FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4424, 439 aa 1>>>pF1KE4424 439 - 439 aa - 439 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0313+/-0.000403; mu= 14.4664+/- 0.025 mean_var=90.5062+/-17.592, 0's: 0 Z-trim(112.1): 186 B-trim: 0 in 0/56 Lambda= 0.134814 statistics sampled from 20745 (20939) to 20745 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.605), E-opt: 0.2 (0.246), width: 16 Scan time: 9.080 The best scores are: opt bits E(85289) NP_002795 (OMIM: 186852) 26S protease regulatory s ( 439) 2826 560.1 4e-159 XP_016873515 (OMIM: 186852) PREDICTED: 26S proteas ( 461) 2599 516.0 8.2e-146 NP_001317141 (OMIM: 602706) 26S protease regulator ( 367) 1120 228.3 2.7e-59 XP_016876959 (OMIM: 602706) PREDICTED: 26S proteas ( 367) 1120 228.3 2.7e-59 NP_002793 (OMIM: 602706) 26S protease regulatory s ( 440) 1120 228.3 3.1e-59 NP_001186092 (OMIM: 601681) 26S protease regulator ( 398) 1055 215.6 1.8e-55 NP_002796 (OMIM: 601681) 26S protease regulatory s ( 406) 1055 215.6 1.9e-55 NP_694546 (OMIM: 602707) 26S protease regulatory s ( 387) 1018 208.4 2.6e-53 NP_006494 (OMIM: 602707) 26S protease regulatory s ( 418) 1018 208.4 2.8e-53 NP_002794 (OMIM: 154365) 26S protease regulatory s ( 433) 982 201.5 3.7e-51 NP_002797 (OMIM: 602708) 26S protease regulatory s ( 403) 944 194.0 5.8e-49 XP_016876961 (OMIM: 602708) PREDICTED: 26S proteas ( 288) 894 184.2 3.8e-46 NP_009057 (OMIM: 167320,601023,613954,616687) tran ( 806) 640 135.1 6.4e-31 XP_011523903 (OMIM: 604581,610246,614487) PREDICTE ( 730) 631 133.3 2e-30 NP_006787 (OMIM: 604581,610246,614487) AFG3-like p ( 797) 631 133.4 2.1e-30 XP_011515297 (OMIM: 611941) PREDICTED: ATPase fami ( 953) 584 124.3 1.4e-27 NP_001304728 (OMIM: 613940,616577) spermatogenesis ( 695) 581 123.6 1.6e-27 XP_011515296 (OMIM: 611941) PREDICTED: ATPase fami (1260) 584 124.3 1.8e-27 XP_011529981 (OMIM: 613940,616577) PREDICTED: sper ( 790) 581 123.6 1.8e-27 XP_016863317 (OMIM: 613940,616577) PREDICTED: sper ( 819) 581 123.6 1.9e-27 NP_054828 (OMIM: 611941) ATPase family AAA domain- (1390) 584 124.4 1.9e-27 NP_001332785 (OMIM: 613940,616577) spermatogenesis ( 892) 581 123.7 2e-27 NP_660208 (OMIM: 613940,616577) spermatogenesis-as ( 893) 581 123.7 2e-27 NP_001230075 (OMIM: 602426) nuclear valosin-contai ( 667) 578 123.0 2.4e-27 XP_011542502 (OMIM: 602426) PREDICTED: nuclear val ( 765) 578 123.0 2.6e-27 XP_011542501 (OMIM: 602426) PREDICTED: nuclear val ( 765) 578 123.0 2.6e-27 XP_011542500 (OMIM: 602426) PREDICTED: nuclear val ( 777) 578 123.0 2.7e-27 XP_016856871 (OMIM: 602426) PREDICTED: nuclear val ( 839) 578 123.1 2.8e-27 XP_016856870 (OMIM: 602426) PREDICTED: nuclear val ( 839) 578 123.1 2.8e-27 XP_016856875 (OMIM: 602426) PREDICTED: nuclear val ( 738) 577 122.8 2.9e-27 XP_011542498 (OMIM: 602426) PREDICTED: nuclear val ( 883) 578 123.1 3e-27 NP_996671 (OMIM: 602426) nuclear valosin-containin ( 750) 577 122.8 3e-27 XP_016856869 (OMIM: 602426) PREDICTED: nuclear val ( 889) 578 123.1 3e-27 NP_001230076 (OMIM: 602426) nuclear valosin-contai ( 765) 577 122.8 3e-27 XP_016856867 (OMIM: 602426) PREDICTED: nuclear val ( 917) 578 123.1 3.1e-27 XP_016856872 (OMIM: 602426) PREDICTED: nuclear val ( 812) 577 122.9 3.2e-27 NP_002524 (OMIM: 602426) nuclear valosin-containin ( 856) 577 122.9 3.3e-27 XP_016856868 (OMIM: 602426) PREDICTED: nuclear val ( 890) 577 122.9 3.4e-27 NP_001303242 (OMIM: 601498,614862,614863,616617) p ( 892) 573 122.1 5.9e-27 XP_011512963 (OMIM: 601498,614862,614863,616617) P ( 952) 573 122.1 6.2e-27 NP_000278 (OMIM: 601498,614862,614863,616617) pero ( 980) 573 122.1 6.3e-27 NP_003110 (OMIM: 602783,607259) paraplegin isoform ( 795) 571 121.7 7e-27 XP_006721327 (OMIM: 602783,607259) PREDICTED: para ( 809) 571 121.7 7.1e-27 XP_016879087 (OMIM: 602783,607259) PREDICTED: para ( 561) 565 120.4 1.2e-26 XP_016863319 (OMIM: 613940,616577) PREDICTED: sper ( 593) 562 119.9 1.9e-26 XP_016879086 (OMIM: 602783,607259) PREDICTED: para ( 618) 562 119.9 1.9e-26 XP_011531234 (OMIM: 615347) PREDICTED: ATPase fami ( 791) 562 119.9 2.3e-26 XP_011531233 (OMIM: 615347) PREDICTED: ATPase fami ( 837) 562 119.9 2.5e-26 XP_011531232 (OMIM: 615347) PREDICTED: ATPase fami ( 841) 562 119.9 2.5e-26 XP_011531231 (OMIM: 615347) PREDICTED: ATPase fami ( 843) 562 119.9 2.5e-26 >>NP_002795 (OMIM: 186852) 26S protease regulatory subun (439 aa) initn: 2826 init1: 2826 opt: 2826 Z-score: 2977.7 bits: 560.1 E(85289): 4e-159 Smith-Waterman score: 2826; 100.0% identity (100.0% similar) in 439 aa overlap (1-439:1-439) 10 20 30 40 50 60 pF1KE4 MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 ARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDY 370 380 390 400 410 420 430 pF1KE4 MEGILEVQAKKKANLQYYA ::::::::::::::::::: NP_002 MEGILEVQAKKKANLQYYA 430 >>XP_016873515 (OMIM: 186852) PREDICTED: 26S protease re (461 aa) initn: 2599 init1: 2599 opt: 2599 Z-score: 2738.8 bits: 516.0 E(85289): 8.2e-146 Smith-Waterman score: 2599; 100.0% identity (100.0% similar) in 403 aa overlap (1-403:1-403) 10 20 30 40 50 60 pF1KE4 MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 ARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDY ::::::::::::::::::::::::::::::::::::::::::: XP_016 ARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAVSGQLGWVRCFVPSCPL 370 380 390 400 410 420 430 pF1KE4 MEGILEVQAKKKANLQYYA XP_016 PGQDGGIWLVETAEGRGLSLREPGKAFRRSDLDSVCPGCRA 430 440 450 460 >>NP_001317141 (OMIM: 602706) 26S protease regulatory su (367 aa) initn: 1107 init1: 1107 opt: 1120 Z-score: 1185.6 bits: 228.3 E(85289): 2.7e-59 Smith-Waterman score: 1135; 45.5% identity (76.2% similar) in 378 aa overlap (55-432:1-358) 30 40 50 60 70 80 pF1KE4 EQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNK :. : .: .... ...: .:. :. . NP_001 MEEEFIRNQEQMKPLEEKQEEERSKVDDLR 10 20 30 90 100 110 120 130 140 pF1KE4 TLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEK :. :... :..: :.. :...::. . ... ....:: . NP_001 GTPMSVGTLEEIID---------------DNH-----AIVSTSVGSEHYVSILSFVDKDL 40 50 60 70 150 160 170 180 190 200 pF1KE4 LKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVL :.:: : .:. . .. .: . : : .:.:.. : : :.::::::.::::. :.. : NP_001 LEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVEL 80 90 100 110 120 130 210 220 230 240 250 260 pF1KE4 PMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDG :..: : .:..::.:::::..::::::::::::.: : ::.::::...: .:.: ..::: NP_001 PLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDG 140 150 160 170 180 190 270 280 290 300 310 320 pF1KE4 AKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNT ::::. : .:.:.::::.::::.:::::::.::...:.::.::::::::::::::. NP_001 PKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRG 200 210 220 230 240 250 330 340 350 360 370 380 pF1KE4 QVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEEL .:::: ::::.. :::::.: ::.:::::::.:.:... ::.:::. .:... ::. ..: NP_001 DVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDL 260 270 280 290 300 310 390 400 410 420 430 pF1KE4 ARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA ::..::. ::.:.:::..:::. ..:.::. .. .: ::. NP_001 IMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL 320 330 340 350 360 >>XP_016876959 (OMIM: 602706) PREDICTED: 26S protease re (367 aa) initn: 1107 init1: 1107 opt: 1120 Z-score: 1185.6 bits: 228.3 E(85289): 2.7e-59 Smith-Waterman score: 1135; 45.5% identity (76.2% similar) in 378 aa overlap (55-432:1-358) 30 40 50 60 70 80 pF1KE4 EQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNK :. : .: .... ...: .:. :. . XP_016 MEEEFIRNQEQMKPLEEKQEEERSKVDDLR 10 20 30 90 100 110 120 130 140 pF1KE4 TLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEK :. :... :..: :.. :...::. . ... ....:: . XP_016 GTPMSVGTLEEIID---------------DNH-----AIVSTSVGSEHYVSILSFVDKDL 40 50 60 70 150 160 170 180 190 200 pF1KE4 LKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVL :.:: : .:. . .. .: . : : .:.:.. : : :.::::::.::::. :.. : XP_016 LEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVEL 80 90 100 110 120 130 210 220 230 240 250 260 pF1KE4 PMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDG :..: : .:..::.:::::..::::::::::::.: : ::.::::...: .:.: ..::: XP_016 PLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDG 140 150 160 170 180 190 270 280 290 300 310 320 pF1KE4 AKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNT ::::. : .:.:.::::.::::.:::::::.::...:.::.::::::::::::::. XP_016 PKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRG 200 210 220 230 240 250 330 340 350 360 370 380 pF1KE4 QVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEEL .:::: ::::.. :::::.: ::.:::::::.:.:... ::.:::. .:... ::. ..: XP_016 DVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDL 260 270 280 290 300 310 390 400 410 420 430 pF1KE4 ARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA ::..::. ::.:.:::..:::. ..:.::. .. .: ::. XP_016 IMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL 320 330 340 350 360 >>NP_002793 (OMIM: 602706) 26S protease regulatory subun (440 aa) initn: 1107 init1: 1107 opt: 1120 Z-score: 1184.4 bits: 228.3 E(85289): 3.1e-59 Smith-Waterman score: 1146; 42.8% identity (72.2% similar) in 432 aa overlap (5-432:27-431) 10 20 30 pF1KE4 MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMST : . . : ...: . : : . : . : NP_002 MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASK-------LPLVT 10 20 30 40 50 40 50 60 70 80 90 pF1KE4 EEIIQRTRLLDSE-IK---IMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVI . : .:: : :: .:. : .: .... ...: .:. :. . :. :... NP_002 PHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLE 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE4 ELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVN :..: :.. :...::. . ... ....:: . :.:: : .: NP_002 EIID---------------DNH-----AIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLN 120 130 140 150 160 170 180 190 200 210 pF1KE4 KDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFEN . . .. .: . : : .:.:.. : : :.::::::.::::. :.. ::..: : .:. NP_002 HKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEE 160 170 180 190 200 210 220 230 240 250 260 270 pF1KE4 LGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFAL .::.:::::..::::::::::::.: : ::.::::...: .:.: ..::: ::::. : . NP_002 MGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRV 220 230 240 250 260 270 280 290 300 310 320 330 pF1KE4 AKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNR :.:.::::.::::.:::::::.::...:.::.::::::::::::::. .:::: :::: NP_002 AEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNR 280 290 300 310 320 330 340 350 360 370 380 390 pF1KE4 VDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGA .. :::::.: ::.:::::::.:.:... ::.:::. .:... ::. ..: ::..:: NP_002 IETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGA 340 350 360 370 380 390 400 410 420 430 pF1KE4 QCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA . ::.:.:::..:::. ..:.::. .. .: ::. NP_002 DIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL 400 410 420 430 440 >>NP_001186092 (OMIM: 601681) 26S protease regulatory su (398 aa) initn: 1041 init1: 1019 opt: 1055 Z-score: 1116.7 bits: 215.6 E(85289): 1.8e-55 Smith-Waterman score: 1055; 45.1% identity (73.7% similar) in 377 aa overlap (55-430:12-385) 30 40 50 60 70 80 pF1KE4 EQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNK ... : .::: . . ..: ....... NP_001 MELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQR 10 20 30 40 90 100 110 120 130 140 pF1KE4 TLPYLVSNVIELLDVDPNDQEEDGANI-DLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAE . .. ..:: . . .:.:. . .. : ...:. . . . : .: . NP_001 NE---LNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDIN 50 60 70 80 90 150 160 170 180 190 200 pF1KE4 KLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIV . :. :.. .::: . . ::.. : :. : :.. : : ::::::::.:. :.: NP_001 DVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIE 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE4 LPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGD ::..: : :: ::: :::::.:::::::::::::: : .: ::....: .::: :::. NP_001 LPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGE 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE4 GAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPN ::..::. :..:.:.::::::.::.:.::..:... ..:: ::::::::::::::::. . NP_001 GARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEAT 220 230 240 250 260 270 330 340 350 360 370 380 pF1KE4 TQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEE ..::: ::::.:::: :::: ::.::::::: :::::: :..:::::::.. .: .. NP_001 KNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRK 280 290 300 310 320 330 390 400 410 420 430 pF1KE4 LARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA .:. .::. :.::.:::: :::. ...:.::. .. .:. : NP_001 IAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK 340 350 360 370 380 390 >>NP_002796 (OMIM: 601681) 26S protease regulatory subun (406 aa) initn: 1041 init1: 1019 opt: 1055 Z-score: 1116.6 bits: 215.6 E(85289): 1.9e-55 Smith-Waterman score: 1055; 45.1% identity (73.7% similar) in 377 aa overlap (55-430:20-393) 30 40 50 60 70 80 pF1KE4 EQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNK ... : .::: . . ..: ....... NP_002 MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQR 10 20 30 40 90 100 110 120 130 140 pF1KE4 TLPYLVSNVIELLDVDPNDQEEDGANI-DLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAE . .. ..:: . . .:.:. . .. : ...:. . . . : .: . NP_002 NE---LNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDIN 50 60 70 80 90 100 150 160 170 180 190 200 pF1KE4 KLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIV . :. :.. .::: . . ::.. : :. : :.. : : ::::::::.:. :.: NP_002 DVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIE 110 120 130 140 150 160 210 220 230 240 250 260 pF1KE4 LPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGD ::..: : :: ::: :::::.:::::::::::::: : .: ::....: .::: :::. NP_002 LPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGE 170 180 190 200 210 220 270 280 290 300 310 320 pF1KE4 GAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPN ::..::. :..:.:.::::::.::.:.::..:... ..:: ::::::::::::::::. . NP_002 GARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEAT 230 240 250 260 270 280 330 340 350 360 370 380 pF1KE4 TQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEE ..::: ::::.:::: :::: ::.::::::: :::::: :..:::::::.. .: .. NP_002 KNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRK 290 300 310 320 330 340 390 400 410 420 430 pF1KE4 LARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA .:. .::. :.::.:::: :::. ...:.::. .. .:. : NP_002 IAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK 350 360 370 380 390 400 >>NP_694546 (OMIM: 602707) 26S protease regulatory subun (387 aa) initn: 997 init1: 959 opt: 1018 Z-score: 1078.0 bits: 208.4 E(85289): 2.6e-53 Smith-Waterman score: 1020; 42.0% identity (73.0% similar) in 374 aa overlap (65-438:33-386) 40 50 60 70 80 90 pF1KE4 KMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVI : . ..: .. .:..: ...: .... . NP_694 EIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKEEVKRIQSIPLVIGQFL 10 20 30 40 50 60 100 110 120 130 140 150 pF1KE4 ELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVN : :: : :.. ..: ..:.. ... .: : :::. :... NP_694 E--AVDQNT------------------AIVGSTTGSNYYVRILSTIDRELLKPNASVALH 70 80 90 100 160 170 180 190 200 210 pF1KE4 KDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFEN : : ....:: : :: . . :..: .:.::::.: : ::. ::. ::..: : ... NP_694 KHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQ 110 120 130 140 150 160 220 230 240 250 260 270 pF1KE4 LGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFAL .::.::.::::::::: :::.::.: : .: :.:....: ..:: ..:.: ..:::.: : NP_694 IGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRL 170 180 190 200 210 220 280 290 300 310 320 330 pF1KE4 AKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNR :::.::.::::::.:::.:::::.. ..:::::: .::::::.:::. :..:::: :::: NP_694 AKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNR 230 240 250 260 270 280 340 350 360 370 380 390 pF1KE4 VDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGA .: ::::::: ::::::::::.:... . :.. . :::.: .:. :. . : ..:: NP_694 ADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGA 290 300 310 320 330 340 400 410 420 430 pF1KE4 QCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA . ...: :.::.:.:.. . .:. .. : : . . ..: NP_694 DINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK 350 360 370 380 >>NP_006494 (OMIM: 602707) 26S protease regulatory subun (418 aa) initn: 959 init1: 959 opt: 1018 Z-score: 1077.5 bits: 208.4 E(85289): 2.8e-53 Smith-Waterman score: 1049; 40.2% identity (72.5% similar) in 400 aa overlap (39-438:38-417) 10 20 30 40 50 60 pF1KE4 SPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQA :.. .: . :..:..... . . : . NP_006 VEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 MKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTST .: .. . .:..: ...: .... .: :: : :.. ..: NP_006 LKKEFLHAQEEVKRIQSIPLVIGQFLE--AVDQNT------------------AIVGSTT 70 80 90 100 130 140 150 160 170 180 pF1KE4 RQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDI ..:.. ... .: : :::. :...: : ....:: : :: . . :..: .:.:: NP_006 GSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADI 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE4 GGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATF ::.: : ::. ::. ::..: : ....::.::.::::::::: :::.::.: : .: :.: NP_006 GGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAF 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE4 LKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQR ....: ..:: ..:.: ..:::.: ::::.::.::::::.:::.:::::.. ..:::::: NP_006 IRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQR 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 TMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQI .::::::.:::. :..:::: ::::.: ::::::: ::::::::::.:... . :.. NP_006 ILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFST 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 HSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQ . :::.: .:. :. . : ..::. ...: :.::.:.:.. . .:. .. : NP_006 ITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVI 350 360 370 380 390 400 430 pF1KE4 AKKKANLQYYA : . . ..: NP_006 KKDEQEHEFYK 410 >>NP_002794 (OMIM: 154365) 26S protease regulatory subun (433 aa) initn: 981 init1: 958 opt: 982 Z-score: 1039.5 bits: 201.5 E(85289): 3.7e-51 Smith-Waterman score: 984; 40.4% identity (66.8% similar) in 416 aa overlap (27-427:3-416) 10 20 30 40 50 pF1KE4 MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRT-RLLD-SEIKIMKS- : .: . : . .: .. : :: ..: ..:. NP_002 MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTY 10 20 30 60 70 80 90 100 pF1KE4 -------EVLRVTHELQAMKDKIKE-----NSEKIKVNKTLPYLVSNVIELLDVDPNDQE .. .: ..: . ::.: .:. . .: :... : . .: . NP_002 GQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVA 40 50 60 70 80 90 110 120 130 140 150 160 pF1KE4 EDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLP . :. ::. .:... . . . : .. : :::....: : :: NP_002 RCTKIINADSEDPKY--IINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLP 100 110 120 130 140 150 170 180 190 200 210 220 pF1KE4 TEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLM . : : :.:.:.: :::.:: .::..: :.. :. : :.: ::::.::::::. NP_002 PKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLL 160 170 180 190 200 210 230 240 250 260 270 280 pF1KE4 YGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFI .::::::::: ::: : .: : :... : .::: ..:.::..::. : .:. : .::. NP_002 FGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFF 220 230 240 250 260 270 290 300 310 320 330 340 pF1KE4 DELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRS ::.:::: :::. .:: :::::::::.::::::.: ..::. :::: : :::::.: NP_002 DEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRP 280 290 300 310 320 330 350 360 370 380 390 400 pF1KE4 GRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGM ::::::::: .:. :.:..:..::.:.:.: :. .: ::: . .::. ..::.:::: NP_002 GRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGM 340 350 360 370 380 390 410 420 430 pF1KE4 IALRRGATELTHEDYMEGILEVQAKKKANLQYYA .:.: :..:..:.. .: NP_002 FAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN 400 410 420 430 439 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:12:28 2016 done: Sun Nov 6 01:12:29 2016 Total Scan time: 9.080 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]