FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5218, 190 aa 1>>>pF1KE5218 190 - 190 aa - 190 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8908+/-0.000341; mu= 15.0161+/- 0.021 mean_var=57.3160+/-11.710, 0's: 0 Z-trim(113.9): 28 B-trim: 11 in 1/52 Lambda= 0.169409 statistics sampled from 23524 (23529) to 23524 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.664), E-opt: 0.2 (0.276), width: 16 Scan time: 5.080 The best scores are: opt bits E(85289) NP_001850 (OMIM: 603085) high affinity copper upta ( 190) 1272 318.8 3.4e-87 NP_001851 (OMIM: 603088) probable low affinity cop ( 143) 223 62.3 4e-10 XP_016869756 (OMIM: 603088) PREDICTED: probable lo ( 199) 222 62.2 6.3e-10 XP_011516518 (OMIM: 603088) PREDICTED: probable lo ( 141) 217 60.9 1.1e-09 >>NP_001850 (OMIM: 603085) high affinity copper uptake p (190 aa) initn: 1272 init1: 1272 opt: 1272 Z-score: 1686.5 bits: 318.8 E(85289): 3.4e-87 Smith-Waterman score: 1272; 100.0% identity (100.0% similar) in 190 aa overlap (1-190:1-190) 10 20 30 40 50 60 pF1KE5 MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 LVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 KTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKA 130 140 150 160 170 180 190 pF1KE5 VVVDITEHCH :::::::::: NP_001 VVVDITEHCH 190 >>NP_001851 (OMIM: 603088) probable low affinity copper (143 aa) initn: 210 init1: 118 opt: 223 Z-score: 302.7 bits: 62.3 E(85289): 4e-10 Smith-Waterman score: 228; 33.6% identity (65.0% similar) in 143 aa overlap (43-174:1-135) 20 30 40 50 60 70 pF1KE5 DSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSGLVINTAGEMAGA : : : :. : :::. ... . :: . NP_001 MAMHFIFSDTAV-LLFDFWSVHSPAGMALS 10 20 80 90 100 110 120 130 pF1KE5 FVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFP- ....:::..:::.:... .:: .:: . ..:. . :: ..:.. ::: NP_001 VLVLLLLAVLYEGIKVGKAKLL--NQVLV---NLPTSISQQTIAETDGDSAGSD--SFPV 30 40 50 60 70 80 140 150 160 170 180 pF1KE5 ----------HLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAV :. :...:.:::::.::.:: :.:: .. ..:. :...::.: NP_001 GRTHHRWYLCHFGQSLIHVIQVVIGYFIMLAVMSYNTWIFLGVVLGSAVGYYLAYPLLST 90 100 110 120 130 140 190 pF1KE5 VVDITEHCH NP_001 A >>XP_016869756 (OMIM: 603088) PREDICTED: probable low af (199 aa) initn: 196 init1: 118 opt: 222 Z-score: 299.2 bits: 62.2 E(85289): 6.3e-10 Smith-Waterman score: 227; 30.5% identity (64.3% similar) in 154 aa overlap (33-174:45-191) 10 20 30 40 50 60 pF1KE5 HSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVE-LLFSGL : : . ....: :... :::. XP_016 FVALVSRRLQDTHMAQLPDKMAANQICLPFHPHTDVCLHRNSFSMHFIFSDTAVLLFDFW 20 30 40 50 60 70 70 80 90 100 110 120 pF1KE5 VINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHK ... . :: . ....:::..:::.:... .:: .:: . ..:. . :: XP_016 SVHSPAGMALSVLVLLLLAVLYEGIKVGKAKLL--NQVLV---NLPTSISQQTIAETDGD 80 90 100 110 120 130 140 150 160 170 pF1KE5 TVGQQMLSFP-----------HLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGT ..:.. ::: :. :...:.:::::.::.:: :.:: .. ..:. :... XP_016 SAGSD--SFPVGRTHHRWYLCHFGQSLIHVIQVVIGYFIMLAVMSYNTWIFLGVVLGSAV 130 140 150 160 170 180 180 190 pF1KE5 GYFLFSWKKAVVVDITEHCH ::.: XP_016 GYYLAYPLLSTA 190 >>XP_011516518 (OMIM: 603088) PREDICTED: probable low af (141 aa) initn: 210 init1: 118 opt: 217 Z-score: 294.9 bits: 60.9 E(85289): 1.1e-09 Smith-Waterman score: 222; 33.3% identity (65.2% similar) in 141 aa overlap (45-174:1-133) 20 30 40 50 60 70 pF1KE5 NSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSGLVINTAGEMAGAFV : : :. : :::. ... . :: . . XP_011 MHFIFSDTAV-LLFDFWSVHSPAGMALSVL 10 20 80 90 100 110 120 130 pF1KE5 AVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFP--- ...:::..:::.:... .:: .:: . ..:. . :: ..:.. ::: XP_011 VLLLLAVLYEGIKVGKAKLL--NQVLV---NLPTSISQQTIAETDGDSAGSD--SFPVGR 30 40 50 60 70 80 140 150 160 170 180 pF1KE5 --------HLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVV :. :...:.:::::.::.:: :.:: .. ..:. :...::.: XP_011 THHRWYLCHFGQSLIHVIQVVIGYFIMLAVMSYNTWIFLGVVLGSAVGYYLAYPLLSTA 90 100 110 120 130 140 190 pF1KE5 DITEHCH 190 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 22:36:41 2016 done: Mon Nov 7 22:36:42 2016 Total Scan time: 5.080 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]