FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4435, 452 aa 1>>>pF1KE4435 452 - 452 aa - 452 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3349+/-0.00094; mu= 17.1812+/- 0.056 mean_var=60.6155+/-12.082, 0's: 0 Z-trim(104.1): 18 B-trim: 0 in 0/49 Lambda= 0.164734 statistics sampled from 7713 (7721) to 7713 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.609), E-opt: 0.2 (0.237), width: 16 Scan time: 2.770 The best scores are: opt bits E(32554) CCDS10359.1 IDH2 gene_id:3418|Hs108|chr15 ( 452) 3074 739.3 1.9e-213 CCDS76792.1 IDH2 gene_id:3418|Hs108|chr15 ( 400) 2726 656.6 1.3e-188 CCDS2381.1 IDH1 gene_id:3417|Hs108|chr2 ( 414) 1934 468.3 6.3e-132 >>CCDS10359.1 IDH2 gene_id:3418|Hs108|chr15 (452 aa) initn: 3074 init1: 3074 opt: 3074 Z-score: 3945.6 bits: 739.3 E(32554): 1.9e-213 Smith-Waterman score: 3074; 100.0% identity (100.0% similar) in 452 aa overlap (1-452:1-452) 10 20 30 40 50 60 pF1KE4 MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH 370 380 390 400 410 420 430 440 450 pF1KE4 GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ :::::::::::::::::::::::::::::::: CCDS10 GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ 430 440 450 >>CCDS76792.1 IDH2 gene_id:3418|Hs108|chr15 (400 aa) initn: 2726 init1: 2726 opt: 2726 Z-score: 3499.4 bits: 656.6 E(32554): 1.3e-188 Smith-Waterman score: 2726; 100.0% identity (100.0% similar) in 400 aa overlap (53-452:1-400) 30 40 50 60 70 80 pF1KE4 PAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYF :::::::::::::::::::::::::::::: CCDS76 MDGDEMTRIIWQFIKEKLILPHVDIQLKYF 10 20 30 90 100 110 120 130 140 pF1KE4 DLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 DLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNI 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE4 LGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 LGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGS 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE4 GVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 GVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRF 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE4 KDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 KDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQ 220 230 240 250 260 270 330 340 350 360 370 380 pF1KE4 GFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 GFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHR 280 290 300 310 320 330 390 400 410 420 430 440 pF1KE4 GKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 GKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIK 340 350 360 370 380 390 450 pF1KE4 SNLDRALGRQ :::::::::: CCDS76 SNLDRALGRQ 400 >>CCDS2381.1 IDH1 gene_id:3417|Hs108|chr2 (414 aa) initn: 1912 init1: 1134 opt: 1934 Z-score: 2481.9 bits: 468.3 E(32554): 6.3e-132 Smith-Waterman score: 1934; 70.8% identity (88.4% similar) in 397 aa overlap (50-445:10-405) 20 30 40 50 60 70 pF1KE4 AWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQL ::::.:::::::::..::::::.:.:...: CCDS23 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDL 10 20 30 80 90 100 110 120 130 pF1KE4 KYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTI . .:::. ::: :.:::: :.: : .:..:.:::::::::: ::::::::.::::::::: CCDS23 HSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTI 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE4 RNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPK ::::::::::: :::::::::: ::.::: :::::.::::.:::::. : ....::. CCDS23 RNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPS 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE4 DGSGVKEWEVYNFP-AGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAY ::. . :.:: .:::.::::: :.:: :::: ::.:..: ::::.:::::::: : CCDS23 DGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKY 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE4 DGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSD :::::::::::.::.::..:. .:::::::::::::::..:: :::.::::::::::::: CCDS23 DGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSD 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE4 ILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRG .:::.::::.::::::::::::.:::::::::::::: .:::. ::::::::::::::: CCDS23 SVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRG 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE4 LEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFL : ::.:::.:..: ::. ::.: .::.:.: ::::::.::.:: ::. .. .::: .:. CCDS23 LAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD-YLNTFEFM 340 350 360 370 380 390 440 450 pF1KE4 DTIKSNLDRALGRQ : . :: CCDS23 DKLGENLKIKLAQAKL 400 410 452 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:09:11 2016 done: Sun Nov 6 01:09:12 2016 Total Scan time: 2.770 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]