FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9526, 438 aa 1>>>pF1KE9526 438 - 438 aa - 438 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9767+/-0.000378; mu= 19.3932+/- 0.023 mean_var=73.5460+/-15.244, 0's: 0 Z-trim(113.9): 238 B-trim: 331 in 1/48 Lambda= 0.149553 statistics sampled from 23227 (23522) to 23227 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.638), E-opt: 0.2 (0.276), width: 16 Scan time: 6.810 The best scores are: opt bits E(85289) NP_003373 (OMIM: 601970) vasoactive intestinal pol ( 438) 3008 658.5 9.5e-189 XP_005249618 (OMIM: 601970) PREDICTED: vasoactive ( 463) 2887 632.4 7.1e-181 XP_006716170 (OMIM: 601970) PREDICTED: vasoactive ( 455) 2624 575.7 8.5e-164 NP_001295188 (OMIM: 601970) vasoactive intestinal ( 422) 2156 474.7 2e-133 XP_016868069 (OMIM: 601970) PREDICTED: vasoactive ( 300) 2040 449.5 5.3e-126 XP_006716171 (OMIM: 601970) PREDICTED: vasoactive ( 392) 2016 444.5 2.4e-124 XP_011514852 (OMIM: 601970) PREDICTED: vasoactive ( 439) 1772 391.9 1.8e-108 NP_001291451 (OMIM: 601970) vasoactive intestinal ( 358) 1634 362.0 1.4e-99 NP_001186566 (OMIM: 102981) pituitary adenylate cy ( 447) 1513 336.0 1.2e-91 NP_004615 (OMIM: 192321) vasoactive intestinal pol ( 457) 1359 302.8 1.2e-81 NP_001238814 (OMIM: 192321) vasoactive intestinal ( 430) 1349 300.6 5.3e-81 XP_005265494 (OMIM: 192321) PREDICTED: vasoactive ( 456) 1348 300.4 6.4e-81 NP_001238811 (OMIM: 192321) vasoactive intestinal ( 416) 1335 297.5 4.2e-80 XP_011532381 (OMIM: 192321) PREDICTED: vasoactive ( 416) 1335 297.5 4.2e-80 XP_005265495 (OMIM: 192321) PREDICTED: vasoactive ( 416) 1335 297.5 4.2e-80 XP_005249675 (OMIM: 102981) PREDICTED: pituitary a ( 411) 1334 297.3 4.8e-80 NP_001109 (OMIM: 102981) pituitary adenylate cycla ( 468) 1334 297.4 5.3e-80 NP_002971 (OMIM: 182098) secretin receptor precurs ( 440) 1328 296.1 1.2e-79 XP_005265496 (OMIM: 192321) PREDICTED: vasoactive ( 410) 1324 295.2 2.1e-79 NP_001238813 (OMIM: 192321) vasoactive intestinal ( 409) 1313 292.8 1.1e-78 XP_016860159 (OMIM: 182098) PREDICTED: secretin re ( 435) 1269 283.3 8.4e-76 XP_011509923 (OMIM: 182098) PREDICTED: secretin re ( 445) 1269 283.3 8.5e-76 XP_016860161 (OMIM: 182098) PREDICTED: secretin re ( 377) 1249 279.0 1.5e-74 XP_016867226 (OMIM: 102981) PREDICTED: pituitary a ( 475) 1166 261.1 4.4e-69 NP_000814 (OMIM: 139191,612781) growth hormone-rel ( 423) 1165 260.9 4.7e-69 XP_016860160 (OMIM: 182098) PREDICTED: secretin re ( 409) 1146 256.8 7.8e-68 XP_011532382 (OMIM: 192321) PREDICTED: vasoactive ( 351) 1028 231.2 3.2e-60 XP_016867227 (OMIM: 102981) PREDICTED: pituitary a ( 439) 987 222.5 1.7e-57 XP_016867225 (OMIM: 102981) PREDICTED: pituitary a ( 489) 987 222.5 1.9e-57 NP_001186565 (OMIM: 102981) pituitary adenylate cy ( 495) 987 222.5 1.9e-57 XP_006715708 (OMIM: 102981) PREDICTED: pituitary a ( 496) 987 222.5 1.9e-57 NP_001186564 (OMIM: 102981) pituitary adenylate cy ( 496) 987 222.5 1.9e-57 XP_011513565 (OMIM: 139191,612781) PREDICTED: grow ( 359) 955 215.5 1.8e-55 XP_005263787 (OMIM: 182098) PREDICTED: secretin re ( 262) 893 202.0 1.5e-51 NP_000155 (OMIM: 137241) gastric inhibitory polype ( 466) 887 200.9 5.7e-51 XP_016860162 (OMIM: 182098) PREDICTED: secretin re ( 267) 873 197.7 3.1e-50 NP_001295347 (OMIM: 137241) gastric inhibitory pol ( 430) 819 186.2 1.4e-46 XP_016879936 (OMIM: 125853,138033) PREDICTED: gluc ( 355) 814 185.1 2.6e-46 XP_011521841 (OMIM: 125853,138033) PREDICTED: gluc ( 444) 814 185.2 3e-46 XP_016879935 (OMIM: 125853,138033) PREDICTED: gluc ( 475) 814 185.2 3.2e-46 XP_006722340 (OMIM: 125853,138033) PREDICTED: gluc ( 477) 814 185.2 3.2e-46 NP_000151 (OMIM: 125853,138033) glucagon receptor ( 477) 814 185.2 3.2e-46 NP_004237 (OMIM: 603659) glucagon-like peptide 2 r ( 553) 769 175.5 3e-43 XP_016880828 (OMIM: 603659) PREDICTED: glucagon-li ( 559) 769 175.5 3e-43 XP_011522379 (OMIM: 603659) PREDICTED: glucagon-li ( 578) 769 175.5 3.1e-43 XP_005256918 (OMIM: 603659) PREDICTED: glucagon-li ( 400) 766 174.8 3.7e-43 XP_016880830 (OMIM: 603659) PREDICTED: glucagon-li ( 448) 766 174.8 4e-43 XP_016880829 (OMIM: 603659) PREDICTED: glucagon-li ( 483) 766 174.8 4.2e-43 NP_002053 (OMIM: 138032) glucagon-like peptide 1 r ( 463) 732 167.5 6.6e-41 XP_016866239 (OMIM: 138032) PREDICTED: glucagon-li ( 468) 732 167.5 6.7e-41 >>NP_003373 (OMIM: 601970) vasoactive intestinal polypep (438 aa) initn: 3008 init1: 3008 opt: 3008 Z-score: 3509.6 bits: 658.5 E(85289): 9.5e-189 Smith-Waterman score: 3008; 100.0% identity (100.0% similar) in 438 aa overlap (1-438:1-438) 10 20 30 40 50 60 pF1KE9 MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNIT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 CWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 CWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 TFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 DVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 FLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 SIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 LCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQ 370 380 390 400 410 420 430 pF1KE9 FHRGSRAQSFLQTETSVI :::::::::::::::::: NP_003 FHRGSRAQSFLQTETSVI 430 >>XP_005249618 (OMIM: 601970) PREDICTED: vasoactive inte (463 aa) initn: 2886 init1: 2886 opt: 2887 Z-score: 3368.2 bits: 632.4 E(85289): 7.1e-181 Smith-Waterman score: 2887; 98.2% identity (98.6% similar) in 434 aa overlap (5-438:35-463) 10 20 30 pF1KE9 MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEE : :.: .:: ::::::::::::::::: XP_005 GAVPGAGSCGRLRGLRVSRGDRGWRWPQMPLGPSL---YLL--VNSIHPECRFHLEIQEE 10 20 30 40 50 40 50 60 70 80 90 pF1KE9 ETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCT 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE9 SDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKL 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE9 HCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIM 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE9 ANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDT 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE9 NDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLI 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE9 PLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRC 360 370 380 390 400 410 400 410 420 430 pF1KE9 PTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI :::::::::::::::::::::::::::::::::::::::::::: XP_005 PTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI 420 430 440 450 460 >>XP_006716170 (OMIM: 601970) PREDICTED: vasoactive inte (455 aa) initn: 2621 init1: 2621 opt: 2624 Z-score: 3061.7 bits: 575.7 E(85289): 8.5e-164 Smith-Waterman score: 2624; 93.5% identity (95.0% similar) in 417 aa overlap (1-409:1-414) 10 20 30 40 50 60 pF1KE9 MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNIT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 CWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 TFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 DVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 FLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 SIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFE 310 320 330 340 350 360 370 380 390 400 410 pF1KE9 LCLGSFQGLVVAVLYCFLNSEVQCELKRKWRS--------RCPTPSASRDYRVCGSSFSR ::::::::::::::::::::::. : . :: :. :. ..: :: XP_006 LCLGSFQGLVVAVLYCFLNSEVSS--WPPWNQAQVLTCFLRC-CPAWCRSPHTCLSSAGS 370 380 390 400 410 420 430 pF1KE9 NGSEGALQFHRGSRAQSFLQTETSVI XP_006 SYCPGPHSSVSPSENPQRHRQTHSSGPSFQTPPSFRPP 420 430 440 450 >>NP_001295188 (OMIM: 601970) vasoactive intestinal poly (422 aa) initn: 2152 init1: 2152 opt: 2156 Z-score: 2516.4 bits: 474.7 E(85289): 2e-133 Smith-Waterman score: 2156; 93.7% identity (95.4% similar) in 347 aa overlap (92-438:80-422) 70 80 90 100 110 120 pF1KE9 WRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKIT : : . .: . .:. . :: :: NP_001 SEGSLPSWSSGPAGAKLNASHEGIGSSSDGNGDSKAATERVVSAMDTVRRKHPE----IT 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE9 FYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDD 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE9 VLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCF 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE9 LAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFIS 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE9 IIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFEL 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE9 CLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQF 350 360 370 380 390 400 430 pF1KE9 HRGSRAQSFLQTETSVI ::::::::::::::::: NP_001 HRGSRAQSFLQTETSVI 410 420 >>XP_016868069 (OMIM: 601970) PREDICTED: vasoactive inte (300 aa) initn: 2040 init1: 2040 opt: 2040 Z-score: 2383.1 bits: 449.5 E(85289): 5.3e-126 Smith-Waterman score: 2040; 100.0% identity (100.0% similar) in 300 aa overlap (139-438:1-300) 110 120 130 140 150 160 pF1KE9 CGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLS :::::::::::::::::::::::::::::: XP_016 MSLATGSIILCLFRKLHCTRNYIHLNLFLS 10 20 30 170 180 190 200 210 220 pF1KE9 FILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLH 40 50 60 70 80 90 230 240 250 260 270 280 pF1KE9 TLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPI 100 110 120 130 140 150 290 300 310 320 330 340 pF1KE9 LISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFP 160 170 180 190 200 210 350 360 370 380 390 400 pF1KE9 ISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGS 220 230 240 250 260 270 410 420 430 pF1KE9 SFSRNGSEGALQFHRGSRAQSFLQTETSVI :::::::::::::::::::::::::::::: XP_016 SFSRNGSEGALQFHRGSRAQSFLQTETSVI 280 290 300 >>XP_006716171 (OMIM: 601970) PREDICTED: vasoactive inte (392 aa) initn: 2007 init1: 2007 opt: 2016 Z-score: 2353.6 bits: 444.5 E(85289): 2.4e-124 Smith-Waterman score: 2016; 90.5% identity (92.9% similar) in 337 aa overlap (81-409:18-351) 60 70 80 90 100 110 pF1KE9 ACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACG :. . :::::::::::::::::::::::: XP_006 MVAEPKSLLRIFILPQKNYTYSCGNISKNCTSDGWSETFPDFVDACG 10 20 30 40 120 130 140 150 160 170 pF1KE9 YSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFI 50 60 70 80 90 100 180 190 200 210 220 230 pF1KE9 LRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTL 110 120 130 140 150 160 240 250 260 270 280 290 pF1KE9 LVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILI 170 180 190 200 210 220 300 310 320 330 340 350 pF1KE9 SIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPIS 230 240 250 260 270 280 360 370 380 390 400 pF1KE9 ISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRS--------RCPTPSASRD ::::::::::::::::::::::::::::::::. : . :: :. :. XP_006 ISSKYQILFELCLGSFQGLVVAVLYCFLNSEVSSW--PPWNQAQVLTCFLRC-CPAWCRS 290 300 310 320 330 340 410 420 430 pF1KE9 YRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI ..: :: XP_006 PHTCLSSAGSSYCPGPHSSVSPSENPQRHRQTHSSGPSFQTPPSFRPP 350 360 370 380 390 >>XP_011514852 (OMIM: 601970) PREDICTED: vasoactive inte (439 aa) initn: 1765 init1: 1765 opt: 1772 Z-score: 2068.4 bits: 391.9 E(85289): 1.8e-108 Smith-Waterman score: 1772; 85.0% identity (88.7% similar) in 326 aa overlap (92-409:80-398) 70 80 90 100 110 120 pF1KE9 WRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKIT : : . .: . .:. . :: :: XP_011 SEGSLPSWSSGPAGAKLNASHEGIGSSSDGNGDSKAATERVVSAMDTVRRKHPE----IT 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE9 FYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDD 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE9 VLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCF 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE9 LAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFIS 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE9 IIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFEL 290 300 310 320 330 340 370 380 390 400 410 pF1KE9 CLGSFQGLVVAVLYCFLNSEVQCELKRKWRS--------RCPTPSASRDYRVCGSSFSRN :::::::::::::::::::::. : . :: :. :. ..: :: XP_011 CLGSFQGLVVAVLYCFLNSEVSS--WPPWNQAQVLTCFLRC-CPAWCRSPHTCLSSAGSS 350 360 370 380 390 400 420 430 pF1KE9 GSEGALQFHRGSRAQSFLQTETSVI XP_011 YCPGPHSSVSPSENPQRHRQTHSSGPSFQTPPSFRPP 410 420 430 >>NP_001291451 (OMIM: 601970) vasoactive intestinal poly (358 aa) initn: 1653 init1: 1632 opt: 1634 Z-score: 1908.6 bits: 362.0 E(85289): 1.4e-99 Smith-Waterman score: 2317; 81.7% identity (81.7% similar) in 438 aa overlap (1-438:1-358) 10 20 30 40 50 60 pF1KE9 MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNIT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 CWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESK- 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 TFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKD NP_001 ------------------------------------------------------------ 190 200 210 220 230 240 pF1KE9 DVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRC ::::::::::::::::::::::::::::::::::::::::: NP_001 -------------------VGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRC 120 130 140 150 160 250 260 270 280 290 300 pF1KE9 FLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFI 170 180 190 200 210 220 310 320 330 340 350 360 pF1KE9 SIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFE 230 240 250 260 270 280 370 380 390 400 410 420 pF1KE9 LCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQ 290 300 310 320 330 340 430 pF1KE9 FHRGSRAQSFLQTETSVI :::::::::::::::::: NP_001 FHRGSRAQSFLQTETSVI 350 >>NP_001186566 (OMIM: 102981) pituitary adenylate cyclas (447 aa) initn: 966 init1: 809 opt: 1513 Z-score: 1766.3 bits: 336.0 E(85289): 1.2e-91 Smith-Waterman score: 1513; 52.3% identity (76.9% similar) in 428 aa overlap (10-429:9-433) 10 20 30 40 50 pF1KE9 MRTLLPPALLTCWLLAPVN-SIHPECRFHLE--IQEEETKCAELLRSQTEKHKACSGVWD :. :: :. ..: .: :. : . :. . :. : . ... .: :.:: NP_001 MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWD 10 20 30 40 50 60 70 80 90 100 110 pF1KE9 NITCWRPANVGETVTVPCPKVFSNFY--SKAGNISKNCTSDGWSETFPDFVDACGYSDPE :::::.::.::: : : ::..: : . : .:.::: ::::: :: . ::::... : NP_001 NITCWKPAHVGEMVLVSCPELFRIFNPDQDMGVVSRNCTEDGWSEPFPHYFDACGFDEYE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 DES--KITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRA .:. . .:. :::.::.:::.::..:.:. .::: :::::::::.::.:::.::.::: NP_001 SETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 ISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLV- :::..:: .::. . . :: : : :: .::..::...:.:::..::::: :::: NP_001 ISVFIKDWILYAEQDSNHC---FISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVE 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 AMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISI ...: :: : : .:::: ::::. .:.. :::..:::::: :: .. ::::. :.. :: NP_001 TFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMNDSTALWWVIKGPVVGSI 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE9 IVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISIS .:::::::.:: ::.::: :::.:::..: : :::.::::::::::.:: ::: : ..: NP_001 MVNFVLFIGIIVILVQKLQSPDMGGNESSIYLRLARSTLLLIPLFGIHYTVFAFSPENVS 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE9 SKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSR .. ...::: ::::::.::::::::::.::: :.:::::: . . :.. :.. NP_001 KRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLAS 360 370 380 390 400 410 420 430 pF1KE9 NGSEGALQFHRGSRAQSFLQTETSVI .: .:. :. :...: NP_001 SGVNGGTQLSILSKSSSQIRMSGLPADNLAT 420 430 440 >>NP_004615 (OMIM: 192321) vasoactive intestinal polypep (457 aa) initn: 1111 init1: 652 opt: 1359 Z-score: 1586.6 bits: 302.8 E(85289): 1.2e-81 Smith-Waterman score: 1361; 46.9% identity (71.3% similar) in 463 aa overlap (1-438:1-457) 10 20 30 40 pF1KE9 MRTLLP-PALLTC-------WLLAPVNS----IHPECRFHLEIQEEETKCAELLRSQTEK :: : :: : : :.:... .. :: . :. .. .: : ..: :. NP_004 MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLE--EAQLEN 10 20 30 40 50 50 60 70 80 90 100 pF1KE9 HK-ACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAG-NISKNCTSDGWSETFPD-F . .:: .:::.::: . :..:.. :: .:. : : : :.:..::..::.. : . NP_004 ETIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPY 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE9 VDACGYSDPE---DESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIH ::: .: ::.. :: ::. ::.::..:: .: ... :: ::::::::::::: NP_004 PIACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIH 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE9 LNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLV ..::.:::::: .:..:: .:..:. . .: . :::: ..::.:::.::::::::: NP_004 MHLFISFILRAAAVFIKDLALFDSGESDQCSEGS---VGCKAAMVFFQYCVMANFFWLLV 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE9 EGLYLHTLL-VAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPW :::::.::: :... :. : .:.:::::.:.. .:: ::...:: ::::: . :. : NP_004 EGLYLYTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSSL-W 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE9 WVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHY :.:. ::: ::.:::.::: ::::::::: ::. .:.: :.:::.::::::::::::: NP_004 WIIKGPILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHY 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE9 MVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASR ..:: :: ... . ...::: .:::::.:::.::::::.::: ::.:::: . NP_004 IMFAFFPDNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGW 360 370 380 390 400 410 410 420 430 pF1KE9 DYRVCGSSFSRNGSEGALQFHR------GSRAQSFLQTETSVI . . : . ::. . : :.: .: .:.:.:.. NP_004 NPKYRHPSGGSNGATCSTQVSMLTRVSPGARRSSSFQAEVSLV 420 430 440 450 438 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 01:55:50 2016 done: Mon Nov 7 01:55:51 2016 Total Scan time: 6.810 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]