Result of FASTA (omim) for
pFN21AE1313
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1313, 218 aa
1>>>pF1KE1313 218 - 218 aa - 218 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2198+/-0.000297; mu= 14.9141+/- 0.019
mean_var=75.5017+/-14.891, 0's: 0 Z-trim(118.5): 29 B-trim: 225 in 1/53
Lambda= 0.147603
statistics sampled from 31466 (31501) to 31466 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.758), E-opt: 0.2 (0.369), width: 16
Scan time: 6.210
The best scores are: opt bits E(85289)
XP_011509265 (OMIM: 605510) PREDICTED: interleukin ( 218) 1492 326.4 2.3e-89
NP_055254 (OMIM: 605510) interleukin-37 isoform 1 ( 218) 1492 326.4 2.3e-89
NP_775297 (OMIM: 605510) interleukin-37 isoform 5 ( 192) 1153 254.1 1.1e-67
NP_775294 (OMIM: 605510) interleukin-37 isoform 2 ( 197) 1153 254.1 1.1e-67
XP_011509266 (OMIM: 605510) PREDICTED: interleukin ( 178) 907 201.7 6.2e-52
NP_775296 (OMIM: 605510) interleukin-37 isoform 4 ( 178) 907 201.7 6.2e-52
NP_775295 (OMIM: 605510) interleukin-37 isoform 3 ( 157) 889 197.8 8.1e-51
NP_062564 (OMIM: 605542) interleukin-36 gamma isof ( 169) 313 75.2 7.2e-14
NP_775270 (OMIM: 605508) interleukin-36 beta isofo ( 157) 311 74.8 9.1e-14
XP_011509264 (OMIM: 605508) PREDICTED: interleukin ( 157) 311 74.8 9.1e-14
XP_011509267 (OMIM: 605509) PREDICTED: interleukin ( 158) 305 73.5 2.2e-13
NP_055255 (OMIM: 605509) interleukin-36 alpha [Hom ( 158) 305 73.5 2.2e-13
XP_016859295 (OMIM: 605509) PREDICTED: interleukin ( 158) 305 73.5 2.2e-13
XP_005263696 (OMIM: 605509) PREDICTED: interleukin ( 158) 305 73.5 2.2e-13
NP_001265497 (OMIM: 605542) interleukin-36 gamma i ( 134) 258 63.4 2e-10
NP_775262 (OMIM: 605507,614204) interleukin-36 rec ( 155) 229 57.3 1.6e-08
NP_036407 (OMIM: 605507,614204) interleukin-36 rec ( 155) 229 57.3 1.6e-08
NP_775184 (OMIM: 615296) interleukin-1 family memb ( 152) 209 53.0 3.1e-07
NP_115945 (OMIM: 615296) interleukin-1 family memb ( 152) 209 53.0 3.1e-07
XP_005263718 (OMIM: 137215,147679,612628,612852) P ( 143) 193 49.6 3.1e-06
XP_011509423 (OMIM: 137215,147679,612628,612852) P ( 143) 193 49.6 3.1e-06
NP_776215 (OMIM: 137215,147679,612628,612852) inte ( 143) 193 49.6 3.1e-06
NP_001305843 (OMIM: 137215,147679,612628,612852) i ( 143) 193 49.6 3.1e-06
NP_000568 (OMIM: 137215,147679,612628,612852) inte ( 159) 193 49.6 3.4e-06
NP_776214 (OMIM: 137215,147679,612628,612852) inte ( 177) 193 49.7 3.7e-06
NP_776213 (OMIM: 137215,147679,612628,612852) inte ( 180) 193 49.7 3.7e-06
NP_055253 (OMIM: 605508) interleukin-36 beta isofo ( 164) 167 44.1 0.00016
XP_016859477 (OMIM: 137215,147720) PREDICTED: inte ( 238) 162 43.2 0.00045
NP_000567 (OMIM: 137215,147720) interleukin-1 beta ( 269) 162 43.2 0.00049
>>XP_011509265 (OMIM: 605510) PREDICTED: interleukin-37 (218 aa)
initn: 1492 init1: 1492 opt: 1492 Z-score: 1725.3 bits: 326.4 E(85289): 2.3e-89
Smith-Waterman score: 1492; 99.1% identity (99.5% similar) in 218 aa overlap (1-218:1-218)
10 20 30 40 50 60
pF1KE1 MSFVGENSGVKMGSEDWEKDEPQCCLEDPAVSPLEPGPSLPAMNFVHTSPKVKNLNPKKF
:::::::::::::::::::::::::::::: ::::::::::.::::::::::::::::::
XP_011 MSFVGENSGVKMGSEDWEKDEPQCCLEDPAGSPLEPGPSLPTMNFVHTSPKVKNLNPKKF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SIHDQDHKVLVLDSGNLIAVPDKNYIRPEIFFALASSLSSASAEKGSPILLGVSKGEFCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIHDQDHKVLVLDSGNLIAVPDKNYIRPEIFFALASSLSSASAEKGSPILLGVSKGEFCL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 YCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTS
130 140 150 160 170 180
190 200 210
pF1KE1 CNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD
::::::::::::::::::::::::::::::::::::::
XP_011 CNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD
190 200 210
>>NP_055254 (OMIM: 605510) interleukin-37 isoform 1 prec (218 aa)
initn: 1492 init1: 1492 opt: 1492 Z-score: 1725.3 bits: 326.4 E(85289): 2.3e-89
Smith-Waterman score: 1492; 99.1% identity (99.5% similar) in 218 aa overlap (1-218:1-218)
10 20 30 40 50 60
pF1KE1 MSFVGENSGVKMGSEDWEKDEPQCCLEDPAVSPLEPGPSLPAMNFVHTSPKVKNLNPKKF
:::::::::::::::::::::::::::::: ::::::::::.::::::::::::::::::
NP_055 MSFVGENSGVKMGSEDWEKDEPQCCLEDPAGSPLEPGPSLPTMNFVHTSPKVKNLNPKKF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SIHDQDHKVLVLDSGNLIAVPDKNYIRPEIFFALASSLSSASAEKGSPILLGVSKGEFCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SIHDQDHKVLVLDSGNLIAVPDKNYIRPEIFFALASSLSSASAEKGSPILLGVSKGEFCL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 YCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 YCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTS
130 140 150 160 170 180
190 200 210
pF1KE1 CNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD
::::::::::::::::::::::::::::::::::::::
NP_055 CNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD
190 200 210
>>NP_775297 (OMIM: 605510) interleukin-37 isoform 5 [Hom (192 aa)
initn: 1153 init1: 1153 opt: 1153 Z-score: 1336.0 bits: 254.1 E(85289): 1.1e-67
Smith-Waterman score: 1153; 100.0% identity (100.0% similar) in 169 aa overlap (50-218:24-192)
20 30 40 50 60 70
pF1KE1 DEPQCCLEDPAVSPLEPGPSLPAMNFVHTSPKVKNLNPKKFSIHDQDHKVLVLDSGNLIA
::::::::::::::::::::::::::::::
NP_775 MSGCDRRETETKGKNSFKKRLRGPKVKNLNPKKFSIHDQDHKVLVLDSGNLIA
10 20 30 40 50
80 90 100 110 120 130
pF1KE1 VPDKNYIRPEIFFALASSLSSASAEKGSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 VPDKNYIRPEIFFALASSLSSASAEKGSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEK
60 70 80 90 100 110
140 150 160 170 180 190
pF1KE1 LMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 LMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHI
120 130 140 150 160 170
200 210
pF1KE1 EFSFQPVCKAEMSPSEVSD
:::::::::::::::::::
NP_775 EFSFQPVCKAEMSPSEVSD
180 190
>>NP_775294 (OMIM: 605510) interleukin-37 isoform 2 [Hom (197 aa)
initn: 1153 init1: 1153 opt: 1153 Z-score: 1335.8 bits: 254.1 E(85289): 1.1e-67
Smith-Waterman score: 1300; 89.9% identity (90.4% similar) in 218 aa overlap (1-218:1-197)
10 20 30 40 50 60
pF1KE1 MSFVGENSGVKMGSEDWEKDEPQCCLEDPAVSPLEPGPSLPAMNFVHTSPKVKNLNPKKF
::::::::::::::::::::::::::: .:::::::::::
NP_775 MSFVGENSGVKMGSEDWEKDEPQCCLE---------------------GPKVKNLNPKKF
10 20 30
70 80 90 100 110 120
pF1KE1 SIHDQDHKVLVLDSGNLIAVPDKNYIRPEIFFALASSLSSASAEKGSPILLGVSKGEFCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 SIHDQDHKVLVLDSGNLIAVPDKNYIRPEIFFALASSLSSASAEKGSPILLGVSKGEFCL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 YCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 YCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTS
100 110 120 130 140 150
190 200 210
pF1KE1 CNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD
::::::::::::::::::::::::::::::::::::::
NP_775 CNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD
160 170 180 190
>>XP_011509266 (OMIM: 605510) PREDICTED: interleukin-37 (178 aa)
initn: 907 init1: 907 opt: 907 Z-score: 1053.3 bits: 201.7 E(85289): 6.2e-52
Smith-Waterman score: 1128; 80.3% identity (81.2% similar) in 218 aa overlap (1-218:1-178)
10 20 30 40 50 60
pF1KE1 MSFVGENSGVKMGSEDWEKDEPQCCLEDPAVSPLEPGPSLPAMNFVHTSPKVKNLNPKKF
:::::::::::::::::::::::::::::: ::::::::::.::::::
XP_011 MSFVGENSGVKMGSEDWEKDEPQCCLEDPAGSPLEPGPSLPTMNFVHT------------
10 20 30 40
70 80 90 100 110 120
pF1KE1 SIHDQDHKVLVLDSGNLIAVPDKNYIRPEIFFALASSLSSASAEKGSPILLGVSKGEFCL
.:::::::::::::::::::::::::::::::
XP_011 ----------------------------KIFFALASSLSSASAEKGSPILLGVSKGEFCL
50 60 70 80
130 140 150 160 170 180
pF1KE1 YCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTS
90 100 110 120 130 140
190 200 210
pF1KE1 CNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD
::::::::::::::::::::::::::::::::::::::
XP_011 CNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD
150 160 170
>>NP_775296 (OMIM: 605510) interleukin-37 isoform 4 [Hom (178 aa)
initn: 907 init1: 907 opt: 907 Z-score: 1053.3 bits: 201.7 E(85289): 6.2e-52
Smith-Waterman score: 1128; 80.3% identity (81.2% similar) in 218 aa overlap (1-218:1-178)
10 20 30 40 50 60
pF1KE1 MSFVGENSGVKMGSEDWEKDEPQCCLEDPAVSPLEPGPSLPAMNFVHTSPKVKNLNPKKF
:::::::::::::::::::::::::::::: ::::::::::.::::::
NP_775 MSFVGENSGVKMGSEDWEKDEPQCCLEDPAGSPLEPGPSLPTMNFVHT------------
10 20 30 40
70 80 90 100 110 120
pF1KE1 SIHDQDHKVLVLDSGNLIAVPDKNYIRPEIFFALASSLSSASAEKGSPILLGVSKGEFCL
.:::::::::::::::::::::::::::::::
NP_775 ----------------------------KIFFALASSLSSASAEKGSPILLGVSKGEFCL
50 60 70 80
130 140 150 160 170 180
pF1KE1 YCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 YCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTS
90 100 110 120 130 140
190 200 210
pF1KE1 CNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD
::::::::::::::::::::::::::::::::::::::
NP_775 CNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD
150 160 170
>>NP_775295 (OMIM: 605510) interleukin-37 isoform 3 [Hom (157 aa)
initn: 889 init1: 889 opt: 889 Z-score: 1033.3 bits: 197.8 E(85289): 8.1e-51
Smith-Waterman score: 956; 72.0% identity (72.0% similar) in 218 aa overlap (1-218:1-157)
10 20 30 40 50 60
pF1KE1 MSFVGENSGVKMGSEDWEKDEPQCCLEDPAVSPLEPGPSLPAMNFVHTSPKVKNLNPKKF
:::::::::::::::::::::::::::
NP_775 MSFVGENSGVKMGSEDWEKDEPQCCLE---------------------------------
10 20
70 80 90 100 110 120
pF1KE1 SIHDQDHKVLVLDSGNLIAVPDKNYIRPEIFFALASSLSSASAEKGSPILLGVSKGEFCL
::::::::::::::::::::::::::::::::
NP_775 ----------------------------EIFFALASSLSSASAEKGSPILLGVSKGEFCL
30 40 50
130 140 150 160 170 180
pF1KE1 YCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 YCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTS
60 70 80 90 100 110
190 200 210
pF1KE1 CNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD
::::::::::::::::::::::::::::::::::::::
NP_775 CNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD
120 130 140 150
>>NP_062564 (OMIM: 605542) interleukin-36 gamma isoform (169 aa)
initn: 264 init1: 120 opt: 313 Z-score: 370.0 bits: 75.2 E(85289): 7.2e-14
Smith-Waterman score: 313; 36.3% identity (67.8% similar) in 146 aa overlap (57-201:22-163)
30 40 50 60 70 80
pF1KE1 EDPAVSPLEPGPSLPAMNFVHTSPKVKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYI
: .:.: ...: .:.. ::.::: .. .
NP_062 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSV
10 20 30 40 50
90 100 110 120 130 140
pF1KE1 RPEIFFALASSLSSASAE-KGSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEKLMKLAA
: ... . : . .:.:: ::... :.::::.: : :.::::..:.: : .
NP_062 TPVTVAVITCKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQ--PTLQLKEQKIMDLYG
60 70 80 90 100
150 160 170 180 190 200
pF1KE1 QKESARRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIEFSFQP
: : .. ::.::::..: . :::.: : ::: .: ..:. .:... . . :
NP_062 QPEPVK-PFLFYRAKTGRTSTLESVAFPDWFIASSKR-DQPIILTSELGKSYNTAFELNI
110 120 130 140 150 160
210
pF1KE1 VCKAEMSPSEVSD
NP_062 ND
>>NP_775270 (OMIM: 605508) interleukin-36 beta isoform 2 (157 aa)
initn: 308 init1: 138 opt: 311 Z-score: 368.1 bits: 74.8 E(85289): 9.1e-14
Smith-Waterman score: 311; 32.1% identity (71.1% similar) in 159 aa overlap (49-206:2-156)
20 30 40 50 60 70
pF1KE1 KDEPQCCLEDPAVSPLEPGPSLPAMNFVHTSPKVKNLNPKKFSIHDQDHKVLVLDSGNLI
.:. .. ::...:.:. . : ::....::
NP_775 MNPQ-REAAPKSYAIRDSRQMVWVLSGNSLI
10 20 30
80 90 100 110 120 130
pF1KE1 AVPDKNYIRPEIFFALASSLSSAS-AEKGSPILLGVSKGEFCLYCDKDKGQSHPSLQLKK
:.: . :.: . .: . : :::. . ::.. ..::.: . .:. :.::::.
NP_775 AAPLSRSIKPVTLHLIACRDTEFSDKEKGNMVYLGIKGKDLCLFCAEIQGK--PTLQLKE
40 50 60 70 80
140 150 160 170 180 190
pF1KE1 EKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRK
...: : ..:. :..::.:.. . :: ....:...::::: :: . ..:. .: . .
NP_775 KNIMDLYVEKK-AQKPFLFFHNKEGSTSVFQSVSYPGWFIATSTTSGQPIFLTKERGITN
90 100 110 120 130 140
200 210
pF1KE1 HIEFSFQPVCKAEMSPSEVSD
. .: .. :
NP_775 NTNFYLDSVE
150
>>XP_011509264 (OMIM: 605508) PREDICTED: interleukin-36 (157 aa)
initn: 308 init1: 138 opt: 311 Z-score: 368.1 bits: 74.8 E(85289): 9.1e-14
Smith-Waterman score: 311; 32.1% identity (71.1% similar) in 159 aa overlap (49-206:2-156)
20 30 40 50 60 70
pF1KE1 KDEPQCCLEDPAVSPLEPGPSLPAMNFVHTSPKVKNLNPKKFSIHDQDHKVLVLDSGNLI
.:. .. ::...:.:. . : ::....::
XP_011 MNPQ-REAAPKSYAIRDSRQMVWVLSGNSLI
10 20 30
80 90 100 110 120 130
pF1KE1 AVPDKNYIRPEIFFALASSLSSAS-AEKGSPILLGVSKGEFCLYCDKDKGQSHPSLQLKK
:.: . :.: . .: . : :::. . ::.. ..::.: . .:. :.::::.
XP_011 AAPLSRSIKPVTLHLIACRDTEFSDKEKGNMVYLGIKGKDLCLFCAEIQGK--PTLQLKE
40 50 60 70 80
140 150 160 170 180 190
pF1KE1 EKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRK
...: : ..:. :..::.:.. . :: ....:...::::: :: . ..:. .: . .
XP_011 KNIMDLYVEKK-AQKPFLFFHNKEGSTSVFQSVSYPGWFIATSTTSGQPIFLTKERGITN
90 100 110 120 130 140
200 210
pF1KE1 HIEFSFQPVCKAEMSPSEVSD
. .: .. :
XP_011 NTNFYLDSVE
150
218 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 00:45:02 2016 done: Mon Nov 7 00:45:03 2016
Total Scan time: 6.210 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]