Result of FASTA (ccds) for
pFN21AB7984
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7984, 324 aa
1>>>pF1KB7984 324 - 324 aa - 324 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.9035+/-0.000782; mu= 5.7939+/- 0.048
mean_var=169.7870+/-35.039, 0's: 0 Z-trim(113.7): 196 B-trim: 11 in 1/52
Lambda= 0.098429
statistics sampled from 14097 (14306) to 14097 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.771), E-opt: 0.2 (0.439), width: 16
Scan time: 2.570
The best scores are: opt bits E(32554)
CCDS3694.1 PITX2 gene_id:5308|Hs108|chr4 ( 324) 2186 321.8 4.6e-88
CCDS3692.1 PITX2 gene_id:5308|Hs108|chr4 ( 317) 1744 259.0 3.5e-69
CCDS3693.1 PITX2 gene_id:5308|Hs108|chr4 ( 271) 1731 257.1 1.1e-68
CCDS4182.1 PITX1 gene_id:5307|Hs108|chr5 ( 314) 1220 184.6 8.8e-47
CCDS7532.1 PITX3 gene_id:5309|Hs108|chr10 ( 302) 1008 154.5 9.8e-38
CCDS14215.1 ARX gene_id:170302|Hs108|chrX ( 562) 387 66.5 5.6e-11
CCDS9028.1 ALX1 gene_id:8092|Hs108|chr12 ( 326) 382 65.6 6e-11
>>CCDS3694.1 PITX2 gene_id:5308|Hs108|chr4 (324 aa)
initn: 2186 init1: 2186 opt: 2186 Z-score: 1694.5 bits: 321.8 E(32554): 4.6e-88
Smith-Waterman score: 2186; 100.0% identity (100.0% similar) in 324 aa overlap (1-324:1-324)
10 20 30 40 50 60
pF1KB7 MNCMKGPLHLEHRAAGTKLSAVSSSSCHHPQPLAMASVLAPGQPRSLDSSKHRLEVHTIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS36 MNCMKGPLHLEHRAAGTKLSAVSSSSCHHPQPLAMASVLAPGQPRSLDSSKHRLEVHTIS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 DTSSPEAAEKDKSQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS36 DTSSPEAAEKDKSQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 TREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS36 TREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 YSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS36 YSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 VPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS36 VPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSS
250 260 270 280 290 300
310 320
pF1KB7 FGYASVQNPASNLSACQYAVDRPV
::::::::::::::::::::::::
CCDS36 FGYASVQNPASNLSACQYAVDRPV
310 320
>>CCDS3692.1 PITX2 gene_id:5308|Hs108|chr4 (317 aa)
initn: 1742 init1: 1742 opt: 1744 Z-score: 1355.5 bits: 259.0 E(32554): 3.5e-69
Smith-Waterman score: 1744; 93.9% identity (95.7% similar) in 279 aa overlap (48-324:39-317)
20 30 40 50 60 70
pF1KB7 KLSAVSSSSCHHPQPLAMASVLAPGQPRSLDSSKHRLEVHTIS--DTSSPEAAEKDKSQQ
:: . : :. . . . : : :::::::
CCDS36 VSACVQLGVQPAAVECLFSKDSEIKKVEFTDSPESRKEAASSKFFPRQHPGANEKDKSQQ
10 20 30 40 50 60
80 90 100 110 120 130
pF1KB7 GKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS36 GKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEAR
70 80 90 100 110 120
140 150 160 170 180 190
pF1KB7 VRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS36 VRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSAS
130 140 150 160 170 180
200 210 220 230 240 250
pF1KB7 LSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS36 LSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNL
190 200 210 220 230 240
260 270 280 290 300 310
pF1KB7 SSPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS36 SSPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSA
250 260 270 280 290 300
320
pF1KB7 CQYAVDRPV
:::::::::
CCDS36 CQYAVDRPV
310
>>CCDS3693.1 PITX2 gene_id:5308|Hs108|chr4 (271 aa)
initn: 1731 init1: 1731 opt: 1731 Z-score: 1346.4 bits: 257.1 E(32554): 1.1e-68
Smith-Waterman score: 1731; 100.0% identity (100.0% similar) in 256 aa overlap (69-324:16-271)
40 50 60 70 80 90
pF1KB7 LAPGQPRSLDSSKHRLEVHTISDTSSPEAAEKDKSQQGKNEDVGAEDPSKKKRQRRQRTH
::::::::::::::::::::::::::::::
CCDS36 METNCRKLVSACVQLEKDKSQQGKNEDVGAEDPSKKKRQRRQRTH
10 20 30 40
100 110 120 130 140 150
pF1KB7 FTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS36 FTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAEL
50 60 70 80 90 100
160 170 180 190 200 210
pF1KB7 CKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS36 CKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMF
110 120 130 140 150 160
220 230 240 250 260 270
pF1KB7 SPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS36 SPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPY
170 180 190 200 210 220
280 290 300 310 320
pF1KB7 VYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV
::::::::::::::::::::::::::::::::::::::::::::::
CCDS36 VYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV
230 240 250 260 270
>>CCDS4182.1 PITX1 gene_id:5307|Hs108|chr5 (314 aa)
initn: 1148 init1: 595 opt: 1220 Z-score: 953.4 bits: 184.6 E(32554): 8.8e-47
Smith-Waterman score: 1228; 62.1% identity (78.2% similar) in 330 aa overlap (1-318:1-312)
10 20 30 40 50
pF1KB7 MNCMKGPLHLEHRAAGTKLSAVSSSSCHHPQPLAMASVLA-PGQPRSLDSSKHRLEVHTI
:. .:: . ::. : . :. .. : :: :..:: . :: ..
CCDS41 MDAFKGGMSLERLPEGLRPPPPP------PHDMGPAFHLARPADPR------EPLE-NSA
10 20 30 40
60 70 80 90 100 110
pF1KB7 SDTSSPEAAEKDKSQQGKN-EDVGA--------EDPSKKKRQRRQRTHFTSQQLQELEAT
:..:. : ::... . :. :: :: .::.:::.:::::::::::::::::::
CCDS41 SESSDTELPEKERGGEPKGPEDSGAGGTGCGGADDPAKKKKQRRQRTHFTSQQLQELEAT
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB7 FQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGL
:::::::::: :::::::::::: ::::::::::::::::::::: .:::.:. :::.::
CCDS41 FQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCKGGYVPQFSGL
110 120 130 140 150 160
180 190 200 210 220
pF1KB7 MQPYDDMYP-GYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSM
.:::.:.: ::::::::::.:. : :::::: :::::. ::::::::: :.:::::.:
CCDS41 VQPYEDVYAAGYSYNNWAAKSLAPAPLSTKSFTFFNSMS--PLSSQSMFSAPSSISSMTM
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB7 SSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPY-VYRDTCNSSL
::: :.:: :.:.:. :::.:::.. :::::. ::::. :. :: ::::::::::
CCDS41 PSSMGPGAVPGMPNSG---LNNINNLTGSSLNSAMSPGACPYGTPASPYSVYRDTCNSSL
230 240 250 260 270 280
290 300 310 320
pF1KB7 ASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV
::::::.::::::::...:.:::.:.::::
CCDS41 ASLRLKSKQHSSFGYGGLQGPASGLNACQYNS
290 300 310
>>CCDS7532.1 PITX3 gene_id:5309|Hs108|chr10 (302 aa)
initn: 1012 init1: 712 opt: 1008 Z-score: 790.9 bits: 154.5 E(32554): 9.8e-38
Smith-Waterman score: 1013; 56.9% identity (77.6% similar) in 304 aa overlap (47-324:6-302)
20 30 40 50 60 70
pF1KB7 TKLSAVSSSSCHHPQPLAMASVLAPGQPRSLDSSKHRLEVHTISDTSSPEAAEKDKSQQG
:. .. : . ..::...:. ... .:
CCDS75 MEFGLLSEAEARSPALSLSDAGTPHPQLPEHGCKG
10 20 30
80 90 100 110 120
pF1KB7 K----NEDVGA-------EDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEI
. .: ..: :: : ::.::::::::::::::::::::::::::::::::::
CCDS75 QEHSDSEKASASLPGGSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEI
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB7 AVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPGYSYNN
:::::::::::::::::::::::::::.:::::::..:. ..::. ::...::::::.:
CCDS75 AVWTNLTEARVRVWFKNRRAKWRKRERSQQAELCKGSFAAPLGGLVPPYEEVYPGYSYGN
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB7 WAAKGLTSASLSTKSFPF-FNSMNVNPLSSQSMFSPPNSIS-SMSMSSSMVPSAVTGVPG
: :.: . :..:.::: :::.::.::.:: .::::.::. :: :.. .:..: : ::
CCDS75 WPPKAL-APPLAAKTFPFAFNSVNVGPLASQPVFSPPSSIAASMVPSAAAAPGTVPG-PG
160 170 180 190 200 210
250 260 270 280 290
pF1KB7 SSLNSLNNLNNLSSPSLN-SAVPTPA--CPYAPP--------TPPYVYRDTCNSSLASLR
. :..:.. . :.: .:: . : :::: . :::::: :::::::::
CCDS75 A----LQGLGG-GPPGLAPAAVSSGAVSCPYASAAAAAAAAASSPYVYRDPCNSSLASLR
220 230 240 250 260
300 310 320
pF1KB7 LKAKQHSSFGYASVQNP--ASNLSACQYAVDRPV
::::::.::.: .:..: :.::: :::::.:::
CCDS75 LKAKQHASFSYPAVHGPPPAANLSPCQYAVERPV
270 280 290 300
>>CCDS14215.1 ARX gene_id:170302|Hs108|chrX (562 aa)
initn: 340 init1: 288 opt: 387 Z-score: 310.6 bits: 66.5 E(32554): 5.6e-11
Smith-Waterman score: 387; 35.4% identity (61.0% similar) in 254 aa overlap (65-300:299-544)
40 50 60 70 80 90
pF1KB7 MASVLAPGQPRSLDSSKHRLEVHTISDTSSPEAAEKDKSQQGKNEDVGA--EDPSKKKRQ
:: :: .... ..:. :. :..:
CCDS14 AATGAVAAAAAAAVATEGGELSPKEELLLHPEDAEGKDGEDSVCLSAGSDSEEGLLKRKQ
270 280 290 300 310 320
100 110 120 130 140 150
pF1KB7 RRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRER
:: :: ::: ::.::: .::...:::. ::::.:. .::::::.:::.::::::::::.
CCDS14 RRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK
330 340 350 360 370 380
160 170 180 190 200
pF1KB7 NQQAELCKNGF---GP-QFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKS-FPFFNSM
:. :. :: . . ..:: : : .. .. :.:. .. . :: :.
CCDS14 AG-AQTHPPGLPFPGPLSATHPLSPYLDASPFPPHHPALDSAWTAAAAAAAAAFP---SL
390 400 410 420 430 440
210 220 230 240 250 260
pF1KB7 NVNPLSSQSMFSPPNSISSMSMSSSMV------PSAVTGVPGSSLNSLNNLNNLSSPSLN
: .: :. :: : . ...:. . :. .. . : .... :.. :. .
CCDS14 PPPP-GSASL--PP-SGAPLGLSTFLGAAVFRHPAFISPAFGRLFSTMAPLTSASTAAAL
450 460 470 480 490 500
270 280 290 300 310
pF1KB7 SAVPTPACPYAPPT-----PPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSAC
:::: : . : . : ::.:.::::::.:..
CCDS14 LRQPTPAVEGAVASGALADPATAAADRRASSIAALRLKAKEHAAQLTQLNILPGTSTGKE
510 520 530 540 550 560
320
pF1KB7 QYAVDRPV
CCDS14 VC
>>CCDS9028.1 ALX1 gene_id:8092|Hs108|chr12 (326 aa)
initn: 396 init1: 348 opt: 382 Z-score: 310.0 bits: 65.6 E(32554): 6e-11
Smith-Waterman score: 430; 33.6% identity (60.1% similar) in 301 aa overlap (3-300:49-320)
10 20
pF1KB7 MNCMK--GPL-HLEHRAAGTKLSAVSSSSCHH
:.. ::: . ::.. . : ..:: ..
CCDS90 DFYMGAGGPLEHVMETLDNESFYSKASAGKCVQAFGPLPRAEHHVRLERTSPCQDSSVNY
20 30 40 50 60 70
30 40 50 60 70 80
pF1KB7 PQPLAMASVLAPGQPRSLDSSKHRLEVHTISDTSSPEAAEKDKSQQGKNEDVGAEDPSKK
....: ::: : . .: . : :: . ..:.. . : . :..
CCDS90 ----GITKV--EGQP--LHTELNRAMDNCNSLRMSPVKGMQEKGELDELGDKCDSNVSSS
80 90 100 110 120 130
90 100 110 120 130 140
pF1KB7 KRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRK
:. ::.:: ::: ::.::: .::...:::. .::..:. :.::::::.:::.::::::::
CCDS90 KK-RRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRK
140 150 160 170 180
150 160 170 180 190 200
pF1KB7 RERNQQAELCKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNV
::: : . :. :. .. . : : :: . : ::... .. ... .: .: .
CCDS90 RERYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWAGNASGGSVVTSCMLPRDTSSCM
190 200 210 220 230 240
210 220 230 240 250 260
pF1KB7 NPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPAC
.: : . : . ::.. :. . . :: :::. . :: ... .
CCDS90 TPYSHS-----PRTDSSYTGFSNH-QNQFSHVP---------LNNFFTDSLLTGATNG--
250 260 270 280 290
270 280 290 300 310 320
pF1KB7 PYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV
.: : : : . ::.: ::.:::.:..
CCDS90 -HAFETKPEFERRS--SSIAVLRMKAKEHTANISWAM
300 310 320
324 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 10:22:25 2016 done: Sat Nov 5 10:22:25 2016
Total Scan time: 2.570 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]