FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2285, 166 aa 1>>>pF1KE2285 166 - 166 aa - 166 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0958+/-0.000359; mu= 13.4653+/- 0.022 mean_var=64.1132+/-12.484, 0's: 0 Z-trim(113.2): 16 B-trim: 0 in 0/52 Lambda= 0.160177 statistics sampled from 22473 (22489) to 22473 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.667), E-opt: 0.2 (0.264), width: 16 Scan time: 4.970 The best scores are: opt bits E(85289) NP_005498 (OMIM: 601442) cofilin-1 [Homo sapiens] ( 166) 1069 255.4 3.1e-68 NP_619579 (OMIM: 601443,610687) cofilin-2 isoform ( 166) 884 212.7 2.3e-55 NP_068733 (OMIM: 601443,610687) cofilin-2 isoform ( 166) 884 212.7 2.3e-55 XP_011534665 (OMIM: 601443,610687) PREDICTED: cofi ( 149) 799 193.0 1.7e-49 NP_001230574 (OMIM: 601443,610687) cofilin-2 isofo ( 149) 799 193.0 1.7e-49 NP_006861 (OMIM: 609114) destrin isoform a [Homo s ( 165) 780 188.6 3.9e-48 XP_011527444 (OMIM: 609114) PREDICTED: destrin iso ( 165) 780 188.6 3.9e-48 XP_011527445 (OMIM: 609114) PREDICTED: destrin iso ( 165) 780 188.6 3.9e-48 NP_001011546 (OMIM: 609114) destrin isoform b [Hom ( 148) 716 173.8 1e-43 XP_011527446 (OMIM: 609114) PREDICTED: destrin iso ( 148) 716 173.8 1e-43 NP_002813 (OMIM: 610932) twinfilin-1 isoform 2 [Ho ( 350) 152 43.7 0.00035 NP_001229326 (OMIM: 610932) twinfilin-1 isoform 1 ( 357) 152 43.7 0.00035 NP_009215 (OMIM: 607433) twinfilin-2 [Homo sapiens ( 349) 134 39.5 0.0062 >>NP_005498 (OMIM: 601442) cofilin-1 [Homo sapiens] (166 aa) initn: 1069 init1: 1069 opt: 1069 Z-score: 1346.1 bits: 255.4 E(85289): 3.1e-68 Smith-Waterman score: 1069; 100.0% identity (100.0% similar) in 166 aa overlap (1-166:1-166) 10 20 30 40 50 60 pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS 70 80 90 100 110 120 130 140 150 160 pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL :::::::::::::::::::::::::::::::::::::::::::::: NP_005 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL 130 140 150 160 >>NP_619579 (OMIM: 601443,610687) cofilin-2 isoform 1 [H (166 aa) initn: 884 init1: 884 opt: 884 Z-score: 1115.1 bits: 212.7 E(85289): 2.3e-55 Smith-Waterman score: 884; 80.7% identity (95.8% similar) in 166 aa overlap (1-166:1-166) 10 20 30 40 50 60 pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV :::::.:.: ::::::::::::::: ::.::::::::::::.::..::.::.:.:::::. NP_619 MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS :.::.:::..:::.:: .:::::::::::::::::::::::::::::::::::::::::: NP_619 GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS 70 80 90 100 110 120 130 140 150 160 pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL :::::::.:::::: :.: ...::: ::.:::::..:.::::::: NP_619 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL 130 140 150 160 >>NP_068733 (OMIM: 601443,610687) cofilin-2 isoform 1 [H (166 aa) initn: 884 init1: 884 opt: 884 Z-score: 1115.1 bits: 212.7 E(85289): 2.3e-55 Smith-Waterman score: 884; 80.7% identity (95.8% similar) in 166 aa overlap (1-166:1-166) 10 20 30 40 50 60 pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV :::::.:.: ::::::::::::::: ::.::::::::::::.::..::.::.:.:::::. NP_068 MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS :.::.:::..:::.:: .:::::::::::::::::::::::::::::::::::::::::: NP_068 GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS 70 80 90 100 110 120 130 140 150 160 pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL :::::::.:::::: :.: ...::: ::.:::::..:.::::::: NP_068 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL 130 140 150 160 >>XP_011534665 (OMIM: 601443,610687) PREDICTED: cofilin- (149 aa) initn: 799 init1: 799 opt: 799 Z-score: 1009.6 bits: 193.0 E(85289): 1.7e-49 Smith-Waterman score: 799; 80.5% identity (96.0% similar) in 149 aa overlap (18-166:1-149) 10 20 30 40 50 60 pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV :::::::: ::.::::::::::::.::..::.::.:.:::::. XP_011 MKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI 10 20 30 40 70 80 90 100 110 120 pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS :.::.:::..:::.:: .:::::::::::::::::::::::::::::::::::::::::: XP_011 GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS 50 60 70 80 90 100 130 140 150 160 pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL :::::::.:::::: :.: ...::: ::.:::::..:.::::::: XP_011 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL 110 120 130 140 >>NP_001230574 (OMIM: 601443,610687) cofilin-2 isoform 2 (149 aa) initn: 799 init1: 799 opt: 799 Z-score: 1009.6 bits: 193.0 E(85289): 1.7e-49 Smith-Waterman score: 799; 80.5% identity (96.0% similar) in 149 aa overlap (18-166:1-149) 10 20 30 40 50 60 pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV :::::::: ::.::::::::::::.::..::.::.:.:::::. NP_001 MKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI 10 20 30 40 70 80 90 100 110 120 pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS :.::.:::..:::.:: .:::::::::::::::::::::::::::::::::::::::::: NP_001 GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS 50 60 70 80 90 100 130 140 150 160 pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL :::::::.:::::: :.: ...::: ::.:::::..:.::::::: NP_001 KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL 110 120 130 140 >>NP_006861 (OMIM: 609114) destrin isoform a [Homo sapie (165 aa) initn: 773 init1: 705 opt: 780 Z-score: 985.2 bits: 188.6 E(85289): 3.9e-48 Smith-Waterman score: 780; 71.1% identity (86.7% similar) in 166 aa overlap (1-166:1-165) 10 20 30 40 50 60 pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV ::::: :.: : ..: :::::: :::::.:::::::.:::: ::: ::.::::::::::: NP_006 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS : :. ::. :: :::.::::::::::..:::::.::.:.:..:::: :::::::::::: NP_006 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS 70 80 90 100 110 120 130 140 150 160 pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL :::::::. ::::: ::: :... : .::::::: ....:: :. NP_006 KDAIKKKFQGIKHECQANGPEDLNRAC-IAEKLGGSLIVAFEGCPV 130 140 150 160 >>XP_011527444 (OMIM: 609114) PREDICTED: destrin isoform (165 aa) initn: 773 init1: 705 opt: 780 Z-score: 985.2 bits: 188.6 E(85289): 3.9e-48 Smith-Waterman score: 780; 71.1% identity (86.7% similar) in 166 aa overlap (1-166:1-165) 10 20 30 40 50 60 pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV ::::: :.: : ..: :::::: :::::.:::::::.:::: ::: ::.::::::::::: XP_011 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS : :. ::. :: :::.::::::::::..:::::.::.:.:..:::: :::::::::::: XP_011 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS 70 80 90 100 110 120 130 140 150 160 pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL :::::::. ::::: ::: :... : .::::::: ....:: :. XP_011 KDAIKKKFQGIKHECQANGPEDLNRAC-IAEKLGGSLIVAFEGCPV 130 140 150 160 >>XP_011527445 (OMIM: 609114) PREDICTED: destrin isoform (165 aa) initn: 773 init1: 705 opt: 780 Z-score: 985.2 bits: 188.6 E(85289): 3.9e-48 Smith-Waterman score: 780; 71.1% identity (86.7% similar) in 166 aa overlap (1-166:1-165) 10 20 30 40 50 60 pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV ::::: :.: : ..: :::::: :::::.:::::::.:::: ::: ::.::::::::::: XP_011 MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS : :. ::. :: :::.::::::::::..:::::.::.:.:..:::: :::::::::::: XP_011 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS 70 80 90 100 110 120 130 140 150 160 pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL :::::::. ::::: ::: :... : .::::::: ....:: :. XP_011 KDAIKKKFQGIKHECQANGPEDLNRAC-IAEKLGGSLIVAFEGCPV 130 140 150 160 >>NP_001011546 (OMIM: 609114) destrin isoform b [Homo sa (148 aa) initn: 709 init1: 641 opt: 716 Z-score: 906.0 bits: 173.8 E(85289): 1e-43 Smith-Waterman score: 716; 72.5% identity (87.9% similar) in 149 aa overlap (18-166:1-148) 10 20 30 40 50 60 pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV ::::: :::::.:::::::.:::: ::: ::.::::::::::: NP_001 MKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV 10 20 30 40 70 80 90 100 110 120 pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS : :. ::. :: :::.::::::::::..:::::.::.:.:..:::: :::::::::::: NP_001 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS 50 60 70 80 90 100 130 140 150 160 pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL :::::::. ::::: ::: :... : .::::::: ....:: :. NP_001 KDAIKKKFQGIKHECQANGPEDLNRAC-IAEKLGGSLIVAFEGCPV 110 120 130 140 >>XP_011527446 (OMIM: 609114) PREDICTED: destrin isoform (148 aa) initn: 709 init1: 641 opt: 716 Z-score: 906.0 bits: 173.8 E(85289): 1e-43 Smith-Waterman score: 716; 72.5% identity (87.9% similar) in 149 aa overlap (18-166:1-148) 10 20 30 40 50 60 pF1KE2 MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV ::::: :::::.:::::::.:::: ::: ::.::::::::::: XP_011 MKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDV 10 20 30 40 70 80 90 100 110 120 pF1KE2 GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS : :. ::. :: :::.::::::::::..:::::.::.:.:..:::: :::::::::::: XP_011 GVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASS 50 60 70 80 90 100 130 140 150 160 pF1KE2 KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL :::::::. ::::: ::: :... : .::::::: ....:: :. XP_011 KDAIKKKFQGIKHECQANGPEDLNRAC-IAEKLGGSLIVAFEGCPV 110 120 130 140 166 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 00:56:11 2016 done: Mon Nov 7 00:56:12 2016 Total Scan time: 4.970 Total Display time: -0.040 Function used was FASTA [36.3.4 Apr, 2011]