FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4396, 417 aa 1>>>pF1KE4396 417 - 417 aa - 417 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6171+/-0.000374; mu= 17.1293+/- 0.023 mean_var=147.6679+/-30.450, 0's: 0 Z-trim(117.3): 216 B-trim: 7 in 2/55 Lambda= 0.105543 statistics sampled from 28869 (29155) to 28869 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.703), E-opt: 0.2 (0.342), width: 16 Scan time: 9.320 The best scores are: opt bits E(85289) NP_006496 (OMIM: 173850) poliovirus receptor isofo ( 417) 2825 442.2 1.2e-123 NP_001129242 (OMIM: 173850) poliovirus receptor is ( 392) 2631 412.6 8.7e-115 NP_001129240 (OMIM: 173850) poliovirus receptor is ( 372) 2300 362.2 1.3e-99 NP_001129241 (OMIM: 173850) poliovirus receptor is ( 364) 2242 353.3 5.6e-97 NP_002847 (OMIM: 600798) nectin-2 isoform alpha pr ( 479) 1008 165.6 2.4e-40 NP_001036189 (OMIM: 600798) nectin-2 isoform delta ( 538) 1006 165.4 3.2e-40 XP_011525494 (OMIM: 600798) PREDICTED: nectin-2 is ( 369) 979 161.0 4.4e-39 NP_976030 (OMIM: 225060,600644) nectin-1 isoform 2 ( 458) 657 112.1 2.9e-24 NP_002846 (OMIM: 225060,600644) nectin-1 isoform 1 ( 517) 650 111.1 6.5e-24 NP_976031 (OMIM: 225060,600644) nectin-1 isoform 3 ( 352) 615 105.6 2.1e-22 XP_016861615 (OMIM: 607147) PREDICTED: nectin-3 is ( 510) 550 95.9 2.5e-19 NP_001230217 (OMIM: 607147) nectin-3 isoform 3 [Ho ( 487) 546 95.2 3.7e-19 XP_016861612 (OMIM: 607147) PREDICTED: nectin-3 is ( 541) 544 95.0 4.8e-19 NP_056295 (OMIM: 607147) nectin-3 isoform 1 precur ( 549) 532 93.2 1.7e-18 XP_016861614 (OMIM: 607147) PREDICTED: nectin-3 is ( 526) 528 92.6 2.6e-18 XP_016861613 (OMIM: 607147) PREDICTED: nectin-3 is ( 534) 526 92.3 3.2e-18 XP_011510965 (OMIM: 607147) PREDICTED: nectin-3 is ( 580) 526 92.3 3.4e-18 NP_001230215 (OMIM: 607147) nectin-3 isoform 2 pre ( 366) 520 91.1 4.8e-18 XP_005245565 (OMIM: 609607,613573) PREDICTED: nect ( 485) 474 84.3 7.3e-16 NP_112178 (OMIM: 609607,613573) nectin-4 precursor ( 510) 474 84.3 7.5e-16 XP_011508325 (OMIM: 609607,613573) PREDICTED: nect ( 460) 473 84.1 7.9e-16 XP_011508324 (OMIM: 609607,613573) PREDICTED: nect ( 486) 473 84.1 8.1e-16 XP_011508323 (OMIM: 609607,613573) PREDICTED: nect ( 511) 473 84.2 8.4e-16 NP_001120645 (OMIM: 609743) cell adhesion molecule ( 398) 349 65.1 3.5e-10 NP_067012 (OMIM: 609743) cell adhesion molecule 3 ( 432) 349 65.2 3.7e-10 XP_016861616 (OMIM: 607147) PREDICTED: nectin-3 is ( 337) 315 59.9 1.1e-08 XP_006713145 (OMIM: 609938) PREDICTED: cell adhesi ( 395) 313 59.6 1.6e-08 XP_016861552 (OMIM: 609938) PREDICTED: cell adhesi ( 397) 313 59.7 1.6e-08 NP_001161147 (OMIM: 609938) cell adhesion molecule ( 404) 313 59.7 1.6e-08 NP_001091987 (OMIM: 605686) cell adhesion molecule ( 414) 311 59.4 2e-08 XP_006713144 (OMIM: 609938) PREDICTED: cell adhesi ( 435) 296 57.1 9.9e-08 NP_001161146 (OMIM: 609938) cell adhesion molecule ( 435) 296 57.1 9.9e-08 NP_694854 (OMIM: 609938) cell adhesion molecule 2 ( 437) 296 57.1 9.9e-08 XP_016861551 (OMIM: 609938) PREDICTED: cell adhesi ( 449) 296 57.1 1e-07 XP_016872947 (OMIM: 605686) PREDICTED: cell adhesi ( 402) 294 56.8 1.2e-07 NP_055148 (OMIM: 605686) cell adhesion molecule 1 ( 442) 294 56.8 1.2e-07 NP_001287973 (OMIM: 605686) cell adhesion molecule ( 453) 294 56.8 1.3e-07 NP_001287972 (OMIM: 605686) cell adhesion molecule ( 471) 294 56.9 1.3e-07 XP_016872946 (OMIM: 605686) PREDICTED: cell adhesi ( 477) 294 56.9 1.3e-07 XP_005271551 (OMIM: 605686) PREDICTED: cell adhesi ( 425) 284 55.3 3.5e-07 NP_001287974 (OMIM: 605686) cell adhesion molecule ( 443) 284 55.3 3.6e-07 XP_016881941 (OMIM: 609744) PREDICTED: cell adhesi ( 369) 274 53.7 9.2e-07 NP_660339 (OMIM: 609744) cell adhesion molecule 4 ( 388) 274 53.7 9.4e-07 NP_954648 (OMIM: 607762) kin of IRRE-like protein ( 583) 268 53.0 2.3e-06 NP_115499 (OMIM: 607762) kin of IRRE-like protein ( 633) 268 53.1 2.4e-06 XP_011525667 (OMIM: 607762) PREDICTED: kin of IRRE ( 658) 268 53.1 2.4e-06 NP_001316459 (OMIM: 607762) kin of IRRE-like prote ( 658) 268 53.1 2.4e-06 XP_016882837 (OMIM: 607762) PREDICTED: kin of IRRE ( 673) 268 53.1 2.5e-06 NP_954649 (OMIM: 607762) kin of IRRE-like protein ( 708) 268 53.1 2.5e-06 XP_011525665 (OMIM: 607762) PREDICTED: kin of IRRE ( 708) 268 53.1 2.5e-06 >>NP_006496 (OMIM: 173850) poliovirus receptor isoform a (417 aa) initn: 2825 init1: 2825 opt: 2825 Z-score: 2341.1 bits: 442.2 E(85289): 1.2e-123 Smith-Waterman score: 2825; 100.0% identity (100.0% similar) in 417 aa overlap (1-417:1-417) 10 20 30 40 50 60 pF1KE4 MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 YTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 YTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 SDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 YYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 YYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 PVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGMSRNAIIFLVLGILVFLILLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGMSRNAIIFLVLGILVFLILLG 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 IGIYFYWSKCSREVLWHCHLCPSSTEHASASANGHVSYSAVSRENSSSQDPQTEGTR ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 IGIYFYWSKCSREVLWHCHLCPSSTEHASASANGHVSYSAVSRENSSSQDPQTEGTR 370 380 390 400 410 >>NP_001129242 (OMIM: 173850) poliovirus receptor isofor (392 aa) initn: 2698 init1: 2631 opt: 2631 Z-score: 2181.8 bits: 412.6 E(85289): 8.7e-115 Smith-Waterman score: 2631; 99.2% identity (99.5% similar) in 389 aa overlap (1-389:1-389) 10 20 30 40 50 60 pF1KE4 MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 YTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 SDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 YYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 PVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGMSRNAIIFLVLGILVFLILLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGMSRNAIIFLVLGILVFLILLG 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 IGIYFYWSKCSREVLWHCHLCPSSTEHASASANGHVSYSAVSRENSSSQDPQTEGTR :::::::::::::::::::::::: .: : NP_001 IGIYFYWSKCSREVLWHCHLCPSSEHHQSCRN 370 380 390 >>NP_001129240 (OMIM: 173850) poliovirus receptor isofor (372 aa) initn: 2300 init1: 2300 opt: 2300 Z-score: 1909.6 bits: 362.2 E(85289): 1.3e-99 Smith-Waterman score: 2407; 89.2% identity (89.2% similar) in 417 aa overlap (1-417:1-372) 10 20 30 40 50 60 pF1KE4 MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 YTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 SDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 YYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 PVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGMSRNAIIFLVLGILVFLILLG ::::::::::::::::::::::::::::::::::::::: NP_001 PVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSG--------------------- 310 320 330 370 380 390 400 410 pF1KE4 IGIYFYWSKCSREVLWHCHLCPSSTEHASASANGHVSYSAVSRENSSSQDPQTEGTR ::::::::::::::::::::::::::::::::: NP_001 ------------------------TEHASASANGHVSYSAVSRENSSSQDPQTEGTR 340 350 360 370 >>NP_001129241 (OMIM: 173850) poliovirus receptor isofor (364 aa) initn: 2425 init1: 2232 opt: 2242 Z-score: 1862.0 bits: 353.3 E(85289): 5.6e-97 Smith-Waterman score: 2323; 87.1% identity (87.3% similar) in 417 aa overlap (1-417:1-364) 10 20 30 40 50 60 pF1KE4 MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 YTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 SDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 YYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 PVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGMSRNAIIFLVLGILVFLILLG :::::::::::::::::::::::::::::: NP_001 PVDKPINTTLICNVTNALGARQAELTVQVK------------------------------ 310 320 330 370 380 390 400 410 pF1KE4 IGIYFYWSKCSREVLWHCHLCPSSTEHASASANGHVSYSAVSRENSSSQDPQTEGTR .::::::::::::::::::::::::::::::::: NP_001 -----------------------GTEHASASANGHVSYSAVSRENSSSQDPQTEGTR 340 350 360 >>NP_002847 (OMIM: 600798) nectin-2 isoform alpha precur (479 aa) initn: 1120 init1: 956 opt: 1008 Z-score: 845.2 bits: 165.6 E(85289): 2.4e-40 Smith-Waterman score: 1135; 49.6% identity (72.3% similar) in 379 aa overlap (9-372:19-389) 10 20 30 40 50 pF1KE4 MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCY :::::. :: :. :: ::. .: : :: .: :::. NP_002 MARAAALLPSRSPPTPLLWPLLLLLLL-----ETGAQDVRVQVLPEVRGQLGGTVELPCH 10 20 30 40 50 60 70 80 90 100 pF1KE4 LQVPNMEVTHVSQLTWARHGESGS---MAVFHQTQGPSYSE----SKRLEFVAARLG--- : .: . ..: .:: : .. .:.:: .:::. :.:: ::.:. . NP_002 L-LPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQ 60 70 80 90 100 110 110 120 130 140 150 pF1KE4 ---AELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLT :::..:.: . :: ::::::::: :.:::.:: ::::.:::.: ::.::: .. NP_002 DTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFS 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE4 GEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGK .:. .: :.: :::::.:.: :.: . .:: : :.::::::: . ::::...:: NP_002 QDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGV 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE4 NVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGY .:::::::::::.: :. :.:.: :::::::::::.:::::...:::.::.::::::::: NP_002 TVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGY 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE4 NWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEH .:::: : .: :::::.::.:. ::. .:::..:.::::.: .:: .. :.: : . NP_002 DWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRA-- 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE4 SGMSRNAIIFLVLG--ILVFLILLGIGIYFYWSKCSREVLWHCHLCPSSTEHASASANGH : . . ... ..: .::.:.: : .. : . : NP_002 SPRDVGPLVWGAVGGTLLVLLLLAGGSLAFILLRVRRRRKSPGGAGGGASGDGGFYDPKA 360 370 380 390 400 410 400 410 pF1KE4 VSYSAVSRENSSSQDPQTEGTR NP_002 QVLGNGDPVFWTPVVPGPMEPDGKDEEEEEEEEKAEKGLMLPPPPALEDDMESQLDGSLI 420 430 440 450 460 470 >>NP_001036189 (OMIM: 600798) nectin-2 isoform delta pre (538 aa) initn: 1152 init1: 964 opt: 1006 Z-score: 843.1 bits: 165.4 E(85289): 3.2e-40 Smith-Waterman score: 1133; 50.0% identity (72.8% similar) in 368 aa overlap (9-363:19-379) 10 20 30 40 50 pF1KE4 MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCY :::::. :: :. :: ::. .: : :: .: :::. NP_001 MARAAALLPSRSPPTPLLWPLLLLLLL-----ETGAQDVRVQVLPEVRGQLGGTVELPCH 10 20 30 40 50 60 70 80 90 100 pF1KE4 LQVPNMEVTHVSQLTWARHGESGS---MAVFHQTQGPSYSE----SKRLEFVAARLG--- : .: . ..: .:: : .. .:.:: .:::. :.:: ::.:. . NP_001 L-LPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQ 60 70 80 90 100 110 110 120 130 140 150 pF1KE4 ---AELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLT :::..:.: . :: ::::::::: :.:::.:: ::::.:::.: ::.::: .. NP_001 DTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFS 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE4 GEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGK .:. .: :.: :::::.:.: :.: . .:: : :.::::::: . ::::...:: NP_001 QDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGV 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE4 NVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGY .:::::::::::.: :. :.:.: :::::::::::.:::::...:::.::.::::::::: NP_001 TVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGY 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE4 NWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEH .:::: : .: :::::.::.:. ::. .:::..:.::::.: .:: .. :.: : . NP_001 DWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAG 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE4 SGMSRNAIIFLVLGILVFLILLGIGIYFYWSKCSREVLWHCHLCPSSTEHASASANGHVS .: . ..:: ... .. . . :: NP_001 AGAT-GGIIGGIIAAIIATAVAATGILICRQQRKEQTLQGAEEDEDLEGPPSYKPPTPKA 360 370 380 390 400 410 >>XP_011525494 (OMIM: 600798) PREDICTED: nectin-2 isofor (369 aa) initn: 1106 init1: 942 opt: 979 Z-score: 822.6 bits: 161.0 E(85289): 4.4e-39 Smith-Waterman score: 1106; 51.3% identity (73.0% similar) in 355 aa overlap (9-345:19-367) 10 20 30 40 50 pF1KE4 MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCY :::::. :: :. :: ::. .: : :: .: :::. XP_011 MARAAALLPSRSPPTPLLWPLLLLLLL-----ETGAQDVRVQVLPEVRGQLGGTVELPCH 10 20 30 40 50 60 70 80 90 100 pF1KE4 LQVPNMEVTHVSQLTWARHGESGS---MAVFHQTQGPSYSE----SKRLEFVAARLG--- : .: . ..: .:: : .. .:.:: .:::. :.:: ::.:. . XP_011 L-LPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQ 60 70 80 90 100 110 110 120 130 140 150 pF1KE4 ---AELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLT :::..:.: . :: ::::::::: :.:::.:: ::::.:::.: ::.::: .. XP_011 DTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFS 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE4 GEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGK .:. .: :.: :::::.:.: :.: . .:: : :.::::::: . ::::...:: XP_011 QDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGV 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE4 NVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGY .:::::::::::.: :. :.:.: :::::::::::.:::::...:::.::.::::::::: XP_011 TVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGY 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE4 NWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVK---EGPP .:::: : .: :::::.::.:. ::. .:::..:.::::.: .:: .. :. . XP_011 DWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRALEDDME 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE4 SEHSG--MSRNAIIFLVLGILVFLILLGIGIYFYWSKCSREVLWHCHLCPSSTEHASASA :. .: .:: :. XP_011 SQLDGSLISRRAVYV 360 >>NP_976030 (OMIM: 225060,600644) nectin-1 isoform 2 pre (458 aa) initn: 477 init1: 183 opt: 657 Z-score: 556.6 bits: 112.1 E(85289): 2.9e-24 Smith-Waterman score: 657; 32.6% identity (64.2% similar) in 380 aa overlap (1-369:6-372) 10 20 30 40 50 pF1KE4 MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPN .: : . : : :: . .. ::. . :::. .. ::.: .:.: : . : NP_976 MARMGLAGAAGRWWGL---ALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANP- 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 MEVTHVSQLTWAR--HGESGSMAVFHQTQGPSY--SESKRLEFVAARLGAELRNASLRMF . ....:.:: . .: . ..:... ..: : .:.:: : . ....:. NP_976 LPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEF----LRPSFTDGTIRLS 60 70 80 90 100 110 120 130 140 150 160 pF1KE4 GLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTG-----EPVPMARC :..:::: : : :.::: :.: .. : :.::: : : .. : . . : .: : NP_976 RLELEDEGVYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATC 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 VSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHE .:..:.::. ..:.. : : . ... . .::::: : . :::: .. ....: :... NP_976 TSANGKPPSVVSWETRLKGEAEYQEIRNP-NGTVTVISRYRLVPSREAHQQSLACIVNYH 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 SFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPL . . ::.: : : :::.: :.:.:::: . .. ::: : .:: : :.:.: : : NP_976 MDRFKESLTLN--VQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSL 240 250 260 270 280 290 300 310 320 330 340 pF1KE4 PPFAVAQGAQLLIR-PVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGMSRNAI : . ::. :... :.. . : ::..:: .:.:.... :.. : : . :.. .: NP_976 PKGVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNITE-KPRPQRGLG-SAA 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE4 IFLVLGILVFLILLGI-GIYFYWSKCSREVLWHCHLCPSSTEHASASANGHVSYSAVSRE .:. . :::::... ..: ... NP_976 RLLAGTVAVFLILVAVLTVFFLYNRQQKSPPETDGAGTDQPLSQKPEPSPSRQSSLVPED 350 360 370 380 390 400 >>NP_002846 (OMIM: 225060,600644) nectin-1 isoform 1 pre (517 aa) initn: 475 init1: 183 opt: 650 Z-score: 550.3 bits: 111.1 E(85289): 6.5e-24 Smith-Waterman score: 655; 34.4% identity (63.3% similar) in 381 aa overlap (1-363:6-374) 10 20 30 40 50 pF1KE4 MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPN .: : . : : :: . .. ::. . :::. .. ::.: .:.: : . : NP_002 MARMGLAGAAGRWWGL---ALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANP- 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 MEVTHVSQLTWAR--HGESGSMAVFHQTQGPSY--SESKRLEFVAARLGAELRNASLRMF . ....:.:: . .: . ..:... ..: : .:.:: : . ....:. NP_002 LPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEF----LRPSFTDGTIRLS 60 70 80 90 100 110 120 130 140 150 160 pF1KE4 GLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTG-----EPVPMARC :..:::: : : :.::: :.: .. : :.::: : : .. : . . : .: : NP_002 RLELEDEGVYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATC 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 VSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHE .:..:.::. ..:.. : : . ... . .::::: : . :::: .. ....: :... NP_002 TSANGKPPSVVSWETRLKGEAEYQEIRNP-NGTVTVISRYRLVPSREAHQQSLACIVNYH 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 SFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPL . . ::.: : : :::.: :.:.:::: . .. ::: : .:: : :.:.: : : NP_002 MDRFKESLTLN--VQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSL 240 250 260 270 280 290 300 310 320 330 pF1KE4 PPFAVAQGAQLLIR-PVDKPINTTLICNVTNALGARQAELTVQVKEGP----PSEH---S : . ::. :... :.. . : ::..:: .:.:.... :.. : : : :: . NP_002 PKGVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRA 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE4 GMSRNAIIFLVLG-ILVFLILLGIGIYFYWSKCSREVLWHCHLCPSSTEHASASANGHVS : .::: : : ::. ::..: :: NP_002 GPVPTAIIGGVAGSILLVLIVVG-GIVVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQH 350 360 370 380 390 400 >>NP_976031 (OMIM: 225060,600644) nectin-1 isoform 3 pre (352 aa) initn: 464 init1: 183 opt: 615 Z-score: 523.3 bits: 105.6 E(85289): 2.1e-22 Smith-Waterman score: 615; 33.3% identity (64.3% similar) in 339 aa overlap (1-329:6-333) 10 20 30 40 50 pF1KE4 MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPN .: : . : : :: . .. ::. . :::. .. ::.: .:.: : . : NP_976 MARMGLAGAAGRWWGL---ALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANP- 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 MEVTHVSQLTWAR--HGESGSMAVFHQTQGPSY--SESKRLEFVAARLGAELRNASLRMF . ....:.:: . .: . ..:... ..: : .:.:: : . ....:. NP_976 LPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEF----LRPSFTDGTIRLS 60 70 80 90 100 110 120 130 140 150 160 pF1KE4 GLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTG-----EPVPMARC :..:::: : : :.::: :.: .. : :.::: : : .. : . . : .: : NP_976 RLELEDEGVYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATC 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 VSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHE .:..:.::. ..:.. : : . ... . .::::: : . :::: .. ....: :... NP_976 TSANGKPPSVVSWETRLKGEAEYQEIRNP-NGTVTVISRYRLVPSREAHQQSLACIVNYH 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 SFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPL . . ::.: : : :::.: :.:.:::: . .. ::: : .:: : :.:.: : : NP_976 MDRFKESLTLN--VQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSL 240 250 260 270 280 290 300 310 320 330 340 pF1KE4 PPFAVAQGAQLLIR-PVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGMSRNAI : . ::. :... :.. . : ::..:: .:.:.... :.. NP_976 PKGVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNITAFCQLIYPGKGRTRA 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE4 IFLVLGILVFLILLGIGIYFYWSKCSREVLWHCHLCPSSTEHASASANGHVSYSAVSREN NP_976 RMF 350 417 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 17:18:23 2016 done: Mon Nov 7 17:18:25 2016 Total Scan time: 9.320 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]