FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4426, 443 aa 1>>>pF1KE4426 443 - 443 aa - 443 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3606+/-0.000395; mu= 17.2269+/- 0.024 mean_var=68.3969+/-13.563, 0's: 0 Z-trim(111.4): 50 B-trim: 0 in 0/53 Lambda= 0.155080 statistics sampled from 19883 (19930) to 19883 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.607), E-opt: 0.2 (0.234), width: 16 Scan time: 7.620 The best scores are: opt bits E(85289) NP_001005502 (OMIM: 114860) carboxypeptidase M pre ( 443) 3050 691.7 9.8e-199 NP_001865 (OMIM: 114860) carboxypeptidase M precur ( 443) 3050 691.7 9.8e-199 NP_938079 (OMIM: 114860) carboxypeptidase M precur ( 443) 3050 691.7 9.8e-199 NP_001186704 (OMIM: 603102) carboxypeptidase D iso (1133) 1245 288.1 7.9e-77 NP_001295 (OMIM: 603102) carboxypeptidase D isofor (1380) 1245 288.2 9.3e-77 NP_001299 (OMIM: 212070,603103) carboxypeptidase N ( 458) 678 161.0 5.7e-39 NP_001864 (OMIM: 114855) carboxypeptidase E prepro ( 476) 657 156.4 1.5e-37 NP_001014448 (OMIM: 603105) carboxypeptidase Z iso ( 515) 593 142.1 3.3e-33 NP_003643 (OMIM: 603105) carboxypeptidase Z isofor ( 641) 593 142.1 4e-33 NP_001014447 (OMIM: 603105) carboxypeptidase Z iso ( 652) 593 142.1 4.1e-33 NP_062555 (OMIM: 609555) probable carboxypeptidase ( 734) 535 129.2 3.6e-29 NP_001171628 (OMIM: 609555) probable carboxypeptid ( 660) 382 94.9 6.7e-19 XP_011513464 (OMIM: 602981) PREDICTED: adipocyte e (1132) 370 92.4 6.7e-18 NP_001120 (OMIM: 602981) adipocyte enhancer-bindin (1158) 370 92.4 6.9e-18 NP_065094 (OMIM: 609562,614417,614418) carboxypept ( 437) 187 51.2 6.5e-06 XP_016869135 (OMIM: 609562,614417,614418) PREDICTE ( 289) 165 46.2 0.00014 XP_011515872 (OMIM: 609562,614417,614418) PREDICTE ( 289) 165 46.2 0.00014 NP_057436 (OMIM: 607635) carboxypeptidase A4 isofo ( 421) 158 44.7 0.00056 NP_001862 (OMIM: 114852) carboxypeptidase B prepro ( 417) 151 43.1 0.0016 NP_001860 (OMIM: 600688) carboxypeptidase A2 precu ( 419) 145 41.8 0.0042 NP_001156918 (OMIM: 607635) carboxypeptidase A4 is ( 388) 140 40.6 0.0086 >>NP_001005502 (OMIM: 114860) carboxypeptidase M precurs (443 aa) initn: 3050 init1: 3050 opt: 3050 Z-score: 3688.9 bits: 691.7 E(85289): 9.8e-199 Smith-Waterman score: 3050; 100.0% identity (100.0% similar) in 443 aa overlap (1-443:1-443) 10 20 30 40 50 60 pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 IMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQPETVAVMKWLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQPETVAVMKWLKT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 ECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 KASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 IINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLP 370 380 390 400 410 420 430 440 pF1KE4 DHSAATKPSLFLFLVSLLHIFFK ::::::::::::::::::::::: NP_001 DHSAATKPSLFLFLVSLLHIFFK 430 440 >>NP_001865 (OMIM: 114860) carboxypeptidase M precursor (443 aa) initn: 3050 init1: 3050 opt: 3050 Z-score: 3688.9 bits: 691.7 E(85289): 9.8e-199 Smith-Waterman score: 3050; 100.0% identity (100.0% similar) in 443 aa overlap (1-443:1-443) 10 20 30 40 50 60 pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 IMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQPETVAVMKWLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQPETVAVMKWLKT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 ECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 KASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 IINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLP 370 380 390 400 410 420 430 440 pF1KE4 DHSAATKPSLFLFLVSLLHIFFK ::::::::::::::::::::::: NP_001 DHSAATKPSLFLFLVSLLHIFFK 430 440 >>NP_938079 (OMIM: 114860) carboxypeptidase M precursor (443 aa) initn: 3050 init1: 3050 opt: 3050 Z-score: 3688.9 bits: 691.7 E(85289): 9.8e-199 Smith-Waterman score: 3050; 100.0% identity (100.0% similar) in 443 aa overlap (1-443:1-443) 10 20 30 40 50 60 pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 VVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 IMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQPETVAVMKWLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 IMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQPETVAVMKWLKT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 ETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 ECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 ECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 KASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 KASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 IINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 IINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLP 370 380 390 400 410 420 430 440 pF1KE4 DHSAATKPSLFLFLVSLLHIFFK ::::::::::::::::::::::: NP_938 DHSAATKPSLFLFLVSLLHIFFK 430 440 >>NP_001186704 (OMIM: 603102) carboxypeptidase D isoform (1133 aa) initn: 1260 init1: 1019 opt: 1245 Z-score: 1500.3 bits: 288.1 E(85289): 7.9e-77 Smith-Waterman score: 1245; 50.7% identity (77.1% similar) in 363 aa overlap (19-377:253-609) 10 20 30 40 pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSI ::..:. :: ::. :..: ..:.:.:. NP_001 TTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSL 230 240 250 260 270 280 50 60 70 80 90 100 pF1KE4 GKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDP ::::..:.:.:. .. : :. : :::::..::::.:.:::::::.::.:: . : :: NP_001 GKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDP 290 300 310 320 330 340 110 120 130 140 150 160 pF1KE4 EITNLINSTRIHIMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQ :.:.:...::::.::::::::.: .. : :::.: :..:::::::: : . : NP_001 EVTDLVHNTRIHLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQ 350 360 370 380 390 400 170 180 190 200 210 220 pF1KE4 PETVAVMKWLKTETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHT :::.:::.:.:. ::::::::::.::..::::. :. : ::.: ::: ::: .: . NP_001 PETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGL-ATYSKS--PDDAVFQQIALS 410 420 430 440 450 230 240 250 260 270 280 pF1KE4 YASRNPNMKKGDECKNKMN---FPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCC :...: .: .: ::: . ::.:.::: ::: . :::::.::. ..:::.:.::.: NP_001 YSKENSQMFQGRPCKNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCV 460 470 480 490 500 510 290 300 310 320 330 340 pF1KE4 KYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQ-NGNPLPNVIVEVQDRKHICPYR ::: :..::.::..:. :::...:::: ::.: :.: .: . :. . : . .: : NP_001 KYPLEKELPNFWEQNRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINH--PVT 520 530 540 550 560 570 350 360 370 380 390 400 pF1KE4 TNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIP : : :.:. ::.::.: :.... :..: .:: . NP_001 TYKTGDYWRLLVPGTYKITASARGYNP-VTKNVTVKSEGAIQVNFTLVRSSTDSNNESKK 580 590 600 610 620 630 410 420 430 440 pF1KE4 VSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLHIFFK NP_001 GKGASSSTNDASDPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFL 640 650 660 670 680 690 >-- initn: 607 init1: 346 opt: 779 Z-score: 936.9 bits: 183.9 E(85289): 1.9e-45 Smith-Waterman score: 779; 34.4% identity (66.9% similar) in 369 aa overlap (14-378:679-1028) 10 20 30 40 pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVT :. :: . :: . . ::. ...:: .: NP_001 DPTTKEFETLIKDLSAENGLESLMLRSSSNLALAL-YRYHSYKDLSEFLRGLVMNYPHIT 650 660 670 680 690 700 50 60 70 80 90 100 pF1KE4 HLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTS .: ..:.:.. :..: : .. :. . :....::..::. :: :::: : ..: . NP_001 NLTNLGQSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLN 710 720 730 740 750 760 110 120 130 140 150 160 pF1KE4 DGKDPEITNLINSTRIHIMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYN :.: .:.:.. ::: :.::.:::: : ... :: .::. : ::. .: : NP_001 YKKNPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFT-----N 770 780 790 800 810 820 170 180 190 200 210 220 pF1KE4 NVSRQPETVAVMKWL-KTETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVF :.: :::: :... : . . : ::. : ::.....::.:. ::.. . ... NP_001 NAS-QPETKAIIENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTV---------ENKETL 830 840 850 860 870 230 240 250 260 270 pF1KE4 QYLAHTYASRNPNMKKGDE-CKNKM--NFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEIT ..:: ::. .:.:. :. : :: :.:.:: : :. :.:.::. ...: ::: NP_001 KHLASLYANNHPSMHMGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEIT 880 890 900 910 920 930 280 290 300 310 320 330 pF1KE4 LELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKH . ::: .: .:::.: .:: ::. .. .:: ::.: : :..:.:. .... ... . NP_001 VYTSCCYFPSAARLPSLWADNKRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIK 940 950 960 970 980 990 340 350 360 370 380 390 pF1KE4 ICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQ . .:.. : ...:: :: . : . . :.. . ..:.. NP_001 V---QTKEGGYFHVLLAPGVHNIIAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGL 1000 1010 1020 1030 1040 400 410 420 430 440 pF1KE4 LDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLHIFFK NP_001 PRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSK 1050 1060 1070 1080 1090 1100 >-- initn: 591 init1: 353 opt: 651 Z-score: 782.1 bits: 155.2 E(85289): 8e-37 Smith-Waterman score: 651; 50.2% identity (75.6% similar) in 205 aa overlap (183-380:3-202) 160 170 180 190 200 210 pF1KE4 NRNFPDAFEYNNVSRQPETVAVMKWLKTETFVLSANLHGGALVASYPFDNGVQ--ATGAL ::::.:::::..:::::::.. . ::: . NP_001 MRFVLSGNLHGGSVVASYPFDDSPEHKATG-I 10 20 30 220 230 240 250 260 pF1KE4 YSRSLTPDDDVFQYLAHTYASRNPNMKKGD-ECKNKMN--FPNGVTNGYSWYPLQGGMQD ::. : ::.::.:::..::: .: :: :. .: . . : .:.::: :: ..::::: NP_001 YSK--TSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQD 40 50 60 70 80 270 280 290 300 310 320 pF1KE4 YNYIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQ-NGNP :::.::.:::::::::::::: .: . :.::. ::: :..::.:::: : :. .:. NP_001 YNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSG 90 100 110 120 130 140 330 340 350 360 370 380 pF1KE4 LPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDP-HITKVIIPEKSQNF : :. . : .: :...:..: ::.::.: ..:.. :. : .:.:.. : NP_001 LENATISVAGINH--NITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATE 150 160 170 180 190 200 390 400 410 420 430 440 pF1KE4 SALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLHIFFK NP_001 VDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLR 210 220 230 240 250 260 >>NP_001295 (OMIM: 603102) carboxypeptidase D isoform 1 (1380 aa) initn: 1260 init1: 1019 opt: 1245 Z-score: 1499.0 bits: 288.2 E(85289): 9.3e-77 Smith-Waterman score: 1245; 50.7% identity (77.1% similar) in 363 aa overlap (19-377:500-856) 10 20 30 40 pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSI ::..:. :: ::. :..: ..:.:.:. NP_001 TTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSL 470 480 490 500 510 520 50 60 70 80 90 100 pF1KE4 GKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDP ::::..:.:.:. .. : :. : :::::..::::.:.:::::::.::.:: . : :: NP_001 GKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDP 530 540 550 560 570 580 110 120 130 140 150 160 pF1KE4 EITNLINSTRIHIMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQ :.:.:...::::.::::::::.: .. : :::.: :..:::::::: : . : NP_001 EVTDLVHNTRIHLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQ 590 600 610 620 630 640 170 180 190 200 210 220 pF1KE4 PETVAVMKWLKTETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHT :::.:::.:.:. ::::::::::.::..::::. :. : ::.: ::: ::: .: . NP_001 PETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGL-ATYSKS--PDDAVFQQIALS 650 660 670 680 690 700 230 240 250 260 270 280 pF1KE4 YASRNPNMKKGDECKNKMN---FPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCC :...: .: .: ::: . ::.:.::: ::: . :::::.::. ..:::.:.::.: NP_001 YSKENSQMFQGRPCKNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCV 710 720 730 740 750 760 290 300 310 320 330 340 pF1KE4 KYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQ-NGNPLPNVIVEVQDRKHICPYR ::: :..::.::..:. :::...:::: ::.: :.: .: . :. . : . .: : NP_001 KYPLEKELPNFWEQNRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINH--PVT 770 780 790 800 810 820 350 360 370 380 390 400 pF1KE4 TNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIP : : :.:. ::.::.: :.... :..: .:: . NP_001 TYKTGDYWRLLVPGTYKITASARGYNP-VTKNVTVKSEGAIQVNFTLVRSSTDSNNESKK 830 840 850 860 870 880 410 420 430 440 pF1KE4 VSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLHIFFK NP_001 GKGASSSTNDASDPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFL 890 900 910 920 930 940 >-- initn: 925 init1: 353 opt: 952 Z-score: 1144.8 bits: 222.6 E(85289): 5e-57 Smith-Waterman score: 1007; 42.5% identity (69.0% similar) in 400 aa overlap (18-380:55-449) 10 20 30 40 pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHS .: ::..: :. ...: . ....: : NP_001 LGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFS 30 40 50 60 70 80 50 60 70 80 pF1KE4 IGKSVKGRNLWVLVV----GRFPKEHRIGI---------------PEFKYVANMHGDETV ::.::.:: :::: . : . : : :. : :.:::::::: NP_001 IGRSVEGRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETV 90 100 110 120 130 140 90 100 110 120 130 140 pF1KE4 GRELLLHLIDYLVTSDGK-DPEITNLINSTRIHIMPSMNPDGFEAVKKPDCYY------- .:..:..: :... . ::... :.:.: ....::.:::::: ... :: . NP_001 SRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLPSLNPDGFERAREGDCGFGDGGPSG 150 160 170 180 190 200 150 160 170 180 190 pF1KE4 SIGRENYNQYDLNRNFPDAF---EYNNVSRQPETVAVMKWLKTETFVLSANLHGGALVAS . ::.: ::::.::: : : ... ::. :...:.. . ::::.:::::..::: NP_001 ASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVAS 210 220 230 240 250 260 200 210 220 230 240 250 pF1KE4 YPFDNGVQ--ATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGD-ECKNKMN--FPNGV ::::.. . ::: .::. : ::.::.:::..::: .: :: :. .: . . : .:. NP_001 YPFDDSPEHKATG-IYSK--TSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGI 270 280 290 300 310 320 260 270 280 290 300 310 pF1KE4 TNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVH ::: :: ..::::::::.::.:::::::::::::: .: . :.::. ::: :..:: NP_001 TNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVH 330 340 350 360 370 380 320 330 340 350 360 370 pF1KE4 LGVKGQVFDQ-NGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDP .:::: : :. .:. : :. . : .: :...:..: ::.::.: ..:.. :. : NP_001 IGVKGFVKDSITGSGLENATISVAGINH--NITTGRFGDFYRLLVPGTYNLTVVLTGYMP 390 400 410 420 430 380 390 400 410 420 430 pF1KE4 -HITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSL .:.:.. : NP_001 LTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPK 440 450 460 470 480 490 >-- initn: 607 init1: 346 opt: 779 Z-score: 935.6 bits: 183.9 E(85289): 2.3e-45 Smith-Waterman score: 779; 34.4% identity (66.9% similar) in 369 aa overlap (14-378:926-1275) 10 20 30 40 pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVT :. :: . :: . . ::. ...:: .: NP_001 DPTTKEFETLIKDLSAENGLESLMLRSSSNLALAL-YRYHSYKDLSEFLRGLVMNYPHIT 900 910 920 930 940 950 50 60 70 80 90 100 pF1KE4 HLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTS .: ..:.:.. :..: : .. :. . :....::..::. :: :::: : ..: . NP_001 NLTNLGQSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLN 960 970 980 990 1000 1010 110 120 130 140 150 160 pF1KE4 DGKDPEITNLINSTRIHIMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYN :.: .:.:.. ::: :.::.:::: : ... :: .::. : ::. .: : NP_001 YKKNPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFT-----N 1020 1030 1040 1050 1060 170 180 190 200 210 220 pF1KE4 NVSRQPETVAVMKWL-KTETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVF :.: :::: :... : . . : ::. : ::.....::.:. ::.. . ... NP_001 NAS-QPETKAIIENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTV---------ENKETL 1070 1080 1090 1100 1110 230 240 250 260 270 pF1KE4 QYLAHTYASRNPNMKKGDE-CKNKM--NFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEIT ..:: ::. .:.:. :. : :: :.:.:: : :. :.:.::. ...: ::: NP_001 KHLASLYANNHPSMHMGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEIT 1120 1130 1140 1150 1160 1170 280 290 300 310 320 330 pF1KE4 LELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKH . ::: .: .:::.: .:: ::. .. .:: ::.: : :..:.:. .... ... . NP_001 VYTSCCYFPSAARLPSLWADNKRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIK 1180 1190 1200 1210 1220 1230 340 350 360 370 380 390 pF1KE4 ICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQ . .:.. : ...:: :: . : . . :.. . ..:.. NP_001 V---QTKEGGYFHVLLAPGVHNIIAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGL 1240 1250 1260 1270 1280 1290 400 410 420 430 440 pF1KE4 LDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLHIFFK NP_001 PRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSK 1300 1310 1320 1330 1340 1350 >>NP_001299 (OMIM: 212070,603103) carboxypeptidase N cat (458 aa) initn: 1047 init1: 364 opt: 678 Z-score: 820.6 bits: 161.0 E(85289): 5.7e-39 Smith-Waterman score: 1049; 43.5% identity (69.2% similar) in 416 aa overlap (6-392:9-419) 10 20 30 40 50 pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNL : : ::. ::: . : .:: . . : : .. ..:...:::.::.::.: NP_001 MSDLLSVFLHLLLLFKLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 WVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTS-DGKDPEITNLINS .:: . : :. :: :::.::::.:..::::.:.: ..: ... .:..::.. NP_001 YVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQD 70 80 90 100 110 120 120 130 140 150 160 pF1KE4 TRIHIMPSMNPDGFE--AVKKPDCY-YSIGRENYNQYDLNRNFPDAFEY----------- :::::.:::::::.: :.. :. : .::.: : :::::::: : NP_001 TRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPN 130 140 150 160 170 180 170 180 190 200 210 pF1KE4 ------NNVSRQ--PETVAVMKWLKTETFVLSANLHGGALVASYPFDNGVQ--ATGALYS .: . : ::: ::..:... .:::::::::::.::.::.:.. . . :. . NP_001 HHLPLPDNWKSQVEPETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRT 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE4 RSL-TPDDDVFQYLAHTYASRNPNMKKGDECKNKMNFPNGVTNGYSWYPLQGGMQDYNYI : :::: .:: ::..:. . : .: .: . ::.:.::: ::: :. ::::.::. NP_001 ASTPTPDDKLFQKLAKVYSYAHGWMFQGWNCGD--YFPDGITNGASWYSLSKGMQDFNYL 250 260 270 280 290 280 290 300 310 320 330 pF1KE4 WAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVI ..:::::::::: :.: ::.: : .:. .::....::: :.::.:.:.: : : :.. NP_001 HTNCFEITLELSCDKFPPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAV 300 310 320 330 340 350 340 350 360 370 380 pF1KE4 VEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHITKVII-PEKSQ--NFSAL . :. .: .. .:.:. ::::: : ...:.::.::. . : . : . :: : NP_001 ISVSGINH--DVTSGDHGDYFRLLLPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFH-L 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE4 KKDILLPFQGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLHIFFK :..: NP_001 KRSIPQVSPVRRAPSRRHGVRAKVQPQARKKEMEMRQLQRGPA 420 430 440 450 >>NP_001864 (OMIM: 114855) carboxypeptidase E preproprot (476 aa) initn: 1053 init1: 364 opt: 657 Z-score: 795.0 bits: 156.4 E(85289): 1.5e-37 Smith-Waterman score: 1015; 42.9% identity (67.5% similar) in 394 aa overlap (18-379:49-438) 10 20 30 40 pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHS ..:.::: .. : .: . ........ NP_001 CGWLLGAEAQEPGAPAAGMRRRRRLQQEDGISFEYHRYPELREALVSVWLQCTAISRIYT 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE4 IGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKD .:.: .::.: :. .. : :. : :::::..::::.:.::::::. : .:: . : NP_001 VGRSFEGRELLVIELSDNPGVHEPGEPEFKYIGNMHGNEAVGRELLIFLAQYLCNEYQKG 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE4 PE-ITNLINSTRIHIMPSMNPDGFE-AVKKPDCY--YSIGRENYNQYDLNRNFPDA--FE : :.:::.:::::::::.:::::: :...: . .:: : . :::::::: . NP_001 NETIVNLIHSTRIHIMPSLNPDGFEKAASQPGELKDWFVGRSNAQGIDLNRNFPDLDRIV 140 150 160 170 180 190 170 180 190 200 pF1KE4 Y---------------------NNVSRQPETVAVMKWLKTETFVLSANLHGGALVASYPF : .:.. ::: ::..:. :::::::::: :::.::. NP_001 YVNEKEGGPNNHLLKNMKKIVDQNTKLAPETKAVIHWIMDIPFVLSANLHGGDLVANYPY 200 210 220 230 240 250 210 220 230 240 250 pF1KE4 DNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGDE--CK---NKMNFPNGVTNG :. .:. . : .::: .:: ::..:.: :: :. .. :. . .: .:.::: NP_001 DE--TRSGSAHEYSSSPDDAIFQSLARAYSSFNPAMSDPNRPPCRKNDDDSSFVDGTTNG 260 270 280 290 300 310 260 270 280 290 300 310 pF1KE4 YSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGV .:: . :::::.::. ..:::::.:::: :.: :: : ..:..:: ::: :..:.: :: NP_001 GAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPPEETLKTYWEDNKNSLISYLEQIHRGV 320 330 340 350 360 370 320 330 340 350 360 370 pF1KE4 KGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHITK :: : : .:::. :. . :. : . : :.:. ::.::.: .....::. : NP_001 KGFVRDLQGNPIANATISVEGIDH--DVTSAKDGDYWRLLIPGNYKLTASAPGYLAITKK 380 390 400 410 420 430 380 390 400 410 420 430 pF1KE4 VIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLV : .: NP_001 VAVPYSPAAGVDFELESFSERKEEEKEELMEWWKMMSETLNF 440 450 460 470 >>NP_001014448 (OMIM: 603105) carboxypeptidase Z isoform (515 aa) initn: 900 init1: 301 opt: 593 Z-score: 717.1 bits: 142.1 E(85289): 3.3e-33 Smith-Waterman score: 903; 38.5% identity (63.1% similar) in 426 aa overlap (20-415:48-467) 10 20 30 40 pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIG :..: : :. .:. . :.. .::: NP_001 EGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIG 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE4 KSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSD--GKD .: ::.: :. . : .:.. :: : ..:.::.:..:::.:..: .:: . : . NP_001 RSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLG-N 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE4 PEITNLINSTRIHIMPSMNPDGFEAVKKPDCYY---SIGRENYNQYDLNRNFPD-AFEYN :.: :.:.::::..:::::::.:.. : . ::.: .. :::::::: . :: NP_001 PRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYY 140 150 160 170 180 190 170 180 190 200 pF1KE4 NVSRQ--------------------PETVAVMKWLKTETFVLSANLHGGALVASYPFDNG ... ::: :.:::..: :::::.:::: ::.::::: . NP_001 RLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFS 200 210 220 230 240 250 210 220 230 240 250 260 pF1KE4 VQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGDECKNKMNF--PNGVTNGYSWYPL . : :::. .:. :...::. .: : .: . :: ... :: .:: . NP_001 -KHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSF 260 270 280 290 300 310 270 280 290 300 310 320 pF1KE4 QGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFD :::.:.::. ..:::::.::.: :.: :: : ..:..:: ::..... :: :.:: : : NP_001 TGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTD 320 330 340 350 360 370 330 340 350 360 370 380 pF1KE4 QNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEK . :.:. :. . :. .: : :.:. :: :: .:. . .::. : ::::: . NP_001 KFGKPVKNARISVKGIRH--DITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPAR 380 390 400 410 420 430 390 400 410 420 430 pF1KE4 SQNFSALKKD-ILLPF-QGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLH . : . : :: :. .: . : . : :: NP_001 MKR--AGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPDPLRARRQPSAD 440 450 460 470 480 490 440 pF1KE4 IFFK NP_001 GSKPWWWSYFTSLSTHRPRWLLKY 500 510 >>NP_003643 (OMIM: 603105) carboxypeptidase Z isoform 2 (641 aa) initn: 900 init1: 301 opt: 593 Z-score: 715.6 bits: 142.1 E(85289): 4e-33 Smith-Waterman score: 903; 38.5% identity (63.1% similar) in 426 aa overlap (20-415:174-593) 10 20 30 40 pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIG :..: : :. .:. . :.. .::: NP_003 EGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIG 150 160 170 180 190 200 50 60 70 80 90 100 pF1KE4 KSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSD--GKD .: ::.: :. . : .:.. :: : ..:.::.:..:::.:..: .:: . : . NP_003 RSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLG-N 210 220 230 240 250 260 110 120 130 140 150 160 pF1KE4 PEITNLINSTRIHIMPSMNPDGFEAVKKPDCYY---SIGRENYNQYDLNRNFPD-AFEYN :.: :.:.::::..:::::::.:.. : . ::.: .. :::::::: . :: NP_003 PRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYY 270 280 290 300 310 320 170 180 190 200 pF1KE4 NVSRQ--------------------PETVAVMKWLKTETFVLSANLHGGALVASYPFDNG ... ::: :.:::..: :::::.:::: ::.::::: . NP_003 RLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFS 330 340 350 360 370 380 210 220 230 240 250 260 pF1KE4 VQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGDECKNKMNF--PNGVTNGYSWYPL . : :::. .:. :...::. .: : .: . :: ... :: .:: . NP_003 -KHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSF 390 400 410 420 430 440 270 280 290 300 310 320 pF1KE4 QGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFD :::.:.::. ..:::::.::.: :.: :: : ..:..:: ::..... :: :.:: : : NP_003 TGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTD 450 460 470 480 490 500 330 340 350 360 370 380 pF1KE4 QNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEK . :.:. :. . :. .: : :.:. :: :: .:. . .::. : ::::: . NP_003 KFGKPVKNARISVKGIRH--DITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPAR 510 520 530 540 550 390 400 410 420 430 pF1KE4 SQNFSALKKD-ILLPF-QGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLH . : . : :: :. .: . : . : :: NP_003 MKR--AGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPDPLRARRQPSAD 560 570 580 590 600 610 440 pF1KE4 IFFK NP_003 GSKPWWWSYFTSLSTHRPRWLLKY 620 630 640 >>NP_001014447 (OMIM: 603105) carboxypeptidase Z isoform (652 aa) initn: 900 init1: 301 opt: 593 Z-score: 715.5 bits: 142.1 E(85289): 4.1e-33 Smith-Waterman score: 903; 38.5% identity (63.1% similar) in 426 aa overlap (20-415:185-604) 10 20 30 40 pF1KE4 MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIG :..: : :. .:. . :.. .::: NP_001 EGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIG 160 170 180 190 200 210 50 60 70 80 90 100 pF1KE4 KSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSD--GKD .: ::.: :. . : .:.. :: : ..:.::.:..:::.:..: .:: . : . NP_001 RSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLG-N 220 230 240 250 260 270 110 120 130 140 150 160 pF1KE4 PEITNLINSTRIHIMPSMNPDGFEAVKKPDCYY---SIGRENYNQYDLNRNFPD-AFEYN :.: :.:.::::..:::::::.:.. : . ::.: .. :::::::: . :: NP_001 PRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYY 280 290 300 310 320 330 170 180 190 200 pF1KE4 NVSRQ--------------------PETVAVMKWLKTETFVLSANLHGGALVASYPFDNG ... ::: :.:::..: :::::.:::: ::.::::: . NP_001 RLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFS 340 350 360 370 380 390 210 220 230 240 250 260 pF1KE4 VQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGDECKNKMNF--PNGVTNGYSWYPL . : :::. .:. :...::. .: : .: . :: ... :: .:: . NP_001 -KHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSF 400 410 420 430 440 450 270 280 290 300 310 320 pF1KE4 QGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFD :::.:.::. ..:::::.::.: :.: :: : ..:..:: ::..... :: :.:: : : NP_001 TGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTD 460 470 480 490 500 510 330 340 350 360 370 380 pF1KE4 QNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEK . :.:. :. . :. .: : :.:. :: :: .:. . .::. : ::::: . NP_001 KFGKPVKNARISVKGIRH--DITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPAR 520 530 540 550 560 570 390 400 410 420 430 pF1KE4 SQNFSALKKD-ILLPF-QGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLH . : . : :: :. .: . : . : :: NP_001 MKR--AGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPDPLRARRQPSAD 580 590 600 610 620 440 pF1KE4 IFFK NP_001 GSKPWWWSYFTSLSTHRPRWLLKY 630 640 650 443 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:11:48 2016 done: Sun Nov 6 01:11:50 2016 Total Scan time: 7.620 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]