::::.::::::::: : . .:.: : . XP_005 RIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPD 170 180 190 200 210 220 250 260 270 280 290 pF1KE5 VEIKRNDDLSWLWNESTALYPSIYLN-TQQSPVAATLYVRNRVREAIRVSKIPDAKSPLP ::. :::.:.::: :::::.::.::. : : . .: ::.::.::.. :. :: XP_005 VEVARNDQLAWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALP 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE5 VFAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYME :...:: ... . : ::. .:. :.::..::::.:...:: . : ..: : .:. XP_005 VYVFTRPTYSRR-LTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLT 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE5 TILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFA-IQLEKGGKFTVR .: ::..::. :...::.. :. .: :.:.: ..: .:::. ..: . . :. .: XP_005 RLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLR 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE5 --GKPTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETE :. . :..... .: :.:: XP_005 PVGELSWADIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALA 410 420 430 440 450 460 >>XP_005265582 (OMIM: 603551) PREDICTED: hyaluronidase-2 (473 aa) initn: 977 init1: 531 opt: 1157 Z-score: 1473.0 bits: 282.0 E(85289): 2.6e-75 Smith-Waterman score: 1157; 40.3% identity (71.8% similar) in 412 aa overlap (34-438:21-430) 10 20 30 40 50 60 pF1KE5 LKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFCLGK . :. :::.. . ::. ::..:.. : . XP_005 MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPR 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 FDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISLQDH . :::.. :. .:: . ..:..:::: :::: :: .:: .: .:.::.::..:: : XP_005 LKVPLDLNAFDVQASPNEGFVNQNITIFYRDRLGLYPRFDS-AGRSVHGGVPQNVSLWAH 60 70 80 90 100 130 140 150 160 170 180 pF1KE5 LDKAKKDITFYMPV-DNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLSLT .: . :. . .. :.::::::.:::.:.:::. ::::. : .:: ... . XP_005 RKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPD 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE5 EATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKK--PGYNGSCFN . ...:. ::: :...:..::.. : .:: ::::.::::::::: : . .:.: : . XP_005 RIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPD 170 180 190 200 210 220 250 260 270 280 290 pF1KE5 VEIKRNDDLSWLWNESTALYPSIYLN-TQQSPVAATLYVRNRVREAIRVSKIPDAKSPLP ::. :::.:.::: :::::.::.::. : : . .: ::.::.::.. :. :: XP_005 VEVARNDQLAWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALP 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE5 VFAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYME :...:: ... . : ::. .:. :.::..::::.:...:: . : ..: : .:. XP_005 VYVFTRPTYSRR-LTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLT 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE5 TILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFA-IQLEKGGKFTVR .: ::..::. :...::.. :. .: :.:.: ..: .:::. ..: . . :. .: XP_005 RLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLR 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE5 --GKPTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETE :. . :..... .: :.:: XP_005 PVGELSWADIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALA 410 420 430 440 450 460 511 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 05:08:52 2016 done: Tue Nov 8 05:08:53 2016 Total Scan time: 8.810 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]