FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3926, 551 aa 1>>>pF1KE3926 551 - 551 aa - 551 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.5501+/-0.000379; mu= 0.8930+/- 0.024 mean_var=271.8275+/-57.040, 0's: 0 Z-trim(122.3): 101 B-trim: 1945 in 1/55 Lambda= 0.077791 statistics sampled from 40214 (40339) to 40214 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.788), E-opt: 0.2 (0.473), width: 16 Scan time: 12.090 The best scores are: opt bits E(85289) NP_112174 (OMIM: 606125) probable E3 ubiquitin-pro ( 551) 3866 447.1 6.5e-125 NP_001332879 (OMIM: 606125) probable E3 ubiquitin- ( 519) 2246 265.3 3.3e-70 NP_005073 (OMIM: 600453) E3 ubiquitin/ISG15 ligase ( 630) 318 49.0 5.3e-05 NP_060677 (OMIM: 616755) E3 ubiquitin-protein liga ( 475) 281 44.7 0.00076 XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 555) 280 44.7 0.00092 NP_741983 (OMIM: 617007) tripartite motif-containi ( 493) 277 44.3 0.0011 NP_006461 (OMIM: 609505) tripartite motif-containi ( 564) 272 43.8 0.0017 NP_001269307 (OMIM: 600986) tripartite motif-conta ( 633) 270 43.6 0.0022 XP_005273509 (OMIM: 617007) PREDICTED: tripartite ( 298) 260 42.2 0.0028 XP_016857120 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 291) 253 41.4 0.0047 NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 253 41.6 0.0068 NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 253 41.6 0.0071 NP_001287681 (OMIM: 609317) E3 ubiquitin-protein l ( 573) 254 41.8 0.0071 XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467) 252 41.5 0.0072 NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 251 41.4 0.0083 XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 391) 247 40.9 0.0093 >>NP_112174 (OMIM: 606125) probable E3 ubiquitin-protein (551 aa) initn: 3866 init1: 3866 opt: 3866 Z-score: 2363.6 bits: 447.1 E(85289): 6.5e-125 Smith-Waterman score: 3866; 100.0% identity (100.0% similar) in 551 aa overlap (1-551:1-551) 10 20 30 40 50 60 pF1KE3 MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPECNQAYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPECNQAYN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 QKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLPAQKVCLRCEAPCCQSHVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 QKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLPAQKVCLRCEAPCCQSHVQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 THLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGHSVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 THLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGHSVC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 DVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLVEEKVNQLKEEVRLQYEKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 DVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLVEEKVNQLKEEVRLQYEKLH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 QLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTEDVSFMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 QLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTEDVSFMK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 NTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTPVPFLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 NTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTPVPFLQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 SVPLYPCGVSSSGAEKRKHSTAFPEASFLETSSGPVGGQYGAAGTASGEGQSGQPLGPCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 SVPLYPCGVSSSGAEKRKHSTAFPEASFLETSSGPVGGQYGAAGTASGEGQSGQPLGPCS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 STQHLVALPGGAQPVHSSPVFPPSQYPNGSAAQQPMLPQYGGRKILVCSVDNCYCSSVAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 STQHLVALPGGAQPVHSSPVFPPSQYPNGSAAQQPMLPQYGGRKILVCSVDNCYCSSVAN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 HGGHQPYPRSGHFPWTVPSQEYSHPLPPTPSVPQSLPSLAVRDWLDASQQPGHQDFYRVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 HGGHQPYPRSGHFPWTVPSQEYSHPLPPTPSVPQSLPSLAVRDWLDASQQPGHQDFYRVY 490 500 510 520 530 540 550 pF1KE3 GQPSTKHYVTS ::::::::::: NP_112 GQPSTKHYVTS 550 >>NP_001332879 (OMIM: 606125) probable E3 ubiquitin-prot (519 aa) initn: 2245 init1: 2245 opt: 2246 Z-score: 1381.4 bits: 265.3 E(85289): 3.3e-70 Smith-Waterman score: 3589; 94.2% identity (94.2% similar) in 551 aa overlap (1-551:1-519) 10 20 30 40 50 60 pF1KE3 MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPECNQAYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPECNQAYN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 QKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLPAQKVCLRCEAPCCQSHVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLPAQKVCLRCEAPCCQSHVQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 THLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGHSVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 THLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGHSVC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 DVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLVEEKVNQLKEEVRLQYEKLH :::::::::: :::::::::::::::::: NP_001 DVEIRRNEIR--------------------------------EKVNQLKEEVRLQYEKLH 190 200 250 260 270 280 290 300 pF1KE3 QLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTEDVSFMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTEDVSFMK 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE3 NTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTPVPFLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTPVPFLQ 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE3 SVPLYPCGVSSSGAEKRKHSTAFPEASFLETSSGPVGGQYGAAGTASGEGQSGQPLGPCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVPLYPCGVSSSGAEKRKHSTAFPEASFLETSSGPVGGQYGAAGTASGEGQSGQPLGPCS 330 340 350 360 370 380 430 440 450 460 470 480 pF1KE3 STQHLVALPGGAQPVHSSPVFPPSQYPNGSAAQQPMLPQYGGRKILVCSVDNCYCSSVAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STQHLVALPGGAQPVHSSPVFPPSQYPNGSAAQQPMLPQYGGRKILVCSVDNCYCSSVAN 390 400 410 420 430 440 490 500 510 520 530 540 pF1KE3 HGGHQPYPRSGHFPWTVPSQEYSHPLPPTPSVPQSLPSLAVRDWLDASQQPGHQDFYRVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HGGHQPYPRSGHFPWTVPSQEYSHPLPPTPSVPQSLPSLAVRDWLDASQQPGHQDFYRVY 450 460 470 480 490 500 550 pF1KE3 GQPSTKHYVTS ::::::::::: NP_001 GQPSTKHYVTS 510 >>NP_005073 (OMIM: 600453) E3 ubiquitin/ISG15 ligase TRI (630 aa) initn: 382 init1: 268 opt: 318 Z-score: 210.8 bits: 49.0 E(85289): 5.3e-05 Smith-Waterman score: 445; 27.4% identity (55.7% similar) in 318 aa overlap (8-306:5-315) 10 20 30 40 50 pF1KE3 MAENWKNC-FEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPECNQAY : . ::: : :::. : ::: :: :::: .:..:.:: ... ::.: .: NP_005 MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVY 10 20 30 40 50 60 70 80 90 100 pF1KE3 NQKPGLEKNLKLTNIVEKF-NALHVEKPPAALHCVFCRRGPPLP-AQ------------K . .: :.:: : :.::.: .: ...::: . : . : : :: : NP_005 QARPQLHKNTVLCNVVEQFLQADLAREPPADVWTPPARASAPSPNAQVACDHCLKEAAVK 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE3 VCLRCEAPCCQSHVQTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQ .:: : : :: :.: :...:. : . :. .: ::: : . : .. .:. NP_005 TCLVCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICH 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE3 YCCYY----SGAHQGHSVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLV : : : ... :.: .:. : . .... . ..: . .. . . NP_005 ICLVEHKTCSPASLSQASADLEAT---LRHKLTVMYSQINGASRALDDVRNRQQDVRMTA 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE3 EEKVNQLKEEVRLQYEKLHQLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKK ..::.::..: : ... ::: . ... . . . . :. . : .. .: . NP_005 NRKVEQLQQE----YTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQT 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE3 LLGSLQLLFDKTEDVSFMKNTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFLNEVAKKE : .. . : .. :........ NP_005 LKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQ 300 310 320 330 340 350 >>NP_060677 (OMIM: 616755) E3 ubiquitin-protein ligase T (475 aa) initn: 261 init1: 161 opt: 281 Z-score: 190.0 bits: 44.7 E(85289): 0.00076 Smith-Waterman score: 316; 24.4% identity (53.1% similar) in 303 aa overlap (8-305:3-251) 10 20 30 40 50 pF1KE3 MAENWKNC-FEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKD--SGLVRCPECNQ : ...::.: ::: .. .::.: :.: ::: :: : :... .: :::: . NP_060 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRR 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 AYNQKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLPAQKVCLRCEAPCCQS .. . :.: .:::.::::..... :: : : :: :. NP_060 TFAE-PALAPSLKLANIVERYSSF------------------PLDAILNARRAARPC-QA 60 70 80 90 120 130 140 150 160 170 pF1KE3 HVQTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGH : : :. . : .... .: . : . :. : NP_060 H-------------------DKVKLF------------CLTDRALLC-FFCDEPALHEQH 100 110 120 180 190 200 210 220 230 pF1KE3 SVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLVEEK--VNQLKEEVRLQ .: .. .:... : : . :.. :.. . : :. ..:.: : ...:. . NP_060 QVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLK--RQLAETKSSTKSLRTTIGEA 130 140 150 160 170 180 240 250 260 270 280 290 pF1KE3 YEKLHQLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTED .:.::.:: : . .: :. :. .. .. . ......... :: . .:. NP_060 FERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDR 190 200 210 220 230 240 300 310 320 330 340 350 pF1KE3 VSFMKNTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTP .:. .. :. NP_060 HTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDP 250 260 270 280 290 300 >>XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquitin-pr (555 aa) initn: 261 init1: 161 opt: 280 Z-score: 188.5 bits: 44.7 E(85289): 0.00092 Smith-Waterman score: 315; 24.3% identity (53.2% similar) in 301 aa overlap (9-305:85-331) 10 20 30 pF1KE3 MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGC ...::.: ::: .. .::.: :.: ::: : XP_016 AAAATGSSDSAGSGLRGCAGPKRWLLSSRGLKDELLCSICLSIYQDPVSLGCEHYFCRRC 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE3 IGEAWAKD--SGLVRCPECNQAYNQKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCR : : :... .: :::: ... . :.: .:::.::::..... XP_016 ITEHWVRQEAQGARDCPECRRTFAE-PALAPSLKLANIVERYSSF--------------- 120 130 140 150 100 110 120 130 140 150 pF1KE3 RGPPLPAQKVCLRCEAPCCQSHVQTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHC :: : : :: :.: : :. . : XP_016 ---PLDAILNARRAARPC-QAH-------------------DKVKLF------------C 160 170 180 160 170 180 190 200 210 pF1KE3 EAEQVAVCQYCCYYSGAHQGHSVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLES .... .: . : . :. :.: .. .:... : : . :.. :.. . : :. XP_016 LTDRALLC-FFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLK- 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 DKRLVEEK--VNQLKEEVRLQYEKLHQLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGE ..:.: : ...:. . .:.::.:: : . .: :. :. .. .. . .. XP_016 -RQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQ 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 RMQEAKKLLGSLQLLFDKTEDVSFMKNTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFL ....... :: . .:. .:. .. :. XP_016 QLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQY 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 NEVAKKEKQLRKMLEGPFSTPVPFLQSVPLYPCGVSSSGAEKRKHSTAFPEASFLETSSG XP_016 TIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSV 370 380 390 400 410 420 >>NP_741983 (OMIM: 617007) tripartite motif-containing p (493 aa) initn: 270 init1: 159 opt: 277 Z-score: 187.4 bits: 44.3 E(85289): 0.0011 Smith-Waterman score: 277; 26.2% identity (51.1% similar) in 393 aa overlap (9-380:15-387) 10 20 30 40 50 pF1KE3 MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPE :.:::.: .: : . : : : :::::::... : . . :: NP_741 MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVS-PTCPV 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 CNQAYNQKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLPAQKVCLRC---- : . . :. : :.:.:::. :. : : : : .. : : NP_741 C-KDRASPADLRTNHTLNNLVEKL--LREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDK 60 70 80 90 100 110 120 130 140 150 160 pF1KE3 EAPCCQSHV----QTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQY : ::. .. : : :: .: : :: ...: : : .. . NP_741 ELLCCSCQADPRHQGHRVQPVKDTAH------DFRAKCRNMEHALR----EKAKAFWAMR 120 130 140 150 160 170 180 190 200 210 220 pF1KE3 CCYYSGAHQGHSVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLV-EEKV : . :. :. .. ...::. . : .. :. .:: : : . . .:.:. .::. NP_741 RSYEAIAK--HNQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKM 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE3 NQLKEEVRLQYEKLHQLLDEDLRQTVEVLDKAQAK----FCSENAAQALHLGERMQEAKK .:: ::... .....: : .. : : : ... ::. . . .. : . .. : NP_741 KQLTEETEVLAHEIERLQMEMKEDDVSFLMKHKSRKRRLFCTMEP-EPVQPGM-LIDVCK 230 240 250 260 270 280 290 300 310 320 330 pF1KE3 LLGSLQL-----LFDKTEDVSFMKNTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFLNE ::::: .. ..:.: : . ... .. .. :: . .. : . : . NP_741 YLGSLQYRVWKKMLASVESVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSS- 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE3 VAKKEKQLRKMLEGPFSTPVPF--LQSVPLYPCGV-SSSGAEKRKHSTAFPEASFLETSS : : . .: . : . ::: . : ..:::: ..:: NP_741 -APCLLGSRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVC 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE3 GPVGGQYGAAGTASGEGQSGQPLGPCSSTQHLVALPGGAQPVHSSPVFPPSQYPNGSAAQ NP_741 RTQGVEGDHCVTSDPATSPLVLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARFGEV 410 420 430 440 450 460 >>NP_006461 (OMIM: 609505) tripartite motif-containing p (564 aa) initn: 159 init1: 131 opt: 272 Z-score: 183.6 bits: 43.8 E(85289): 0.0017 Smith-Waterman score: 279; 25.1% identity (53.4% similar) in 307 aa overlap (92-390:77-366) 70 80 90 100 110 pF1KE3 KPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFC----RRGPPLPAQKVCLRCEAPCCQS : :: :: . : : :: : . :. NP_006 SSEKLGRETEEQDSDSAEQGDPAGEGKEVLCDFCLDDTRR---VKAVKSCLTCMVNYCEE 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE3 HVQTHLQQPSTARGHLLVEADDVRAWS-CPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQG :.: : : ..:::.: . : :: :.. : .: .:: :: :.: NP_006 HLQPH-QVNIKLQSHLLTEPVKDHNWRYCPAHHSPLSAFCCPDQQCICQDCCQ---EHSG 110 120 130 140 150 180 190 200 210 220 230 pF1KE3 HSVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLVEEKVNQLKEEVRLQY :.. ... : . . :. : ::.. . :. . .:..... : .:...: ...:. NP_006 HTIVSLDAARRDKEAELQCTQLDLERKLKLNENAISRLQANQKSVLVSVSEVKAVAEMQF 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE3 EKLHQLLDEDLRQTVEVLD-KAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTED .: . . ... :. : :: . . :. .: :: : : .: :. . .. NP_006 GELLAAVRKAQANVMLFLEEKEQAALSQANGIKA-HLEYRSAEMEKSKQELERMAAISNT 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE3 VSFMKNTKSVKILMDRTQTCTSSSLSPTKIGHLNSKL--FLNEVAKKEKQLRKMLEGPFS :.:... . : : : :. :..:: . . .... .: ..::. .. NP_006 VQFLEEYCKFKNTEDIT--------FPSVYVGLKDKLSGIRKVITESTVHLIQLLEN-YK 280 290 300 310 320 360 370 380 390 400 410 pF1KE3 TPVPFLQSVPLYPCGVSSSGAEKRKHSTAFPEASFLETSSGPVGGQYGAAGTASGEGQSG . ... : .. :.. .::. :. :: : : NP_006 KKLQEFSKEEEYDIRTQVSAVVQRKYWTSKPEPSTREQFLQYAYDITFDPDTAHKYLRLQ 330 340 350 360 370 380 420 430 440 450 460 470 pF1KE3 QPLGPCSSTQHLVALPGGAQPVHSSPVFPPSQYPNGSAAQQPMLPQYGGRKILVCSVDNC NP_006 EENRKVTNTTPWEHPYPDLPSRFLHWRQVLSQQSLYLHRYYFEVEIFGAGTYVGLTCKGI 390 400 410 420 430 440 >>NP_001269307 (OMIM: 600986) tripartite motif-containin (633 aa) initn: 80 init1: 80 opt: 270 Z-score: 181.7 bits: 43.6 E(85289): 0.0022 Smith-Waterman score: 270; 23.9% identity (55.2% similar) in 268 aa overlap (52-311:4-265) 30 40 50 60 70 pF1KE3 FVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPEC--NQAYNQK--PGLEKNLKLTNIVEK :: : . ... :: .:: : .::. NP_001 MFPCPACQGDVELGERGLAGLFRNLTLERVVER 10 20 30 80 90 100 110 120 130 pF1KE3 F-NALHVEKPPAALHCVFCRRGPPLPAQKVCLRCEAPCCQSHVQT-HLQQPSTARGHLLV . ... : .:. : .:. ::: : : : .:.: :. . : . :. . . NP_001 YRQSVSV---GGAILCQLCK-PPPLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTL 40 50 60 70 80 140 150 160 170 180 190 pF1KE3 EADDVRAWS--CPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGHSVCDVEIRRNEIRKML . . : . ::.:. ..:.. : ::: : .:.::.. : . .. : NP_001 PTLSFRPKGLMCPDHKEEVTHYCKTCQRLVCQLC-RVRRTHSGHKITPVLSAYQALKDKL 90 100 110 120 130 140 200 210 220 230 240 250 pF1KE3 MKQQDRLEEREQDIEDQLYKLESDKRLVEEKVNQLKEEVRLQYEKLHQLLDEDLRQTVEV :. . .. .. :. .:: : .: . .: :::: . : .:.: . ... NP_001 TKSLTYILGNQDTVQTQICELEEAVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQA 150 160 170 180 190 200 260 270 280 290 300 310 pF1KE3 LDKAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTEDVSFMKNTKSVKILMDRTQ ... : . .. .:: .. . . ... :.: : .. .:.. :.. .:... . : NP_001 IEECQQERLARLSAQ-IQEHRSLLDGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARAT 210 220 230 240 250 260 320 330 340 350 360 370 pF1KE3 TCTSSSLSPTKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTPVPFLQSVPLYPCGVSSSG NP_001 EALQTFRPAASSSFRHCQLDVGREMKLLTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLP 270 280 290 300 310 320 >>XP_005273509 (OMIM: 617007) PREDICTED: tripartite moti (298 aa) initn: 245 init1: 159 opt: 260 Z-score: 180.0 bits: 42.2 E(85289): 0.0028 Smith-Waterman score: 260; 28.8% identity (52.8% similar) in 250 aa overlap (9-246:15-248) 10 20 30 40 50 pF1KE3 MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPE :.:::.: .: : . : : : :::::::... : . . . :: XP_005 MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPT-CPV 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 CNQAYNQKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLPAQKVCLRC---- :.. . :. : :.:.:::. :. : : : : .. : : XP_005 CKD-RASPADLRTNHTLNNLVEKL--LREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDK 60 70 80 90 100 110 120 130 140 150 160 pF1KE3 EAPCCQSHV----QTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQY : ::. .. : : :: .: : :: ...: : : .. . XP_005 ELLCCSCQADPRHQGHRVQPVKDTAH------DFRAKCRNMEHALR----EKAKAFWAMR 120 130 140 150 160 170 180 190 200 210 220 pF1KE3 CCYYSGAHQGHSVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLV-EEKV : . :. :. .. ...::. . : .. :. .:: : : . . .:.:. .::. XP_005 RSYEAIAK--HNQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKM 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE3 NQLKEEVRL---QYEKLHQLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKKL .:: ::... . :.:.. . :: XP_005 KQLTEETEVLAHEIERLQMEMKEDDVSFLMTLLHHGARASPARHAYRCLQVPGLPAVPRL 230 240 250 260 270 280 >>XP_016857120 (OMIM: 616755) PREDICTED: E3 ubiquitin-pr (291 aa) initn: 230 init1: 161 opt: 253 Z-score: 175.9 bits: 41.4 E(85289): 0.0047 Smith-Waterman score: 258; 26.4% identity (51.5% similar) in 227 aa overlap (9-233:85-255) 10 20 30 pF1KE3 MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGC ...::.: ::: .. .::.: :.: ::: : XP_016 AAAATGSSDSAGSGLRGCAGPKRWLLSSRGLKDELLCSICLSIYQDPVSLGCEHYFCRRC 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE3 IGEAWAKD--SGLVRCPECNQAYNQKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCR : : :... .: :::: ... . :.: .:::.::::..... XP_016 ITEHWVRQEAQGARDCPECRRTFAE-PALAPSLKLANIVERYSSF--------------- 120 130 140 150 100 110 120 130 140 150 pF1KE3 RGPPLPAQKVCLRCEAPCCQSHVQTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHC :: : : :: :.: : :. . : XP_016 ---PLDAILNARRAARPC-QAH-------------------DKVKLF------------C 160 170 180 160 170 180 190 200 210 pF1KE3 EAEQVAVCQYCCYYSGAHQGHSVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLES .... .: . : . :. :.: .. .:... : : . :.. :.. . : :. XP_016 LTDRALLC-FFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLK- 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 DKRLVEEKVNQLKEEVRLQYEKLHQLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERM ..:.: : .:.. .: XP_016 -RQLAETK--ELRQSLRNALGLWRSSWGLKTPLETQIYAPAWPPTHCGVSGRS 250 260 270 280 290 551 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 08:52:50 2016 done: Sun Nov 6 08:52:51 2016 Total Scan time: 12.090 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]