FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3933, 221 aa 1>>>pF1KE3933 221 - 221 aa - 221 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5576+/-0.000267; mu= 16.5739+/- 0.017 mean_var=149.1584+/-30.940, 0's: 0 Z-trim(123.9): 169 B-trim: 0 in 0/57 Lambda= 0.105015 statistics sampled from 44440 (44635) to 44440 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.834), E-opt: 0.2 (0.523), width: 16 Scan time: 6.750 The best scores are: opt bits E(85289) XP_016865393 (OMIM: 609315) PREDICTED: tripartite ( 221) 1525 241.3 9.4e-64 NP_203128 (OMIM: 609315) tripartite motif-containi ( 221) 1525 241.3 9.4e-64 NP_976038 (OMIM: 609315) tripartite motif-containi ( 511) 1418 225.6 1.2e-58 NP_963921 (OMIM: 610530) E3 ubiquitin-protein liga ( 518) 305 57.0 6.7e-08 XP_006714995 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 520) 305 57.0 6.8e-08 XP_006714994 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 525) 305 57.0 6.8e-08 XP_006714993 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 541) 305 57.0 6.9e-08 XP_006714992 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 543) 305 57.0 6.9e-08 NP_291027 (OMIM: 610530) E3 ubiquitin-protein liga ( 630) 305 57.1 7.6e-08 XP_016856907 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 293 54.8 1.6e-07 XP_016856908 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 293 54.8 1.6e-07 NP_001128327 (OMIM: 606123) E3 ubiquitin-protein l ( 343) 293 54.9 1.9e-07 XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 293 55.1 2.3e-07 NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 293 55.1 2.3e-07 NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 293 55.1 2.3e-07 XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 293 55.1 2.3e-07 XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 293 55.1 2.3e-07 NP_060543 (OMIM: 613184) E3 ubiquitin-protein liga ( 485) 260 50.1 7.3e-06 NP_258411 (OMIM: 611041) tripartite motif-containi ( 638) 251 49.0 2.2e-05 NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 249 48.5 2.4e-05 XP_016866815 (OMIM: 607524) PREDICTED: RING finger ( 230) 235 45.9 6.5e-05 NP_739575 (OMIM: 607524) RING finger protein 39 is ( 354) 235 46.2 8.4e-05 NP_079512 (OMIM: 607524) RING finger protein 39 is ( 420) 235 46.3 9.3e-05 NP_003132 (OMIM: 109092) E3 ubiquitin-protein liga ( 475) 233 46.0 0.00012 NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 224 44.7 0.00032 NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 224 44.7 0.00033 NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 222 44.4 0.0004 NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 222 44.4 0.00041 NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468) 219 43.9 0.00053 XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 391) 214 43.1 0.00081 XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 450) 214 43.1 0.00088 XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467) 214 43.2 0.0009 NP_569074 (OMIM: 605684) tripartite motif-containi ( 270) 198 40.4 0.0035 NP_067629 (OMIM: 605684) tripartite motif-containi ( 488) 198 40.8 0.0049 NP_001003827 (OMIM: 605684) tripartite motif-conta ( 488) 198 40.8 0.0049 NP_908975 (OMIM: 606469) tripartite motif-containi ( 241) 193 39.6 0.0055 NP_908974 (OMIM: 606469) tripartite motif-containi ( 452) 193 40.0 0.008 XP_011515918 (OMIM: 606469) PREDICTED: tripartite ( 452) 193 40.0 0.008 NP_149047 (OMIM: 606469) tripartite motif-containi ( 540) 193 40.1 0.0089 XP_011515917 (OMIM: 606469) PREDICTED: tripartite ( 540) 193 40.1 0.0089 XP_005251373 (OMIM: 606469) PREDICTED: tripartite ( 547) 193 40.1 0.0089 NP_908973 (OMIM: 606469) tripartite motif-containi ( 548) 193 40.1 0.0089 XP_011515915 (OMIM: 606469) PREDICTED: tripartite ( 548) 193 40.1 0.0089 XP_011515916 (OMIM: 606469) PREDICTED: tripartite ( 548) 193 40.1 0.0089 >>XP_016865393 (OMIM: 609315) PREDICTED: tripartite moti (221 aa) initn: 1525 init1: 1525 opt: 1525 Z-score: 1265.6 bits: 241.3 E(85289): 9.4e-64 Smith-Waterman score: 1525; 99.5% identity (100.0% similar) in 221 aa overlap (1-221:1-221) 10 20 30 40 50 60 pF1KE3 MAAVGPRTGPGTGAEALALAAELQGEATCSICLELFREPVSVECGHSFCRACIGRCWERP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAVGPRTGPGTGAEALALAAELQGEATCSICLELFREPVSVECGHSFCRACIGRCWERP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GAGSVGAATRAPPFPLPCPQCREPARPSQLRPNRELAAVATLLRRFSLPAAAPGEHGSQA ::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::: XP_016 GAGSVGAATRAPPFPLPCPQCREPARPSQLRPNRQLAAVATLLRRFSLPAAAPGEHGSQA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 AAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESR 130 140 150 160 170 180 190 200 210 220 pF1KE3 LRVLKKELEDCEVFRSTEKKESKELLVSQAPAGPPWDITEA ::::::::::::::::::::::::::::::::::::::::: XP_016 LRVLKKELEDCEVFRSTEKKESKELLVSQAPAGPPWDITEA 190 200 210 220 >>NP_203128 (OMIM: 609315) tripartite motif-containing p (221 aa) initn: 1525 init1: 1525 opt: 1525 Z-score: 1265.6 bits: 241.3 E(85289): 9.4e-64 Smith-Waterman score: 1525; 99.5% identity (100.0% similar) in 221 aa overlap (1-221:1-221) 10 20 30 40 50 60 pF1KE3 MAAVGPRTGPGTGAEALALAAELQGEATCSICLELFREPVSVECGHSFCRACIGRCWERP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_203 MAAVGPRTGPGTGAEALALAAELQGEATCSICLELFREPVSVECGHSFCRACIGRCWERP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GAGSVGAATRAPPFPLPCPQCREPARPSQLRPNRELAAVATLLRRFSLPAAAPGEHGSQA ::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::: NP_203 GAGSVGAATRAPPFPLPCPQCREPARPSQLRPNRQLAAVATLLRRFSLPAAAPGEHGSQA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 AAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_203 AAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESR 130 140 150 160 170 180 190 200 210 220 pF1KE3 LRVLKKELEDCEVFRSTEKKESKELLVSQAPAGPPWDITEA ::::::::::::::::::::::::::::::::::::::::: NP_203 LRVLKKELEDCEVFRSTEKKESKELLVSQAPAGPPWDITEA 190 200 210 220 >>NP_976038 (OMIM: 609315) tripartite motif-containing p (511 aa) initn: 1438 init1: 1418 opt: 1418 Z-score: 1174.2 bits: 225.6 E(85289): 1.2e-58 Smith-Waterman score: 1418; 98.1% identity (99.5% similar) in 210 aa overlap (1-210:1-210) 10 20 30 40 50 60 pF1KE3 MAAVGPRTGPGTGAEALALAAELQGEATCSICLELFREPVSVECGHSFCRACIGRCWERP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_976 MAAVGPRTGPGTGAEALALAAELQGEATCSICLELFREPVSVECGHSFCRACIGRCWERP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GAGSVGAATRAPPFPLPCPQCREPARPSQLRPNRELAAVATLLRRFSLPAAAPGEHGSQA ::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::: NP_976 GAGSVGAATRAPPFPLPCPQCREPARPSQLRPNRQLAAVATLLRRFSLPAAAPGEHGSQA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 AAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_976 AAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESR 130 140 150 160 170 180 190 200 210 220 pF1KE3 LRVLKKELEDCEVFRSTEKKESKELLVSQAPAGPPWDITEA :::::::::::::::::::::::::: ..: NP_976 LRVLKKELEDCEVFRSTEKKESKELLKQMAAEQEKVGAEFQALRAFLVEQEGRLLGRLEE 190 200 210 220 230 240 >>NP_963921 (OMIM: 610530) E3 ubiquitin-protein ligase T (518 aa) initn: 467 init1: 229 opt: 305 Z-score: 262.8 bits: 57.0 E(85289): 6.7e-08 Smith-Waterman score: 305; 37.4% identity (67.6% similar) in 139 aa overlap (72-205:172-302) 50 60 70 80 90 pF1KE3 VECGHSFCRACIGRCWERPGAGSVGAATRAPPFPLP-----CPQCREPARPSQLRPNREL :: : : :::::. ..::: .: NP_963 EEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQL 150 160 170 180 190 200 100 110 120 130 140 150 pF1KE3 AAVATLLRRFSLPAAAPGEHGSQAAAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAR : .. ..:.. :. ::. ::... : .: : .::.:. : .:::::: ..: NP_963 ANMVQVIRQMH-PT--PGR-GSRVTDQGI----CPKHQEALKLFCEVDEEAICVVCRESR 210 220 230 240 250 160 170 180 190 200 210 pF1KE3 EHREHAVLPLDEAVQEAKELLESRLRVLKKELEDCEVFRSTEKKESKELLVSQAPAGPPW :..:.:.::.:.::: : :..... :.:.:: . ... :... :: NP_963 SHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAV 260 270 280 290 300 310 220 pF1KE3 DITEA NP_963 ASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQ 320 330 340 350 360 370 >>XP_006714995 (OMIM: 610530) PREDICTED: E3 ubiquitin-pr (520 aa) initn: 467 init1: 229 opt: 305 Z-score: 262.8 bits: 57.0 E(85289): 6.8e-08 Smith-Waterman score: 305; 37.4% identity (67.6% similar) in 139 aa overlap (72-205:172-302) 50 60 70 80 90 pF1KE3 VECGHSFCRACIGRCWERPGAGSVGAATRAPPFPLP-----CPQCREPARPSQLRPNREL :: : : :::::. ..::: .: XP_006 EEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQL 150 160 170 180 190 200 100 110 120 130 140 150 pF1KE3 AAVATLLRRFSLPAAAPGEHGSQAAAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAR : .. ..:.. :. ::. ::... : .: : .::.:. : .:::::: ..: XP_006 ANMVQVIRQMH-PT--PGR-GSRVTDQGI----CPKHQEALKLFCEVDEEAICVVCRESR 210 220 230 240 250 160 170 180 190 200 210 pF1KE3 EHREHAVLPLDEAVQEAKELLESRLRVLKKELEDCEVFRSTEKKESKELLVSQAPAGPPW :..:.:.::.:.::: : :..... :.:.:: . ... :... :: XP_006 SHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAV 260 270 280 290 300 310 220 pF1KE3 DITEA XP_006 ASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQ 320 330 340 350 360 370 >>XP_006714994 (OMIM: 610530) PREDICTED: E3 ubiquitin-pr (525 aa) initn: 467 init1: 229 opt: 305 Z-score: 262.7 bits: 57.0 E(85289): 6.8e-08 Smith-Waterman score: 305; 37.4% identity (67.6% similar) in 139 aa overlap (72-205:172-302) 50 60 70 80 90 pF1KE3 VECGHSFCRACIGRCWERPGAGSVGAATRAPPFPLP-----CPQCREPARPSQLRPNREL :: : : :::::. ..::: .: XP_006 EEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQL 150 160 170 180 190 200 100 110 120 130 140 150 pF1KE3 AAVATLLRRFSLPAAAPGEHGSQAAAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAR : .. ..:.. :. ::. ::... : .: : .::.:. : .:::::: ..: XP_006 ANMVQVIRQMH-PT--PGR-GSRVTDQGI----CPKHQEALKLFCEVDEEAICVVCRESR 210 220 230 240 250 160 170 180 190 200 210 pF1KE3 EHREHAVLPLDEAVQEAKELLESRLRVLKKELEDCEVFRSTEKKESKELLVSQAPAGPPW :..:.:.::.:.::: : :..... :.:.:: . ... :... :: XP_006 SHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAV 260 270 280 290 300 310 220 pF1KE3 DITEA XP_006 ASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQ 320 330 340 350 360 370 >>XP_006714993 (OMIM: 610530) PREDICTED: E3 ubiquitin-pr (541 aa) initn: 467 init1: 229 opt: 305 Z-score: 262.6 bits: 57.0 E(85289): 6.9e-08 Smith-Waterman score: 305; 37.4% identity (67.6% similar) in 139 aa overlap (72-205:172-302) 50 60 70 80 90 pF1KE3 VECGHSFCRACIGRCWERPGAGSVGAATRAPPFPLP-----CPQCREPARPSQLRPNREL :: : : :::::. ..::: .: XP_006 EEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQL 150 160 170 180 190 200 100 110 120 130 140 150 pF1KE3 AAVATLLRRFSLPAAAPGEHGSQAAAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAR : .. ..:.. :. ::. ::... : .: : .::.:. : .:::::: ..: XP_006 ANMVQVIRQMH-PT--PGR-GSRVTDQGI----CPKHQEALKLFCEVDEEAICVVCRESR 210 220 230 240 250 160 170 180 190 200 210 pF1KE3 EHREHAVLPLDEAVQEAKELLESRLRVLKKELEDCEVFRSTEKKESKELLVSQAPAGPPW :..:.:.::.:.::: : :..... :.:.:: . ... :... :: XP_006 SHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAV 260 270 280 290 300 310 220 pF1KE3 DITEA XP_006 ASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQ 320 330 340 350 360 370 >>XP_006714992 (OMIM: 610530) PREDICTED: E3 ubiquitin-pr (543 aa) initn: 467 init1: 229 opt: 305 Z-score: 262.6 bits: 57.0 E(85289): 6.9e-08 Smith-Waterman score: 305; 37.4% identity (67.6% similar) in 139 aa overlap (72-205:172-302) 50 60 70 80 90 pF1KE3 VECGHSFCRACIGRCWERPGAGSVGAATRAPPFPLP-----CPQCREPARPSQLRPNREL :: : : :::::. ..::: .: XP_006 EEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQL 150 160 170 180 190 200 100 110 120 130 140 150 pF1KE3 AAVATLLRRFSLPAAAPGEHGSQAAAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAR : .. ..:.. :. ::. ::... : .: : .::.:. : .:::::: ..: XP_006 ANMVQVIRQMH-PT--PGR-GSRVTDQGI----CPKHQEALKLFCEVDEEAICVVCRESR 210 220 230 240 250 160 170 180 190 200 210 pF1KE3 EHREHAVLPLDEAVQEAKELLESRLRVLKKELEDCEVFRSTEKKESKELLVSQAPAGPPW :..:.:.::.:.::: : :..... :.:.:: . ... :... :: XP_006 SHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAV 260 270 280 290 300 310 220 pF1KE3 DITEA XP_006 ASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQ 320 330 340 350 360 370 >>NP_291027 (OMIM: 610530) E3 ubiquitin-protein ligase T (630 aa) initn: 467 init1: 229 opt: 305 Z-score: 261.9 bits: 57.1 E(85289): 7.6e-08 Smith-Waterman score: 305; 37.4% identity (67.6% similar) in 139 aa overlap (72-205:172-302) 50 60 70 80 90 pF1KE3 VECGHSFCRACIGRCWERPGAGSVGAATRAPPFPLP-----CPQCREPARPSQLRPNREL :: : : :::::. ..::: .: NP_291 EEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQL 150 160 170 180 190 200 100 110 120 130 140 150 pF1KE3 AAVATLLRRFSLPAAAPGEHGSQAAAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAR : .. ..:.. :. ::. ::... : .: : .::.:. : .:::::: ..: NP_291 ANMVQVIRQMH-PT--PGR-GSRVTDQGI----CPKHQEALKLFCEVDEEAICVVCRESR 210 220 230 240 250 160 170 180 190 200 210 pF1KE3 EHREHAVLPLDEAVQEAKELLESRLRVLKKELEDCEVFRSTEKKESKELLVSQAPAGPPW :..:.:.::.:.::: : :..... :.:.:: . ... :... :: NP_291 SHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAV 260 270 280 290 300 310 220 pF1KE3 DITEA NP_291 ASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQ 320 330 340 350 360 370 >>XP_016856907 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (262 aa) initn: 486 init1: 209 opt: 293 Z-score: 256.0 bits: 54.8 E(85289): 1.6e-07 Smith-Waterman score: 468; 41.6% identity (60.5% similar) in 190 aa overlap (15-204:2-173) 10 20 30 40 50 60 pF1KE3 MAAVGPRTGPGTGAEALALAAELQGEATCSICLELFREPVSVECGHSFCRACIGRCWERP ::. :: .:: ::::::::. : .:: . :::.:::::: ::. XP_016 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEK- 10 20 30 40 70 80 90 100 110 120 pF1KE3 GAGSVGAATRAPPFPLPCPQCREPARPSQLRPNRELAAVATLLRRFSLPAAAPGEHGSQA . :. : : :: ::.::: . .: ::: :. :: . .. :: . .. XP_016 ARGKKGRRKRKGSFP--CPECREMSPQRNLLPNRLLTKVAEMAQQH------PGLQKQDL 50 60 70 80 90 130 140 150 160 170 180 pF1KE3 AAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESR : .: ::.::.:: : ::::: ..:::: : ::: .:::: : :: XP_016 ---------CQEHHEPLKLFCQKDQSPICVVCRESREHRLHRVLPAEEAVQGYKLKLEED 100 110 120 130 140 190 200 210 220 pF1KE3 LRVLKKELEDCEVFRSTEKKESKELLVSQAPAGPPWDITEA .. :.... ... :.. : XP_016 MEYLREQITRTGNLQAREEQSLAEWQGKVKERRERIVLEFEKMNLYLVEEEQRLLQALET 150 160 170 180 190 200 221 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 08:49:18 2016 done: Sun Nov 6 08:49:19 2016 Total Scan time: 6.750 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]