FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2384, 316 aa 1>>>pF1KE2384 316 - 316 aa - 316 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8597+/-0.000359; mu= 18.8922+/- 0.022 mean_var=71.5265+/-14.443, 0's: 0 Z-trim(113.6): 66 B-trim: 47 in 1/50 Lambda= 0.151649 statistics sampled from 22888 (22956) to 22888 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.269), width: 16 Scan time: 7.530 The best scores are: opt bits E(85289) NP_001619 (OMIM: 103880) aldose reductase isoform ( 316) 2138 476.8 2.4e-134 NP_064695 (OMIM: 604707) aldo-keto reductase famil ( 316) 1573 353.2 4e-97 XP_011514543 (OMIM: 616336) PREDICTED: aldo-keto r ( 316) 1489 334.9 1.4e-91 XP_016867713 (OMIM: 616336) PREDICTED: aldo-keto r ( 344) 1401 315.6 9e-86 NP_001074007 (OMIM: 616336) aldo-keto reductase fa ( 344) 1401 315.6 9e-86 NP_001333071 (OMIM: 103880) aldose reductase isofo ( 172) 1159 262.4 4.7e-70 XP_005250291 (OMIM: 103880) PREDICTED: aldose redu ( 172) 1159 262.4 4.7e-70 NP_005980 (OMIM: 235555,604741) 3-oxo-5-beta-stero ( 326) 1095 248.7 1.2e-65 NP_001189342 (OMIM: 103830) alcohol dehydrogenase ( 325) 1080 245.4 1.2e-64 NP_001189343 (OMIM: 103830) alcohol dehydrogenase ( 325) 1080 245.4 1.2e-64 NP_697021 (OMIM: 103830) alcohol dehydrogenase [NA ( 325) 1080 245.4 1.2e-64 NP_006057 (OMIM: 103830) alcohol dehydrogenase [NA ( 325) 1080 245.4 1.2e-64 NP_001344 (OMIM: 600449) aldo-keto reductase famil ( 323) 1069 243.0 6.3e-64 NP_995317 (OMIM: 600450,614279) aldo-keto reductas ( 323) 1064 241.9 1.3e-63 NP_001345 (OMIM: 600450,614279) aldo-keto reductas ( 323) 1064 241.9 1.3e-63 NP_001809 (OMIM: 600451,614279) aldo-keto reductas ( 323) 1061 241.2 2.1e-63 NP_001240837 (OMIM: 603966) aldo-keto reductase fa ( 323) 1048 238.4 1.5e-62 NP_003730 (OMIM: 603966) aldo-keto reductase famil ( 323) 1046 237.9 2.1e-62 XP_011514718 (OMIM: 604707) PREDICTED: aldo-keto r ( 277) 1029 234.2 2.4e-61 NP_001177836 (OMIM: 235555,604741) 3-oxo-5-beta-st ( 290) 980 223.5 4.2e-58 XP_011538794 (OMIM: 103830) PREDICTED: alcohol deh ( 214) 663 154.0 2.5e-37 XP_011538793 (OMIM: 103830) PREDICTED: alcohol deh ( 214) 663 154.0 2.5e-37 XP_011514719 (OMIM: 604707) PREDICTED: aldo-keto r ( 175) 645 150.0 3.4e-36 NP_001307956 (OMIM: 600450,614279) aldo-keto reduc ( 297) 609 142.3 1.2e-33 NP_001177835 (OMIM: 235555,604741) 3-oxo-5-beta-st ( 285) 456 108.8 1.4e-23 XP_016871280 (OMIM: 600449) PREDICTED: aldo-keto r ( 297) 394 95.3 1.7e-19 NP_001128713 (OMIM: 600450,614279) aldo-keto reduc ( 139) 382 92.3 6e-19 NP_001240838 (OMIM: 603966) aldo-keto reductase fa ( 138) 369 89.5 4.3e-18 NP_003462 (OMIM: 601141) voltage-gated potassium c ( 408) 145 40.9 0.0054 NP_742128 (OMIM: 601142) voltage-gated potassium c ( 353) 144 40.6 0.0056 XP_005263571 (OMIM: 601142) PREDICTED: voltage-gat ( 353) 144 40.6 0.0056 XP_016858109 (OMIM: 601142) PREDICTED: voltage-gat ( 400) 144 40.7 0.0061 XP_016858108 (OMIM: 601142) PREDICTED: voltage-gat ( 420) 144 40.7 0.0064 XP_016858107 (OMIM: 601142) PREDICTED: voltage-gat ( 420) 144 40.7 0.0064 NP_001186791 (OMIM: 601142) voltage-gated potassiu ( 415) 142 40.3 0.0085 XP_016858110 (OMIM: 601142) PREDICTED: voltage-gat ( 435) 142 40.3 0.0088 >>NP_001619 (OMIM: 103880) aldose reductase isoform 1 [H (316 aa) initn: 2138 init1: 2138 opt: 2138 Z-score: 2532.8 bits: 476.8 E(85289): 2.4e-134 Smith-Waterman score: 2138; 100.0% identity (100.0% similar) in 316 aa overlap (1-316:1-316) 10 20 30 40 50 60 pF1KE2 MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA 250 260 270 280 290 300 310 pF1KE2 LLSCTSHKDYPFHEEF :::::::::::::::: NP_001 LLSCTSHKDYPFHEEF 310 >>NP_064695 (OMIM: 604707) aldo-keto reductase family 1 (316 aa) initn: 1613 init1: 1573 opt: 1573 Z-score: 1864.7 bits: 353.2 E(85289): 4e-97 Smith-Waterman score: 1573; 70.6% identity (91.5% similar) in 316 aa overlap (1-316:1-316) 10 20 30 40 50 60 pF1KE2 MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ ::. . :.. :::::.:::::::: :.: ::::::::.::::::::.:::::.::: ::: NP_064 MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK ::..:..::::.:::::::: :. :. ::. : .:::.::::.:::.:::::: ::: : NP_064 EKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP ..:: :..::.. . ...::.: :::::::::::::.:.:::.:.:.: .:::::::::: NP_064 DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK ..::.:::::::::::::::.::::.::::::::::::::::::::::::::.:: :::: NP_064 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA :.::.::::::: .:::..:::::::: ::.::..::::.::...:.:.::.:::::.: NP_064 HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACN 250 260 270 280 290 300 310 pF1KE2 LLSCTSHKDYPFHEEF .:. . .::::. :. NP_064 VLQSSHLEDYPFNAEY 310 >>XP_011514543 (OMIM: 616336) PREDICTED: aldo-keto reduc (316 aa) initn: 1529 init1: 1489 opt: 1489 Z-score: 1765.4 bits: 334.9 E(85289): 1.4e-91 Smith-Waterman score: 1489; 67.4% identity (88.6% similar) in 316 aa overlap (1-316:1-316) 10 20 30 40 50 60 pF1KE2 MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ ::. . :.. :::::.:::::.: :.: ::::::::. :::::::. :.:..::: ::: XP_011 MATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK ::..:..: ::.::::::.: :. :. ::. : .:::.::::.:::.:::::: ::: : XP_011 EKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP .::: :..::.. . ..::.: :::::::::::::.:.:::::.:.: .:::::::::: XP_011 DFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK ..::.:::::::::::::::.::::.::::::::::::::::::::::::::.:: :::: XP_011 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA :.:::::::::: .:::..:::::.:: .:.::..::::.::...:.:.::.:::::. XP_011 HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFD 250 260 270 280 290 300 310 pF1KE2 LLSCTSHKDYPFHEEF . . .:.:: :. XP_011 FKEFSHLEDFPFDAEY 310 >>XP_016867713 (OMIM: 616336) PREDICTED: aldo-keto reduc (344 aa) initn: 1408 init1: 1387 opt: 1401 Z-score: 1660.9 bits: 315.6 E(85289): 9e-86 Smith-Waterman score: 1401; 68.4% identity (89.3% similar) in 291 aa overlap (26-316:54-344) 10 20 30 40 50 pF1KE2 MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEV :.: ::::::::. :::::::. :.:..:: XP_016 VGPLTGLKSSLLKDTTSAGPLLRPYPASLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEV 30 40 50 60 70 80 60 70 80 90 100 110 pF1KE2 GVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTG : :::::..:..: ::.::::::.: :. :. ::. : .:::.::::.:::.:::::: : XP_016 GEAIQEKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQG 90 100 110 120 130 140 120 130 140 150 160 170 pF1KE2 FKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPG :: : .::: :..::.. . ..::.: :::::::::::::.:.:::::.:.: .::::: XP_016 FKTGDDFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPG 150 160 170 180 190 200 180 190 200 210 220 230 pF1KE2 LKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIK :::::..::.:::::::::::::::.::::.::::::::::::::::::::::::::.:: XP_016 LKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIK 210 220 230 240 250 260 240 250 260 270 280 290 pF1KE2 AIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRN :::::.:::::::::: .:::..:::::.:: .:.::..::::.::...:.:.::.::: XP_016 EIAAKHKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRN 270 280 290 300 310 320 300 310 pF1KE2 WRVCALLSCTSHKDYPFHEEF ::. . . .:.:: :. XP_016 WRAFDFKEFSHLEDFPFDAEY 330 340 >>NP_001074007 (OMIM: 616336) aldo-keto reductase family (344 aa) initn: 1408 init1: 1387 opt: 1401 Z-score: 1660.9 bits: 315.6 E(85289): 9e-86 Smith-Waterman score: 1401; 68.4% identity (89.3% similar) in 291 aa overlap (26-316:54-344) 10 20 30 40 50 pF1KE2 MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEV :.: ::::::::. :::::::. :.:..:: NP_001 VGPLTGLKSSLLKDTTSAGPLLRPYPASLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEV 30 40 50 60 70 80 60 70 80 90 100 110 pF1KE2 GVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTG : :::::..:..: ::.::::::.: :. :. ::. : .:::.::::.:::.:::::: : NP_001 GEAIQEKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQG 90 100 110 120 130 140 120 130 140 150 160 170 pF1KE2 FKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPG :: : .::: :..::.. . ..::.: :::::::::::::.:.:::::.:.: .::::: NP_001 FKTGDDFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPG 150 160 170 180 190 200 180 190 200 210 220 230 pF1KE2 LKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIK :::::..::.:::::::::::::::.::::.::::::::::::::::::::::::::.:: NP_001 LKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIK 210 220 230 240 250 260 240 250 260 270 280 290 pF1KE2 AIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRN :::::.:::::::::: .:::..:::::.:: .:.::..::::.::...:.:.::.::: NP_001 EIAAKHKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRN 270 280 290 300 310 320 300 310 pF1KE2 WRVCALLSCTSHKDYPFHEEF ::. . . .:.:: :. NP_001 WRAFDFKEFSHLEDFPFDAEY 330 340 >>NP_001333071 (OMIM: 103880) aldose reductase isoform 2 (172 aa) initn: 1159 init1: 1159 opt: 1159 Z-score: 1378.7 bits: 262.4 E(85289): 4.7e-70 Smith-Waterman score: 1159; 100.0% identity (100.0% similar) in 172 aa overlap (145-316:1-172) 120 130 140 150 160 170 pF1KE2 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP :::::::::::::::::::::::::::::: NP_001 MEELVDEGLVKAIGISNFNHLQVEMILNKP 10 20 30 180 190 200 210 220 230 pF1KE2 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRI 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE2 KAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNR 100 110 120 130 140 150 300 310 pF1KE2 NWRVCALLSCTSHKDYPFHEEF :::::::::::::::::::::: NP_001 NWRVCALLSCTSHKDYPFHEEF 160 170 >>XP_005250291 (OMIM: 103880) PREDICTED: aldose reductas (172 aa) initn: 1159 init1: 1159 opt: 1159 Z-score: 1378.7 bits: 262.4 E(85289): 4.7e-70 Smith-Waterman score: 1159; 100.0% identity (100.0% similar) in 172 aa overlap (145-316:1-172) 120 130 140 150 160 170 pF1KE2 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP :::::::::::::::::::::::::::::: XP_005 MEELVDEGLVKAIGISNFNHLQVEMILNKP 10 20 30 180 190 200 210 220 230 pF1KE2 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRI 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE2 KAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNR 100 110 120 130 140 150 300 310 pF1KE2 NWRVCALLSCTSHKDYPFHEEF :::::::::::::::::::::: XP_005 NWRVCALLSCTSHKDYPFHEEF 160 170 >>NP_005980 (OMIM: 235555,604741) 3-oxo-5-beta-steroid 4 (326 aa) initn: 1024 init1: 756 opt: 1095 Z-score: 1299.4 bits: 248.7 E(85289): 1.2e-65 Smith-Waterman score: 1095; 50.0% identity (77.0% similar) in 318 aa overlap (4-316:9-326) 10 20 30 40 50 pF1KE2 MASRLLLNNGAKMPILGLGTWK----SPPGQVTEAVKVAIDVGYRHIDCAHVYQN :. :..: ..::.::::.. .: : . .::::::.:::::: :..::: NP_005 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 ENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIH :.::: ::.::. : :.::..: .::: : : .:. . ..:: :.:::.:::.:. NP_005 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 WPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMIL : .:::: :..: ::.:. . .:. :: ::: : ::::..:.::::. :.:.:: NP_005 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 NKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP-WAKPEDPSLLE ::::::.::. ::.:::::.:: ::...::.. ::.:::::::. : :.. .: ::. NP_005 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 DPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLL : ..... ..:::.::...:: .::..:::::: . ::: :::..::: :. ..: . NP_005 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE 250 260 270 280 290 300 300 310 pF1KE2 SYNRNWRVCALLSCTSHKDYPFHEEF . :.: : :: .: .::::.:. NP_005 ALNKNVRFVELLMWRDHPEYPFHDEY 310 320 >>NP_001189342 (OMIM: 103830) alcohol dehydrogenase [NAD (325 aa) initn: 1076 init1: 484 opt: 1080 Z-score: 1281.7 bits: 245.4 E(85289): 1.2e-64 Smith-Waterman score: 1087; 49.5% identity (75.7% similar) in 325 aa overlap (2-316:3-325) 10 20 30 40 50 pF1KE2 MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAI :: .::..: :::..::::::: :::: ::: :..::::::::: .: :: :.: :. NP_001 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 QEKLRE-QVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKP .: . ..: :::::..:::: : :. :. : .:::.::.:.::::::.::: .:. NP_001 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 GKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKY : . :: . .:.. ..:. .:: :.: :: .:::.:.:.:::: :.. ::. ... NP_001 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR- 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 KPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIA ::: :.::::::.:..:: .::..:. ::::::::: :: : :..: :::.: . :.: NP_001 -PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALA 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 AKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWR- :.... ::.:.:. .::... ::::.:: :: .:.::::: .: ..: : . :.::: NP_001 EKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 240 250 260 270 280 290 300 310 pF1KE2 VCALLSC--------TSHKDYPFHEEF . .:. ..: :::.. . NP_001 IVPMLTVDGKRVPRDAGHPLYPFNDPY 300 310 320 >>NP_001189343 (OMIM: 103830) alcohol dehydrogenase [NAD (325 aa) initn: 1076 init1: 484 opt: 1080 Z-score: 1281.7 bits: 245.4 E(85289): 1.2e-64 Smith-Waterman score: 1087; 49.5% identity (75.7% similar) in 325 aa overlap (2-316:3-325) 10 20 30 40 50 pF1KE2 MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAI :: .::..: :::..::::::: :::: ::: :..::::::::: .: :: :.: :. NP_001 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 QEKLRE-QVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKP .: . ..: :::::..:::: : :. :. : .:::.::.:.::::::.::: .:. NP_001 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 GKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKY : . :: . .:.. ..:. .:: :.: :: .:::.:.:.:::: :.. ::. ... NP_001 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR- 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 KPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIA ::: :.::::::.:..:: .::..:. ::::::::: :: : :..: :::.: . :.: NP_001 -PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALA 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 AKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWR- :.... ::.:.:. .::... ::::.:: :: .:.::::: .: ..: : . :.::: NP_001 EKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 240 250 260 270 280 290 300 310 pF1KE2 VCALLSC--------TSHKDYPFHEEF . .:. ..: :::.. . NP_001 IVPMLTVDGKRVPRDAGHPLYPFNDPY 300 310 320 316 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 01:57:05 2016 done: Mon Nov 7 01:57:06 2016 Total Scan time: 7.530 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]