FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9530, 415 aa 1>>>pF1KE9530 415 - 415 aa - 415 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3382+/-0.000447; mu= 17.0106+/- 0.028 mean_var=95.7905+/-23.193, 0's: 0 Z-trim(111.4): 663 B-trim: 2100 in 2/50 Lambda= 0.131043 statistics sampled from 19206 (20000) to 19206 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.594), E-opt: 0.2 (0.234), width: 16 Scan time: 8.500 The best scores are: opt bits E(85289) NP_064552 (OMIM: 605108) neuromedin-U receptor 2 [ ( 415) 2776 535.8 7.3e-152 XP_011535972 (OMIM: 605108) PREDICTED: neuromedin- ( 321) 2075 403.2 4.8e-112 XP_011508791 (OMIM: 604153) PREDICTED: neuromedin- ( 313) 883 177.8 3.2e-44 XP_006712259 (OMIM: 604153) PREDICTED: neuromedin- ( 333) 883 177.9 3.4e-44 XP_006712258 (OMIM: 604153) PREDICTED: neuromedin- ( 370) 883 177.9 3.7e-44 XP_011508790 (OMIM: 604153) PREDICTED: neuromedin- ( 376) 883 177.9 3.7e-44 XP_011508789 (OMIM: 604153) PREDICTED: neuromedin- ( 403) 883 177.9 3.9e-44 NP_006047 (OMIM: 604153) neuromedin-U receptor 1 [ ( 426) 883 178.0 4e-44 NP_940799 (OMIM: 601898) growth hormone secretagog ( 366) 578 120.2 8.3e-27 NP_001718 (OMIM: 300107) bombesin receptor subtype ( 399) 454 96.8 1e-19 NP_937822 (OMIM: 606925) pyroglutamylated RFamide ( 431) 449 95.9 2e-19 NP_001498 (OMIM: 602885) motilin receptor [Homo sa ( 412) 429 92.1 2.7e-18 XP_011527129 (OMIM: 162651) PREDICTED: neurotensin ( 336) 427 91.7 3.1e-18 NP_002522 (OMIM: 162651) neurotensin receptor type ( 418) 427 91.7 3.6e-18 NP_002502 (OMIM: 162341) neuromedin-B receptor iso ( 390) 414 89.3 1.9e-17 NP_001048 (OMIM: 162321) substance-K receptor [Hom ( 398) 414 89.3 1.9e-17 NP_000903 (OMIM: 165196) kappa-type opioid recepto ( 380) 412 88.9 2.4e-17 NP_001305426 (OMIM: 165196) kappa-type opioid rece ( 409) 412 88.9 2.5e-17 NP_005305 (OMIM: 305670) gastrin-releasing peptide ( 384) 411 88.7 2.7e-17 NP_057624 (OMIM: 605569) probable G-protein couple ( 423) 407 88.0 4.9e-17 NP_001049 (OMIM: 162323) substance-P receptor isof ( 407) 402 87.0 9.2e-17 NP_001035269 (OMIM: 606111) melanin-concentrating ( 340) 394 85.4 2.3e-16 NP_115892 (OMIM: 606111) melanin-concentrating hor ( 340) 394 85.4 2.3e-16 NP_071429 (OMIM: 607448) neuropeptide FF receptor ( 430) 389 84.6 5.3e-16 NP_004239 (OMIM: 600895) prolactin-releasing pepti ( 370) 388 84.3 5.4e-16 NP_056542 (OMIM: 162323) substance-P receptor isof ( 311) 384 83.5 8.1e-16 NP_000106 (OMIM: 131244,277580,600155,600501) endo ( 442) 384 83.6 1e-15 NP_001116131 (OMIM: 131244,277580,600155,600501) e ( 442) 384 83.6 1e-15 NP_000900 (OMIM: 162641) neuropeptide Y receptor t ( 384) 383 83.4 1.1e-15 XP_011530312 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 383 83.4 1.1e-15 XP_005263088 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 383 83.4 1.1e-15 NP_001188326 (OMIM: 131244,277580,600155,600501) e ( 532) 384 83.7 1.2e-15 NP_003982 (OMIM: 131244,277580,600155,600501) endo ( 436) 381 83.1 1.5e-15 NP_004113 (OMIM: 601898) growth hormone secretagog ( 289) 376 81.9 2.2e-15 NP_444264 (OMIM: 607449) neuropeptide FF receptor ( 420) 376 82.1 2.9e-15 NP_001138228 (OMIM: 607449) neuropeptide FF recept ( 423) 376 82.1 2.9e-15 NP_004876 (OMIM: 607449) neuropeptide FF receptor ( 522) 376 82.2 3.3e-15 NP_000901 (OMIM: 162642) neuropeptide Y receptor t ( 381) 374 81.7 3.5e-15 XP_005263090 (OMIM: 162642) PREDICTED: neuropeptid ( 381) 374 81.7 3.5e-15 XP_005263091 (OMIM: 162642) PREDICTED: neuropeptid ( 381) 374 81.7 3.5e-15 NP_001050 (OMIM: 162332,614840) neuromedin-K recep ( 465) 360 79.1 2.5e-14 NP_001265429 (OMIM: 102776) adenosine receptor A2a ( 412) 355 78.1 4.4e-14 NP_000666 (OMIM: 102776) adenosine receptor A2a [H ( 412) 355 78.1 4.4e-14 NP_001265426 (OMIM: 102776) adenosine receptor A2a ( 412) 355 78.1 4.4e-14 NP_001265428 (OMIM: 102776) adenosine receptor A2a ( 412) 355 78.1 4.4e-14 NP_001265427 (OMIM: 102776) adenosine receptor A2a ( 412) 355 78.1 4.4e-14 NP_001138757 (OMIM: 600018) mu-type opioid recepto ( 389) 354 77.9 4.8e-14 NP_001008504 (OMIM: 600018) mu-type opioid recepto ( 392) 354 77.9 4.9e-14 NP_001138755 (OMIM: 600018) mu-type opioid recepto ( 397) 354 77.9 4.9e-14 NP_000905 (OMIM: 600018) mu-type opioid receptor i ( 400) 354 77.9 4.9e-14 >>NP_064552 (OMIM: 605108) neuromedin-U receptor 2 [Homo (415 aa) initn: 2776 init1: 2776 opt: 2776 Z-score: 2847.4 bits: 535.8 E(85289): 7.3e-152 Smith-Waterman score: 2776; 99.5% identity (99.8% similar) in 415 aa overlap (1-415:1-415) 10 20 30 40 50 60 pF1KE9 MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAFLCGPRRSHFFLPVSVVYVPIFVVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAFLCGPRRSHFFLPVSVVYVPIFVVGV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 IGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 IGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 FKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 FKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSLP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 NTSIHGIKFHYFPNGSLVPGSATFTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMA ::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::: NP_064 NTSIHGIKFHYFPNGSLVPGSATCTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LRLKKDKSLEADEGNANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSFVEEWSES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 LRLKKDKSLEADEGNANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSFVEEWSES 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 LAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVISSFHKQWHSQHDPQLPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 LAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVISSFHKQWHSQHDPQLPPA 310 320 330 340 350 360 370 380 390 400 410 pF1KE9 QRNIFLTECHFVELTEDIGPQFPCQSSMHNSHLPTALSSEQMSRTNYQSFHFNKT ::::::::::::::::::::::::::::::::::.:::::::::::::::::::: NP_064 QRNIFLTECHFVELTEDIGPQFPCQSSMHNSHLPAALSSEQMSRTNYQSFHFNKT 370 380 390 400 410 >>XP_011535972 (OMIM: 605108) PREDICTED: neuromedin-U re (321 aa) initn: 2075 init1: 2075 opt: 2075 Z-score: 2132.6 bits: 403.2 E(85289): 4.8e-112 Smith-Waterman score: 2075; 99.7% identity (99.7% similar) in 313 aa overlap (1-313:1-313) 10 20 30 40 50 60 pF1KE9 MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAFLCGPRRSHFFLPVSVVYVPIFVVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAFLCGPRRSHFFLPVSVVYVPIFVVGV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 IGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 FKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSLP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 NTSIHGIKFHYFPNGSLVPGSATFTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMA ::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::: XP_011 NTSIHGIKFHYFPNGSLVPGSATCTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LRLKKDKSLEADEGNANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSFVEEWSES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRLKKDKSLEADEGNANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSFVEEWSES 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 LAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVISSFHKQWHSQHDPQLPPA ::::::::::::: XP_011 LAAVFNLVHVVSGKTLAGFGA 310 320 >>XP_011508791 (OMIM: 604153) PREDICTED: neuromedin-U re (313 aa) initn: 870 init1: 870 opt: 883 Z-score: 914.8 bits: 177.8 E(85289): 3.2e-44 Smith-Waterman score: 884; 49.3% identity (78.5% similar) in 274 aa overlap (20-283:36-307) 10 20 30 40 pF1KE9 MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAF-LCGPRRSHFFLPV :: . :: :.: : . ::.....:.:. XP_011 LNCSVLPGDLYPGGARNPMACNGSAARGHFDP--EDLNLTDEALRLKYLGPQQTELFMPI 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 SVVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWR ..:. :::::..:: :.:::::.:.::.:::::::::::::::::::.:.:::.::::. XP_011 CATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWH 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 NYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILG :::::.: ::::.: ::: ::.::.:..:..:::::::..::..:. . :: .. :.:: XP_011 NYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLG 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 IVWGFSVLFSLPNTSIHGIKFHYFPNGSLVPGSATFTVIKPMWIYNFIIQVTSFLFYLLP :::...: ::::::.:::. . : . :: ::. ...: .::...:.:..::. :: XP_011 AVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLP 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE9 MTVISVLYYLMALRLKKDKSLEADE----GNANIQR--PCR-KSVNKMLFVLVLVFAIC- :...:::: :..:::.... : .: :.: . :: .. .. .. ... : XP_011 MAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLSACE 250 260 270 280 290 300 290 300 310 320 330 pF1KE9 -WAPFHIDRLFFSFVEEWSESLAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQ : : XP_011 AWPPARHLLS 310 >>XP_006712259 (OMIM: 604153) PREDICTED: neuromedin-U re (333 aa) initn: 870 init1: 870 opt: 883 Z-score: 914.4 bits: 177.9 E(85289): 3.4e-44 Smith-Waterman score: 888; 51.1% identity (79.1% similar) in 268 aa overlap (20-272:36-301) 10 20 30 40 pF1KE9 MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAF-LCGPRRSHFFLPV :: . :: :.: : . ::.....:.:. XP_006 LNCSVLPGDLYPGGARNPMACNGSAARGHFDP--EDLNLTDEALRLKYLGPQQTELFMPI 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 SVVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWR ..:. :::::..:: :.:::::.:.::.:::::::::::::::::::.:.:::.::::. XP_006 CATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWH 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 NYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILG :::::.: ::::.: ::: ::.::.:..:..:::::::..::..:. . :: .. :.:: XP_006 NYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLG 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 IVWGFSVLFSLPNTSIHGIKFHYFPNGSLVPGSATFTVIKPMWIYNFIIQVTSFLFYLLP :::...: ::::::.:::. . : . :: ::. ...: .::...:.:..::. :: XP_006 AVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLP 190 200 210 220 230 240 230 240 250 260 270 pF1KE9 MTVISVLYYLMALRLKKDKSLEADE----GNANIQR--PCR--------KSVNKMLFVLV :...:::: :..:::.... : .: :.: . :: ..:.:::.: XP_006 MAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLWVKE 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE9 LVFAICWAPFHIDRLFFSFVEEWSESLAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRF XP_006 FWTLSTADIYWYMMDQASWVTQRGTCIWSK 310 320 330 >>XP_006712258 (OMIM: 604153) PREDICTED: neuromedin-U re (370 aa) initn: 900 init1: 870 opt: 883 Z-score: 913.9 bits: 177.9 E(85289): 3.7e-44 Smith-Waterman score: 895; 49.0% identity (76.6% similar) in 290 aa overlap (20-294:36-321) 10 20 30 40 pF1KE9 MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAFLCGPRRSHFFLPVS :: . .:.. : .: ::.....:.:. XP_006 LNCSVLPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYL-GPQQTELFMPIC 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 VVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRN ..:. :::::..:: :.:::::.:.::.:::::::::::::::::::.:.:::.::::.: XP_006 ATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWHN 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 YPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGI ::::.: ::::.: ::: ::.::.:..:..:::::::..::..:. . :: .. :.:: XP_006 YPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGA 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 VWGFSVLFSLPNTSIHGIKFHYFPNGSLVPGSATFTVIKPMWIYNFIIQVTSFLFYLLPM :::...: ::::::.:::. . : . :: ::. ...: .::...:.:..::. ::: XP_006 VWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLPM 190 200 210 220 230 240 230 240 250 260 270 pF1KE9 TVISVLYYLMALRLKKDKSLEADE----GNANIQR--PCR--------KSVNKMLFVLVL ...:::: :..:::.... : .: :.: . :: ..:.:::. :: XP_006 AIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLYFQVL 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE9 VFAICWAPFHIDRL-FFSFVEEWSESLAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRF . :.: : : ::. XP_006 D---GFLPIHQPPLSFTSFLIPPSVHLPYSASVPEGVKEFWTLSTADIYWYMMDQASWVT 310 320 330 340 350 360 >>XP_011508790 (OMIM: 604153) PREDICTED: neuromedin-U re (376 aa) initn: 900 init1: 870 opt: 883 Z-score: 913.8 bits: 177.9 E(85289): 3.7e-44 Smith-Waterman score: 895; 49.0% identity (76.6% similar) in 290 aa overlap (20-294:36-321) 10 20 30 40 pF1KE9 MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAFLCGPRRSHFFLPVS :: . .:.. : .: ::.....:.:. XP_011 LNCSVLPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYL-GPQQTELFMPIC 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 VVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRN ..:. :::::..:: :.:::::.:.::.:::::::::::::::::::.:.:::.::::.: XP_011 ATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWHN 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 YPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGI ::::.: ::::.: ::: ::.::.:..:..:::::::..::..:. . :: .. :.:: XP_011 YPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGA 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 VWGFSVLFSLPNTSIHGIKFHYFPNGSLVPGSATFTVIKPMWIYNFIIQVTSFLFYLLPM :::...: ::::::.:::. . : . :: ::. ...: .::...:.:..::. ::: XP_011 VWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLPM 190 200 210 220 230 240 230 240 250 260 270 pF1KE9 TVISVLYYLMALRLKKDKSLEADE----GNANIQR--PCR--------KSVNKMLFVLVL ...:::: :..:::.... : .: :.: . :: ..:.:::. :: XP_011 AIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLYFQVL 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE9 VFAICWAPFHIDRL-FFSFVEEWSESLAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRF . :.: : : ::. XP_011 D---GFLPIHQPPLSFTSFLIPPSVHLPYSASVPEGEYTGIILPFSEKGLISLKIESPRL 310 320 330 340 350 360 >>XP_011508789 (OMIM: 604153) PREDICTED: neuromedin-U re (403 aa) initn: 1208 init1: 870 opt: 883 Z-score: 913.4 bits: 177.9 E(85289): 3.9e-44 Smith-Waterman score: 1194; 50.8% identity (79.4% similar) in 354 aa overlap (20-353:13-364) 10 20 30 40 50 pF1KE9 MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAF-LCGPRRSHFFLPVSVVYVPIFVVG :: . :: :.: : . ::.....:.:. ..:. ::::: XP_011 MACNGSAARGHFDP--EDLNLTDEALRLKYLGPQQTELFMPICATYLLIFVVG 10 20 30 40 50 60 70 80 90 100 110 pF1KE9 VIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGC ..:: :.:::::.:.::.:::::::::::::::::::.:.:::.::::.:::::.: :: XP_011 AVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWHNYPFLLGVGGC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 YFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSL ::.: ::: ::.::.:..:..:::::::..::..:. . :: .. :.:: :::...: :: XP_011 YFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 PNTSIHGIKFHYFPNGSLVPGSATFTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLM ::::.:::. . : . :: ::. ...: .::...:.:..::. :::...:::: :. XP_011 PNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLLI 180 190 200 210 220 230 240 250 260 270 280 pF1KE9 ALRLKKDKSLEADE----GNANIQR--PCR--------KSVNKMLFVLVLVFAICWAPFH .:::.... : .: :.: . :: ..:.:::::::.::.::::::: XP_011 GLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLFVLVVVFGICWAPFH 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE9 IDRLFFSFVEEWSESLAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVI--- ::...: : .:...: .:. :::.::.::::.::.::..:.:.: ::. .::... XP_011 ADRVMWSVVSQWTDGLHLAFQHVHVISGIFFYLGSAANPVLYSLMSSRFRETFQEALCLG 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE9 SSFHK--QWHSQHDPQLPPAQRNIFLTECHFVELTEDIGPQFPCQSSMHNSHLPTALSSE . :. ::.: XP_011 ACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQQETDPS 360 370 380 390 400 >>NP_006047 (OMIM: 604153) neuromedin-U receptor 1 [Homo (426 aa) initn: 1208 init1: 870 opt: 883 Z-score: 913.1 bits: 178.0 E(85289): 4e-44 Smith-Waterman score: 1194; 50.8% identity (79.4% similar) in 354 aa overlap (20-353:36-387) 10 20 30 40 pF1KE9 MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAF-LCGPRRSHFFLPV :: . :: :.: : . ::.....:.:. NP_006 LNCSVLPGDLYPGGARNPMACNGSAARGHFDP--EDLNLTDEALRLKYLGPQQTELFMPI 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 SVVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWR ..:. :::::..:: :.:::::.:.::.:::::::::::::::::::.:.:::.::::. NP_006 CATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWH 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 NYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILG :::::.: ::::.: ::: ::.::.:..:..:::::::..::..:. . :: .. :.:: NP_006 NYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLG 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 IVWGFSVLFSLPNTSIHGIKFHYFPNGSLVPGSATFTVIKPMWIYNFIIQVTSFLFYLLP :::...: ::::::.:::. . : . :: ::. ...: .::...:.:..::. :: NP_006 AVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLP 190 200 210 220 230 240 230 240 250 260 270 pF1KE9 MTVISVLYYLMALRLKKDKSLEADE----GNANIQR--PCR--------KSVNKMLFVLV :...:::: :..:::.... : .: :.: . :: ..:.::::::: NP_006 MAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLFVLV 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE9 LVFAICWAPFHIDRLFFSFVEEWSESLAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRF .::.::::::: ::...: : .:...: .:. :::.::.::::.::.::..:.:.: :: NP_006 VVFGICWAPFHADRVMWSVVSQWTDGLHLAFQHVHVISGIFFYLGSAANPVLYSLMSSRF 310 320 330 340 350 360 340 350 360 370 380 pF1KE9 QAAFQNVI---SSFHK--QWHSQHDPQLPPAQRNIFLTECHFVELTEDIGPQFPCQSSMH . .::... . :. ::.: NP_006 RETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQQET 370 380 390 400 410 420 >>NP_940799 (OMIM: 601898) growth hormone secretagogue r (366 aa) initn: 447 init1: 209 opt: 578 Z-score: 602.3 bits: 120.2 E(85289): 8.3e-27 Smith-Waterman score: 578; 34.7% identity (67.0% similar) in 294 aa overlap (48-337:46-333) 20 30 40 50 60 70 pF1KE9 LEDPFQKHLNSTEEYLAFLCGPRRSHFFLPVSVVYVPIFVVGVIGNVLVCLVILQHQAMK :... : .::::. ::.:. ::. . . .. NP_940 LADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELR 20 30 40 50 60 70 80 90 100 110 120 130 pF1KE9 TPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSI : :: :: :.: ::::..: :::.. ..:. :. :: . : . . :. .:..:.: NP_940 TTTNLYLSSMAFSDLLIFLC-MPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTI 80 90 100 110 120 130 140 150 160 170 180 190 pF1KE9 TTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGIKFHYFPNGSL :..::::: :: :.:::. :. :. .. ..:. . . : . :.. : ::. NP_940 TALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVE-H--ENGTD 140 150 160 170 180 190 200 210 220 230 240 250 pF1KE9 VPGSATFTVIKPMWIYNFIIQV---TSFLFYLLPMTVISVLYYLMALRLKKDKSLEADEG : ... . . . .. : .: .:..::. ..::: :.. .: . . .: : NP_940 -PWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVG 200 210 220 230 240 250 260 270 280 290 300 310 pF1KE9 NANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFS-FVEEWSESLAAVFNLVHVVSG :... .:.. ::: :.:..: .:: :::. : .:: : : .: . . ..:: NP_940 -ASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSF 260 270 280 290 300 320 330 340 350 360 370 pF1KE9 VFFYLSSAVNPIIYNLLSRRFQAAFQNVISSFHKQWHSQHDPQLPPAQRNIFLTECHFVE :.::::.:.:::.::..:.....: NP_940 VLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT 310 320 330 340 350 360 >>NP_001718 (OMIM: 300107) bombesin receptor subtype-3 [ (399 aa) initn: 444 init1: 196 opt: 454 Z-score: 475.1 bits: 96.8 E(85289): 1e-19 Smith-Waterman score: 454; 29.7% identity (63.2% similar) in 296 aa overlap (48-339:50-342) 20 30 40 50 60 70 pF1KE9 LEDPFQKHLNSTEEYLAFLCGPRRSHFFLPVSVVYVPIFVVGVIGNVLVCLVILQHQAMK . ..:. :. ::..::... :... ..:. NP_001 TESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQ 20 30 40 50 60 70 80 90 100 110 120 130 pF1KE9 TPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSI : : .. ::: .:::.:: .:... . . .::: .:: . . : .:.... NP_001 TVPNIFITSLAFGDLLLLLTCVPVDATH-YLAEGWLFGRIGCKVLSFIRLTSVGVSVFTL 80 90 100 110 120 130 140 150 160 170 180 190 pF1KE9 TTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGIKFHYFPNGSL : .:..:: :...:.. . ... .. : :: :..:.::.. . .. :: .. NP_001 TILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNM 140 150 160 170 180 190 200 210 220 230 240 250 pF1KE9 VPGSAT-FTVIKPMWIYNFIIQVTSFL-FYLLPMTVISVLYYLMALRLKKDK-SLEADE- . : : . : : . . : .. :: ::..:...::: : :.: : :. .. ..: NP_001 TFESCTSYPVSKKL--LQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQ 200 210 220 230 240 250 260 270 280 290 300 310 pF1KE9 GNANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSFVEEWSESLAAVFNLVHVVSG ..: : :: . . ..::: .::.:: : :. :. ::. . . .:. . . : NP_001 SHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSR 260 270 280 290 300 310 320 330 340 350 360 370 pF1KE9 VFFYLSSAVNPIIYNLLSRRFQAAFQNVISSFHKQWHSQHDPQLPPAQRNIFLTECHFVE :. . .: :::. ::. :: :. NP_001 VLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLAVMGTVPGTGS 320 330 340 350 360 370 415 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 01:07:34 2016 done: Mon Nov 7 01:07:36 2016 Total Scan time: 8.500 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]