FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3587, 238 aa 1>>>pF1KE3587 238 - 238 aa - 238 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4311+/-0.000271; mu= 15.2154+/- 0.017 mean_var=84.7627+/-17.092, 0's: 0 Z-trim(120.8): 19 B-trim: 80 in 2/47 Lambda= 0.139307 statistics sampled from 36485 (36508) to 36485 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.763), E-opt: 0.2 (0.428), width: 16 Scan time: 6.660 The best scores are: opt bits E(85289) NP_004943 (OMIM: 601381) ephrin-A3 precursor [Homo ( 238) 1669 344.2 1.1e-94 NP_001396 (OMIM: 602756) ephrin-A2 precursor [Homo ( 213) 561 121.5 1.1e-27 XP_006714628 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 201) 545 118.3 1e-26 NP_001953 (OMIM: 601535) ephrin-A5 precursor [Homo ( 228) 541 117.5 1.9e-26 NP_004419 (OMIM: 191164) ephrin-A1 isoform a precu ( 205) 495 108.2 1.1e-23 XP_016881939 (OMIM: 602756) PREDICTED: ephrin-A2 i ( 202) 477 104.6 1.3e-22 XP_016881938 (OMIM: 602756) PREDICTED: ephrin-A2 i ( 298) 477 104.8 1.8e-22 XP_011541552 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 210) 453 99.8 3.8e-21 NP_872626 (OMIM: 191164) ephrin-A1 isoform b precu ( 183) 437 96.6 3.2e-20 NP_005218 (OMIM: 601380) ephrin-A4 isoform a precu ( 201) 333 75.7 6.7e-14 NP_872632 (OMIM: 601380) ephrin-A4 isoform c precu ( 193) 332 75.5 7.5e-14 XP_011541553 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 148) 328 74.6 1.1e-13 XP_016864694 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 148) 328 74.6 1.1e-13 NP_872631 (OMIM: 601380) ephrin-A4 isoform b precu ( 207) 324 73.9 2.4e-13 NP_001397 (OMIM: 602297) ephrin-B3 precursor [Homo ( 340) 220 53.2 6.9e-07 >>NP_004943 (OMIM: 601381) ephrin-A3 precursor [Homo sap (238 aa) initn: 1669 init1: 1669 opt: 1669 Z-score: 1820.6 bits: 344.2 E(85289): 1.1e-94 Smith-Waterman score: 1669; 100.0% identity (100.0% similar) in 238 aa overlap (1-238:1-238) 10 20 30 40 50 60 pF1KE3 MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 IYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNASQGFKRWECNRPHAPHSPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 IYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNASQGFKRWECNRPHAPHSPI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVPT 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 LPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFLAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFLAS 190 200 210 220 230 >>NP_001396 (OMIM: 602756) ephrin-A2 precursor [Homo sap (213 aa) initn: 478 init1: 266 opt: 561 Z-score: 617.8 bits: 121.5 E(85289): 1.1e-27 Smith-Waterman score: 561; 53.4% identity (71.3% similar) in 174 aa overlap (2-165:4-170) 10 20 30 40 50 pF1KE3 MAAAPLL-LLLLLVPVPLLPLL-AQGPGGALGNRHAVYWNSSNQHLRRE------GYT : ::: :::::.:.: :. :. . : ..:.::::: :: ... ::: NP_001 MAPAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYT 10 20 30 40 50 60 60 70 80 90 100 pF1KE3 VQVNVNDYLDIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNASQ-GFKRWE :.:..::::::::::: :: :. :.::::::. .:. .:. : :::::: NP_001 VEVSINDYLDIYCPHY-------GAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWE 70 80 90 100 110 110 120 130 140 150 160 pF1KE3 CNRPHAPHSPIKFSEKFQRYSAFSLGYEFHAGHEYYYIS-TPTHNLHWKCLRMKVFVCCA :::: :: .:.::::::: .. ::::.::. :::::::: :: . . :::.::.: NP_001 CNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPT 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE3 STSHSGEKPVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGI NP_001 NETLYEAPEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS 180 190 200 210 >>XP_006714628 (OMIM: 601535) PREDICTED: ephrin-A5 isofo (201 aa) initn: 521 init1: 258 opt: 545 Z-score: 600.8 bits: 118.3 E(85289): 1e-26 Smith-Waterman score: 545; 47.7% identity (74.7% similar) in 174 aa overlap (8-177:6-171) 10 20 30 40 50 pF1KE3 MAAAPLLLLLLLVPVPLLPLLAQGPGG-ALGNRHAVYWNSSNQHLRREGYTVQVNVNDYL .: :. : . ...: ::. :...:.:::::::: ...: : ..: .:::: XP_006 MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYL 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 DIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCN-ASQGFKRWECNRPHAPHS :..::::..: : .:.::::::. .:: .:. .:.:::::::::::.:.. XP_006 DVFCPHYEDSV--------PEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 PIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPT-HNLHWKCLRMKVFVC-CASTSHSGEK :.::::::: .. ::::.::. :.::.:::. : . .::..:::: .: : . . XP_006 PLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNDTVHESAE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 PVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFL : XP_006 PSRGENAAQTPRIPSRLLAILLFLLAMLLTL 180 190 200 >>NP_001953 (OMIM: 601535) ephrin-A5 precursor [Homo sap (228 aa) initn: 521 init1: 258 opt: 541 Z-score: 595.7 bits: 117.5 E(85289): 1.9e-26 Smith-Waterman score: 541; 49.7% identity (77.0% similar) in 161 aa overlap (8-165:6-158) 10 20 30 40 50 pF1KE3 MAAAPLLLLLLLVPVPLLPLLAQGPGG-ALGNRHAVYWNSSNQHLRREGYTVQVNVNDYL .: :. : . ...: ::. :...:.:::::::: ...: : ..: .:::: NP_001 MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYL 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 DIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCN-ASQGFKRWECNRPHAPHS :..::::..: : .:.::::::. .:: .:. .:.:::::::::::.:.. NP_001 DVFCPHYEDSV--------PEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 PIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPT-HNLHWKCLRMKVFVCCASTSHSGEKP :.::::::: .. ::::.::. :.::.:::. : . .::..:::: NP_001 PLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 VPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFLA NP_001 HDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL 180 190 200 210 220 >>NP_004419 (OMIM: 191164) ephrin-A1 isoform a precursor (205 aa) initn: 503 init1: 271 opt: 495 Z-score: 546.3 bits: 108.2 E(85289): 1.1e-23 Smith-Waterman score: 504; 40.3% identity (66.1% similar) in 221 aa overlap (19-238:7-204) 10 20 30 40 50 60 pF1KE3 MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLD :::. . : ..::.:.::::: ..: : ::..:..:::.: NP_004 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVD 10 20 30 40 70 80 90 100 110 pF1KE3 IYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNA-SQGFKRWECNRPHAPHSP : ::::.. .:. .: :::.::.: .. :. :. :. ::.:::: : :.: NP_004 IICPHYEDHSVADAA-------MEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGP 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE3 IKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVP :.::::::.. :.:: ::. :: ::::: : :. . .:::.:: : .. .:: NP_004 EKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHEDRCLRLKVTVS-GKITHS------ 110 120 130 140 150 180 190 200 210 220 230 pF1KE3 TLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFLAS :: .:. : . ...:.: .. .:: : : . .::: . .. . .: . NP_004 --PQAHDNPQEK-----RLAADDPEV-RVLHSI-GHSAAPRLFPLAWTVLLLPLLLLQTP 160 170 180 190 200 >>XP_016881939 (OMIM: 602756) PREDICTED: ephrin-A2 isofo (202 aa) initn: 434 init1: 262 opt: 477 Z-score: 526.9 bits: 104.6 E(85289): 1.3e-22 Smith-Waterman score: 477; 59.2% identity (75.8% similar) in 120 aa overlap (48-165:47-159) 20 30 40 50 60 70 pF1KE3 LPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLDIYCPHYNSSGVGPGAGP ::::.:..::::::::::: :: XP_016 RFGTRASGLVRLRIALEPGRFHAGAGDDGGGYTVEVSINDYLDIYCPHY-------GAPL 20 30 40 50 60 80 90 100 110 120 130 pF1KE3 GPGGGAEQYVLYMVSRNGYRTCNASQ-GFKRWECNRPHAPHSPIKFSEKFQRYSAFSLGY :. :.::::::. .:. .:. : :::::::::: :: .:.::::::: .. ::::. XP_016 PPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGF 70 80 90 100 110 120 140 150 160 170 180 190 pF1KE3 EFHAGHEYYYIS-TPTHNLHWKCLRMKVFVCCASTSHSGEKPVPTLPQFTMGPNVKINVL ::. :::::::: :: . . :::.::.: XP_016 EFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSPGGCRLF 130 140 150 160 170 180 >>XP_016881938 (OMIM: 602756) PREDICTED: ephrin-A2 isofo (298 aa) initn: 434 init1: 262 opt: 477 Z-score: 524.6 bits: 104.8 E(85289): 1.8e-22 Smith-Waterman score: 477; 59.2% identity (75.8% similar) in 120 aa overlap (48-165:143-255) 20 30 40 50 60 70 pF1KE3 LPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLDIYCPHYNSSGVGPGAGP ::::.:..::::::::::: :: XP_016 RFGTRASGLVRLRIALEPGRFHAGAGDDGGGYTVEVSINDYLDIYCPHY-------GAPL 120 130 140 150 160 80 90 100 110 120 130 pF1KE3 GPGGGAEQYVLYMVSRNGYRTCNASQ-GFKRWECNRPHAPHSPIKFSEKFQRYSAFSLGY :. :.::::::. .:. .:. : :::::::::: :: .:.::::::: .. ::::. XP_016 PPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGF 170 180 190 200 210 220 140 150 160 170 180 190 pF1KE3 EFHAGHEYYYIS-TPTHNLHWKCLRMKVFVCCASTSHSGEKPVPTLPQFTMGPNVKINVL ::. :::::::: :: . . :::.::.: XP_016 EFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSPGGCRLF 230 240 250 260 270 280 >>XP_011541552 (OMIM: 601535) PREDICTED: ephrin-A5 isofo (210 aa) initn: 443 init1: 258 opt: 453 Z-score: 500.6 bits: 99.8 E(85289): 3.8e-21 Smith-Waterman score: 453; 48.2% identity (75.5% similar) in 139 aa overlap (32-165:10-140) 10 20 30 40 50 pF1KE3 AAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQ---HLRREGYTVQVNVNDY : ... :...: ..: : ..: .::: XP_011 MQTLEPACFRFSLHTNTNKQCTLGFQRGDYHIDVCINDY 10 20 30 60 70 80 90 100 110 pF1KE3 LDIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCN-ASQGFKRWECNRPHAPH ::..::::..: : .:.::::::. .:: .:. .:.:::::::::::.:. XP_011 LDVFCPHYEDSV--------PEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPN 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE3 SPIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPT-HNLHWKCLRMKVFVCCASTSHSGEK .:.::::::: .. ::::.::. :.::.:::. : . .::..:::: XP_011 GPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIG 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE3 PVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFL XP_011 VHDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL 160 170 180 190 200 210 >>NP_872626 (OMIM: 191164) ephrin-A1 isoform b precursor (183 aa) initn: 448 init1: 216 opt: 437 Z-score: 484.0 bits: 96.6 E(85289): 3.2e-20 Smith-Waterman score: 437; 49.6% identity (74.0% similar) in 131 aa overlap (19-148:7-130) 10 20 30 40 50 60 pF1KE3 MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLD :::. . : ..::.:.::::: ..: : ::..:..:::.: NP_872 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVD 10 20 30 40 70 80 90 100 110 pF1KE3 IYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNA-SQGFKRWECNRPHAPHSP : ::::.. .:. .: :::.::.: .. :. :. :. ::.:::: : :.: NP_872 IICPHYEDHSVADAA-------MEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGP 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE3 IKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVP :.::::::.. :.:: ::. :: ::::: NP_872 EKLSEKFQRFTPFTLGKEFKEGHSYYYISHSPQAHDNPQEKRLAADDPEVRVLHSIGHSA 110 120 130 140 150 160 >>NP_005218 (OMIM: 601380) ephrin-A4 isoform a precursor (201 aa) initn: 378 init1: 218 opt: 333 Z-score: 370.5 bits: 75.7 E(85289): 6.7e-14 Smith-Waterman score: 474; 45.1% identity (67.6% similar) in 173 aa overlap (8-178:3-164) 10 20 30 40 50 60 pF1KE3 MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLD :: :: : .:.. :. . ::.::::::: .: : .:....::::: NP_005 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLD 10 20 30 40 50 70 80 90 100 110 pF1KE3 IYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNAS--QGFKRWECNRPHAPHS : ::::. :::: : : ..::::. ::..:.: ...::: :. : . : NP_005 IVCPHYE--------GPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPFG-H- 60 70 80 90 100 120 130 140 150 160 170 pF1KE3 PIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPV ..::::.::.. ::::.:: :. :::::.:: . .:::..: ::: . . .:: NP_005 -VQFSEKIQRFTPFSLGFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERKSESAHPV 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE3 PTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFLAS NP_005 GSPGESGTSGWRGGDTPSPLCLLLLLLLLILRLLRIL 170 180 190 200 238 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 01:00:24 2016 done: Mon Nov 7 01:00:25 2016 Total Scan time: 6.660 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]