FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1325, 502 aa 1>>>pF1KE1325 502 - 502 aa - 502 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 15.8806+/-0.000482; mu= -27.7209+/- 0.030 mean_var=905.1992+/-186.480, 0's: 0 Z-trim(126.1): 91 B-trim: 0 in 0/62 Lambda= 0.042629 statistics sampled from 51266 (51456) to 51266 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.832), E-opt: 0.2 (0.603), width: 16 Scan time: 10.140 The best scores are: opt bits E(85289) NP_000368 (OMIM: 300299,300392,313900) wiskott-Ald ( 502) 3619 237.7 6e-62 XP_016885275 (OMIM: 300299,300392,313900) PREDICTE ( 590) 3487 229.7 1.8e-59 XP_011542279 (OMIM: 300299,300392,313900) PREDICTE ( 450) 2367 160.7 8.4e-39 NP_003932 (OMIM: 605056) neural Wiskott-Aldrich sy ( 505) 863 68.2 6.3e-11 XP_016857330 (OMIM: 606373,616193) PREDICTED: form (1102) 458 43.7 0.0034 XP_016857329 (OMIM: 606373,616193) PREDICTED: form (1102) 458 43.7 0.0034 XP_016857328 (OMIM: 606373,616193) PREDICTED: form (1159) 458 43.7 0.0035 XP_011542539 (OMIM: 606373,616193) PREDICTED: form (1360) 458 43.8 0.0039 XP_016857327 (OMIM: 606373,616193) PREDICTED: form (1384) 458 43.8 0.0039 XP_016857326 (OMIM: 606373,616193) PREDICTED: form (1417) 458 43.8 0.004 NP_064450 (OMIM: 606373,616193) formin-2 isoform 2 (1722) 458 43.9 0.0046 NP_001292353 (OMIM: 606373,616193) formin-2 isofor (1726) 458 43.9 0.0046 >>NP_000368 (OMIM: 300299,300392,313900) wiskott-Aldrich (502 aa) initn: 3619 init1: 3619 opt: 3619 Z-score: 1233.2 bits: 237.7 E(85289): 6e-62 Smith-Waterman score: 3619; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:1-502) 10 20 30 40 50 60 pF1KE1 MSGGPMGGRPGGRGAPAVQQNIPSTLLQDHENQRLFEMLGRKCLTLATAVVQLYLALPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MSGGPMGGRPGGRGAPAVQQNIPSTLLQDHENQRLFEMLGRKCLTLATAVVQLYLALPPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 AEHWTKEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AEHWTKEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 DCQAGLNFADEDEAQAFRALVQEKIQKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DCQAGLNFADEDEAQAFRALVQEKIQKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PGGDQGGPPVGPLSLGLATVDIQNPDITSSRYRGLPAPGPSPADKKRSGKKKISKADIGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PGGDQGGPPVGPLSLGLATVDIQNPDITSSRYRGLPAPGPSPADKKRSGKKKISKADIGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 EAVRQEMRRQEPLPPPPPPSRGGNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EAVRQEMRRQEPLPPPPPPSRGGNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 PPGRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPALV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PPGRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPALV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 PAGGLAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PAGGLAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSRA 430 440 450 460 470 480 490 500 pF1KE1 IHSSDEGEDQAGDEDEDDEWDD :::::::::::::::::::::: NP_000 IHSSDEGEDQAGDEDEDDEWDD 490 500 >>XP_016885275 (OMIM: 300299,300392,313900) PREDICTED: w (590 aa) initn: 3482 init1: 3482 opt: 3487 Z-score: 1188.5 bits: 229.7 E(85289): 1.8e-59 Smith-Waterman score: 3487; 98.8% identity (99.6% similar) in 493 aa overlap (1-492:1-493) 10 20 30 40 50 60 pF1KE1 MSGGPMGGRPGGRGAPAVQQNIPSTLLQDHENQRLFEMLGRKCLTLATAVVQLYLALPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSGGPMGGRPGGRGAPAVQQNIPSTLLQDHENQRLFEMLGRKCLTLATAVVQLYLALPPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 AEHWTKEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEHWTKEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 DCQAGLNFADEDEAQAFRALVQEKIQKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DCQAGLNFADEDEAQAFRALVQEKIQKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PGGDQGGPPVGPLSLGLATVDIQNPDITSSRYRGLPAPGPSPADKKRSGKKKISKADIGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGGDQGGPPVGPLSLGLATVDIQNPDITSSRYRGLPAPGPSPADKKRSGKKKISKADIGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 EAVRQEMRRQEPLPPPPPPSRGGNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAVRQEMRRQEPLPPPPPPSRGGNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 PPGRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPALV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPGRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPALV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 PAGGLAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAGGLAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSRA 430 440 450 460 470 480 490 500 pF1KE1 IHSS-DEGEDQAGDEDEDDEWDD :::: ... .::: XP_016 IHSSGSRSVSQAGVQWCNHGSVQPQPPRLKRSSRLSSQSSWDYRRVPPYLANFWCFFGSD 490 500 510 520 530 540 >>XP_011542279 (OMIM: 300299,300392,313900) PREDICTED: w (450 aa) initn: 2221 init1: 2221 opt: 2367 Z-score: 817.6 bits: 160.7 E(85289): 8.4e-39 Smith-Waterman score: 3090; 89.6% identity (89.6% similar) in 502 aa overlap (1-502:1-450) 10 20 30 40 50 60 pF1KE1 MSGGPMGGRPGGRGAPAVQQNIPSTLLQDHENQRLFEMLGRKCLTLATAVVQLYLALPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSGGPMGGRPGGRGAPAVQQNIPSTLLQDHENQRLFEMLGRKCLTLATAVVQLYLALPPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 AEHWTKEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AEHWTKEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 DCQAGLNFADEDEAQAFRALVQEKIQKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DCQAGLNFADEDEAQAFRALVQEKIQKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PGGDQGGPPVGPLSLGLATVDIQNPDITSSRYRGLPAPGPSPADKKRSGKKKISKADIGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGGDQGGPPVGPLSLGLATVDIQNPDITSSRYRGLPAPGPSPADKKRSGKKKISKADIGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 EAVRQEMRRQEPLPPPPPPSRGGNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPP :::::::::: XP_011 EAVRQEMRRQ-------------------------------------------------- 310 370 380 390 400 410 420 pF1KE1 PPGRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPALV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 --GRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPALV 320 330 340 350 360 430 440 450 460 470 480 pF1KE1 PAGGLAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PAGGLAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSRA 370 380 390 400 410 420 490 500 pF1KE1 IHSSDEGEDQAGDEDEDDEWDD :::::::::::::::::::::: XP_011 IHSSDEGEDQAGDEDEDDEWDD 430 440 450 >>NP_003932 (OMIM: 605056) neural Wiskott-Aldrich syndro (505 aa) initn: 1526 init1: 606 opt: 863 Z-score: 317.1 bits: 68.2 E(85289): 6.3e-11 Smith-Waterman score: 1546; 48.3% identity (66.6% similar) in 530 aa overlap (16-498:11-499) 10 20 30 40 50 60 pF1KE1 MSGGPMGGRPGGRGAPAVQQNIPSTLLQDHENQRLFEMLGRKCLTLATAVVQLYLALPPG : :. : :: .::. :: .::.::.:...:::::: : NP_003 MSSVQQQPPPPRRVTNVGSLLLTPQENESLFTFLGKKCVTMSSAVVQLYAA--DR 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 AEHWTKEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGD :.:. :..:.::::::.:::.:.. .. :.::::::::...::..: .::::::: NP_003 NCMWSKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 DCQAGLNFADEDEAQAFRALVQEKIQKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLH ::..::::.:.::. :: : . . .: ::.: ::. NP_003 TCQVALNFANEEEAKKFRKAVTDLLGRR-QRKSEKRRD---------------------- 120 130 140 150 190 200 210 220 230 pF1KE1 PGGDQGGPPVGPLSLGLATVDIQNPDITSSRYRGLPAPGPSPADKKRSGK---KKISKAD :: :: .: .:::::.::.::..:. : . . : . .:..:: :...::: NP_003 -------PPNGP-NLPMATVDIKNPEITTNRFYGPQVNNISHTKEKKKGKAKKKRLTKAD 160 170 180 190 200 240 250 260 270 280 290 pF1KE1 IGAPSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQ ::.::.:.:..::::::..:::.:::::.:..::. ::::::: : ::::.:::::: NP_003 IGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKT 210 220 230 240 250 260 300 310 320 330 340 pF1KE1 GGLEAVRQEMRRQEPLPPPPPPSRGGNQLPRPPIVGGN------KGRSGPLPP---VPLG ::.:::..:.::: : ::::::::: : :: ... .::..: :: .: . NP_003 GGVEAVKNELRRQAP--PPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTA 270 280 290 300 310 320 350 360 370 380 390 400 pF1KE1 IAPPPPTPRG-----PPPPGRGGPPPPPP-PATGRSGPLPPPPPGAG-GPPMPPPPPPPP :::: : ::::.: ::::: :... ::: :::: : :: :::::::: NP_003 APPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPPP 330 340 350 360 370 380 410 420 430 pF1KE1 PPPSSGNGPAPPPLPPA----LVP--AGGLAP-------GG---------------GRGA ::: :: ::: :. :: ::. : :. :: : NP_003 PPP----GPPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLKKVEQNSRPVSCSGRDA 390 400 410 420 430 440 450 460 470 480 490 pF1KE1 LLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSRAIHSSDEGEDQAGD :::::::::::... . ::. : : . :.:::::.::::::.::::::: ::. . NP_003 LLDQIRQGIQLKSVADGQESTP--PTPAPTSGIVGALMEVMQKRSKAIHSSDEDEDEDDE 440 450 460 470 480 490 500 pF1KE1 EDEDDEWDD :: .: NP_003 EDFEDDDEWED 500 >>XP_016857330 (OMIM: 606373,616193) PREDICTED: formin-2 (1102 aa) initn: 313 init1: 313 opt: 458 Z-score: 178.4 bits: 43.7 E(85289): 0.0034 Smith-Waterman score: 503; 31.1% identity (48.5% similar) in 379 aa overlap (116-466:96-454) 90 100 110 120 130 140 pF1KE1 RLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGDDCQAGLNFADEDEAQAFRALVQEKI : .:: : .: . .: :.. : : ..: XP_016 LRTKIAELERQYPALDTEVASGHQGLENGVTASGDVCLEALRL-EEKEVRHHRILEAKSI 70 80 90 100 110 120 150 160 170 180 190 200 pF1KE1 QKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLHPGGDQGGPPV---GPLSLGLAT--V : ...: : ::. ::: : : : ..:: . . .:: .. . XP_016 QTSPTEEGG---VLTLPPVD-------GLPGRPPCPPGAESGPQTKFCSEISLIVSPRRI 130 140 150 160 170 210 220 230 240 250 pF1KE1 DIQNPDITSSRYRGLPAPGPS---PADKKRSGKKKISKADIGAPSGFKHVSHVGWDPQNG ..: . .. . : : :: : . . :.. .:.. .: :. .:. XP_016 SVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQP--PHSISTEFQTSHEHSVSSAFKNS 180 190 200 210 220 230 260 270 280 290 300 310 pF1KE1 FDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEAVRQE--MRRQEPLPP .. . : : : ... .. : . . :. : .. : ::: XP_016 CNIPS-PPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPST-AIPQPPPLQGTEMLPP 240 250 260 270 280 290 320 330 340 350 360 370 pF1KE1 PPPPSRGGNQLPRPPIVGGNKGRSGPLPPVP-LGIAPPPPTPRG---PPPPGRGGPPPPP :::: :.. : ::. :.. ::::.: :: :::: : . :::: :. : : XP_016 PPPPLPGAGIPPPPPLPGAGI---LPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLP 300 310 320 330 340 380 390 400 410 pF1KE1 PPATGRSGPLPPPPPGAGGPPMPP------PPPPP-------PPPPSSGNG-PAPPPLPP :: : . : ::: :::: :: :: ::::: :::: : : : ::::: XP_016 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE1 ALVPAGGLAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKR : .: ::.: : . : : .. ::: . :. XP_016 AGIPPPPPLPGAGIPP--PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 410 420 430 440 450 460 480 490 500 pF1KE1 SRAIHSSDEGEDQAGDEDEDDEWDD XP_016 PPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 470 480 490 500 510 520 >>XP_016857329 (OMIM: 606373,616193) PREDICTED: formin-2 (1102 aa) initn: 313 init1: 313 opt: 458 Z-score: 178.4 bits: 43.7 E(85289): 0.0034 Smith-Waterman score: 503; 31.1% identity (48.5% similar) in 379 aa overlap (116-466:96-454) 90 100 110 120 130 140 pF1KE1 RLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGDDCQAGLNFADEDEAQAFRALVQEKI : .:: : .: . .: :.. : : ..: XP_016 LRTKIAELERQYPALDTEVASGHQGLENGVTASGDVCLEALRL-EEKEVRHHRILEAKSI 70 80 90 100 110 120 150 160 170 180 190 200 pF1KE1 QKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLHPGGDQGGPPV---GPLSLGLAT--V : ...: : ::. ::: : : : ..:: . . .:: .. . XP_016 QTSPTEEGG---VLTLPPVD-------GLPGRPPCPPGAESGPQTKFCSEISLIVSPRRI 130 140 150 160 170 210 220 230 240 250 pF1KE1 DIQNPDITSSRYRGLPAPGPS---PADKKRSGKKKISKADIGAPSGFKHVSHVGWDPQNG ..: . .. . : : :: : . . :.. .:.. .: :. .:. XP_016 SVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQP--PHSISTEFQTSHEHSVSSAFKNS 180 190 200 210 220 230 260 270 280 290 300 310 pF1KE1 FDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEAVRQE--MRRQEPLPP .. . : : : ... .. : . . :. : .. : ::: XP_016 CNIPS-PPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPST-AIPQPPPLQGTEMLPP 240 250 260 270 280 290 320 330 340 350 360 370 pF1KE1 PPPPSRGGNQLPRPPIVGGNKGRSGPLPPVP-LGIAPPPPTPRG---PPPPGRGGPPPPP :::: :.. : ::. :.. ::::.: :: :::: : . :::: :. : : XP_016 PPPPLPGAGIPPPPPLPGAGI---LPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLP 300 310 320 330 340 380 390 400 410 pF1KE1 PPATGRSGPLPPPPPGAGGPPMPP------PPPPP-------PPPPSSGNG-PAPPPLPP :: : . : ::: :::: :: :: ::::: :::: : : : ::::: XP_016 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE1 ALVPAGGLAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKR : .: ::.: : . : : .. ::: . :. XP_016 AGIPPPPPLPGAGIPP--PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 410 420 430 440 450 460 480 490 500 pF1KE1 SRAIHSSDEGEDQAGDEDEDDEWDD XP_016 PPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 470 480 490 500 510 520 >>XP_016857328 (OMIM: 606373,616193) PREDICTED: formin-2 (1159 aa) initn: 313 init1: 313 opt: 458 Z-score: 178.1 bits: 43.7 E(85289): 0.0035 Smith-Waterman score: 503; 31.1% identity (48.5% similar) in 379 aa overlap (116-466:153-511) 90 100 110 120 130 140 pF1KE1 RLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGDDCQAGLNFADEDEAQAFRALVQEKI : .:: : .: . .: :.. : : ..: XP_016 LRTKIAELERQYPALDTEVASGHQGLENGVTASGDVCLEALRL-EEKEVRHHRILEAKSI 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE1 QKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLHPGGDQGGPPV---GPLSLGLAT--V : ...: : ::. ::: : : : ..:: . . .:: .. . XP_016 QTSPTEEGG---VLTLPPVD-------GLPGRPPCPPGAESGPQTKFCSEISLIVSPRRI 190 200 210 220 230 210 220 230 240 250 pF1KE1 DIQNPDITSSRYRGLPAPGPS---PADKKRSGKKKISKADIGAPSGFKHVSHVGWDPQNG ..: . .. . : : :: : . . :.. .:.. .: :. .:. XP_016 SVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQP--PHSISTEFQTSHEHSVSSAFKNS 240 250 260 270 280 260 270 280 290 300 310 pF1KE1 FDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEAVRQE--MRRQEPLPP .. . : : : ... .. : . . :. : .. : ::: XP_016 CNIPS-PPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPST-AIPQPPPLQGTEMLPP 290 300 310 320 330 340 320 330 340 350 360 370 pF1KE1 PPPPSRGGNQLPRPPIVGGNKGRSGPLPPVP-LGIAPPPPTPRG---PPPPGRGGPPPPP :::: :.. : ::. :.. ::::.: :: :::: : . :::: :. : : XP_016 PPPPLPGAGIPPPPPLPGAGI---LPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLP 350 360 370 380 390 400 380 390 400 410 pF1KE1 PPATGRSGPLPPPPPGAGGPPMPP------PPPPP-------PPPPSSGNG-PAPPPLPP :: : . : ::: :::: :: :: ::::: :::: : : : ::::: XP_016 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 410 420 430 440 450 460 420 430 440 450 460 470 pF1KE1 ALVPAGGLAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKR : .: ::.: : . : : .. ::: . :. XP_016 AGIPPPPPLPGAGIPP--PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 470 480 490 500 510 520 480 490 500 pF1KE1 SRAIHSSDEGEDQAGDEDEDDEWDD XP_016 PPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 530 540 550 560 570 580 >>XP_011542539 (OMIM: 606373,616193) PREDICTED: formin-2 (1360 aa) initn: 313 init1: 313 opt: 458 Z-score: 177.3 bits: 43.8 E(85289): 0.0039 Smith-Waterman score: 503; 31.1% identity (48.5% similar) in 379 aa overlap (116-466:720-1078) 90 100 110 120 130 140 pF1KE1 RLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGDDCQAGLNFADEDEAQAFRALVQEKI : .:: : .: . .: :.. : : ..: XP_011 LRTKIAELERQYPALDTEVASGHQGLENGVTASGDVCLEALRL-EEKEVRHHRILEAKSI 690 700 710 720 730 740 150 160 170 180 190 200 pF1KE1 QKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLHPGGDQGGPPV---GPLSLGLAT--V : ...: : ::. ::: : : : ..:: . . .:: .. . XP_011 QTSPTEEGG---VLTLPPVD-------GLPGRPPCPPGAESGPQTKFCSEISLIVSPRRI 750 760 770 780 790 210 220 230 240 250 pF1KE1 DIQNPDITSSRYRGLPAPGPS---PADKKRSGKKKISKADIGAPSGFKHVSHVGWDPQNG ..: . .. . : : :: : . . :.. .:.. .: :. .:. XP_011 SVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQP--PHSISTEFQTSHEHSVSSAFKNS 800 810 820 830 840 850 260 270 280 290 300 310 pF1KE1 FDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEAVRQE--MRRQEPLPP .. . : : : ... .. : . . :. : .. : ::: XP_011 CNIPS-PPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPST-AIPQPPPLQGTEMLPP 860 870 880 890 900 910 320 330 340 350 360 370 pF1KE1 PPPPSRGGNQLPRPPIVGGNKGRSGPLPPVP-LGIAPPPPTPRG---PPPPGRGGPPPPP :::: :.. : ::. :.. ::::.: :: :::: : . :::: :. : : XP_011 PPPPLPGAGIPPPPPLPGAGI---LPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLP 920 930 940 950 960 970 380 390 400 410 pF1KE1 PPATGRSGPLPPPPPGAGGPPMPP------PPPPP-------PPPPSSGNG-PAPPPLPP :: : . : ::: :::: :: :: ::::: :::: : : : ::::: XP_011 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 980 990 1000 1010 1020 1030 420 430 440 450 460 470 pF1KE1 ALVPAGGLAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKR : .: ::.: : . : : .. ::: . :. XP_011 AGIPPPPPLPGAGIPP--PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1040 1050 1060 1070 1080 480 490 500 pF1KE1 SRAIHSSDEGEDQAGDEDEDDEWDD XP_011 PPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1090 1100 1110 1120 1130 1140 >>XP_016857327 (OMIM: 606373,616193) PREDICTED: formin-2 (1384 aa) initn: 313 init1: 313 opt: 458 Z-score: 177.2 bits: 43.8 E(85289): 0.0039 Smith-Waterman score: 503; 31.1% identity (48.5% similar) in 379 aa overlap (116-466:720-1078) 90 100 110 120 130 140 pF1KE1 RLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGDDCQAGLNFADEDEAQAFRALVQEKI : .:: : .: . .: :.. : : ..: XP_016 LRTKIAELERQYPALDTEVASGHQGLENGVTASGDVCLEALRL-EEKEVRHHRILEAKSI 690 700 710 720 730 740 150 160 170 180 190 200 pF1KE1 QKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLHPGGDQGGPPV---GPLSLGLAT--V : ...: : ::. ::: : : : ..:: . . .:: .. . XP_016 QTSPTEEGG---VLTLPPVD-------GLPGRPPCPPGAESGPQTKFCSEISLIVSPRRI 750 760 770 780 790 210 220 230 240 250 pF1KE1 DIQNPDITSSRYRGLPAPGPS---PADKKRSGKKKISKADIGAPSGFKHVSHVGWDPQNG ..: . .. . : : :: : . . :.. .:.. .: :. .:. XP_016 SVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQP--PHSISTEFQTSHEHSVSSAFKNS 800 810 820 830 840 850 260 270 280 290 300 310 pF1KE1 FDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEAVRQE--MRRQEPLPP .. . : : : ... .. : . . :. : .. : ::: XP_016 CNIPS-PPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPST-AIPQPPPLQGTEMLPP 860 870 880 890 900 910 320 330 340 350 360 370 pF1KE1 PPPPSRGGNQLPRPPIVGGNKGRSGPLPPVP-LGIAPPPPTPRG---PPPPGRGGPPPPP :::: :.. : ::. :.. ::::.: :: :::: : . :::: :. : : XP_016 PPPPLPGAGIPPPPPLPGAGI---LPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLP 920 930 940 950 960 970 380 390 400 410 pF1KE1 PPATGRSGPLPPPPPGAGGPPMPP------PPPPP-------PPPPSSGNG-PAPPPLPP :: : . : ::: :::: :: :: ::::: :::: : : : ::::: XP_016 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 980 990 1000 1010 1020 1030 420 430 440 450 460 470 pF1KE1 ALVPAGGLAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKR : .: ::.: : . : : .. ::: . :. XP_016 AGIPPPPPLPGAGIPP--PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1040 1050 1060 1070 1080 480 490 500 pF1KE1 SRAIHSSDEGEDQAGDEDEDDEWDD XP_016 PPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1090 1100 1110 1120 1130 1140 >>XP_016857326 (OMIM: 606373,616193) PREDICTED: formin-2 (1417 aa) initn: 313 init1: 313 opt: 458 Z-score: 177.1 bits: 43.8 E(85289): 0.004 Smith-Waterman score: 503; 31.1% identity (48.5% similar) in 379 aa overlap (116-466:720-1078) 90 100 110 120 130 140 pF1KE1 RLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGDDCQAGLNFADEDEAQAFRALVQEKI : .:: : .: . .: :.. : : ..: XP_016 LRTKIAELERQYPALDTEVASGHQGLENGVTASGDVCLEALRL-EEKEVRHHRILEAKSI 690 700 710 720 730 740 150 160 170 180 190 200 pF1KE1 QKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLHPGGDQGGPPV---GPLSLGLAT--V : ...: : ::. ::: : : : ..:: . . .:: .. . XP_016 QTSPTEEGG---VLTLPPVD-------GLPGRPPCPPGAESGPQTKFCSEISLIVSPRRI 750 760 770 780 790 210 220 230 240 250 pF1KE1 DIQNPDITSSRYRGLPAPGPS---PADKKRSGKKKISKADIGAPSGFKHVSHVGWDPQNG ..: . .. . : : :: : . . :.. .:.. .: :. .:. XP_016 SVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQP--PHSISTEFQTSHEHSVSSAFKNS 800 810 820 830 840 850 260 270 280 290 300 310 pF1KE1 FDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEAVRQE--MRRQEPLPP .. . : : : ... .. : . . :. : .. : ::: XP_016 CNIPS-PPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPST-AIPQPPPLQGTEMLPP 860 870 880 890 900 910 320 330 340 350 360 370 pF1KE1 PPPPSRGGNQLPRPPIVGGNKGRSGPLPPVP-LGIAPPPPTPRG---PPPPGRGGPPPPP :::: :.. : ::. :.. ::::.: :: :::: : . :::: :. : : XP_016 PPPPLPGAGIPPPPPLPGAGI---LPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLP 920 930 940 950 960 970 380 390 400 410 pF1KE1 PPATGRSGPLPPPPPGAGGPPMPP------PPPPP-------PPPPSSGNG-PAPPPLPP :: : . : ::: :::: :: :: ::::: :::: : : : ::::: XP_016 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 980 990 1000 1010 1020 1030 420 430 440 450 460 470 pF1KE1 ALVPAGGLAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKR : .: ::.: : . : : .. ::: . :. XP_016 AGIPPPPPLPGAGIPP--PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1040 1050 1060 1070 1080 480 490 500 pF1KE1 SRAIHSSDEGEDQAGDEDEDDEWDD XP_016 PPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1090 1100 1110 1120 1130 1140 502 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 01:39:49 2016 done: Mon Nov 7 01:39:50 2016 Total Scan time: 10.140 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]