FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3588, 786 aa 1>>>pF1KE3588 786 - 786 aa - 786 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.6340+/-0.000359; mu= 8.8887+/- 0.023 mean_var=128.4971+/-25.363, 0's: 0 Z-trim(117.6): 41 B-trim: 33 in 1/55 Lambda= 0.113143 statistics sampled from 29670 (29711) to 29670 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.712), E-opt: 0.2 (0.348), width: 16 Scan time: 10.970 The best scores are: opt bits E(85289) NP_001752 (OMIM: 600227) cyclin-F isoform 1 [Homo ( 786) 5305 877.8 0 XP_016879311 (OMIM: 600227) PREDICTED: cyclin-F is ( 867) 5271 872.2 0 NP_001310467 (OMIM: 600227) cyclin-F isoform 2 [Ho ( 478) 3212 536.0 1.4e-151 XP_016879312 (OMIM: 600227) PREDICTED: cyclin-F is ( 446) 2447 411.1 5.1e-114 NP_001104517 (OMIM: 604036) cyclin-A1 isoform c [H ( 421) 399 76.8 2.1e-13 NP_001104516 (OMIM: 604036) cyclin-A1 isoform c [H ( 421) 399 76.8 2.1e-13 XP_011533596 (OMIM: 604036) PREDICTED: cyclin-A1 i ( 421) 399 76.8 2.1e-13 XP_011533597 (OMIM: 604036) PREDICTED: cyclin-A1 i ( 421) 399 76.8 2.1e-13 XP_011533598 (OMIM: 604036) PREDICTED: cyclin-A1 i ( 421) 399 76.8 2.1e-13 NP_001104515 (OMIM: 604036) cyclin-A1 isoform b [H ( 464) 399 76.9 2.3e-13 NP_003905 (OMIM: 604036) cyclin-A1 isoform a [Homo ( 465) 399 76.9 2.3e-13 NP_001228 (OMIM: 123835) cyclin-A2 [Homo sapiens] ( 432) 377 73.3 2.6e-12 XP_016885407 (OMIM: 300456) PREDICTED: G2/mitotic- (1395) 301 61.1 3.8e-08 NP_149020 (OMIM: 300456) G2/mitotic-specific cycli (1395) 301 61.1 3.8e-08 XP_016885406 (OMIM: 300456) PREDICTED: G2/mitotic- (1396) 301 61.1 3.8e-08 XP_016885405 (OMIM: 300456) PREDICTED: G2/mitotic- (1403) 301 61.1 3.9e-08 XP_016885402 (OMIM: 300456) PREDICTED: G2/mitotic- (1404) 301 61.1 3.9e-08 XP_016885404 (OMIM: 300456) PREDICTED: G2/mitotic- (1404) 301 61.1 3.9e-08 XP_016885403 (OMIM: 300456) PREDICTED: G2/mitotic- (1404) 301 61.1 3.9e-08 NP_114172 (OMIM: 123836) G2/mitotic-specific cycli ( 433) 286 58.4 7.6e-08 NP_004692 (OMIM: 602755) G2/mitotic-specific cycli ( 398) 274 56.4 2.8e-07 NP_391990 (OMIM: 300456) G2/mitotic-specific cycli ( 291) 236 50.2 1.6e-05 NP_001750 (OMIM: 123833,615938) G1/S-specific cycl ( 289) 212 46.2 0.00023 NP_444284 (OMIM: 168461,193300,254500) G1/S-specif ( 295) 206 45.3 0.00047 >>NP_001752 (OMIM: 600227) cyclin-F isoform 1 [Homo sapi (786 aa) initn: 5305 init1: 5305 opt: 5305 Z-score: 4685.4 bits: 877.8 E(85289): 0 Smith-Waterman score: 5305; 100.0% identity (100.0% similar) in 786 aa overlap (1-786:1-786) 10 20 30 40 50 60 pF1KE3 MGSGGVVHCRCAKCFCYPTKRRIRRRPRNLTILSLPEDVLFHILKWLSVEDILAVRAVHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGSGGVVHCRCAKCFCYPTKRRIRRRPRNLTILSLPEDVLFHILKWLSVEDILAVRAVHS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 QLKDLVDNHASVWACASFQELWPSPGNLKLFERAAEKGNFEAAVKLGIAYLYNEGLSVSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLKDLVDNHASVWACASFQELWPSPGNLKLFERAAEKGNFEAAVKLGIAYLYNEGLSVSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 EARAEVNGLKASRFFSLAERLNVGAAPFIWLFIRPPWSVSGSCCKAVVHESLRAECQLQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EARAEVNGLKASRFFSLAERLNVGAAPFIWLFIRPPWSVSGSCCKAVVHESLRAECQLQR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 THKASILHCLGRVLSLFEDEEKQQQAHDLFEEAAHQGCLTSSYLLWESDRRTDVSDPGRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 THKASILHCLGRVLSLFEDEEKQQQAHDLFEEAAHQGCLTSSYLLWESDRRTDVSDPGRC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LHSFRKLRDYAAKGCWEAQLSLAKACANANQLGLEVRASSEIVCQLFQASQAVSKQQVFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHSFRKLRDYAAKGCWEAQLSLAKACANANQLGLEVRASSEIVCQLFQASQAVSKQQVFS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 VQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRYLRRRLVPRYRLQLLGIACM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRYLRRRLVPRYRLQLLGIACM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 VICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIVSALEGKIRVPTVVDYKEVLLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIVSALEGKIRVPTVVDYKEVLLTL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 VPVELRTQHLCSFLCELSLLHTSLSAYAPARLAAAALLLARLTHGQTQPWTTQLWDLTGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPVELRTQHLCSFLCELSLLHTSLSAYAPARLAAAALLLARLTHGQTQPWTTQLWDLTGF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 SYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRFEDKRYGEISQEEVLSYSQLCAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRFEDKRYGEISQEEVLSYSQLCAAL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 GVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKRKRENSLQEDRGSFVTTPTAELSSQEETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKRKRENSLQEDRGSFVTTPTAELSSQEETL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 LGSFLDWSLDCCSGYEGDQESEGEKEGDVTAPSGILDVTVVYLNPEQHCCQESSDEEACP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGSFLDWSLDCCSGYEGDQESEGEKEGDVTAPSGILDVTVVYLNPEQHCCQESSDEEACP 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 EDKGPQDPQALALDTQIPATPGPKPLVRTSREPGKDVTTSGYSSVSTASPTSSVDGGLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDKGPQDPQALALDTQIPATPGPKPLVRTSREPGKDVTTSGYSSVSTASPTSSVDGGLGA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 LPQPTSVLSLDSDSHTQPCHHQARKSCLQCRPPSPPESSVPQQQVKRINLCIHSEEEDMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPQPTSVLSLDSDSHTQPCHHQARKSCLQCRPPSPPESSVPQQQVKRINLCIHSEEEDMN 730 740 750 760 770 780 pF1KE3 LGLVRL :::::: NP_001 LGLVRL >>XP_016879311 (OMIM: 600227) PREDICTED: cyclin-F isofor (867 aa) initn: 5271 init1: 5271 opt: 5271 Z-score: 4654.8 bits: 872.2 E(85289): 0 Smith-Waterman score: 5271; 99.7% identity (99.9% similar) in 784 aa overlap (3-786:84-867) 10 20 30 pF1KE3 MGSGGVVHCRCAKCFCYPTKRRIRRRPRNLTI : .::::::::::::::::::::::::::: XP_016 TTQQSGHHGGRLPELRMPCAPGPKRRPTRASRAVVHCRCAKCFCYPTKRRIRRRPRNLTI 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE3 LSLPEDVLFHILKWLSVEDILAVRAVHSQLKDLVDNHASVWACASFQELWPSPGNLKLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSLPEDVLFHILKWLSVEDILAVRAVHSQLKDLVDNHASVWACASFQELWPSPGNLKLFE 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE3 RAAEKGNFEAAVKLGIAYLYNEGLSVSDEARAEVNGLKASRFFSLAERLNVGAAPFIWLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAAEKGNFEAAVKLGIAYLYNEGLSVSDEARAEVNGLKASRFFSLAERLNVGAAPFIWLF 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE3 IRPPWSVSGSCCKAVVHESLRAECQLQRTHKASILHCLGRVLSLFEDEEKQQQAHDLFEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IRPPWSVSGSCCKAVVHESLRAECQLQRTHKASILHCLGRVLSLFEDEEKQQQAHDLFEE 240 250 260 270 280 290 220 230 240 250 260 270 pF1KE3 AAHQGCLTSSYLLWESDRRTDVSDPGRCLHSFRKLRDYAAKGCWEAQLSLAKACANANQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAHQGCLTSSYLLWESDRRTDVSDPGRCLHSFRKLRDYAAKGCWEAQLSLAKACANANQL 300 310 320 330 340 350 280 290 300 310 320 330 pF1KE3 GLEVRASSEIVCQLFQASQAVSKQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLEVRASSEIVCQLFQASQAVSKQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLH 360 370 380 390 400 410 340 350 360 370 380 390 pF1KE3 LTVECVDRYLRRRLVPRYRLQLLGIACMVICTRFISKEILTIREAVWLTDNTYKYEDLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTVECVDRYLRRRLVPRYRLQLLGIACMVICTRFISKEILTIREAVWLTDNTYKYEDLVR 420 430 440 450 460 470 400 410 420 430 440 450 pF1KE3 MMGEIVSALEGKIRVPTVVDYKEVLLTLVPVELRTQHLCSFLCELSLLHTSLSAYAPARL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MMGEIVSALEGKIRVPTVVDYKEVLLTLVPVELRTQHLCSFLCELSLLHTSLSAYAPARL 480 490 500 510 520 530 460 470 480 490 500 510 pF1KE3 AAAALLLARLTHGQTQPWTTQLWDLTGFSYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAAALLLARLTHGQTQPWTTQLWDLTGFSYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTA 540 550 560 570 580 590 520 530 540 550 560 570 pF1KE3 VKQRFEDKRYGEISQEEVLSYSQLCAALGVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKQRFEDKRYGEISQEEVLSYSQLCAALGVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKR 600 610 620 630 640 650 580 590 600 610 620 630 pF1KE3 KRENSLQEDRGSFVTTPTAELSSQEETLLGSFLDWSLDCCSGYEGDQESEGEKEGDVTAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRENSLQEDRGSFVTTPTAELSSQEETLLGSFLDWSLDCCSGYEGDQESEGEKEGDVTAP 660 670 680 690 700 710 640 650 660 670 680 690 pF1KE3 SGILDVTVVYLNPEQHCCQESSDEEACPEDKGPQDPQALALDTQIPATPGPKPLVRTSRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGILDVTVVYLNPEQHCCQESSDEEACPEDKGPQDPQALALDTQIPATPGPKPLVRTSRE 720 730 740 750 760 770 700 710 720 730 740 750 pF1KE3 PGKDVTTSGYSSVSTASPTSSVDGGLGALPQPTSVLSLDSDSHTQPCHHQARKSCLQCRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGKDVTTSGYSSVSTASPTSSVDGGLGALPQPTSVLSLDSDSHTQPCHHQARKSCLQCRP 780 790 800 810 820 830 760 770 780 pF1KE3 PSPPESSVPQQQVKRINLCIHSEEEDMNLGLVRL :::::::::::::::::::::::::::::::::: XP_016 PSPPESSVPQQQVKRINLCIHSEEEDMNLGLVRL 840 850 860 >>NP_001310467 (OMIM: 600227) cyclin-F isoform 2 [Homo s (478 aa) initn: 3212 init1: 3212 opt: 3212 Z-score: 2842.4 bits: 536.0 E(85289): 1.4e-151 Smith-Waterman score: 3212; 100.0% identity (100.0% similar) in 478 aa overlap (309-786:1-478) 280 290 300 310 320 330 pF1KE3 SSEIVCQLFQASQAVSKQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECV :::::::::::::::::::::::::::::: NP_001 MRYILIDWLVEVATMKDFTSLCLHLTVECV 10 20 30 340 350 360 370 380 390 pF1KE3 DRYLRRRLVPRYRLQLLGIACMVICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRYLRRRLVPRYRLQLLGIACMVICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIV 40 50 60 70 80 90 400 410 420 430 440 450 pF1KE3 SALEGKIRVPTVVDYKEVLLTLVPVELRTQHLCSFLCELSLLHTSLSAYAPARLAAAALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SALEGKIRVPTVVDYKEVLLTLVPVELRTQHLCSFLCELSLLHTSLSAYAPARLAAAALL 100 110 120 130 140 150 460 470 480 490 500 510 pF1KE3 LARLTHGQTQPWTTQLWDLTGFSYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LARLTHGQTQPWTTQLWDLTGFSYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRFE 160 170 180 190 200 210 520 530 540 550 560 570 pF1KE3 DKRYGEISQEEVLSYSQLCAALGVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKRKRENSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKRYGEISQEEVLSYSQLCAALGVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKRKRENSL 220 230 240 250 260 270 580 590 600 610 620 630 pF1KE3 QEDRGSFVTTPTAELSSQEETLLGSFLDWSLDCCSGYEGDQESEGEKEGDVTAPSGILDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEDRGSFVTTPTAELSSQEETLLGSFLDWSLDCCSGYEGDQESEGEKEGDVTAPSGILDV 280 290 300 310 320 330 640 650 660 670 680 690 pF1KE3 TVVYLNPEQHCCQESSDEEACPEDKGPQDPQALALDTQIPATPGPKPLVRTSREPGKDVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVVYLNPEQHCCQESSDEEACPEDKGPQDPQALALDTQIPATPGPKPLVRTSREPGKDVT 340 350 360 370 380 390 700 710 720 730 740 750 pF1KE3 TSGYSSVSTASPTSSVDGGLGALPQPTSVLSLDSDSHTQPCHHQARKSCLQCRPPSPPES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSGYSSVSTASPTSSVDGGLGALPQPTSVLSLDSDSHTQPCHHQARKSCLQCRPPSPPES 400 410 420 430 440 450 760 770 780 pF1KE3 SVPQQQVKRINLCIHSEEEDMNLGLVRL :::::::::::::::::::::::::::: NP_001 SVPQQQVKRINLCIHSEEEDMNLGLVRL 460 470 >>XP_016879312 (OMIM: 600227) PREDICTED: cyclin-F isofor (446 aa) initn: 2447 init1: 2447 opt: 2447 Z-score: 2168.0 bits: 411.1 E(85289): 5.1e-114 Smith-Waterman score: 2447; 99.4% identity (99.7% similar) in 363 aa overlap (3-365:84-446) 10 20 30 pF1KE3 MGSGGVVHCRCAKCFCYPTKRRIRRRPRNLTI : .::::::::::::::::::::::::::: XP_016 TTQQSGHHGGRLPELRMPCAPGPKRRPTRASRAVVHCRCAKCFCYPTKRRIRRRPRNLTI 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE3 LSLPEDVLFHILKWLSVEDILAVRAVHSQLKDLVDNHASVWACASFQELWPSPGNLKLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSLPEDVLFHILKWLSVEDILAVRAVHSQLKDLVDNHASVWACASFQELWPSPGNLKLFE 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE3 RAAEKGNFEAAVKLGIAYLYNEGLSVSDEARAEVNGLKASRFFSLAERLNVGAAPFIWLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAAEKGNFEAAVKLGIAYLYNEGLSVSDEARAEVNGLKASRFFSLAERLNVGAAPFIWLF 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE3 IRPPWSVSGSCCKAVVHESLRAECQLQRTHKASILHCLGRVLSLFEDEEKQQQAHDLFEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IRPPWSVSGSCCKAVVHESLRAECQLQRTHKASILHCLGRVLSLFEDEEKQQQAHDLFEE 240 250 260 270 280 290 220 230 240 250 260 270 pF1KE3 AAHQGCLTSSYLLWESDRRTDVSDPGRCLHSFRKLRDYAAKGCWEAQLSLAKACANANQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAHQGCLTSSYLLWESDRRTDVSDPGRCLHSFRKLRDYAAKGCWEAQLSLAKACANANQL 300 310 320 330 340 350 280 290 300 310 320 330 pF1KE3 GLEVRASSEIVCQLFQASQAVSKQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLEVRASSEIVCQLFQASQAVSKQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLH 360 370 380 390 400 410 340 350 360 370 380 390 pF1KE3 LTVECVDRYLRRRLVPRYRLQLLGIACMVICTRFISKEILTIREAVWLTDNTYKYEDLVR ::::::::::::::::::::::::::::::::: XP_016 LTVECVDRYLRRRLVPRYRLQLLGIACMVICTR 420 430 440 400 410 420 430 440 450 pF1KE3 MMGEIVSALEGKIRVPTVVDYKEVLLTLVPVELRTQHLCSFLCELSLLHTSLSAYAPARL >>NP_001104517 (OMIM: 604036) cyclin-A1 isoform c [Homo (421 aa) initn: 306 init1: 306 opt: 399 Z-score: 361.7 bits: 76.8 E(85289): 2.1e-13 Smith-Waterman score: 399; 28.1% identity (58.8% similar) in 342 aa overlap (200-529:84-413) 170 180 190 200 210 220 pF1KE3 ESLRAECQLQRTHKASILHCLGRVLSLFEDEEKQQQAHDLFEEAAHQG----CLTSSYLL .: .:. :.. . .:: : . . NP_001 GQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMA 60 70 80 90 100 110 230 240 250 260 270 280 pF1KE3 WESDRRTDVSDPGRCLHSFRKLRDYAAKGCWEAQLSLAKACANANQLGLEVRASSEIVCQ .:. ..:.. :: : : :. . . .. :: . . ..:: .: .: . . NP_001 FEDVYEVDTGTLKSDLH-F--LLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEE 120 130 140 150 160 170 290 300 310 320 330 340 pF1KE3 LFQASQAVS-----KQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDR ..: . . : . .. : ... :: ::.::::::. . . :.:.:. .:: NP_001 IYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDR 180 190 200 210 220 230 350 360 370 380 390 pF1KE3 YLRRRLVPRYRLQLLGIACMVICTRFISKEILT--IREAVWLTDNTYKYEDLVRMMGEIV .: : : .:::.: : :.. ... .:: . : :..::.:: ..:..: .. NP_001 FLSCMSVLRGKLQLVGTAAMLLASKY--EEIYPPEVDEFVYITDDTYTKRQLLKMEHLLL 240 250 260 270 280 400 410 420 430 440 450 pF1KE3 SALEGKIRVPTVVDYKEVLLTLVPVELRTQHLCSFLCELSLLHTS-LSAYAPARLAAAAL ..: . :::. .. : : .::..: ... :::::... . : :. .::::. NP_001 KVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAF 290 300 310 320 330 340 460 470 480 490 500 510 pF1KE3 LLARLTHGQTQPWTTQLWDLTGFSYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRF :: : .. . : : .::.: ...::. ::: . : :. .: :..... NP_001 CLANYTVNK-HFWPETLAAFTGYSLSEIVPCLSELHKAYL--DIPHRPQQ----AIREKY 350 360 370 380 390 400 520 530 540 550 560 570 pF1KE3 EDKRYGEISQEEVLSYSQLCAALGVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKRKRENS . ..: .: : NP_001 KASKYLCVSLMEPPAVLLLQ 410 420 >>NP_001104516 (OMIM: 604036) cyclin-A1 isoform c [Homo (421 aa) initn: 306 init1: 306 opt: 399 Z-score: 361.7 bits: 76.8 E(85289): 2.1e-13 Smith-Waterman score: 399; 28.1% identity (58.8% similar) in 342 aa overlap (200-529:84-413) 170 180 190 200 210 220 pF1KE3 ESLRAECQLQRTHKASILHCLGRVLSLFEDEEKQQQAHDLFEEAAHQG----CLTSSYLL .: .:. :.. . .:: : . . NP_001 GQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMA 60 70 80 90 100 110 230 240 250 260 270 280 pF1KE3 WESDRRTDVSDPGRCLHSFRKLRDYAAKGCWEAQLSLAKACANANQLGLEVRASSEIVCQ .:. ..:.. :: : : :. . . .. :: . . ..:: .: .: . . NP_001 FEDVYEVDTGTLKSDLH-F--LLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEE 120 130 140 150 160 170 290 300 310 320 330 340 pF1KE3 LFQASQAVS-----KQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDR ..: . . : . .. : ... :: ::.::::::. . . :.:.:. .:: NP_001 IYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDR 180 190 200 210 220 230 350 360 370 380 390 pF1KE3 YLRRRLVPRYRLQLLGIACMVICTRFISKEILT--IREAVWLTDNTYKYEDLVRMMGEIV .: : : .:::.: : :.. ... .:: . : :..::.:: ..:..: .. NP_001 FLSCMSVLRGKLQLVGTAAMLLASKY--EEIYPPEVDEFVYITDDTYTKRQLLKMEHLLL 240 250 260 270 280 400 410 420 430 440 450 pF1KE3 SALEGKIRVPTVVDYKEVLLTLVPVELRTQHLCSFLCELSLLHTS-LSAYAPARLAAAAL ..: . :::. .. : : .::..: ... :::::... . : :. .::::. NP_001 KVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAF 290 300 310 320 330 340 460 470 480 490 500 510 pF1KE3 LLARLTHGQTQPWTTQLWDLTGFSYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRF :: : .. . : : .::.: ...::. ::: . : :. .: :..... NP_001 CLANYTVNK-HFWPETLAAFTGYSLSEIVPCLSELHKAYL--DIPHRPQQ----AIREKY 350 360 370 380 390 400 520 530 540 550 560 570 pF1KE3 EDKRYGEISQEEVLSYSQLCAALGVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKRKRENS . ..: .: : NP_001 KASKYLCVSLMEPPAVLLLQ 410 420 >>XP_011533596 (OMIM: 604036) PREDICTED: cyclin-A1 isofo (421 aa) initn: 306 init1: 306 opt: 399 Z-score: 361.7 bits: 76.8 E(85289): 2.1e-13 Smith-Waterman score: 399; 28.1% identity (58.8% similar) in 342 aa overlap (200-529:84-413) 170 180 190 200 210 220 pF1KE3 ESLRAECQLQRTHKASILHCLGRVLSLFEDEEKQQQAHDLFEEAAHQG----CLTSSYLL .: .:. :.. . .:: : . . XP_011 GQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMA 60 70 80 90 100 110 230 240 250 260 270 280 pF1KE3 WESDRRTDVSDPGRCLHSFRKLRDYAAKGCWEAQLSLAKACANANQLGLEVRASSEIVCQ .:. ..:.. :: : : :. . . .. :: . . ..:: .: .: . . XP_011 FEDVYEVDTGTLKSDLH-F--LLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEE 120 130 140 150 160 170 290 300 310 320 330 340 pF1KE3 LFQASQAVS-----KQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDR ..: . . : . .. : ... :: ::.::::::. . . :.:.:. .:: XP_011 IYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDR 180 190 200 210 220 230 350 360 370 380 390 pF1KE3 YLRRRLVPRYRLQLLGIACMVICTRFISKEILT--IREAVWLTDNTYKYEDLVRMMGEIV .: : : .:::.: : :.. ... .:: . : :..::.:: ..:..: .. XP_011 FLSCMSVLRGKLQLVGTAAMLLASKY--EEIYPPEVDEFVYITDDTYTKRQLLKMEHLLL 240 250 260 270 280 400 410 420 430 440 450 pF1KE3 SALEGKIRVPTVVDYKEVLLTLVPVELRTQHLCSFLCELSLLHTS-LSAYAPARLAAAAL ..: . :::. .. : : .::..: ... :::::... . : :. .::::. XP_011 KVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAF 290 300 310 320 330 340 460 470 480 490 500 510 pF1KE3 LLARLTHGQTQPWTTQLWDLTGFSYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRF :: : .. . : : .::.: ...::. ::: . : :. .: :..... XP_011 CLANYTVNK-HFWPETLAAFTGYSLSEIVPCLSELHKAYL--DIPHRPQQ----AIREKY 350 360 370 380 390 400 520 530 540 550 560 570 pF1KE3 EDKRYGEISQEEVLSYSQLCAALGVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKRKRENS . ..: .: : XP_011 KASKYLCVSLMEPPAVLLLQ 410 420 >>XP_011533597 (OMIM: 604036) PREDICTED: cyclin-A1 isofo (421 aa) initn: 306 init1: 306 opt: 399 Z-score: 361.7 bits: 76.8 E(85289): 2.1e-13 Smith-Waterman score: 399; 28.1% identity (58.8% similar) in 342 aa overlap (200-529:84-413) 170 180 190 200 210 220 pF1KE3 ESLRAECQLQRTHKASILHCLGRVLSLFEDEEKQQQAHDLFEEAAHQG----CLTSSYLL .: .:. :.. . .:: : . . XP_011 GQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMA 60 70 80 90 100 110 230 240 250 260 270 280 pF1KE3 WESDRRTDVSDPGRCLHSFRKLRDYAAKGCWEAQLSLAKACANANQLGLEVRASSEIVCQ .:. ..:.. :: : : :. . . .. :: . . ..:: .: .: . . XP_011 FEDVYEVDTGTLKSDLH-F--LLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEE 120 130 140 150 160 170 290 300 310 320 330 340 pF1KE3 LFQASQAVS-----KQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDR ..: . . : . .. : ... :: ::.::::::. . . :.:.:. .:: XP_011 IYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDR 180 190 200 210 220 230 350 360 370 380 390 pF1KE3 YLRRRLVPRYRLQLLGIACMVICTRFISKEILT--IREAVWLTDNTYKYEDLVRMMGEIV .: : : .:::.: : :.. ... .:: . : :..::.:: ..:..: .. XP_011 FLSCMSVLRGKLQLVGTAAMLLASKY--EEIYPPEVDEFVYITDDTYTKRQLLKMEHLLL 240 250 260 270 280 400 410 420 430 440 450 pF1KE3 SALEGKIRVPTVVDYKEVLLTLVPVELRTQHLCSFLCELSLLHTS-LSAYAPARLAAAAL ..: . :::. .. : : .::..: ... :::::... . : :. .::::. XP_011 KVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAF 290 300 310 320 330 340 460 470 480 490 500 510 pF1KE3 LLARLTHGQTQPWTTQLWDLTGFSYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRF :: : .. . : : .::.: ...::. ::: . : :. .: :..... XP_011 CLANYTVNK-HFWPETLAAFTGYSLSEIVPCLSELHKAYL--DIPHRPQQ----AIREKY 350 360 370 380 390 400 520 530 540 550 560 570 pF1KE3 EDKRYGEISQEEVLSYSQLCAALGVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKRKRENS . ..: .: : XP_011 KASKYLCVSLMEPPAVLLLQ 410 420 >>XP_011533598 (OMIM: 604036) PREDICTED: cyclin-A1 isofo (421 aa) initn: 306 init1: 306 opt: 399 Z-score: 361.7 bits: 76.8 E(85289): 2.1e-13 Smith-Waterman score: 399; 28.1% identity (58.8% similar) in 342 aa overlap (200-529:84-413) 170 180 190 200 210 220 pF1KE3 ESLRAECQLQRTHKASILHCLGRVLSLFEDEEKQQQAHDLFEEAAHQG----CLTSSYLL .: .:. :.. . .:: : . . XP_011 GQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMA 60 70 80 90 100 110 230 240 250 260 270 280 pF1KE3 WESDRRTDVSDPGRCLHSFRKLRDYAAKGCWEAQLSLAKACANANQLGLEVRASSEIVCQ .:. ..:.. :: : : :. . . .. :: . . ..:: .: .: . . XP_011 FEDVYEVDTGTLKSDLH-F--LLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEE 120 130 140 150 160 170 290 300 310 320 330 340 pF1KE3 LFQASQAVS-----KQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDR ..: . . : . .. : ... :: ::.::::::. . . :.:.:. .:: XP_011 IYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDR 180 190 200 210 220 230 350 360 370 380 390 pF1KE3 YLRRRLVPRYRLQLLGIACMVICTRFISKEILT--IREAVWLTDNTYKYEDLVRMMGEIV .: : : .:::.: : :.. ... .:: . : :..::.:: ..:..: .. XP_011 FLSCMSVLRGKLQLVGTAAMLLASKY--EEIYPPEVDEFVYITDDTYTKRQLLKMEHLLL 240 250 260 270 280 400 410 420 430 440 450 pF1KE3 SALEGKIRVPTVVDYKEVLLTLVPVELRTQHLCSFLCELSLLHTS-LSAYAPARLAAAAL ..: . :::. .. : : .::..: ... :::::... . : :. .::::. XP_011 KVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAF 290 300 310 320 330 340 460 470 480 490 500 510 pF1KE3 LLARLTHGQTQPWTTQLWDLTGFSYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRF :: : .. . : : .::.: ...::. ::: . : :. .: :..... XP_011 CLANYTVNK-HFWPETLAAFTGYSLSEIVPCLSELHKAYL--DIPHRPQQ----AIREKY 350 360 370 380 390 400 520 530 540 550 560 570 pF1KE3 EDKRYGEISQEEVLSYSQLCAALGVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKRKRENS . ..: .: : XP_011 KASKYLCVSLMEPPAVLLLQ 410 420 >>NP_001104515 (OMIM: 604036) cyclin-A1 isoform b [Homo (464 aa) initn: 306 init1: 306 opt: 399 Z-score: 361.0 bits: 76.9 E(85289): 2.3e-13 Smith-Waterman score: 399; 28.1% identity (58.8% similar) in 342 aa overlap (200-529:127-456) 170 180 190 200 210 220 pF1KE3 ESLRAECQLQRTHKASILHCLGRVLSLFEDEEKQQQAHDLFEEAAHQG----CLTSSYLL .: .:. :.. . .:: : . . NP_001 GQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMA 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE3 WESDRRTDVSDPGRCLHSFRKLRDYAAKGCWEAQLSLAKACANANQLGLEVRASSEIVCQ .:. ..:.. :: : : :. . . .. :: . . ..:: .: .: . . NP_001 FEDVYEVDTGTLKSDLH-F--LLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEE 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE3 LFQASQAVS-----KQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDR ..: . . : . .. : ... :: ::.::::::. . . :.:.:. .:: NP_001 IYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDR 220 230 240 250 260 270 350 360 370 380 390 pF1KE3 YLRRRLVPRYRLQLLGIACMVICTRFISKEILT--IREAVWLTDNTYKYEDLVRMMGEIV .: : : .:::.: : :.. ... .:: . : :..::.:: ..:..: .. NP_001 FLSCMSVLRGKLQLVGTAAMLLASKY--EEIYPPEVDEFVYITDDTYTKRQLLKMEHLLL 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE3 SALEGKIRVPTVVDYKEVLLTLVPVELRTQHLCSFLCELSLLHTS-LSAYAPARLAAAAL ..: . :::. .. : : .::..: ... :::::... . : :. .::::. NP_001 KVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAF 340 350 360 370 380 390 460 470 480 490 500 510 pF1KE3 LLARLTHGQTQPWTTQLWDLTGFSYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRF :: : .. . : : .::.: ...::. ::: . : :. .: :..... NP_001 CLANYTVNK-HFWPETLAAFTGYSLSEIVPCLSELHKAYL--DIPHRPQQ----AIREKY 400 410 420 430 440 520 530 540 550 560 570 pF1KE3 EDKRYGEISQEEVLSYSQLCAALGVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKRKRENS . ..: .: : NP_001 KASKYLCVSLMEPPAVLLLQ 450 460 786 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 01:42:12 2016 done: Mon Nov 7 01:42:14 2016 Total Scan time: 10.970 Total Display time: 0.130 Function used was FASTA [36.3.4 Apr, 2011]