FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1511, 322 aa 1>>>pF1KE1511 322 - 322 aa - 322 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2902+/-0.000351; mu= 15.8629+/- 0.022 mean_var=62.9827+/-12.603, 0's: 0 Z-trim(113.9): 11 B-trim: 0 in 0/50 Lambda= 0.161608 statistics sampled from 23465 (23474) to 23465 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.662), E-opt: 0.2 (0.275), width: 16 Scan time: 7.750 The best scores are: opt bits E(85289) NP_000036 (OMIM: 207800,608313) arginase-1 isoform ( 322) 2133 505.8 4.7e-143 NP_001231367 (OMIM: 207800,608313) arginase-1 isof ( 330) 2107 499.8 3.2e-141 NP_001163 (OMIM: 107830) arginase-2, mitochondrial ( 354) 1336 320.0 4.4e-87 XP_011534103 (OMIM: 207800,608313) PREDICTED: argi ( 237) 884 214.6 1.7e-55 >>NP_000036 (OMIM: 207800,608313) arginase-1 isoform 2 [ (322 aa) initn: 2133 init1: 2133 opt: 2133 Z-score: 2689.3 bits: 505.8 E(85289): 4.7e-143 Smith-Waterman score: 2133; 100.0% identity (100.0% similar) in 322 aa overlap (1-322:1-322) 10 20 30 40 50 60 pF1KE1 MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT 250 260 270 280 290 300 310 320 pF1KE1 LACFGLAREGNHKPIDYLNPPK :::::::::::::::::::::: NP_000 LACFGLAREGNHKPIDYLNPPK 310 320 >>NP_001231367 (OMIM: 207800,608313) arginase-1 isoform (330 aa) initn: 2119 init1: 1858 opt: 2107 Z-score: 2656.4 bits: 499.8 E(85289): 3.2e-141 Smith-Waterman score: 2107; 97.6% identity (97.6% similar) in 330 aa overlap (1-322:1-330) 10 20 30 40 50 pF1KE1 MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQ--------ECDVKDYGD ::::::::::::::::::::::::::::::::::::::::::: ::::::::: NP_001 MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQVTQNFLILECDVKDYGD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 LPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 RVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 DIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFD 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE1 VDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRT 250 260 270 280 290 300 300 310 320 pF1KE1 VNTAVAITLACFGLAREGNHKPIDYLNPPK :::::::::::::::::::::::::::::: NP_001 VNTAVAITLACFGLAREGNHKPIDYLNPPK 310 320 330 >>NP_001163 (OMIM: 107830) arginase-2, mitochondrial pre (354 aa) initn: 1353 init1: 1110 opt: 1336 Z-score: 1684.4 bits: 320.0 E(85289): 4.4e-87 Smith-Waterman score: 1336; 60.1% identity (85.4% similar) in 316 aa overlap (7-321:25-340) 10 20 30 40 pF1KE1 MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKE ....::::::.:: : :::.::...:.:::...:. NP_001 MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 QECDVKDYGDLPFADIPNDSPFQ-IVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDH : .::.::: :. .:.:. .. .. :::::: :...:: :... ..: ..::::: NP_001 LGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDH 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE1 SLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPG :::::.:::::: ::: :.:::::.::::::::.:::::::::::::.::. :.:..:: NP_001 SLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE1 FSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLG :::. ::::. .::::::::::: ::.:::. :.:::: ..::::: ::::.:.. :.: NP_001 FSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIG 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE1 RKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPS ...::::::::.:..::...::::::::::::::::.::.:::..:::::.::..::::. NP_001 KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQ 250 260 270 280 290 300 290 300 310 320 pF1KE1 LGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK :. . ::. :.: :: . . :: .:::.: : : : NP_001 LATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI 310 320 330 340 350 >>XP_011534103 (OMIM: 207800,608313) PREDICTED: arginase (237 aa) initn: 876 init1: 876 opt: 884 Z-score: 1117.5 bits: 214.6 E(85289): 1.7e-55 Smith-Waterman score: 1367; 73.6% identity (73.6% similar) in 322 aa overlap (1-322:1-237) 10 20 30 40 50 60 pF1KE1 MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV :::::::::::::::::::::::::::::::::::::::::: XP_011 DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHS------------------ 70 80 90 100 130 140 150 160 170 180 pF1KE1 IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR XP_011 ------------------------------------------------------------ 190 200 210 220 230 240 pF1KE1 DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 -------YILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF 110 120 130 140 150 250 260 270 280 290 300 pF1KE1 TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT 160 170 180 190 200 210 310 320 pF1KE1 LACFGLAREGNHKPIDYLNPPK :::::::::::::::::::::: XP_011 LACFGLAREGNHKPIDYLNPPK 220 230 322 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 00:44:31 2016 done: Mon Nov 7 00:44:32 2016 Total Scan time: 7.750 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]