FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8012, 708 aa 1>>>pF1KB8012 708 - 708 aa - 708 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.6865+/-0.000339; mu= 5.5719+/- 0.021 mean_var=218.2857+/-44.197, 0's: 0 Z-trim(121.8): 64 B-trim: 1978 in 1/61 Lambda= 0.086808 statistics sampled from 38792 (38856) to 38792 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.773), E-opt: 0.2 (0.456), width: 16 Scan time: 11.460 The best scores are: opt bits E(85289) XP_016873130 (OMIM: 602709) PREDICTED: amyloid bet ( 708) 4833 618.3 3.1e-176 NP_663722 (OMIM: 602709) amyloid beta A4 precursor ( 708) 4833 618.3 3.1e-176 NP_001155 (OMIM: 602709) amyloid beta A4 precursor ( 710) 4819 616.6 1e-175 XP_006718278 (OMIM: 602709) PREDICTED: amyloid bet ( 802) 4819 616.6 1.1e-175 XP_016873129 (OMIM: 602709) PREDICTED: amyloid bet ( 713) 4813 615.8 1.8e-175 XP_006718277 (OMIM: 602709) PREDICTED: amyloid bet ( 713) 4813 615.8 1.8e-175 XP_016873128 (OMIM: 602709) PREDICTED: amyloid bet ( 715) 4799 614.1 6e-175 XP_006718275 (OMIM: 602709) PREDICTED: amyloid bet ( 715) 4799 614.1 6e-175 NP_001244252 (OMIM: 602709) amyloid beta A4 precur ( 488) 3243 419.1 2.1e-116 NP_001244254 (OMIM: 602709) amyloid beta A4 precur ( 475) 3229 417.3 6.8e-116 NP_001244248 (OMIM: 602709) amyloid beta A4 precur ( 490) 3229 417.3 7e-116 XP_006718276 (OMIM: 602709) PREDICTED: amyloid bet ( 806) 3160 408.9 4e-113 XP_006718273 (OMIM: 602709) PREDICTED: amyloid bet ( 806) 3160 408.9 4e-113 XP_016873131 (OMIM: 602709) PREDICTED: amyloid bet ( 449) 3095 400.5 7.3e-111 NP_001244250 (OMIM: 602709) amyloid beta A4 precur ( 451) 3081 398.8 2.5e-110 NP_001244249 (OMIM: 602709) amyloid beta A4 precur ( 451) 3081 398.8 2.5e-110 XP_011518342 (OMIM: 602709) PREDICTED: amyloid bet ( 451) 3081 398.8 2.5e-110 NP_001244255 (OMIM: 602709) amyloid beta A4 precur ( 451) 3081 398.8 2.5e-110 XP_016863645 (OMIM: 104300,602710) PREDICTED: amyl ( 723) 1924 254.0 1.5e-66 XP_016863646 (OMIM: 104300,602710) PREDICTED: amyl ( 723) 1924 254.0 1.5e-66 XP_006714074 (OMIM: 104300,602710) PREDICTED: amyl ( 740) 1924 254.0 1.5e-66 XP_016863640 (OMIM: 104300,602710) PREDICTED: amyl ( 740) 1924 254.0 1.5e-66 XP_016863639 (OMIM: 104300,602710) PREDICTED: amyl ( 740) 1924 254.0 1.5e-66 XP_016863641 (OMIM: 104300,602710) PREDICTED: amyl ( 739) 1922 253.8 1.8e-66 XP_006714075 (OMIM: 104300,602710) PREDICTED: amyl ( 739) 1922 253.8 1.8e-66 XP_011518340 (OMIM: 602709) PREDICTED: amyloid bet ( 547) 1685 224.0 1.2e-57 XP_011518339 (OMIM: 602709) PREDICTED: amyloid bet ( 547) 1685 224.0 1.2e-57 XP_011518344 (OMIM: 602709) PREDICTED: amyloid bet ( 586) 1685 224.0 1.3e-57 XP_006718274 (OMIM: 602709) PREDICTED: amyloid bet ( 811) 1685 224.1 1.6e-57 XP_006718272 (OMIM: 602709) PREDICTED: amyloid bet ( 811) 1685 224.1 1.6e-57 NP_001159522 (OMIM: 104300,602710) amyloid beta A4 ( 758) 1619 215.8 4.8e-55 XP_016863634 (OMIM: 104300,602710) PREDICTED: amyl ( 759) 1616 215.5 6.3e-55 NP_004298 (OMIM: 104300,602710) amyloid beta A4 pr ( 759) 1616 215.5 6.3e-55 XP_016863638 (OMIM: 104300,602710) PREDICTED: amyl ( 743) 1609 214.6 1.1e-54 XP_006714073 (OMIM: 104300,602710) PREDICTED: amyl ( 760) 1609 214.6 1.2e-54 XP_016863632 (OMIM: 104300,602710) PREDICTED: amyl ( 760) 1609 214.6 1.2e-54 XP_016863633 (OMIM: 104300,602710) PREDICTED: amyl ( 760) 1609 214.6 1.2e-54 XP_016863637 (OMIM: 104300,602710) PREDICTED: amyl ( 744) 1603 213.8 1.9e-54 XP_016863635 (OMIM: 104300,602710) PREDICTED: amyl ( 744) 1603 213.8 1.9e-54 XP_016863636 (OMIM: 104300,602710) PREDICTED: amyl ( 744) 1603 213.8 1.9e-54 XP_016863631 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1603 213.8 1.9e-54 XP_006714070 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1603 213.8 1.9e-54 XP_006714068 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1603 213.8 1.9e-54 XP_011511988 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1603 213.8 1.9e-54 XP_006714072 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1603 213.8 1.9e-54 XP_006714071 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1603 213.8 1.9e-54 XP_016863647 (OMIM: 104300,602710) PREDICTED: amyl ( 721) 1587 211.8 7.5e-54 XP_011511989 (OMIM: 104300,602710) PREDICTED: amyl ( 738) 1587 211.8 7.6e-54 XP_016863642 (OMIM: 104300,602710) PREDICTED: amyl ( 738) 1587 211.8 7.6e-54 XP_016863643 (OMIM: 104300,602710) PREDICTED: amyl ( 738) 1587 211.8 7.6e-54 >>XP_016873130 (OMIM: 602709) PREDICTED: amyloid beta A4 (708 aa) initn: 4833 init1: 4833 opt: 4833 Z-score: 3285.0 bits: 618.3 E(85289): 3.1e-176 Smith-Waterman score: 4833; 100.0% identity (100.0% similar) in 708 aa overlap (1-708:1-708) 10 20 30 40 50 60 pF1KB8 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 TWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 RNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 DLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQMLKCHVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQMLKCHVF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 RCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 FQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 ECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCL 610 620 630 640 650 660 670 680 690 700 pF1KB8 DARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP 670 680 690 700 >>NP_663722 (OMIM: 602709) amyloid beta A4 precursor pro (708 aa) initn: 4833 init1: 4833 opt: 4833 Z-score: 3285.0 bits: 618.3 E(85289): 3.1e-176 Smith-Waterman score: 4833; 100.0% identity (100.0% similar) in 708 aa overlap (1-708:1-708) 10 20 30 40 50 60 pF1KB8 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_663 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_663 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_663 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_663 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_663 DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 TWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_663 TWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 RNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_663 RNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 DLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQMLKCHVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_663 DLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQMLKCHVF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 RCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_663 RCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 FQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_663 FQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 ECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_663 ECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCL 610 620 630 640 650 660 670 680 690 700 pF1KB8 DARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP :::::::::::::::::::::::::::::::::::::::::::::::: NP_663 DARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP 670 680 690 700 >>NP_001155 (OMIM: 602709) amyloid beta A4 precursor pro (710 aa) initn: 3209 init1: 3157 opt: 4819 Z-score: 3275.5 bits: 616.6 E(85289): 1e-175 Smith-Waterman score: 4819; 99.7% identity (99.7% similar) in 710 aa overlap (1-708:1-710) 10 20 30 40 50 60 pF1KB8 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 TWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 RNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGK 370 380 390 400 410 420 430 440 450 460 470 pF1KB8 DLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGR--DFAYVARDKLTQMLKCH ::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::: NP_001 DLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRERDFAYVARDKLTQMLKCH 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB8 VFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELV 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB8 QKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAV 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB8 LGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQK 610 620 630 640 650 660 660 670 680 690 700 pF1KB8 CLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP 670 680 690 700 710 >>XP_006718278 (OMIM: 602709) PREDICTED: amyloid beta A4 (802 aa) initn: 3209 init1: 3157 opt: 4819 Z-score: 3274.7 bits: 616.6 E(85289): 1.1e-175 Smith-Waterman score: 4819; 99.7% identity (99.7% similar) in 710 aa overlap (1-708:93-802) 10 20 30 pF1KB8 MSVPSSLSQSAINANSHGGPALSLPLPLHA :::::::::::::::::::::::::::::: XP_006 PPFGLQPRPRVSRRGCGTRALRGAQGAAKAMSVPSSLSQSAINANSHGGPALSLPLPLHA 70 80 90 100 110 120 40 50 60 70 80 90 pF1KB8 AHNQLLNAKLQATAVGPKDLRSAMGEGGGPEPGPANAKWLKEGQNQLRRAATAHRDQNRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AHNQLLNAKLQATAVGPKDLRSAMGEGGGPEPGPANAKWLKEGQNQLRRAATAHRDQNRN 130 140 150 160 170 180 100 110 120 130 140 150 pF1KB8 VTLTLAEEASQEPEMAPLGPKGLIHLYSELELSAHNAANRGLRGPGLIISTQEQGPDEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VTLTLAEEASQEPEMAPLGPKGLIHLYSELELSAHNAANRGLRGPGLIISTQEQGPDEGE 190 200 210 220 230 240 160 170 180 190 200 210 pF1KB8 EKAAGEAEEEEEDDDDEEEEEDLSSPPGLPEPLESVEAPPRPQALTDGPREHSKSASLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EKAAGEAEEEEEDDDDEEEEEDLSSPPGLPEPLESVEAPPRPQALTDGPREHSKSASLLF 250 260 270 280 290 300 220 230 240 250 260 270 pF1KB8 GMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYY 310 320 330 340 350 360 280 290 300 310 320 330 pF1KB8 WHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELG 370 380 390 400 410 420 340 350 360 370 380 390 pF1KB8 LKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRS 430 440 450 460 470 480 400 410 420 430 440 450 pF1KB8 SVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISI 490 500 510 520 530 540 460 470 480 490 500 pF1KB8 RVWGVGRDSGR--DFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNAR ::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RVWGVGRDSGRERDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNAR 550 560 570 580 590 600 510 520 530 540 550 560 pF1KB8 CLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVL 610 620 630 640 650 660 570 580 590 600 610 620 pF1KB8 SSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPA 670 680 690 700 710 720 630 640 650 660 670 680 pF1KB8 SFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVR 730 740 750 760 770 780 690 700 pF1KB8 RGVQSLWGSLKPKRLGAHTP :::::::::::::::::::: XP_006 RGVQSLWGSLKPKRLGAHTP 790 800 >>XP_016873129 (OMIM: 602709) PREDICTED: amyloid beta A4 (713 aa) initn: 3374 init1: 3262 opt: 4813 Z-score: 3271.4 bits: 615.8 E(85289): 1.8e-175 Smith-Waterman score: 4813; 99.3% identity (99.3% similar) in 713 aa overlap (1-708:1-713) 10 20 30 40 50 60 pF1KB8 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 -----DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASHLADSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQ 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 EESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB8 EKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGG 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB8 WGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQML 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB8 KCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKN 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB8 ELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQT 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB8 EAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLR 610 620 630 640 650 660 660 670 680 690 700 pF1KB8 YQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP 670 680 690 700 710 >>XP_006718277 (OMIM: 602709) PREDICTED: amyloid beta A4 (713 aa) initn: 3374 init1: 3262 opt: 4813 Z-score: 3271.4 bits: 615.8 E(85289): 1.8e-175 Smith-Waterman score: 4813; 99.3% identity (99.3% similar) in 713 aa overlap (1-708:1-713) 10 20 30 40 50 60 pF1KB8 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 -----DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ASHLADSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQ 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 EESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB8 EKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGG 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB8 WGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQML 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB8 KCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKN 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB8 ELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQT 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB8 EAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLR 610 620 630 640 650 660 660 670 680 690 700 pF1KB8 YQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP 670 680 690 700 710 >>XP_016873128 (OMIM: 602709) PREDICTED: amyloid beta A4 (715 aa) initn: 3264 init1: 1685 opt: 4799 Z-score: 3261.9 bits: 614.1 E(85289): 6e-175 Smith-Waterman score: 4799; 99.0% identity (99.0% similar) in 715 aa overlap (1-708:1-715) 10 20 30 40 50 60 pF1KB8 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 -----DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASHLADSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQ 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 EESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB8 EKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGG 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB8 WGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGR--DFAYVARDKLTQ :::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: XP_016 WGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRERDFAYVARDKLTQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB8 MLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAP 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB8 KNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQ 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB8 QTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACM 610 620 630 640 650 660 660 670 680 690 700 pF1KB8 LRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP 670 680 690 700 710 >>XP_006718275 (OMIM: 602709) PREDICTED: amyloid beta A4 (715 aa) initn: 3264 init1: 1685 opt: 4799 Z-score: 3261.9 bits: 614.1 E(85289): 6e-175 Smith-Waterman score: 4799; 99.0% identity (99.0% similar) in 715 aa overlap (1-708:1-715) 10 20 30 40 50 60 pF1KB8 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 -----DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ASHLADSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQ 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 EESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB8 EKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGG 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB8 WGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGR--DFAYVARDKLTQ :::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: XP_006 WGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRERDFAYVARDKLTQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB8 MLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAP 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB8 KNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQ 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB8 QTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACM 610 620 630 640 650 660 660 670 680 690 700 pF1KB8 LRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP 670 680 690 700 710 >>NP_001244252 (OMIM: 602709) amyloid beta A4 precursor (488 aa) initn: 3243 init1: 3243 opt: 3243 Z-score: 2211.0 bits: 419.1 E(85289): 2.1e-116 Smith-Waterman score: 3243; 100.0% identity (100.0% similar) in 468 aa overlap (241-708:21-488) 220 230 240 250 260 270 pF1KB8 GMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYY :::::::::::::::::::::::::::::: NP_001 MSAMFSQDFFLAIILQDSSADSFWNPNAFETDSDLPAGWMRVQDTSGTYY 10 20 30 40 50 280 290 300 310 320 330 pF1KB8 WHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELG 60 70 80 90 100 110 340 350 360 370 380 390 pF1KB8 LKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRS 120 130 140 150 160 170 400 410 420 430 440 450 pF1KB8 SVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISI 180 190 200 210 220 230 460 470 480 490 500 510 pF1KB8 RVWGVGRDSGRDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVWGVGRDSGRDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCL 240 250 260 270 280 290 520 530 540 550 560 570 pF1KB8 VNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSS 300 310 320 330 340 350 580 590 600 610 620 630 pF1KB8 SSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASF 360 370 380 390 400 410 640 650 660 670 680 690 pF1KB8 CCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRG 420 430 440 450 460 470 700 pF1KB8 VQSLWGSLKPKRLGAHTP :::::::::::::::::: NP_001 VQSLWGSLKPKRLGAHTP 480 >>NP_001244254 (OMIM: 602709) amyloid beta A4 precursor (475 aa) initn: 1685 init1: 1685 opt: 3229 Z-score: 2201.6 bits: 417.3 E(85289): 6.8e-116 Smith-Waterman score: 3229; 99.6% identity (99.6% similar) in 470 aa overlap (241-708:6-475) 220 230 240 250 260 270 pF1KB8 GMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYY :::::::::::::::::::::::::::::: NP_001 MTQMRDSFWNPNAFETDSDLPAGWMRVQDTSGTYY 10 20 30 280 290 300 310 320 330 pF1KB8 WHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELG 40 50 60 70 80 90 340 350 360 370 380 390 pF1KB8 LKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRS 100 110 120 130 140 150 400 410 420 430 440 450 pF1KB8 SVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISI 160 170 180 190 200 210 460 470 480 490 500 pF1KB8 RVWGVGRDSGR--DFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNAR ::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVWGVGRDSGRERDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNAR 220 230 240 250 260 270 510 520 530 540 550 560 pF1KB8 CLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVL 280 290 300 310 320 330 570 580 590 600 610 620 pF1KB8 SSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPA 340 350 360 370 380 390 630 640 650 660 670 680 pF1KB8 SFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVR 400 410 420 430 440 450 690 700 pF1KB8 RGVQSLWGSLKPKRLGAHTP :::::::::::::::::::: NP_001 RGVQSLWGSLKPKRLGAHTP 460 470 708 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 01:54:37 2016 done: Mon Nov 7 01:54:39 2016 Total Scan time: 11.460 Total Display time: 0.190 Function used was FASTA [36.3.4 Apr, 2011]