FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3649, 437 aa 1>>>pF1KE3649 437 - 437 aa - 437 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8260+/-0.000319; mu= 20.2928+/- 0.020 mean_var=67.0840+/-13.323, 0's: 0 Z-trim(116.7): 12 B-trim: 0 in 0/54 Lambda= 0.156590 statistics sampled from 28081 (28090) to 28081 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.697), E-opt: 0.2 (0.329), width: 16 Scan time: 8.800 The best scores are: opt bits E(85289) NP_002019 (OMIM: 134636) protein farnesyltransfera ( 437) 3048 697.3 2e-200 NP_004573 (OMIM: 179080) geranylgeranyl transferas ( 331) 421 103.8 7.1e-22 NP_005014 (OMIM: 602031) geranylgeranyl transferas ( 377) 337 84.8 4e-16 XP_005272077 (OMIM: 602031) PREDICTED: geranylgera ( 381) 337 84.8 4.1e-16 XP_011541792 (OMIM: 602031) PREDICTED: geranylgera ( 408) 337 84.9 4.3e-16 XP_011541794 (OMIM: 602031) PREDICTED: geranylgera ( 285) 310 78.6 2.2e-14 >>NP_002019 (OMIM: 134636) protein farnesyltransferase s (437 aa) initn: 3048 init1: 3048 opt: 3048 Z-score: 3719.5 bits: 697.3 E(85289): 2e-200 Smith-Waterman score: 3048; 100.0% identity (100.0% similar) in 437 aa overlap (1-437:1-437) 10 20 30 40 50 60 pF1KE3 MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 IVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 GVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPV 370 380 390 400 410 420 430 pF1KE3 PGFEELKDETSAEPATD ::::::::::::::::: NP_002 PGFEELKDETSAEPATD 430 >>NP_004573 (OMIM: 179080) geranylgeranyl transferase ty (331 aa) initn: 490 init1: 209 opt: 421 Z-score: 513.7 bits: 103.8 E(85289): 7.1e-22 Smith-Waterman score: 521; 29.9% identity (59.5% similar) in 338 aa overlap (76-410:21-321) 50 60 70 80 90 100 pF1KE3 IEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYL-KRGLRQLTDAYE-CLDAS-RPW ::: :. . : .. : :: :.. : NP_004 MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKK--DDYEYCMSEYLRMS 10 20 30 40 110 120 130 140 150 160 pF1KE3 LCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCI :: : ..:. . . .. .. :.. :: ::.... :. ::: : .::. : . NP_004 GIYWGLTVMDLMGQ-LHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILTL 50 60 70 80 90 100 170 180 190 200 210 220 pF1KE3 IGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLF .. ..:. .:...:. .:.. :::: . ::.:.: ..::... .: . . NP_004 Y---DSINVIDVNKVVEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINV 110 120 130 140 150 160 230 240 250 260 270 280 pF1KE3 EGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQM : . :.. :.:..::.: :: :.:.: .: . :.: .. ...: : :. ::. NP_004 EKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQL 170 180 190 200 210 220 290 300 310 320 330 340 pF1KE3 RFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMC ::..:: .:: : :::.: . : .. : ::. .. :...:: : NP_004 P-SGGLNGRPEKLPDVCYSWWVLASLKIIGRL------------HWI-DREKLRNFILAC 230 240 250 260 270 350 360 370 380 390 400 pF1KE3 CQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYN . .::. :.:: : .:: . ..:::. :: :. ..:..::. NP_004 QDEETGGFADRPGDMVDPFHTLFGIAGLSL--------------LG--EEQIKPVNPVFC 280 290 300 310 410 420 430 pF1KE3 IGPDKVIQATTYFLQKPVPGFEELKDETSAEPATD . :..:.: NP_004 M-PEEVLQRVNVQPELVS 320 330 >>NP_005014 (OMIM: 602031) geranylgeranyl transferase ty (377 aa) initn: 324 init1: 132 opt: 337 Z-score: 410.4 bits: 84.8 E(85289): 4e-16 Smith-Waterman score: 392; 28.4% identity (55.6% similar) in 338 aa overlap (70-377:17-336) 40 50 60 70 80 90 pF1KE3 VETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDAS :: . :..: ....: :. : . : :..: NP_005 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETS 10 20 30 40 100 110 120 130 140 pF1KE3 RPWLCYWILHSLELLD--------EPIPQIVATDVCQFLELCQSPEGGFGGG-------- : . .. : .:..:: . : : . .: . . . :: :. NP_005 RLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFN 50 60 70 80 90 100 150 160 170 180 190 pF1KE3 PGQYP---------HLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFL-M :.. : :.: ::.... : :.: . . .:.: : : .:. :::: . NP_005 PSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSR--VNKEACLAGLRALQLEDGSFCAV 110 120 130 140 150 160 200 210 220 230 240 250 pF1KE3 HVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTF :.: :.: .:::. . . : . .. . .: : .....:.. :.:.::: :: NP_005 PEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTF 170 180 190 200 210 220 260 270 280 290 300 pF1KE3 CGLAALVIL-KRERSLNLKSL---LQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLP ::.:.: .. : :. .. : : .: :: ..:..:: :: :: ::::: .. : NP_005 CGIASLCLMGKLEEVFSEKELNRIKRWCIMRQ---QNGYHGRPNKPVDTCYSFWVGATLK 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE3 LLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSG ::. ... :... ..::: . .::. : . : :. . . : NP_005 LLK-----------IFQYTNFEKN--RNYILSTQDRLVGGFAKWPDSHPDALHAYFGICG 290 300 310 320 370 380 390 400 410 420 pF1KE3 LSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFEELKDE ::. .. : NP_005 LSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST 330 340 350 360 370 >>XP_005272077 (OMIM: 602031) PREDICTED: geranylgeranyl (381 aa) initn: 324 init1: 132 opt: 337 Z-score: 410.3 bits: 84.8 E(85289): 4.1e-16 Smith-Waterman score: 392; 28.4% identity (55.6% similar) in 338 aa overlap (70-377:17-336) 40 50 60 70 80 90 pF1KE3 VETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDAS :: . :..: ....: :. : . : :..: XP_005 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETS 10 20 30 40 100 110 120 130 140 pF1KE3 RPWLCYWILHSLELLD--------EPIPQIVATDVCQFLELCQSPEGGFGGG-------- : . .. : .:..:: . : : . .: . . . :: :. XP_005 RLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFN 50 60 70 80 90 100 150 160 170 180 190 pF1KE3 PGQYP---------HLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFL-M :.. : :.: ::.... : :.: . . .:.: : : .:. :::: . XP_005 PSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSR--VNKEACLAGLRALQLEDGSFCAV 110 120 130 140 150 160 200 210 220 230 240 250 pF1KE3 HVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTF :.: :.: .:::. . . : . .. . .: : .....:.. :.:.::: :: XP_005 PEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTF 170 180 190 200 210 220 260 270 280 290 300 pF1KE3 CGLAALVIL-KRERSLNLKSL---LQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLP ::.:.: .. : :. .. : : .: :: ..:..:: :: :: ::::: .. : XP_005 CGIASLCLMGKLEEVFSEKELNRIKRWCIMRQ---QNGYHGRPNKPVDTCYSFWVGATLK 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE3 LLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSG ::. ... :... ..::: . .::. : . : :. . . : XP_005 LLK-----------IFQYTNFEKN--RNYILSTQDRLVGGFAKWPDSHPDALHAYFGICG 290 300 310 320 370 380 390 400 410 420 pF1KE3 LSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFEELKDE ::. .. : XP_005 LSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVESYNQISC 330 340 350 360 370 380 >>XP_011541792 (OMIM: 602031) PREDICTED: geranylgeranyl (408 aa) initn: 320 init1: 132 opt: 337 Z-score: 409.9 bits: 84.9 E(85289): 4.3e-16 Smith-Waterman score: 392; 28.4% identity (55.6% similar) in 338 aa overlap (70-377:17-336) 40 50 60 70 80 90 pF1KE3 VETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDAS :: . :..: ....: :. : . : :..: XP_011 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETS 10 20 30 40 100 110 120 130 140 pF1KE3 RPWLCYWILHSLELLD--------EPIPQIVATDVCQFLELCQSPEGGFGGG-------- : . .. : .:..:: . : : . .: . . . :: :. XP_011 RLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFN 50 60 70 80 90 100 150 160 170 180 190 pF1KE3 PGQYP---------HLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFL-M :.. : :.: ::.... : :.: . . .:.: : : .:. :::: . XP_011 PSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSR--VNKEACLAGLRALQLEDGSFCAV 110 120 130 140 150 160 200 210 220 230 240 250 pF1KE3 HVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTF :.: :.: .:::. . . : . .. . .: : .....:.. :.:.::: :: XP_011 PEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTF 170 180 190 200 210 220 260 270 280 290 300 pF1KE3 CGLAALVIL-KRERSLNLKSL---LQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLP ::.:.: .. : :. .. : : .: :: ..:..:: :: :: ::::: .. : XP_011 CGIASLCLMGKLEEVFSEKELNRIKRWCIMRQ---QNGYHGRPNKPVDTCYSFWVGATLK 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE3 LLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSG ::. ... :... ..::: . .::. : . : :. . . : XP_011 LLK-----------IFQYTNFEKN--RNYILSTQDRLVGGFAKWPDSHPDALHAYFGICG 290 300 310 320 370 380 390 400 410 420 pF1KE3 LSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFEELKDE ::. .. : XP_011 LSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENKEFPGLKDLCFKNIGS 330 340 350 360 370 380 >>XP_011541794 (OMIM: 602031) PREDICTED: geranylgeranyl (285 aa) initn: 324 init1: 132 opt: 310 Z-score: 379.1 bits: 78.6 E(85289): 2.2e-14 Smith-Waterman score: 328; 30.9% identity (59.1% similar) in 230 aa overlap (153-377:2-213) 130 140 150 160 170 180 pF1KE3 ATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQYLY ::.... : :.: . . .:.: : : XP_011 MTYTGLSCLVILGDDLSR--VNKEACLAGLR 10 20 190 200 210 220 230 240 pF1KE3 SLKQPDGSFL-MHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGG .:. :::: . :.: :.: .:::. . . : . .. . .: : .....:.. XP_011 ALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQ 30 40 50 60 70 80 250 260 270 280 290 pF1KE3 VPGMEAHGGYTFCGLAALVIL-KRERSLNLKSL---LQWVTSRQMRFEGGFQGRCNKLVD :.:.::: ::::.:.: .. : :. .. : : .: :: ..:..:: :: :: XP_011 GAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQ---QNGYHGRPNKPVD 90 100 110 120 130 140 300 310 320 330 340 350 pF1KE3 GCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKS ::::: .. : ::. ... :... ..::: . .::. : . XP_011 TCYSFWVGATLKLLK-----------IFQYTNFEKN--RNYILSTQDRLVGGFAKWPDSH 150 160 170 180 190 360 370 380 390 400 410 pF1KE3 RDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQ : :. . . :::. .. : XP_011 PDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENKEFP 200 210 220 230 240 250 437 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 00:46:11 2016 done: Mon Nov 7 00:46:13 2016 Total Scan time: 8.800 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]