FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3931, 545 aa 1>>>pF1KE3931 545 - 545 aa - 545 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.7216+/-0.000319; mu= 9.6359+/- 0.020 mean_var=182.9767+/-37.271, 0's: 0 Z-trim(123.1): 227 B-trim: 1746 in 1/57 Lambda= 0.094815 statistics sampled from 41932 (42213) to 41932 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.792), E-opt: 0.2 (0.495), width: 16 Scan time: 12.760 The best scores are: opt bits E(85289) NP_291027 (OMIM: 610530) E3 ubiquitin-protein liga ( 630) 3738 523.4 7.9e-148 XP_006714992 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 543) 2791 393.8 7e-109 XP_006714995 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 520) 2788 393.4 9.1e-109 NP_963921 (OMIM: 610530) E3 ubiquitin-protein liga ( 518) 2772 391.2 4.1e-108 XP_006714993 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 541) 2772 391.2 4.2e-108 XP_006714994 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 525) 2767 390.5 6.7e-108 NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 869 130.9 9e-30 NP_976038 (OMIM: 609315) tripartite motif-containi ( 511) 780 118.7 4.3e-26 NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 666 103.1 2.2e-21 XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 450) 656 101.7 5e-21 XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 656 101.7 5.2e-21 XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 656 101.7 5.2e-21 NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 656 101.7 5.2e-21 NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 656 101.7 5.2e-21 XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 656 101.7 5.2e-21 NP_060543 (OMIM: 613184) E3 ubiquitin-protein liga ( 485) 653 101.3 7.1e-21 NP_006769 (OMIM: 605701) tripartite motif-containi ( 481) 619 96.7 1.8e-19 XP_011512523 (OMIM: 605701) PREDICTED: tripartite ( 499) 619 96.7 1.8e-19 XP_011512525 (OMIM: 605701) PREDICTED: tripartite ( 499) 619 96.7 1.8e-19 XP_011512524 (OMIM: 605701) PREDICTED: tripartite ( 499) 619 96.7 1.8e-19 NP_439893 (OMIM: 605701) tripartite motif-containi ( 395) 613 95.8 2.7e-19 XP_011512527 (OMIM: 605701) PREDICTED: tripartite ( 413) 613 95.8 2.8e-19 NP_006065 (OMIM: 606559) E3 ubiquitin-protein liga ( 498) 582 91.6 6e-18 NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 571 90.1 1.7e-17 NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 571 90.1 1.8e-17 NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 544 86.4 2.3e-16 NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468) 531 84.6 7.3e-16 XP_005249434 (OMIM: 600830) PREDICTED: tripartite ( 539) 532 84.8 7.3e-16 NP_003440 (OMIM: 600830) tripartite motif-containi ( 539) 532 84.8 7.3e-16 XP_006715243 (OMIM: 600830) PREDICTED: tripartite ( 539) 532 84.8 7.3e-16 XP_005249431 (OMIM: 600830) PREDICTED: tripartite ( 539) 532 84.8 7.3e-16 XP_005249435 (OMIM: 600830) PREDICTED: tripartite ( 539) 532 84.8 7.3e-16 XP_005249433 (OMIM: 600830) PREDICTED: tripartite ( 539) 532 84.8 7.3e-16 XP_005249432 (OMIM: 600830) PREDICTED: tripartite ( 539) 532 84.8 7.3e-16 NP_001229712 (OMIM: 600830) tripartite motif-conta ( 539) 532 84.8 7.3e-16 NP_001128327 (OMIM: 606123) E3 ubiquitin-protein l ( 343) 521 83.1 1.5e-15 NP_067629 (OMIM: 605684) tripartite motif-containi ( 488) 502 80.7 1.2e-14 NP_001003827 (OMIM: 605684) tripartite motif-conta ( 488) 502 80.7 1.2e-14 XP_005253240 (OMIM: 608487) PREDICTED: tripartite ( 493) 493 79.5 2.8e-14 NP_149023 (OMIM: 608487) tripartite motif-containi ( 493) 493 79.5 2.8e-14 XP_016856908 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 485 78.1 3.7e-14 XP_016856907 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 485 78.1 3.7e-14 NP_001186502 (OMIM: 606559) E3 ubiquitin-protein l ( 494) 488 78.8 4.5e-14 NP_001268380 (OMIM: 612548) E3 ubiquitin-protein l ( 487) 481 77.8 8.6e-14 NP_835226 (OMIM: 612548) E3 ubiquitin-protein liga ( 487) 481 77.8 8.6e-14 NP_976042 (OMIM: 609315) tripartite motif-containi ( 329) 475 76.8 1.1e-13 NP_001268379 (OMIM: 612548) E3 ubiquitin-protein l ( 486) 473 76.7 1.8e-13 XP_011514091 (OMIM: 612548) PREDICTED: E3 ubiquiti ( 486) 473 76.7 1.8e-13 NP_976039 (OMIM: 609315) tripartite motif-containi ( 303) 466 75.6 2.5e-13 NP_976040 (OMIM: 609315) tripartite motif-containi ( 303) 466 75.6 2.5e-13 >>NP_291027 (OMIM: 610530) E3 ubiquitin-protein ligase T (630 aa) initn: 3738 init1: 3738 opt: 3738 Z-score: 2775.0 bits: 523.4 E(85289): 7.9e-148 Smith-Waterman score: 3738; 100.0% identity (100.0% similar) in 545 aa overlap (1-545:86-630) 10 20 30 pF1KE3 MRDEDYEGDMEEEVEEEEEGVFWTSGMSRS :::::::::::::::::::::::::::::: NP_291 RDELDREEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRS 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE3 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_291 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE3 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_291 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE3 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_291 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE 240 250 260 270 280 290 220 230 240 250 260 270 pF1KE3 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_291 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE 300 310 320 330 340 350 280 290 300 310 320 330 pF1KE3 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_291 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD 360 370 380 390 400 410 340 350 360 370 380 390 pF1KE3 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_291 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV 420 430 440 450 460 470 400 410 420 430 440 450 pF1KE3 LGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_291 LGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRR 480 490 500 510 520 530 460 470 480 490 500 510 pF1KE3 RLHLPQQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_291 RLHLPQQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNA 540 550 560 570 580 590 520 530 540 pF1KE3 ETLAHVHTFSAAFLGERVFPFFRVLSKGTRIKLCP ::::::::::::::::::::::::::::::::::: NP_291 ETLAHVHTFSAAFLGERVFPFFRVLSKGTRIKLCP 600 610 620 630 >>XP_006714992 (OMIM: 610530) PREDICTED: E3 ubiquitin-pr (543 aa) initn: 2788 init1: 2788 opt: 2791 Z-score: 2075.7 bits: 393.8 E(85289): 7e-109 Smith-Waterman score: 2791; 93.7% identity (95.0% similar) in 443 aa overlap (1-443:86-527) 10 20 30 pF1KE3 MRDEDYEGDMEEEVEEEEEGVFWTSGMSRS :::::::::::::::::::::::::::::: XP_006 RDELDREEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRS 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE3 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE3 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE3 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE 240 250 260 270 280 290 220 230 240 250 260 270 pF1KE3 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE 300 310 320 330 340 350 280 290 300 310 320 330 pF1KE3 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD 360 370 380 390 400 410 340 350 360 370 380 390 pF1KE3 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV 420 430 440 450 460 470 400 410 420 430 440 450 pF1KE3 LGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRR :::::::::::::::: . .: : :.. .: :: . : :: XP_006 LGAQGFRSGRHYWEVEEPKEPSWP-PAQPSLTYYVCPTGLHGSLIMRTAAWSSLPVCLAQ 480 490 500 510 520 530 460 470 480 490 500 510 pF1KE3 RLHLPQQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNA XP_006 PWDWNLSRG 540 >>XP_006714995 (OMIM: 610530) PREDICTED: E3 ubiquitin-pr (520 aa) initn: 2783 init1: 2783 opt: 2788 Z-score: 2073.7 bits: 393.4 E(85289): 9.1e-109 Smith-Waterman score: 2788; 98.5% identity (99.0% similar) in 413 aa overlap (1-413:86-498) 10 20 30 pF1KE3 MRDEDYEGDMEEEVEEEEEGVFWTSGMSRS :::::::::::::::::::::::::::::: XP_006 RDELDREEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRS 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE3 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE3 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE3 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE 240 250 260 270 280 290 220 230 240 250 260 270 pF1KE3 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE 300 310 320 330 340 350 280 290 300 310 320 330 pF1KE3 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD 360 370 380 390 400 410 340 350 360 370 380 390 pF1KE3 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV 420 430 440 450 460 470 400 410 420 430 440 450 pF1KE3 LGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRR :::::::::::::::: . .: XP_006 LGAQGFRSGRHYWEVEEPKEPSWPPAQPSLTYYVCPTDRPEFSFT 480 490 500 510 520 >>NP_963921 (OMIM: 610530) E3 ubiquitin-protein ligase T (518 aa) initn: 2772 init1: 2772 opt: 2772 Z-score: 2061.9 bits: 391.2 E(85289): 4.1e-108 Smith-Waterman score: 2772; 100.0% identity (100.0% similar) in 404 aa overlap (1-404:86-489) 10 20 30 pF1KE3 MRDEDYEGDMEEEVEEEEEGVFWTSGMSRS :::::::::::::::::::::::::::::: NP_963 RDELDREEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRS 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE3 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE3 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE3 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE 240 250 260 270 280 290 220 230 240 250 260 270 pF1KE3 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE 300 310 320 330 340 350 280 290 300 310 320 330 pF1KE3 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD 360 370 380 390 400 410 340 350 360 370 380 390 pF1KE3 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_963 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV 420 430 440 450 460 470 400 410 420 430 440 450 pF1KE3 LGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRR :::::::::::::: NP_963 LGAQGFRSGRHYWEEPKEPSWPPAQPSLTYYVCPTDRPEFSFT 480 490 500 510 >>XP_006714993 (OMIM: 610530) PREDICTED: E3 ubiquitin-pr (541 aa) initn: 2772 init1: 2772 opt: 2772 Z-score: 2061.7 bits: 391.2 E(85289): 4.2e-108 Smith-Waterman score: 2772; 100.0% identity (100.0% similar) in 404 aa overlap (1-404:86-489) 10 20 30 pF1KE3 MRDEDYEGDMEEEVEEEEEGVFWTSGMSRS :::::::::::::::::::::::::::::: XP_006 RDELDREEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRS 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE3 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE3 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE3 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE 240 250 260 270 280 290 220 230 240 250 260 270 pF1KE3 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE 300 310 320 330 340 350 280 290 300 310 320 330 pF1KE3 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD 360 370 380 390 400 410 340 350 360 370 380 390 pF1KE3 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV 420 430 440 450 460 470 400 410 420 430 440 450 pF1KE3 LGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRR :::::::::::::: XP_006 LGAQGFRSGRHYWEEPKEPSWPPAQPSLTYYVCPTGLHGSLIMRTAAWSSLPVCLAQPWD 480 490 500 510 520 530 >>XP_006714994 (OMIM: 610530) PREDICTED: E3 ubiquitin-pr (525 aa) initn: 2869 init1: 2767 opt: 2767 Z-score: 2058.2 bits: 390.5 E(85289): 6.7e-108 Smith-Waterman score: 2767; 99.3% identity (99.8% similar) in 406 aa overlap (1-406:86-491) 10 20 30 pF1KE3 MRDEDYEGDMEEEVEEEEEGVFWTSGMSRS :::::::::::::::::::::::::::::: XP_006 RDELDREEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRS 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE3 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE3 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE3 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE 240 250 260 270 280 290 220 230 240 250 260 270 pF1KE3 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE 300 310 320 330 340 350 280 290 300 310 320 330 pF1KE3 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD 360 370 380 390 400 410 340 350 360 370 380 390 pF1KE3 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV 420 430 440 450 460 470 400 410 420 430 440 450 pF1KE3 LGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRR ::::::::::::: .. XP_006 LGAQGFRSGRHYWSLKNPPGLQLSLLSPTMSVQQTGQNLASLERDLEWSP 480 490 500 510 520 >>NP_742013 (OMIM: 605700) E3 ubiquitin-protein ligase T (488 aa) initn: 1011 init1: 472 opt: 869 Z-score: 655.4 bits: 130.9 E(85289): 9e-30 Smith-Waterman score: 999; 37.1% identity (65.6% similar) in 453 aa overlap (94-545:62-478) 70 80 90 100 110 120 pF1KE3 DEEDEEEVLEEVEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQLANMVQVI : : :: :::. ::.::: ::..::.. NP_742 CLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVEIA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE3 RQMHPTPGRGSRVTDQGICPKHQEALKLFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQ .:.. . .. :...::.:.:::.::: :.::.:..: :..:. :.::::....: NP_742 KQLQAVK---RKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQ 100 110 120 130 140 190 200 210 220 230 240 pF1KE3 EYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAVASEFGRLTRFLAEEQ ::: ::: .:::...:. . . :..::.. ::: ..:. . :: .: : : ::: NP_742 EYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRRLDEEQ 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE3 AGLERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQGGLRLLQDIKETFNR : ::.: .. : : :..:... .:..: ::.. . :.:...:.:.: :... NP_742 QVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEK 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE3 CEEVQLQPPEVWSPDPCQPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALMLSP ::.:. . : . . :. .::. ... .:.::::.:::: :.:: NP_742 CEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLI----ADVTLDPETAHPNLVLSE 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE3 DRRGVRLAERR-QEVADHPKRFSADCCVLGAQGFRSGRHYWEVEVGGRRGWAVGAAREST ::..:...: : ... : :.::. :::...:: ::::::::::: . ::::. :.:. NP_742 DRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSV 330 340 350 360 370 380 430 440 450 460 470 480 pF1KE3 HHKEKVGPGGSSVGSGDASSSRHHHRRRRLHLPQQPLLQREVWCVGTNGKRYQAQSSTEQ .: .. : ::. . ..: :: .: : ..: NP_742 SRKGELTP-----------------------LPETGYWRVRLW----NGDKY-AATTTPF 390 400 410 490 500 510 520 530 540 pF1KE3 TLLSPSEKPRRFGVYLDYEAGRLGFYNAETLAHVHTFSAAFLGERVFPFFRVLSKGTRIK : : . ::.: :..:::::: :.:::. .:..::. .: :...:.: .. : . NP_742 TPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFT-EKLWPLFYPGIRAGRKN 420 430 440 450 460 470 pF1KE3 LCP : NP_742 AAPLTIRPPTDWE 480 >>NP_976038 (OMIM: 609315) tripartite motif-containing p (511 aa) initn: 954 init1: 399 opt: 780 Z-score: 589.4 bits: 118.7 E(85289): 4.3e-26 Smith-Waterman score: 907; 36.6% identity (61.7% similar) in 475 aa overlap (87-545:72-511) 60 70 80 90 100 110 pF1KE3 EEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQL :: : : :::::. ..::: :: NP_976 VECGHSFCRACIGRCWERPGAGSVGAATRAPPFPLP-----CPQCREPARPSQLRPNRQL 50 60 70 80 90 120 130 140 150 160 pF1KE3 ANMVQVIRQMH-PT--PGR-GSRVTDQGI----CPKHQEALKLFCEVDEEAICVVCRESR : .. ..:.. :. ::. ::... : .: : .::.:. : .:::::: ..: NP_976 AAVATLLRRFSLPAAAPGEHGSQAAAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAR 100 110 120 130 140 150 170 180 190 200 210 220 pF1KE3 SHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAV :..:.:.::.:.::: : :..... :.:.:: . ... :... :: .:: .: : NP_976 EHREHAVLPLDEAVQEAKELLESRLRVLKKELEDCEVFRSTEKKESKELLKQMAAEQEKV 160 170 180 190 200 210 230 240 250 260 270 280 pF1KE3 ASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQ ..:: : ::.:... : ::.:. . . . ..:. . .:::.: .. :: .:. NP_976 GAEFQALRAFLVEQEGRLLGRLEELSREVAQKQNENLAQLGVEITQLSKLSSQIQETAQK 220 230 240 250 260 270 290 300 310 320 330 340 pF1KE3 GGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTDAIVRKMSRMFCQAAR--- : .::..: :..:: .: : . : . . . : ... : . : . : NP_976 PDLDFLQEFKSTLSRCSNVPGPKPTTVSSEMKNKVWNVSLKTFVLKGMLKKFKEDLRGEL 280 290 300 310 320 330 350 360 370 380 390 400 pF1KE3 -----VDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCVLGAQGFRSGR :.::::::::.: :.:: : .::::.:: :.. .:: ::... ::.. :: ::: NP_976 EKEEKVELTLDPDTANPRLILSLDLKGVRLGERAQDLPNHPCRFDTNTRVLASCGFSSGR 340 350 360 370 380 390 410 420 430 440 450 460 pF1KE3 HYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRRRLHLPQQPLL :.::::::.. ::: :.::::. ::. : : NP_976 HHWEVEVGSKDGWAFGVARESV--------------------------RRKGLTPFTP-- 400 410 420 470 480 490 500 510 520 pF1KE3 QREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNAETLAHVHTFS .. :: . :: .: : .: :.. :: .. : : :: :.: ..:: .: . :..:: NP_976 EEGVWALQLNGGQYWAVTSPERSPLSCGHLSR-VRVALDLEVGAVSFYAVEDMRHLYTFR 430 440 450 460 470 480 530 540 pF1KE3 AAFLGERVFPFFRVLSKGTRIKLCP . : :::::.: : : :: ... : NP_976 VNFQ-ERVFPLFSVCSTGTYLRIWP 490 500 510 >>NP_067076 (OMIM: 605700) E3 ubiquitin-protein ligase T (518 aa) initn: 984 init1: 445 opt: 666 Z-score: 505.0 bits: 103.1 E(85289): 2.2e-21 Smith-Waterman score: 940; 35.2% identity (61.5% similar) in 483 aa overlap (94-545:62-508) 70 80 90 100 110 120 pF1KE3 DEEDEEEVLEEVEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQLANMVQVI : : :: :::. ::.::: ::..::.. NP_067 CLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVEIA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE3 RQMHPTPGRGSRVTDQGICPKHQEALKLFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQ .:.. . .. :...::.:.:::.::: :.::.:..: :..:. :.::::....: NP_067 KQLQAVK---RKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQ 100 110 120 130 140 190 200 210 220 230 240 pF1KE3 EYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAVASEFGRLTRFLAEEQ ::: ::: .:::...:. . . :..::.. ::: ..:. . :: .: : : ::: NP_067 EYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRRLDEEQ 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE3 AGLERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQGGLRLLQDIKETF-- : ::.: .. : : :..:... .:..: ::.. . :.:...:.:.: :. NP_067 QVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEK 210 220 230 240 250 260 310 320 330 pF1KE3 ----------------------------NRCEEVQLQPPEVWSPDPCQPHSHDFLTDAIV ::::.:. . : . . :. . NP_067 NIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELEKNFSNFPRQYFAL 270 280 290 300 310 320 340 350 360 370 380 390 pF1KE3 RKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERR-QEVADHPKRFSADCCVLG ::. ... .:.::::.:::: :.:: ::..:...: : ... : :.::. :::. NP_067 RKILKQLI----ADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLA 330 340 350 360 370 380 400 410 420 430 440 450 pF1KE3 AQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRRRL ..:: ::::::::::: . ::::. :.:. .: .. : NP_067 TEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTP---------------------- 390 400 410 420 460 470 480 490 500 510 pF1KE3 HLPQQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNAET ::. . ..: :: .: : ..: : : . ::.: :..:::::: :.:::. NP_067 -LPETGYWRVRLW----NGDKY-AATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTD 430 440 450 460 470 520 530 540 pF1KE3 LAHVHTFSAAFLGERVFPFFRVLSKGTRIKLCP .:..::. .: :...:.: .. : . : NP_067 RSHIYTFTDTFT-EKLWPLFYPGIRAGRKNAAPLTIRPPTDWE 480 490 500 510 >>XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (450 aa) initn: 679 init1: 405 opt: 656 Z-score: 498.4 bits: 101.7 E(85289): 5e-21 Smith-Waterman score: 735; 32.9% identity (60.8% similar) in 441 aa overlap (96-532:33-429) 70 80 90 100 110 120 pF1KE3 EDEEEVLEEVEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQ : ::.::. :.:.. :: :...... .: XP_011 TCGHNFCRACIQLSWEKARGKKGRRKRKGSFPCPECREMSPQRNLLPNRLLTKVAEMAQQ 10 20 30 40 50 60 130 140 150 160 170 180 pF1KE3 MHPTPGRGSRVTDQGICPKHQEALKLFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEY :: : . : .: .:.: :::::. :. ::::::::: :. : :.: ::.:: : XP_011 -HP--G----LQKQDLCQEHHEPLKLFCQKDQSPICVVCRESREHRLHRVLPAEEAVQGY 70 80 90 100 110 190 200 210 220 230 240 pF1KE3 KAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAG : ::. .: ::... . ...:.::. ..: ....: . .. :: ... .:.::. XP_011 KLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVKERRERIVLEFEKMNLYLVEEEQR 120 130 140 150 160 170 250 260 270 280 290 300 pF1KE3 LERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCE : . :. .: .: ... : .:. .: :: . .::: :: :..:::.:: ..: . XP_011 LLQALETEEEETASRLRESVACLDRQGHSLELLLLQLEERSTQGPLQMLQDMKEPLSRKN 180 190 200 210 220 230 310 320 330 340 350 360 pF1KE3 EVQLQPPEVWSPDPCQPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDR .:..: ::: .: : .:.. . : .. : : . :.. : .:.: :.: .: XP_011 NVSVQCPEV-AP-PTRPRTVCRVPGQI--EVLRGFLE----DVVPDATSAYPYLLLYESR 240 250 260 270 280 370 380 390 400 410 420 pF1KE3 RGVRLAERRQEVADHPK-RFSADCCVLGAQGFRSGRHYWEV--EVGGRRGWAVGAAREST . :. . . : :: : :..: .: :::::::: .. : ::.:. :... XP_011 QRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMNITGDALWALGVCRDNV 290 300 310 320 330 340 430 440 450 460 470 480 pF1KE3 HHKEKVGPGGSSVGSGDASSSRHHHRRRRLHLPQQPLLQREVWCVG-TNGKRYQAQSSTE .:..: :. : . : : ..: .: . :. XP_011 SRKDRV--------------------------PKCP--ENGFWVVQLSKGTKYLSTFSAL 350 360 370 490 500 510 520 530 540 pF1KE3 QTLLSPSEKPRRFGVYLDYEAGRLGFYNAETLAHVHTFSAAFLGERVFPFFRVLSKGTRI .. : : ..:..::.:::...::.. .:.::.: : . . ::: XP_011 TPVML-MEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQ 380 390 400 410 420 430 pF1KE3 KLCP XP_011 MVISTVTMWVKG 440 450 545 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:46:25 2016 done: Sun Nov 6 01:46:27 2016 Total Scan time: 12.760 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]