FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1489, 455 aa 1>>>pF1KE1489 455 - 455 aa - 455 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.1664+/-0.000361; mu= 5.1853+/- 0.022 mean_var=201.8315+/-40.214, 0's: 0 Z-trim(120.7): 76 B-trim: 0 in 0/57 Lambda= 0.090278 statistics sampled from 36152 (36233) to 36152 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.763), E-opt: 0.2 (0.425), width: 16 Scan time: 9.820 The best scores are: opt bits E(85289) NP_001056 (OMIM: 142680,191190,614810) tumor necro ( 455) 3212 430.9 3.5e-120 NP_001333020 (OMIM: 142680,191190,614810) tumor ne ( 347) 2426 328.4 1.9e-89 NP_001333021 (OMIM: 142680,191190,614810) tumor ne ( 302) 1857 254.2 3.4e-67 NP_683866 (OMIM: 603366) tumor necrosis factor rec ( 426) 483 75.4 3.3e-13 NP_002333 (OMIM: 600979) tumor necrosis factor rec ( 435) 329 55.4 3.6e-07 NP_001257916 (OMIM: 600979) tumor necrosis factor ( 416) 319 54.1 8.6e-07 XP_006719046 (OMIM: 600979) PREDICTED: tumor necro ( 255) 311 52.8 1.2e-06 XP_005253745 (OMIM: 600979) PREDICTED: tumor necro ( 399) 313 53.3 1.4e-06 NP_001034753 (OMIM: 603366) tumor necrosis factor ( 181) 297 50.9 3.4e-06 NP_683871 (OMIM: 603366) tumor necrosis factor rec ( 234) 275 48.1 3e-05 NP_683868 (OMIM: 603366) tumor necrosis factor rec ( 372) 268 47.4 7.9e-05 NP_683867 (OMIM: 603366) tumor necrosis factor rec ( 380) 268 47.4 8.1e-05 NP_003781 (OMIM: 603366) tumor necrosis factor rec ( 417) 268 47.4 8.6e-05 NP_003811 (OMIM: 602746) tumor necrosis factor rec ( 283) 240 43.6 0.00081 NP_002537 (OMIM: 239000,602643) tumor necrosis fac ( 401) 233 42.8 0.002 XP_011540743 (OMIM: 153243) PREDICTED: tumor necro ( 594) 229 42.5 0.0038 NP_001234 (OMIM: 153243) tumor necrosis factor rec ( 595) 229 42.5 0.0038 NP_001233 (OMIM: 186711,615122) CD27 antigen precu ( 260) 222 41.2 0.0039 NP_001284534 (OMIM: 602746) tumor necrosis factor ( 184) 218 40.6 0.0043 XP_006711082 (OMIM: 602746) PREDICTED: tumor necro ( 197) 216 40.4 0.0054 >>NP_001056 (OMIM: 142680,191190,614810) tumor necrosis (455 aa) initn: 3212 init1: 3212 opt: 3212 Z-score: 2278.7 bits: 430.9 E(85289): 3.5e-120 Smith-Waterman score: 3212; 100.0% identity (100.0% similar) in 455 aa overlap (1-455:1-455) 10 20 30 40 50 60 pF1KE1 MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 RDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 SCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 SKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 PGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 AVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLEL 370 380 390 400 410 420 430 440 450 pF1KE1 LGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR ::::::::::::::::::::::::::::::::::: NP_001 LGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR 430 440 450 >>NP_001333020 (OMIM: 142680,191190,614810) tumor necros (347 aa) initn: 2426 init1: 2426 opt: 2426 Z-score: 1727.0 bits: 328.4 E(85289): 1.9e-89 Smith-Waterman score: 2426; 100.0% identity (100.0% similar) in 347 aa overlap (109-455:1-347) 80 90 100 110 120 130 pF1KE1 TDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSE :::::::::::::::::::::::::::::: NP_001 MGQVEISSCTVDRDTVCGCRKNQYRHYWSE 10 20 30 140 150 160 170 180 190 pF1KE1 NLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQ 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE1 IENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGE 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE1 LEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPY 160 170 180 190 200 210 320 330 340 350 360 370 pF1KE1 QGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRL 220 230 240 250 260 270 380 390 400 410 420 430 pF1KE1 GLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIE 280 290 300 310 320 330 440 450 pF1KE1 EALCGPAALPPAPSLLR ::::::::::::::::: NP_001 EALCGPAALPPAPSLLR 340 >>NP_001333021 (OMIM: 142680,191190,614810) tumor necros (302 aa) initn: 1857 init1: 1857 opt: 1857 Z-score: 1327.3 bits: 254.2 E(85289): 3.4e-67 Smith-Waterman score: 1857; 99.6% identity (100.0% similar) in 272 aa overlap (184-455:31-302) 160 170 180 190 200 210 pF1KE1 VHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVL .::::::::::::::::::::::::::::: NP_001 MQWRDLGSLQPLPPRFKQFSCFSLPSSWDYSCKKSLECTKLCLPQIENVKGTEDSGTTVL 10 20 30 40 50 60 220 230 240 250 260 270 pF1KE1 LPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSF 70 80 90 100 110 120 280 290 300 310 320 330 pF1KE1 SPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDP 130 140 150 160 170 180 340 350 360 370 380 390 pF1KE1 IPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNG 190 200 210 220 230 240 400 410 420 430 440 450 pF1KE1 RCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALCGPAALPPAPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALCGPAALPPAPSL 250 260 270 280 290 300 pF1KE1 LR :: NP_001 LR >>NP_683866 (OMIM: 603366) tumor necrosis factor recepto (426 aa) initn: 415 init1: 132 opt: 483 Z-score: 358.2 bits: 75.4 E(85289): 3.3e-13 Smith-Waterman score: 538; 28.9% identity (50.8% similar) in 429 aa overlap (34-444:20-426) 10 20 30 40 50 60 pF1KE1 STVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREK---RDSVCPQGKYIHPQNNSICCT :: : . :. : . .: . . .:: NP_683 MEQRPRGCAAVAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCR 10 20 30 40 70 80 90 100 110 pF1KE1 KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLR-HCLSCSKCRKEMGQVEISSCTV : : :: : : .. : : . .: : ::: .: :. : .. .:: . .:.. NP_683 GCPAGHYLKAPCTEPCGNSTCLVCPQDTFLAWENHHNSECARCQACDEQASQVALENCSA 50 60 70 80 90 100 120 130 140 150 160 pF1KE1 DRDTVCGCRKNQYRHYWSENLFQC-----FNCSLCLN-GTVH----LSCQEKQNTVCTCH :: :::. . . . .. :: : :. ::. :..: : :..... :: NP_683 VADTRCGCKPGWFVEC---QVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDTDCGTCL 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 AGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLF ::. . . :::: . :: . : .. . . :. :.. :: . :: NP_683 PGFYEHGDGCVSCPTPPPSLAGAPWGAVQSAVPLSVAGGRVGVFWVQVLLAGLVVPLLLG 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 IGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVP : : :.. : : .. : . :.: :. .: . ..: : NP_683 ATLTYTYRH---------CWPHKPLVTADEAG--MEALTPPPATHLSPLDSAHTLLAP-P 230 240 250 260 270 290 300 310 320 330 340 pF1KE1 SSTFTSSSTYTPGDC--PNFAAPRREVAPPYQGA-DPILATALASDPIPNPLQKWEDSAH .:. .. :. :.. .. . : . : . . ::. : : . :. : NP_683 DSSEKICTVQLVGNSWTPGYPETQEALCPQVTWSWDQLPSRALG--PAAAPTLSPESPAG 280 290 300 310 320 330 350 360 370 380 390 400 pF1KE1 KPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLAT .: . : :: :.. :: ::::::: ::: . ::. .:.. :: .:. :: :: NP_683 SPAMMLQPGPQ-LYDVMDAVPARRWKEFVRTLGLREAEIEAVEVEIGR-FRDQQYEMLKR 340 350 360 370 380 390 410 420 430 440 450 pF1KE1 WRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALC-GPAALPPAPSLLR ::.. : : : . .:. : : ::.::.. : :: NP_683 WRQQQP---AGLGAVYAALERMGLDGCVEDLRSRLQRGP 400 410 420 >>NP_002333 (OMIM: 600979) tumor necrosis factor recepto (435 aa) initn: 161 init1: 98 opt: 329 Z-score: 249.7 bits: 55.4 E(85289): 3.6e-07 Smith-Waterman score: 332; 30.3% identity (49.4% similar) in 346 aa overlap (4-319:7-321) 10 20 30 40 50 pF1KE1 MGLSTVPDLLL-PLVL--LELLVGIYPSGVIGLVPHLGDREK-RDSVCPQGKYIHPQ ...: : :::: . ::.. :..: :. .. . ::. . .: .:: NP_002 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVP---PYASENQTCRDQ---EKEYYEPQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 NNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVE . :::..: :::. : . .:: : : .:.. :.: : : : :: : NP_002 HR-ICCSRCPPGTYVSAKC-SRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEE 60 70 80 90 100 110 120 130 140 150 160 pF1KE1 ISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSL---CLNGTVHLSCQE--KQNTVCT- :. :: : : : :. ... :. ..: .: : : :: .: : :. :. NP_002 IAPCTSKRKTQCRCQPGMFCAAWA---LECTHCELLSDCPPGTEAELKDEVGKGNNHCVP 120 130 140 150 160 170 180 190 200 210 pF1KE1 CHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPL---------VI :.:: : .: . :. .: . : .: . :: .: :: :: .. NP_002 CKAGHF--QNTSSPSARCQPHTRCENQGL--VEAAPGTAQSDTTCKNPLEPLPPEMSGTM 170 180 190 200 210 220 220 230 240 250 260 pF1KE1 FFGLCLLSLLFIGLMYRYQR--WKS------KLYSIVCGKSTPEKEGE--LEGTTTKPLA .. :: : :. :. ::: :: :.. : :. :: . :. : : NP_002 LMLAVLLPLAFFLLLATVFSCIWKSHPSLCRKLGSLL--KRRPQGEGPNPVAGSWEPPKA 230 240 250 260 270 280 270 280 290 300 310 320 pF1KE1 PNPSFSPTPGFT-PTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILAT .: : : .. : : :. :. . :: : ::: :.. : : NP_002 -HPYF---PDLVQPLL---PI-SGDVSPVSTGLP------AAPVLEAGVPQQQSPLDLTR 290 300 310 320 330 340 350 360 370 380 pF1KE1 ALASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDR NP_002 EPQLEPGEQSQVAHGTNGIHVTGGSMTITGNIYIYNGPVLGGPPGPGDLPATPEPPYPIP 330 340 350 360 370 380 >>NP_001257916 (OMIM: 600979) tumor necrosis factor rece (416 aa) initn: 188 init1: 98 opt: 319 Z-score: 242.9 bits: 54.1 E(85289): 8.6e-07 Smith-Waterman score: 322; 29.5% identity (48.3% similar) in 325 aa overlap (21-319:5-302) 10 20 30 40 50 pF1KE1 MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREK-RDSVCPQGKYIHPQNNSICC :: .. . . :. .. . ::. . .: .::. ::: NP_001 MEATGISLASQLKVPPYASENQTCRDQ---EKEYYEPQHR-ICC 10 20 30 40 60 70 80 90 100 110 pF1KE1 TKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTV ..: :::. : .:: : : .:.. :.: : : : :: ::. :: NP_001 SRCPPGTYVSAKCSRI-RDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTS 50 60 70 80 90 120 130 140 150 160 170 pF1KE1 DRDTVCGCRKNQYRHYWSENLFQCFNCSL---CLNGTVHLSCQE--KQNTVCT-CHAGFF : : : :. ... :. ..: .: : : :: .: : :. :. :.:: : NP_001 KRKTQCRCQPGMFCAAWA---LECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHF 100 110 120 130 140 150 180 190 200 210 220 pF1KE1 LRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPL---------VIFFGLCL .: . :. .: . : .: . :: .: :: :: .... : NP_001 --QNTSSPSARCQPHTRCENQGL--VEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVL 160 170 180 190 200 210 230 240 250 260 270 pF1KE1 LSLLFIGLMYRYQR--WKS------KLYSIVCGKSTPEKEGE--LEGTTTKPLAPNPSFS : : :. :. ::: :: :.. : :. :: . :. : : .: : NP_001 LPLAFFLLLATVFSCIWKSHPSLCRKLGSLL--KRRPQGEGPNPVAGSWEPPKA-HPYF- 220 230 240 250 260 280 290 300 310 320 330 pF1KE1 PTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDPI : .. : :. :. . :: : ::: :.. : : NP_001 --PDLVQPL--LPI-SGDVSPVSTGLP------AAPVLEAGVPQQQSPLDLTREPQLEPG 270 280 290 300 310 340 350 360 370 380 390 pF1KE1 PNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGR NP_001 EQSQVAHGTNGIHVTGGSMTITGNIYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGP 320 330 340 350 360 370 >>XP_006719046 (OMIM: 600979) PREDICTED: tumor necrosis (255 aa) initn: 188 init1: 98 opt: 311 Z-score: 240.1 bits: 52.8 E(85289): 1.2e-06 Smith-Waterman score: 311; 31.8% identity (52.5% similar) in 223 aa overlap (4-216:7-214) 10 20 30 40 50 pF1KE1 MGLSTVPDLLL-PLVL--LELLVGIYPSGVIGLVPHLGDREK-RDSVCPQGKYIHPQ ...: : :::: . ::.. :..: :. .. . ::. . .: .:: XP_006 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVP---PYASENQTCRDQ---EKEYYEPQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 NNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVE . :::..: :::. : .:: : : .:.. :.: : : : :: : XP_006 HR-ICCSRCPPGTYVSAKCSRI-RDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEE 60 70 80 90 100 110 120 130 140 150 160 pF1KE1 ISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSL---CLNGTVHLSCQE--KQNTVCT- :. :: : : : :. ... :. ..: .: : : :: .: : :. :. XP_006 IAPCTSKRKTQCRCQPGMFCAAWA---LECTHCELLSDCPPGTEAELKDEVGKGNNHCVP 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 CHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSL :.:: : .: . :. .: . : .: . :: .: :: :: XP_006 CKAGHF--QNTSSPSARCQPHTRCENQGL--VEAAPGTAQSDTTCKNPLEPLPPEMSEPA 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 LFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSP XP_006 LSKGVENLQALLYQAATGSSEASFPTLSPL 230 240 250 >>XP_005253745 (OMIM: 600979) PREDICTED: tumor necrosis (399 aa) initn: 215 init1: 98 opt: 313 Z-score: 238.9 bits: 53.3 E(85289): 1.4e-06 Smith-Waterman score: 313; 29.4% identity (49.8% similar) in 289 aa overlap (4-281:7-273) 10 20 30 40 50 pF1KE1 MGLSTVPDLLL-PLVL--LELLVGIYPSGVIGLVPHLGDREK-RDSVCPQGKYIHPQ ...: : :::: . ::.. :..: :. .. . ::. . .: .:: XP_005 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVP---PYASENQTCRDQ---EKEYYEPQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 NNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVE . :::..: :::. : . .:: : : .:.. :.: : : : :: : XP_005 HR-ICCSRCPPGTYVSAKC-SRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEE 60 70 80 90 100 110 120 130 140 150 160 pF1KE1 ISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSL---CLNGTVHLSCQE--KQNTVCT- :. :: : : : :. ... :. ..: .: : : :: .: : :. :. XP_005 IAPCTSKRKTQCRCQPGMFCAAWA---LECTHCELLSDCPPGTEAELKDEVGKGNNHCVP 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 CHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSL :.:: : .: . :. .: . : .: . :: .: :: :: . :: XP_005 CKAGHF--QNTSSPSARCQPHTRCENQGL--VEAAPGTAQSDTTCKNPLEPLPPEMSGSL 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 LFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAP-NPSFSPTPGFTPTLGFS : .: ... . : :. : : ..:: : . . ::. : XP_005 L-------KRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGDVSPVSTGLPAAPVL 230 240 250 260 270 290 300 310 320 330 340 pF1KE1 PVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAH XP_005 EAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGNIYIYNGPVLGGPPG 280 290 300 310 320 330 >>NP_001034753 (OMIM: 603366) tumor necrosis factor rece (181 aa) initn: 222 init1: 116 opt: 297 Z-score: 232.2 bits: 50.9 E(85289): 3.4e-06 Smith-Waterman score: 297; 30.7% identity (54.0% similar) in 163 aa overlap (34-182:20-179) 10 20 30 40 50 60 pF1KE1 STVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREK---RDSVCPQGKYIHPQNNSICCT :: : . :. : . .: . . .:: NP_001 MEQRPRGCAAVAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCR 10 20 30 40 70 80 90 100 110 pF1KE1 KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLR-HCLSCSKCRKEMGQVEISSCTV : : :: : : .. : : . .: : ::: .: :. : .. .:: . .:.. NP_001 GCPAGHYLKAPCTEPCGNSTCLVCPQDTFLAWENHHNSECARCQACDEQASQVALENCSA 50 60 70 80 90 100 120 130 140 150 160 pF1KE1 DRDTVCGCRKNQYRHYWSENLFQC-----FNCSLCLN-GTVH----LSCQEKQNTVCTCH :: :::. . . . .. :: : :. ::. :..: : :..... :: NP_001 VADTRCGCKPGWFVEC---QVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDTDCGTCL 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 AGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLF ::. . . :::: NP_001 PGFYEHGDGCVSCPT 170 180 >>NP_683871 (OMIM: 603366) tumor necrosis factor recepto (234 aa) initn: 227 init1: 132 opt: 275 Z-score: 215.2 bits: 48.1 E(85289): 3e-05 Smith-Waterman score: 275; 30.9% identity (54.1% similar) in 207 aa overlap (242-444:41-234) 220 230 240 250 260 270 pF1KE1 VLLPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNP : .. : .. : :. .:. :.: : NP_683 VAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPADEAGMEA-----LTPPP 20 30 40 50 60 280 290 300 310 320 pF1KE1 SFSPTPGFTPTLGFSPVPSSTFTSSSTYTPGDC--PNFAAPRREVAPPYQGA-DPILATA . .: . ..: :.:. .. :. :.. .. . : . : . . : NP_683 ATHLSPLDSAHTLLAP-PDSSEKICTVQLVGNSWTPGYPETQEALCPQVTWSWDQLPSRA 70 80 90 100 110 120 330 340 350 360 370 380 pF1KE1 LASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRL :. : : . :. : .: . : :: :.. :: ::::::: ::: . ::. . NP_683 LG--PAAAPTLSPESPAGSPAMMLQPGPQ-LYDVMDAVPARRWKEFVRTLGLREAEIEAV 130 140 150 160 170 180 390 400 410 420 430 440 pF1KE1 ELQNGRCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALC-GPAAL :.. :: .:. :: :: ::.. : : : . .:. : : ::.::.. : :: NP_683 EVEIGR-FRDQQYEMLKRWRQQQP---AGLGAVYAALERMGLDGCVEDLRSRLQRGP 190 200 210 220 230 450 pF1KE1 PPAPSLLR 455 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 01:57:41 2016 done: Mon Nov 7 01:57:43 2016 Total Scan time: 9.820 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]