FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4576, 763 aa 1>>>pF1KE4576 763 - 763 aa - 763 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8350+/-0.000436; mu= 17.1814+/- 0.027 mean_var=69.5139+/-13.879, 0's: 0 Z-trim(110.4): 59 B-trim: 22 in 1/49 Lambda= 0.153829 statistics sampled from 18645 (18704) to 18645 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.576), E-opt: 0.2 (0.219), width: 16 Scan time: 8.660 The best scores are: opt bits E(85289) NP_000173 (OMIM: 600890,609015,609016) trifunction ( 763) 4923 1102.3 0 NP_005318 (OMIM: 231530,601609,609975) hydroxyacyl ( 314) 548 131.3 6.3e-30 NP_001159887 (OMIM: 607037,615605) peroxisomal bif ( 627) 484 117.1 2.2e-25 XP_011510819 (OMIM: 607037,615605) PREDICTED: pero ( 627) 484 117.1 2.2e-25 NP_001957 (OMIM: 607037,615605) peroxisomal bifunc ( 723) 484 117.2 2.5e-25 XP_006713588 (OMIM: 607037,615605) PREDICTED: pero ( 515) 466 113.1 3e-24 XP_016861328 (OMIM: 607037,615605) PREDICTED: pero ( 515) 466 113.1 3e-24 NP_001317956 (OMIM: 231530,601609,609975) hydroxya ( 318) 460 111.7 4.8e-24 NP_001171634 (OMIM: 231530,601609,609975) hydroxya ( 331) 437 106.6 1.7e-22 NP_001689 (OMIM: 250950,600529) methylglutaconyl-C ( 339) 378 93.5 1.5e-18 XP_005252123 (OMIM: 250950,600529) PREDICTED: meth ( 349) 374 92.7 2.9e-18 XP_016870338 (OMIM: 250950,600529) PREDICTED: meth ( 323) 366 90.9 9.3e-18 XP_005252124 (OMIM: 250950,600529) PREDICTED: meth ( 333) 362 90.0 1.8e-17 XP_005252126 (OMIM: 250950,600529) PREDICTED: meth ( 298) 352 87.7 7.5e-17 XP_016870339 (OMIM: 250950,600529) PREDICTED: meth ( 230) 341 85.3 3.2e-16 XP_011517104 (OMIM: 250950,600529) PREDICTED: meth ( 230) 341 85.3 3.2e-16 NP_004083 (OMIM: 602292,616277) enoyl-CoA hydratas ( 290) 333 83.5 1.4e-15 XP_016870340 (OMIM: 250950,600529) PREDICTED: meth ( 214) 329 82.6 1.9e-15 NP_001293119 (OMIM: 250950,600529) methylglutacony ( 310) 272 70.0 1.7e-11 XP_006717213 (OMIM: 250950,600529) PREDICTED: meth ( 320) 272 70.0 1.8e-11 NP_001910 (OMIM: 600305) enoyl-CoA delta isomerase ( 302) 259 67.1 1.2e-10 XP_005252129 (OMIM: 250950,600529) PREDICTED: meth ( 255) 241 63.1 1.7e-09 XP_011517102 (OMIM: 250950,600529) PREDICTED: meth ( 265) 237 62.2 3.2e-09 NP_055177 (OMIM: 250620,610690) 3-hydroxyisobutyry ( 386) 239 62.7 3.3e-09 XP_011509255 (OMIM: 250620,610690) PREDICTED: 3-hy ( 386) 239 62.7 3.3e-09 NP_932164 (OMIM: 250620,610690) 3-hydroxyisobutyry ( 338) 238 62.5 3.5e-09 NP_001137442 (OMIM: 603778) chromodomain Y-like pr ( 412) 223 59.2 4.2e-08 NP_001137443 (OMIM: 603778) chromodomain Y-like pr ( 412) 223 59.2 4.2e-08 NP_057058 (OMIM: 609877) lambda-crystallin homolog ( 319) 221 58.7 4.5e-08 XP_011513299 (OMIM: 603778) PREDICTED: chromodomai ( 522) 223 59.2 5.1e-08 NP_004815 (OMIM: 603778) chromodomain Y-like prote ( 544) 223 59.2 5.3e-08 XP_005267105 (OMIM: 612136) PREDICTED: ethylmalony ( 301) 209 56.0 2.7e-07 XP_005267104 (OMIM: 612136) PREDICTED: ethylmalony ( 301) 209 56.0 2.7e-07 NP_001002030 (OMIM: 612136) ethylmalonyl-CoA decar ( 301) 209 56.0 2.7e-07 NP_001132982 (OMIM: 612136) ethylmalonyl-CoA decar ( 307) 209 56.0 2.7e-07 XP_016881937 (OMIM: 600696) PREDICTED: delta(3,5)- ( 248) 207 55.5 3.1e-07 NP_001389 (OMIM: 600696) delta(3,5)-Delta(2,4)-die ( 328) 207 55.6 4e-07 NP_001171500 (OMIM: 600305) enoyl-CoA delta isomer ( 285) 205 55.1 4.8e-07 NP_004816 (OMIM: 400018,415000) testis-specific ch ( 541) 195 53.0 3.9e-06 XP_005266473 (OMIM: 609877) PREDICTED: lambda-crys ( 217) 189 51.5 4.4e-06 NP_733841 (OMIM: 400016,415000) testis-specific ch ( 540) 194 52.8 4.6e-06 NP_004671 (OMIM: 400016,415000) testis-specific ch ( 554) 194 52.8 4.7e-06 XP_011529814 (OMIM: 400016,415000) PREDICTED: test ( 470) 193 52.5 4.7e-06 NP_001099014 (OMIM: 612136) ethylmalonyl-CoA decar ( 226) 185 50.6 8.4e-06 XP_016866545 (OMIM: 612136) PREDICTED: ethylmalony ( 226) 185 50.6 8.4e-06 XP_016876113 (OMIM: 609877) PREDICTED: lambda-crys ( 234) 182 50.0 1.4e-05 XP_011534244 (OMIM: 612136) PREDICTED: ethylmalony ( 189) 174 48.2 3.9e-05 >>NP_000173 (OMIM: 600890,609015,609016) trifunctional e (763 aa) initn: 4923 init1: 4923 opt: 4923 Z-score: 5899.4 bits: 1102.3 E(85289): 0 Smith-Waterman score: 4923; 100.0% identity (100.0% similar) in 763 aa overlap (1-763:1-763) 10 20 30 40 50 60 pF1KE4 MVACRAIGILSRFSAFRILRSRGYICRNFTGSSALLTRTHINYGVKGDVAVVRINSPNSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MVACRAIGILSRFSAFRILRSRGYICRNFTGSSALLTRTHINYGVKGDVAVVRINSPNSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VNTLSKELHSEFSEVMNEIWASDQIRSAVLISSKPGCFIAGADINMLAACKTLQEVTQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VNTLSKELHSEFSEVMNEIWASDQIRSAVLISSKPGCFIAGADINMLAACKTLQEVTQLS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 QEAQRIVEKLEKSTKPIVAAINGSCLGGGLEVAISCQYRIATKDRKTVLGTPEVLLGALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QEAQRIVEKLEKSTKPIVAAINGSCLGGGLEVAISCQYRIATKDRKTVLGTPEVLLGALP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GAGGTQRLPKMVGVPAALDMMLTGRSIRADRAKKMGLVDQLVEPLGPGLKPPEERTIEYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GAGGTQRLPKMVGVPAALDMMLTGRSIRADRAKKMGLVDQLVEPLGPGLKPPEERTIEYL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 EEVAITFAKGLADKKISPKRDKGLVEKLTAYAMTIPFVRQQVYKKVEEKVRKQTKGLYPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EEVAITFAKGLADKKISPKRDKGLVEKLTAYAMTIPFVRQQVYKKVEEKVRKQTKGLYPA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 PLKIIDVVKTGIEQGSDAGYLCESQKFGELVMTKESKALMGLYHGQVLCKKNKFGAPQKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PLKIIDVVKTGIEQGSDAGYLCESQKFGELVMTKESKALMGLYHGQVLCKKNKFGAPQKD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 VKHLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VKHLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 ERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 ISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 DGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAATLVDEVGVDVAKHVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAATLVDEVGVDVAKHVA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 EDLGKVFGERFGGGNPELLTQMVSKGFLGRKSGKGFYIYQEGVKRKDLNSDMDSILASLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EDLGKVFGERFGGGNPELLTQMVSKGFLGRKSGKGFYIYQEGVKRKDLNSDMDSILASLK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 LPPKSEVSSDEDIQFRLVTRFVNEAVMCLQEGILATPAEGDIGAVFGLGFPPCLGGPFRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LPPKSEVSSDEDIQFRLVTRFVNEAVMCLQEGILATPAEGDIGAVFGLGFPPCLGGPFRF 670 680 690 700 710 720 730 740 750 760 pF1KE4 VDLYGAQKIVDRLKKYEAAYGKQFTPCQLLADHANSPNKKFYQ ::::::::::::::::::::::::::::::::::::::::::: NP_000 VDLYGAQKIVDRLKKYEAAYGKQFTPCQLLADHANSPNKKFYQ 730 740 750 760 >>NP_005318 (OMIM: 231530,601609,609975) hydroxyacyl-coe (314 aa) initn: 380 init1: 252 opt: 548 Z-score: 658.3 bits: 131.3 E(85289): 6.3e-30 Smith-Waterman score: 548; 33.9% identity (65.4% similar) in 289 aa overlap (361-640:27-314) 340 350 360 370 380 390 pF1KE4 VMTKESKALMGLYHGQVLCKKNKFGAPQKDVKHLAILGAGLMGAGIAQVSVDKGLKTILK :::....:.::::::::::.. : ..: NP_005 MAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLV 10 20 30 40 50 400 410 420 430 440 pF1KE4 DATLTALDRGQQQVFKGLNDKVKKK------ALTSFERDSIFSNLTGQLDYQGFEKADMV : : : .... . ..: .::: : : . .. . :. . ...:.: NP_005 DQTEDILAKSKKGIEESLRKVAKKKFAENPKAGDEFVEKTLSTIATSTDAASVVHSTDLV 60 70 80 90 100 110 450 460 470 480 490 500 pF1KE4 IEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALPISEIAAVSKRPEKVIGMHYFSPVD .::. :.:..:....:... .: :::::::.: :. :: .. : .. :.:.:.:: NP_005 VEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVP 120 130 140 150 160 170 510 520 530 540 550 560 pF1KE4 KMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQE :.:.:.: : ::. : : : . :: . :: ::: ..: :.:.. :.::. .. NP_005 VMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYER 180 190 200 210 220 230 570 580 590 600 610 620 pF1KE4 GVDPKKLD---SLTTSFGFPVGAATLVDEVGVDVAKHVAEDLGKVFGERFGGGNPELLTQ : : .: : .. . :.:.: :.: ::.:..: ... .. .: :.. NP_005 G-DASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHEMDAENPLHQPSPSLNK 240 250 260 270 280 290 630 640 650 660 670 680 pF1KE4 MVSKGFLGRKSGKGFYIYQEGVKRKDLNSDMDSILASLKLPPKSEVSSDEDIQFRLVTRF .:... .:.:.:.::: :. NP_005 LVAENKFGKKTGEGFYKYK 300 310 >>NP_001159887 (OMIM: 607037,615605) peroxisomal bifunct (627 aa) initn: 783 init1: 385 opt: 484 Z-score: 576.7 bits: 117.1 E(85289): 2.2e-25 Smith-Waterman score: 902; 30.3% identity (61.1% similar) in 647 aa overlap (146-761:3-616) 120 130 140 150 160 170 pF1KE4 VTQLSQEAQRIVEKLEKSTKPIVAAINGSCLGGGLEVAISCQYRIATKDRKTVLGTPEVL .:::::.:..:.:::: . . .: ::: NP_001 MAFGGGLELALGCHYRIAHAEAQ--VGLPEVT 10 20 30 180 190 200 210 220 230 pF1KE4 LGALPGAGGTQRLPKMVGVPAALDMMLTGRSIRADRAKKMGLVDQLVEPLGPGLKPPEER :: :::: ::: ::...:::::::.. .:: : ::.: :.:..:..:. : :: NP_001 LGLLPGARGTQLLPRLTGVPAALDLITSGRRILADEALKLGILDKVVNS-----DPVEE- 40 50 60 70 80 240 250 260 270 280 290 pF1KE4 TIEYLEEVAITFAKGLADKKISPKRDKGLVEKLTAYAMTIPFVRQQVYKKVEEKVRKQTK :: ::. ..:. . .: : .: ...: . ....... :.:.: NP_001 --------AIRFAQRVSDQPLESRR---LCNK---PIQSLPNM-DSIFSEALLKMRRQHP 90 100 110 120 300 310 320 330 340 350 pF1KE4 GLYPAPLKIIDVVKTGIEQGSDAGYLCESQKFGELVMTKESKALMGLYHGQVLCKKNKFG : : . .:..... ..: : . : :... ...::. . .. : ::.. NP_001 GCL-AQEACVRAVQAAVQYPYEVGIKKEEELFLYLLQSGQARALQYAFFAER--KANKWS 130 140 150 160 170 180 360 370 380 390 400 pF1KE4 APQ---------KDVKHLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFK .:. . :. ....: : :: ::. . . .: :. . : ..... . NP_001 TPSGASWKTASARPVSSVGVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKMITS 190 200 210 220 230 240 410 420 430 440 450 460 pF1KE4 GLNDKVKKKALTSFERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVI :. ...: .. .. ::... : .:.:::::::..:::..:. :. :: NP_001 VLEKEASKMQQSGHPWSGPKPRLTSSVKELG--GVDLVIEAVFEEMSLKKQVFAELSAVC 250 260 270 280 290 300 470 480 490 500 510 520 pF1KE4 PDHCIFASNTSALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAV . .. .::::: ..:::. . ::. ::: :.:::. :.:::.: .. .: : :... NP_001 KPEAFLCTNTSALDVDEIASSTDRPHLVIGTHFFSPAHVMKLLEVIPSQYSSPTTIATVM 310 320 330 340 350 360 530 540 550 560 570 580 pF1KE4 AVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAAT .. : :. .:: . :: .: : :..... .:.:: :...:.. ::: .: NP_001 NLSKKIKKIGVVVGNCFGFVGNRMLNPYYNQAYFLLEEGSKPEEVDQVLEEFGFKMGPFR 370 380 390 400 410 420 590 600 610 620 630 pF1KE4 LVDEVGVDVAKHVAEDLGKVFGERFGG------GN------PELLTQMVSKGFLGRKSGK . : .:.::. . . : . . : :: :..: .. : .:.:.:: NP_001 VSDLAGLDVGWKSRKGQGLTGPTLLPGTPARKRGNRRYCPIPDVLCEL---GRFGQKTGK 430 440 450 460 470 480 640 650 660 670 680 pF1KE4 GFYIYQEG---VKRKD--LNSDMDSILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCL :.: :.. ... : :.. .. . .. :.. .:.:: .. : . ..::: : NP_001 GWYQYDKPLGRIHKPDPWLSKFLSRYRKTHHIEPRT-ISQDEILE-RCLYSLINEAFRIL 490 500 510 520 530 690 700 710 720 730 740 pF1KE4 QEGILATPAEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKIVDRLKKY--EAAYGKQFTPC ::: :.: . :. . : :.: :::. ... : ....:.:: . :. : NP_001 GEGIAASPEHIDVVYLHGYGWPRHKGGPMFYASTVGLPTVLEKLQKYYRQNPDIPQLEPS 540 550 560 570 580 590 750 760 pF1KE4 QLL---ADHANSPNKKFYQ . : :...: : :.. NP_001 DYLKKLASQGNPPLKEWQSLAGSPSSKL 600 610 620 >>XP_011510819 (OMIM: 607037,615605) PREDICTED: peroxiso (627 aa) initn: 783 init1: 385 opt: 484 Z-score: 576.7 bits: 117.1 E(85289): 2.2e-25 Smith-Waterman score: 902; 30.3% identity (61.1% similar) in 647 aa overlap (146-761:3-616) 120 130 140 150 160 170 pF1KE4 VTQLSQEAQRIVEKLEKSTKPIVAAINGSCLGGGLEVAISCQYRIATKDRKTVLGTPEVL .:::::.:..:.:::: . . .: ::: XP_011 MAFGGGLELALGCHYRIAHAEAQ--VGLPEVT 10 20 30 180 190 200 210 220 230 pF1KE4 LGALPGAGGTQRLPKMVGVPAALDMMLTGRSIRADRAKKMGLVDQLVEPLGPGLKPPEER :: :::: ::: ::...:::::::.. .:: : ::.: :.:..:..:. : :: XP_011 LGLLPGARGTQLLPRLTGVPAALDLITSGRRILADEALKLGILDKVVNS-----DPVEE- 40 50 60 70 80 240 250 260 270 280 290 pF1KE4 TIEYLEEVAITFAKGLADKKISPKRDKGLVEKLTAYAMTIPFVRQQVYKKVEEKVRKQTK :: ::. ..:. . .: : .: ...: . ....... :.:.: XP_011 --------AIRFAQRVSDQPLESRR---LCNK---PIQSLPNM-DSIFSEALLKMRRQHP 90 100 110 120 300 310 320 330 340 350 pF1KE4 GLYPAPLKIIDVVKTGIEQGSDAGYLCESQKFGELVMTKESKALMGLYHGQVLCKKNKFG : : . .:..... ..: : . : :... ...::. . .. : ::.. XP_011 GCL-AQEACVRAVQAAVQYPYEVGIKKEEELFLYLLQSGQARALQYAFFAER--KANKWS 130 140 150 160 170 180 360 370 380 390 400 pF1KE4 APQ---------KDVKHLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFK .:. . :. ....: : :: ::. . . .: :. . : ..... . XP_011 TPSGASWKTASARPVSSVGVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKMITS 190 200 210 220 230 240 410 420 430 440 450 460 pF1KE4 GLNDKVKKKALTSFERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVI :. ...: .. .. ::... : .:.:::::::..:::..:. :. :: XP_011 VLEKEASKMQQSGHPWSGPKPRLTSSVKELG--GVDLVIEAVFEEMSLKKQVFAELSAVC 250 260 270 280 290 300 470 480 490 500 510 520 pF1KE4 PDHCIFASNTSALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAV . .. .::::: ..:::. . ::. ::: :.:::. :.:::.: .. .: : :... XP_011 KPEAFLCTNTSALDVDEIASSTDRPHLVIGTHFFSPAHVMKLLEVIPSQYSSPTTIATVM 310 320 330 340 350 360 530 540 550 560 570 580 pF1KE4 AVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAAT .. : :. .:: . :: .: : :..... .:.:: :...:.. ::: .: XP_011 NLSKKIKKIGVVVGNCFGFVGNRMLNPYYNQAYFLLEEGSKPEEVDQVLEEFGFKMGPFR 370 380 390 400 410 420 590 600 610 620 630 pF1KE4 LVDEVGVDVAKHVAEDLGKVFGERFGG------GN------PELLTQMVSKGFLGRKSGK . : .:.::. . . : . . : :: :..: .. : .:.:.:: XP_011 VSDLAGLDVGWKSRKGQGLTGPTLLPGTPARKRGNRRYCPIPDVLCEL---GRFGQKTGK 430 440 450 460 470 480 640 650 660 670 680 pF1KE4 GFYIYQEG---VKRKD--LNSDMDSILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCL :.: :.. ... : :.. .. . .. :.. .:.:: .. : . ..::: : XP_011 GWYQYDKPLGRIHKPDPWLSKFLSRYRKTHHIEPRT-ISQDEILE-RCLYSLINEAFRIL 490 500 510 520 530 690 700 710 720 730 740 pF1KE4 QEGILATPAEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKIVDRLKKY--EAAYGKQFTPC ::: :.: . :. . : :.: :::. ... : ....:.:: . :. : XP_011 GEGIAASPEHIDVVYLHGYGWPRHKGGPMFYASTVGLPTVLEKLQKYYRQNPDIPQLEPS 540 550 560 570 580 590 750 760 pF1KE4 QLL---ADHANSPNKKFYQ . : :...: : :.. XP_011 DYLKKLASQGNPPLKEWQSLAGSPSSKL 600 610 620 >>NP_001957 (OMIM: 607037,615605) peroxisomal bifunction (723 aa) initn: 847 init1: 385 opt: 484 Z-score: 575.7 bits: 117.2 E(85289): 2.5e-25 Smith-Waterman score: 1028; 30.2% identity (61.2% similar) in 744 aa overlap (49-761:11-712) 20 30 40 50 60 70 pF1KE4 LRSRGYICRNFTGSSALLTRTHINYGVKGDVAVVRINSPNSKVNTLSKELHSEFSEVMNE .:..:. .: ::..: : ...: ... NP_001 MAEYTRLHNALALIRLRNP--PVNAISTTLLRDIKEGLQK 10 20 30 80 90 100 110 120 130 pF1KE4 IWASDQIRSAVLISSKPGCFIAGADINMLAACKTLQEVTQLSQEAQRIVEKLEKSTKPIV . :. :..: . : : ::::: ..: .:. . ..:...... ::.: NP_001 AVIDHTIK-AIVICGAEGKFSAGADIRGFSAPRTF------GLTLGHVVDEIQRNEKPVV 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE4 AAINGSCLGGGLEVAISCQYRIATKDRKTVLGTPEVLLGALPGAGGTQRLPKMVGVPAAL :::.: .:::::.:..:.:::: . . .: ::: :: :::: ::: ::...:::::: NP_001 AAIQGMAFGGGLELALGCHYRIAHAEAQ--VGLPEVTLGLLPGARGTQLLPRLTGVPAAL 100 110 120 130 140 200 210 220 230 240 250 pF1KE4 DMMLTGRSIRADRAKKMGLVDQLVEPLGPGLKPPEERTIEYLEEVAITFAKGLADKKISP :.. .:: : ::.: :.:..:..:. : :: :: ::. ..:. . NP_001 DLITSGRRILADEALKLGILDKVVNS-----DPVEE---------AIRFAQRVSDQPLES 150 160 170 180 190 260 270 280 290 300 310 pF1KE4 KRDKGLVEKLTAYAMTIPFVRQQVYKKVEEKVRKQTKGLYPAPLKIIDVVKTGIEQGSDA .: : .: ...: . ....... :.:.: : : . .:..... .. NP_001 RR---LCNK---PIQSLPNM-DSIFSEALLKMRRQHPGCL-AQEACVRAVQAAVQYPYEV 200 210 220 230 240 320 330 340 350 360 pF1KE4 GYLCESQKFGELVMTKESKALMGLYHGQVLCKKNKFGAPQ---------KDVKHLAILGA : : . : :... ...::. . .. : ::...:. . :. ....: NP_001 GIKKEEELFLYLLQSGQARALQYAFFAER--KANKWSTPSGASWKTASARPVSSVGVVGL 250 260 270 280 290 300 370 380 390 400 410 420 pF1KE4 GLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSFERDSIFSNL : :: ::. . . .: :. . : ..... . :. ...: .. .. : NP_001 GTMGRGIVISFARARIPVIAVDSDKNQLATANKMITSVLEKEASKMQQSGHPWSGPKPRL 310 320 330 340 350 360 430 440 450 460 470 480 pF1KE4 TGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALPISEIAAVSK :... : .:.:::::::..:::..:. :. :: . .. .::::: ..:::. . NP_001 TSSVKELG--GVDLVIEAVFEEMSLKKQVFAELSAVCKPEAFLCTNTSALDVDEIASSTD 370 380 390 400 410 420 490 500 510 520 530 540 pF1KE4 RPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVKDGPGFYTTR ::. ::: :.:::. :.:::.: .. .: : :... .. : :. .:: . :: .: NP_001 RPHLVIGTHFFSPAHVMKLLEVIPSQYSSPTTIATVMNLSKKIKKIGVVVGNCFGFVGNR 430 440 450 460 470 480 550 560 570 580 590 600 pF1KE4 CLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAATLVDEVGVDVAKHVAEDLGKVFGE : :..... .:.:: :...:.. ::: .: . : .:.::. . . : . NP_001 MLNPYYNQAYFLLEEGSKPEEVDQVLEEFGFKMGPFRVSDLAGLDVGWKSRKGQGLTGPT 490 500 510 520 530 540 610 620 630 640 650 pF1KE4 RFGG------GN------PELLTQMVSKGFLGRKSGKGFYIYQEG---VKRKD--LNSDM . : :: :..: .. : .:.:.:::.: :.. ... : :.. . NP_001 LLPGTPARKRGNRRYCPIPDVLCEL---GRFGQKTGKGWYQYDKPLGRIHKPDPWLSKFL 550 560 570 580 590 600 660 670 680 690 700 710 pF1KE4 DSILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCLQEGILATPAEGDIGAVFGLGFPP . . .. :.. .:.:: : : . ..::: : ::: :.: . :. . : :.: NP_001 SRYRKTHHIEPRT-ISQDE-ILERCLYSLINEAFRILGEGIAASPEHIDVVYLHGYGWPR 610 620 630 640 650 720 730 740 750 760 pF1KE4 CLGGPFRFVDLYGAQKIVDRLKKY--EAAYGKQFTPCQLL---ADHANSPNKKFYQ :::. ... : ....:.:: . :. : . : :...: : :.. NP_001 HKGGPMFYASTVGLPTVLEKLQKYYRQNPDIPQLEPSDYLKKLASQGNPPLKEWQSLAGS 660 670 680 690 700 710 NP_001 PSSKL 720 >>XP_006713588 (OMIM: 607037,615605) PREDICTED: peroxiso (515 aa) initn: 507 init1: 385 opt: 466 Z-score: 556.4 bits: 113.1 E(85289): 3e-24 Smith-Waterman score: 629; 27.6% identity (59.9% similar) in 511 aa overlap (282-761:4-504) 260 270 280 290 300 310 pF1KE4 ADKKISPKRDKGLVEKLTAYAMTIPFVRQQVYKKVEEKVRKQTKGLYPAPLKIIDVVKTG ..... :.:.: : : . .:... XP_006 MDSIFSEALLKMRRQHPGCL-AQEACVRAVQAA 10 20 30 320 330 340 350 360 pF1KE4 IEQGSDAGYLCESQKFGELVMTKESKALMGLYHGQVLCKKNKFGAPQ---------KDVK .. ..: : . : :... ...::. . .. : ::...:. . :. XP_006 VQYPYEVGIKKEEELFLYLLQSGQARALQYAFFAER--KANKWSTPSGASWKTASARPVS 40 50 60 70 80 90 370 380 390 400 410 420 pF1KE4 HLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSFER ....: : :: ::. . . .: :. . : ..... . :. ...: .. XP_006 SVGVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKMITSVLEKEASKMQQSGHPW 100 110 120 130 140 150 430 440 450 460 470 480 pF1KE4 DSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALPIS .. ::... : .:.:::::::..:::..:. :. :: . .. .::::: .. XP_006 SGPKPRLTSSVKELG--GVDLVIEAVFEEMSLKKQVFAELSAVCKPEAFLCTNTSALDVD 160 170 180 190 200 490 500 510 520 530 540 pF1KE4 EIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVKDG :::. . ::. ::: :.:::. :.:::.: .. .: : :... .. : :. .:: . XP_006 EIASSTDRPHLVIGTHFFSPAHVMKLLEVIPSQYSSPTTIATVMNLSKKIKKIGVVVGNC 210 220 230 240 250 260 550 560 570 580 590 600 pF1KE4 PGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAATLVDEVGVDVAKHVAED :: .: : :..... .:.:: :...:.. ::: .: . : .:.::. . . XP_006 FGFVGNRMLNPYYNQAYFLLEEGSKPEEVDQVLEEFGFKMGPFRVSDLAGLDVGWKSRKG 270 280 290 300 310 320 610 620 630 640 pF1KE4 LGKVFGERFGG------GN------PELLTQMVSKGFLGRKSGKGFYIYQEG---VKRKD : . . : :: :..: .. : .:.:.:::.: :.. ... : XP_006 QGLTGPTLLPGTPARKRGNRRYCPIPDVLCEL---GRFGQKTGKGWYQYDKPLGRIHKPD 330 340 350 360 370 380 650 660 670 680 690 700 pF1KE4 --LNSDMDSILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCLQEGILATPAEGDIGAV :.. .. . .. :.. .:.:: .. : . ..::: : ::: :.: . :. . XP_006 PWLSKFLSRYRKTHHIEPRT-ISQDEILE-RCLYSLINEAFRILGEGIAASPEHIDVVYL 390 400 410 420 430 440 710 720 730 740 750 760 pF1KE4 FGLGFPPCLGGPFRFVDLYGAQKIVDRLKKY--EAAYGKQFTPCQLL---ADHANSPNKK : :.: :::. ... : ....:.:: . :. : . : :...: : :. XP_006 HGYGWPRHKGGPMFYASTVGLPTVLEKLQKYYRQNPDIPQLEPSDYLKKLASQGNPPLKE 450 460 470 480 490 500 pF1KE4 FYQ . XP_006 WQSLAGSPSSKL 510 >>XP_016861328 (OMIM: 607037,615605) PREDICTED: peroxiso (515 aa) initn: 507 init1: 385 opt: 466 Z-score: 556.4 bits: 113.1 E(85289): 3e-24 Smith-Waterman score: 629; 27.6% identity (59.9% similar) in 511 aa overlap (282-761:4-504) 260 270 280 290 300 310 pF1KE4 ADKKISPKRDKGLVEKLTAYAMTIPFVRQQVYKKVEEKVRKQTKGLYPAPLKIIDVVKTG ..... :.:.: : : . .:... XP_016 MDSIFSEALLKMRRQHPGCL-AQEACVRAVQAA 10 20 30 320 330 340 350 360 pF1KE4 IEQGSDAGYLCESQKFGELVMTKESKALMGLYHGQVLCKKNKFGAPQ---------KDVK .. ..: : . : :... ...::. . .. : ::...:. . :. XP_016 VQYPYEVGIKKEEELFLYLLQSGQARALQYAFFAER--KANKWSTPSGASWKTASARPVS 40 50 60 70 80 90 370 380 390 400 410 420 pF1KE4 HLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSFER ....: : :: ::. . . .: :. . : ..... . :. ...: .. XP_016 SVGVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKMITSVLEKEASKMQQSGHPW 100 110 120 130 140 150 430 440 450 460 470 480 pF1KE4 DSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALPIS .. ::... : .:.:::::::..:::..:. :. :: . .. .::::: .. XP_016 SGPKPRLTSSVKELG--GVDLVIEAVFEEMSLKKQVFAELSAVCKPEAFLCTNTSALDVD 160 170 180 190 200 490 500 510 520 530 540 pF1KE4 EIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVKDG :::. . ::. ::: :.:::. :.:::.: .. .: : :... .. : :. .:: . XP_016 EIASSTDRPHLVIGTHFFSPAHVMKLLEVIPSQYSSPTTIATVMNLSKKIKKIGVVVGNC 210 220 230 240 250 260 550 560 570 580 590 600 pF1KE4 PGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAATLVDEVGVDVAKHVAED :: .: : :..... .:.:: :...:.. ::: .: . : .:.::. . . XP_016 FGFVGNRMLNPYYNQAYFLLEEGSKPEEVDQVLEEFGFKMGPFRVSDLAGLDVGWKSRKG 270 280 290 300 310 320 610 620 630 640 pF1KE4 LGKVFGERFGG------GN------PELLTQMVSKGFLGRKSGKGFYIYQEG---VKRKD : . . : :: :..: .. : .:.:.:::.: :.. ... : XP_016 QGLTGPTLLPGTPARKRGNRRYCPIPDVLCEL---GRFGQKTGKGWYQYDKPLGRIHKPD 330 340 350 360 370 380 650 660 670 680 690 700 pF1KE4 --LNSDMDSILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCLQEGILATPAEGDIGAV :.. .. . .. :.. .:.:: .. : . ..::: : ::: :.: . :. . XP_016 PWLSKFLSRYRKTHHIEPRT-ISQDEILE-RCLYSLINEAFRILGEGIAASPEHIDVVYL 390 400 410 420 430 440 710 720 730 740 750 760 pF1KE4 FGLGFPPCLGGPFRFVDLYGAQKIVDRLKKY--EAAYGKQFTPCQLL---ADHANSPNKK : :.: :::. ... : ....:.:: . :. : . : :...: : :. XP_016 HGYGWPRHKGGPMFYASTVGLPTVLEKLQKYYRQNPDIPQLEPSDYLKKLASQGNPPLKE 450 460 470 480 490 500 pF1KE4 FYQ . XP_016 WQSLAGSPSSKL 510 >>NP_001317956 (OMIM: 231530,601609,609975) hydroxyacyl- (318 aa) initn: 280 init1: 252 opt: 460 Z-score: 552.6 bits: 111.7 E(85289): 4.8e-24 Smith-Waterman score: 460; 31.2% identity (63.0% similar) in 276 aa overlap (374-640:44-318) 350 360 370 380 390 400 pF1KE4 HGQVLCKKNKFGAPQKDVKHLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQ : . .:.. : ..: : : : .... NP_001 LGVCWRKEHDPAEMLRVGRAELGGWKPSWEAIVKEVAAATGHTVVLVDQTEDILAKSKKG 20 30 40 50 60 70 410 420 430 440 450 pF1KE4 VFKGLNDKVKKK------ALTSFERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHR . ..: .::: : : . .. . :. . ...:.:.::. :.:..:.. NP_001 IEESLRKVAKKKFAENPKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAIVENLKVKNE 80 90 100 110 120 130 460 470 480 490 500 510 pF1KE4 VLKEVEAVIPDHCIFASNTSALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKT ..:... .: :::::::.: :. :: .. : .. :.:.:.:: :.:.:.: : : NP_001 LFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMKLVEVIKTPMT 140 150 160 170 180 190 520 530 540 550 560 570 pF1KE4 SKDTSASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLD---SL :. : : : . :: . :: ::: ..: :.:.. :.::. ..: : .: : .. NP_001 SQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYERG-DASKEDIDTAM 200 210 220 230 240 250 580 590 600 610 620 630 pF1KE4 TTSFGFPVGAATLVDEVGVDVAKHVAEDLGKVFGERFGGGNPELLTQMVSKGFLGRKSGK . :.:.: :.: ::.:..: ... .. .: :...:... .:.:.:. NP_001 KLGAGYPMGPFELLDYVGLDTTKFIVDGWHEMDAENPLHQPSPSLNKLVAENKFGKKTGE 260 270 280 290 300 310 640 650 660 670 680 690 pF1KE4 GFYIYQEGVKRKDLNSDMDSILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCLQEGIL ::: :. NP_001 GFYKYK >>NP_001171634 (OMIM: 231530,601609,609975) hydroxyacyl- (331 aa) initn: 372 init1: 244 opt: 437 Z-score: 524.8 bits: 106.6 E(85289): 1.7e-22 Smith-Waterman score: 509; 32.1% identity (62.3% similar) in 305 aa overlap (361-640:27-331) 340 350 360 370 380 390 pF1KE4 VMTKESKALMGLYHGQVLCKKNKFGAPQKDVKHLAILGAGLMGAGIAQVSVDKGLKTILK :::....:.::::::::::.. : ..: NP_001 MAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLV 10 20 30 40 50 400 410 420 430 440 pF1KE4 DATLTALDRGQQQVFKGLNDKVKKK------ALTSFERDSIFSNLTGQLDYQGFEKADMV : : : .... . ..: .::: : : . .. . :. . ...:.: NP_001 DQTEDILAKSKKGIEESLRKVAKKKFAENPKAGDEFVEKTLSTIATSTDAASVVHSTDLV 60 70 80 90 100 110 450 460 470 480 490 500 pF1KE4 IEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALPISEIAAVSKRPEKVIGMHYFSPVD .::. :.:..:....:... .: :::::::.: :. :: .. : .. :.:.:.:: NP_001 VEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVP 120 130 140 150 160 170 510 520 530 540 550 560 pF1KE4 KMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQE :.:.:.: : ::. : : : . :: . :: ::: ..: :.:.. :.::. .. NP_001 VMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYER 180 190 200 210 220 230 570 580 590 600 pF1KE4 ----------GV------DPKKLD---SLTTSFGFPVGAATLVDEVGVDVAKHVAEDLGK :. : .: : .. . :.:.: :.: ::.:..: ... . NP_001 DFQTCGDSNSGLGFSLKGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHE 240 250 260 270 280 290 610 620 630 640 650 660 pF1KE4 VFGERFGGGNPELLTQMVSKGFLGRKSGKGFYIYQEGVKRKDLNSDMDSILASLKLPPKS . .: :...:... .:.:.:.::: :. NP_001 MDAENPLHQPSPSLNKLVAENKFGKKTGEGFYKYK 300 310 320 330 670 680 690 700 710 720 pF1KE4 EVSSDEDIQFRLVTRFVNEAVMCLQEGILATPAEGDIGAVFGLGFPPCLGGPFRFVDLYG >>NP_001689 (OMIM: 250950,600529) methylglutaconyl-CoA h (339 aa) initn: 356 init1: 133 opt: 378 Z-score: 453.8 bits: 93.5 E(85289): 1.5e-18 Smith-Waterman score: 378; 30.4% identity (63.8% similar) in 260 aa overlap (22-276:65-317) 10 20 30 40 50 pF1KE4 MVACRAIGILSRFSAFRILRSRGYICRNFTGSSALLTRTHINYGVKGDVAV ::: .. . : .: :.. .: ..: NP_001 RLPGSLAGRRAGPAIWAQGWVPAAGGPAPKRGY-SSEMKTEDELRVR-HLEEENRG-IVV 40 50 60 70 80 90 60 70 80 90 100 110 pF1KE4 VRINSPNSKVNTLSKELHSEFSEVMNEIWASDQIRSAVLISSKPGCFIAGADINMLAACK . :: .: :.:::.: . .:.... . .. ..:. .. : :: : ::::.. : . NP_001 LGINRAYGK-NSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMS 100 110 120 130 140 150 120 130 140 150 160 170 pF1KE4 TLQEVTQLSQEAQRIVEKLEKSTKPIVAAINGSCLGGGLEVAISCQYRIATKDRKTVLGT . .:: . .. . ... . . : .:::.: ::::::.:..:. :.:... : .: NP_001 S-SEVGPFVSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAK--MGL 160 170 180 190 200 180 190 200 210 220 pF1KE4 PEVLLGALPGAGGTQRLPKMVGVPAALDMMLTGRSIRADRAKKMGLVDQLVEPLGPG--- :. :. .::.:::::::. .:. : ......: . . .:: .::.....: : NP_001 VETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLEQNQEGDAA 210 220 230 240 250 260 230 240 250 260 270 280 pF1KE4 LKPPEERTIEYLEE--VAITFAKGLADKKISPKRDKGLVEKLTAYAMTIPFVRQQVYKKV . . . :.: . ::. :: .. . ::. . . ::.::: NP_001 YRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIPTKDRLEGLLA 270 280 290 300 310 320 290 300 310 320 330 340 pF1KE4 EEKVRKQTKGLYPAPLKIIDVVKTGIEQGSDAGYLCESQKFGELVMTKESKALMGLYHGQ NP_001 FKEKRPPRYKGE 330 763 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 23:48:48 2016 done: Sat Nov 5 23:48:49 2016 Total Scan time: 8.660 Total Display time: 0.140 Function used was FASTA [36.3.4 Apr, 2011]