FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1488, 285 aa 1>>>pF1KE1488 285 - 285 aa - 285 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6545+/-0.00029; mu= 14.5921+/- 0.018 mean_var=80.5365+/-16.199, 0's: 0 Z-trim(118.1): 18 B-trim: 0 in 0/53 Lambda= 0.142915 statistics sampled from 30609 (30625) to 30609 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.726), E-opt: 0.2 (0.359), width: 16 Scan time: 7.590 The best scores are: opt bits E(85289) NP_006564 (OMIM: 603969) tumor necrosis factor lig ( 285) 1847 389.8 3.1e-108 NP_001139117 (OMIM: 603969) tumor necrosis factor ( 266) 906 195.8 7.4e-50 NP_003799 (OMIM: 604472) tumor necrosis factor lig ( 250) 308 72.5 9.2e-13 NP_742085 (OMIM: 604472) tumor necrosis factor lig ( 247) 299 70.6 3.3e-12 NP_001185551 (OMIM: 604472) tumor necrosis factor ( 223) 297 70.2 4e-12 NP_001185553 (OMIM: 604472) tumor necrosis factor ( 205) 296 70.0 4.3e-12 NP_001185552 (OMIM: 604472) tumor necrosis factor ( 222) 296 70.0 4.6e-12 NP_742084 (OMIM: 604472) tumor necrosis factor lig ( 234) 284 67.5 2.7e-11 >>NP_006564 (OMIM: 603969) tumor necrosis factor ligand (285 aa) initn: 1847 init1: 1847 opt: 1847 Z-score: 2064.2 bits: 389.8 E(85289): 3.1e-108 Smith-Waterman score: 1847; 100.0% identity (100.0% similar) in 285 aa overlap (1-285:1-285) 10 20 30 40 50 60 pF1KE1 MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 GEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 KENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 KENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETL 190 200 210 220 230 240 250 260 270 280 pF1KE1 PNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL ::::::::::::::::::::::::::::::::::::::::::::: NP_006 PNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL 250 260 270 280 >>NP_001139117 (OMIM: 603969) tumor necrosis factor liga (266 aa) initn: 924 init1: 906 opt: 906 Z-score: 1016.1 bits: 195.8 E(85289): 7.4e-50 Smith-Waterman score: 1677; 93.3% identity (93.3% similar) in 285 aa overlap (1-285:1-266) 10 20 30 40 50 60 pF1KE1 MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 GEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEE ::::::::::::::::::::: :::::::::::::::::::: NP_001 GEGNSSQNSRNKRAVQGPEET-------------------GSYTFVPWLLSFKRGSALEE 130 140 150 160 190 200 210 220 230 240 pF1KE1 KENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETL 170 180 190 200 210 220 250 260 270 280 pF1KE1 PNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL ::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL 230 240 250 260 >>NP_003799 (OMIM: 604472) tumor necrosis factor ligand (250 aa) initn: 298 init1: 135 opt: 308 Z-score: 350.1 bits: 72.5 E(85289): 9.2e-13 Smith-Waterman score: 320; 31.3% identity (62.2% similar) in 217 aa overlap (73-284:52-250) 50 60 70 80 90 100 pF1KE1 KDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPA--GAGAPKA : .: ::: :.. .. :. : : : NP_003 VREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQ 30 40 50 60 70 80 110 120 130 140 150 160 pF1KE1 GLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQK .: : . .:. .: ... ::..::: .. .. :.:. . : . . NP_003 SLPEQS--SDALEAWE--------NGERSRKRRAVLTQKQKKQHSVLHLVPINAT-SKDD 90 100 110 120 130 170 180 190 200 210 220 pF1KE1 GSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVF .. : : : ...:: .:. . . ....: ...:.:::. : :..::....:. NP_003 SDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSRE----- 140 150 160 170 180 230 240 250 260 270 pF1KE1 GDELSLVTLFRCIQNMPETLPN---NSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVT . ::::::..:: . :. :::::::. .:..:: :.. ::: :...:. : NP_003 -GQGRQETLFRCIRSMP-SHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGT 190 200 210 220 230 240 280 pF1KE1 FFGALKLL :.: .:: NP_003 FLGFVKL 250 >>NP_742085 (OMIM: 604472) tumor necrosis factor ligand (247 aa) initn: 289 init1: 126 opt: 299 Z-score: 340.2 bits: 70.6 E(85289): 3.3e-12 Smith-Waterman score: 311; 31.0% identity (62.0% similar) in 213 aa overlap (73-280:52-246) 50 60 70 80 90 100 pF1KE1 KDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPA--GAGAPKA : .: ::: :.. .. :. : : : NP_742 VREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQ 30 40 50 60 70 80 110 120 130 140 150 160 pF1KE1 GLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQK .: : . .:. .: ... ::..::: .. .. :.:. . : . . NP_742 SLPEQS--SDALEAWE--------NGERSRKRRAVLTQKQKKQHSVLHLVPINAT-SKDD 90 100 110 120 130 170 180 190 200 210 220 pF1KE1 GSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVF .. : : : ...:: .:. . . ....: ...:.:::. : :..::....:. NP_742 SDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSRE----- 140 150 160 170 180 230 240 250 260 270 pF1KE1 GDELSLVTLFRCIQNMPETLPN---NSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVT . ::::::..:: . :. :::::::. .:..:: :.. ::: :...:. : NP_742 -GQGRQETLFRCIRSMP-SHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGT 190 200 210 220 230 240 280 pF1KE1 FFGALKLL :.: NP_742 FLGL >>NP_001185551 (OMIM: 604472) tumor necrosis factor liga (223 aa) initn: 295 init1: 135 opt: 297 Z-score: 338.6 bits: 70.2 E(85289): 4e-12 Smith-Waterman score: 297; 33.5% identity (66.5% similar) in 167 aa overlap (121-284:67-223) 100 110 120 130 140 150 pF1KE1 LPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLI : :. :::... . ::. .. :.:. NP_001 AALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQSLPEQ--QHSVLHLV 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE1 ADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGH . : . . .. : : : ...:: .:. . . ....: ...:.:::. : :..::. NP_001 PINAT-SKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ 100 110 120 130 140 150 220 230 240 250 260 pF1KE1 LIQRKKVHVFGDELSLVTLFRCIQNMPETLPN---NSCYSAGIAKLEEGDELQLAIPREN ...:. . ::::::..:: . :. :::::::. .:..:: :.. ::: NP_001 VVSRE------GQGRQETLFRCIRSMP-SHPDRAYNSCYSAGVFHLHQGDILSVIIPRAR 160 170 180 190 200 270 280 pF1KE1 AQISLDGDVTFFGALKLL :...:. ::.: .:: NP_001 AKLNLSPHGTFLGFVKL 210 220 >>NP_001185553 (OMIM: 604472) tumor necrosis factor liga (205 aa) initn: 295 init1: 135 opt: 296 Z-score: 338.0 bits: 70.0 E(85289): 4.3e-12 Smith-Waterman score: 296; 33.5% identity (66.5% similar) in 167 aa overlap (121-284:50-205) 100 110 120 130 140 150 pF1KE1 LPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLI : :. :::... . ::. .. :.:. NP_001 AALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQSLPEQ---HSVLHLV 20 30 40 50 60 70 160 170 180 190 200 210 pF1KE1 ADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGH . : . . .. : : : ...:: .:. . . ....: ...:.:::. : :..::. NP_001 PINAT-SKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ 80 90 100 110 120 130 220 230 240 250 260 pF1KE1 LIQRKKVHVFGDELSLVTLFRCIQNMPETLPN---NSCYSAGIAKLEEGDELQLAIPREN ...:. . ::::::..:: . :. :::::::. .:..:: :.. ::: NP_001 VVSRE------GQGRQETLFRCIRSMP-SHPDRAYNSCYSAGVFHLHQGDILSVIIPRAR 140 150 160 170 180 270 280 pF1KE1 AQISLDGDVTFFGALKLL :...:. ::.: .:: NP_001 AKLNLSPHGTFLGFVKL 190 200 >>NP_001185552 (OMIM: 604472) tumor necrosis factor liga (222 aa) initn: 295 init1: 135 opt: 296 Z-score: 337.5 bits: 70.0 E(85289): 4.6e-12 Smith-Waterman score: 296; 33.5% identity (66.5% similar) in 167 aa overlap (121-284:67-222) 100 110 120 130 140 150 pF1KE1 LPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLI : :. :::... . ::. .. :.:. NP_001 AALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQSLPEQ---HSVLHLV 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE1 ADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGH . : . . .. : : : ...:: .:. . . ....: ...:.:::. : :..::. NP_001 PINAT-SKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ 100 110 120 130 140 150 220 230 240 250 260 pF1KE1 LIQRKKVHVFGDELSLVTLFRCIQNMPETLPN---NSCYSAGIAKLEEGDELQLAIPREN ...:. . ::::::..:: . :. :::::::. .:..:: :.. ::: NP_001 VVSRE------GQGRQETLFRCIRSMP-SHPDRAYNSCYSAGVFHLHQGDILSVIIPRAR 160 170 180 190 200 270 280 pF1KE1 AQISLDGDVTFFGALKLL :...:. ::.: .:: NP_001 AKLNLSPHGTFLGFVKL 210 220 >>NP_742084 (OMIM: 604472) tumor necrosis factor ligand (234 aa) initn: 315 init1: 135 opt: 284 Z-score: 323.8 bits: 67.5 E(85289): 2.7e-11 Smith-Waterman score: 287; 31.8% identity (59.4% similar) in 217 aa overlap (73-284:52-234) 50 60 70 80 90 100 pF1KE1 KDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPA--GAGAPKA : .: ::: :.. .. :. : : : NP_742 VREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQ 30 40 50 60 70 80 110 120 130 140 150 160 pF1KE1 GLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQK .: : . .:. .: ... ::..::: .:: . ::.. NP_742 SLPEQS--SDALEAWE--------NGERSRKRRAV------LTQ---KQKNDSDV----- 90 100 110 170 180 190 200 210 220 pF1KE1 GSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVF : : : ...:: .:. . . ....: ...:.:::. : :..::....:. NP_742 ---TEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSRE----- 120 130 140 150 160 230 240 250 260 270 pF1KE1 GDELSLVTLFRCIQNMPETLPN---NSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVT . ::::::..:: . :. :::::::. .:..:: :.. ::: :...:. : NP_742 -GQGRQETLFRCIRSMP-SHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGT 170 180 190 200 210 220 280 pF1KE1 FFGALKLL :.: .:: NP_742 FLGFVKL 230 285 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 00:43:55 2016 done: Mon Nov 7 00:43:56 2016 Total Scan time: 7.590 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]