FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5221, 259 aa 1>>>pF1KE5221 259 - 259 aa - 259 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6646+/-0.000361; mu= 12.1316+/- 0.022 mean_var=65.3492+/-13.396, 0's: 0 Z-trim(112.8): 26 B-trim: 0 in 0/49 Lambda= 0.158655 statistics sampled from 21917 (21936) to 21917 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.629), E-opt: 0.2 (0.257), width: 16 Scan time: 5.380 The best scores are: opt bits E(85289) NP_001038 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-d ( 259) 1813 423.8 1.5e-118 NP_001311252 (OMIM: 184753) 3-oxo-5-alpha-steroid ( 186) 1171 276.8 1.9e-74 NP_000339 (OMIM: 264600,607306) 3-oxo-5-alpha-ster ( 254) 806 193.3 3.6e-49 NP_001311251 (OMIM: 184753) 3-oxo-5-alpha-steroid ( 212) 762 183.2 3.3e-46 XP_011531374 (OMIM: 264600,607306) PREDICTED: 3-ox ( 169) 649 157.3 1.6e-38 XP_011531371 (OMIM: 264600,607306) PREDICTED: 3-ox ( 180) 646 156.7 2.8e-38 NP_612510 (OMIM: 610057,614020) very-long-chain en ( 308) 204 55.6 1.3e-07 NP_001308099 (OMIM: 610057,614020) very-long-chain ( 323) 204 55.6 1.3e-07 XP_011526744 (OMIM: 610057,614020) PREDICTED: very ( 329) 204 55.6 1.4e-07 XP_006723008 (OMIM: 610057,614020) PREDICTED: very ( 341) 204 55.6 1.4e-07 XP_005265824 (OMIM: 611715,612379,612713) PREDICTE ( 207) 191 52.5 7e-07 XP_016864090 (OMIM: 611715,612379,612713) PREDICTE ( 273) 165 46.6 5.6e-05 NP_078868 (OMIM: 611715,612379,612713) polyprenol ( 318) 165 46.6 6.4e-05 XP_005265823 (OMIM: 611715,612379,612713) PREDICTE ( 273) 151 43.4 0.00051 >>NP_001038 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-dehyd (259 aa) initn: 1813 init1: 1813 opt: 1813 Z-score: 2249.4 bits: 423.8 E(85289): 1.5e-118 Smith-Waterman score: 1813; 100.0% identity (100.0% similar) in 259 aa overlap (1-259:1-259) 10 20 30 40 50 60 pF1KE5 MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY 190 200 210 220 230 240 250 pF1KE5 LRKFEEYPKFRKIIIPFLF ::::::::::::::::::: NP_001 LRKFEEYPKFRKIIIPFLF 250 >>NP_001311252 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-de (186 aa) initn: 1171 init1: 1171 opt: 1171 Z-score: 1457.5 bits: 276.8 E(85289): 1.9e-74 Smith-Waterman score: 1171; 100.0% identity (100.0% similar) in 162 aa overlap (98-259:25-186) 70 80 90 100 110 120 pF1KE5 LYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCN :::::::::::::::::::::::::::::: NP_001 MTLPWRTWSEWKQITSFTVFPALLRCLIYPFLMRGGKPMPLLACTMAIMFCTCN 10 20 30 40 50 130 140 150 160 170 180 pF1KE5 GYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPR 60 70 80 90 100 110 190 200 210 220 230 240 pF1KE5 GGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEY 120 130 140 150 160 170 250 pF1KE5 PKFRKIIIPFLF :::::::::::: NP_001 PKFRKIIIPFLF 180 >>NP_000339 (OMIM: 264600,607306) 3-oxo-5-alpha-steroid (254 aa) initn: 772 init1: 608 opt: 806 Z-score: 1003.8 bits: 193.3 E(85289): 3.6e-49 Smith-Waterman score: 806; 52.7% identity (74.3% similar) in 226 aa overlap (36-259:31-254) 10 20 30 40 50 60 pF1KE5 GVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRH--ALPSHRLRVPARAAWVVQELPS : ::.: .: :.:::::: .::::: NP_000 MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 LALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMF .:.: : . : . :. .::..: .:: :: ..: .: :: .:.: . . : NP_000 FAVPAGILARQPLS-LFGPPGTVLLGLFCLHYFHRTFVYSLLNRG-RPYPAILILRGTAF 70 80 90 100 110 130 140 150 160 170 180 pF1KE5 CTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGY :: :: ::. :: .:: : : : :: :: .: :.. :: ::::::.:::.:::::. .: NP_000 CTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISY 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE5 KIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRK .::.:::: ::..::..:::.:: :::::.::. . :::::..:::. :: .::..::. NP_000 RIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKM 180 190 200 210 220 230 250 pF1KE5 FEEYPKFRKIIIPFLF ::.::: :: .:::.: NP_000 FEDYPKSRKALIPFIF 240 250 >>NP_001311251 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-de (212 aa) initn: 761 init1: 761 opt: 762 Z-score: 950.7 bits: 183.2 E(85289): 3.3e-46 Smith-Waterman score: 762; 91.6% identity (95.0% similar) in 119 aa overlap (142-259:94-212) 120 130 140 150 160 170 pF1KE5 MPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDW-VTDPRFLIGFGLWLTGMLINIHSDH :..: .. :::::::::::::::::: NP_001 PGWCRSCPRWPCRSTSTPASPPRVSAARPTASSWPCSSSTTGIGFGLWLTGMLINIHSDH 70 80 90 100 110 120 180 190 200 210 220 230 pF1KE5 ILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLS 130 140 150 160 170 180 240 250 pF1KE5 GRAKEHHEWYLRKFEEYPKFRKIIIPFLF ::::::::::::::::::::::::::::: NP_001 GRAKEHHEWYLRKFEEYPKFRKIIIPFLF 190 200 210 >>XP_011531374 (OMIM: 264600,607306) PREDICTED: 3-oxo-5- (169 aa) initn: 625 init1: 608 opt: 649 Z-score: 812.5 bits: 157.3 E(85289): 1.6e-38 Smith-Waterman score: 649; 55.8% identity (78.5% similar) in 163 aa overlap (97-259:8-169) 70 80 90 100 110 120 pF1KE5 PLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTC .: ..: .: :: .:.: . . ::: XP_011 MRSWSLTYRTFVYSLLNRG-RPYPAILILRGTAFCTG 10 20 30 130 140 150 160 170 180 pF1KE5 NGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIP :: ::. :: .:: : : : :: :: .: :.. :: ::::::.:::.:::::. .:.:: XP_011 NGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIP 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE5 RGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEE .:::: ::..::..:::.:: :::::.::. . :::::..:::. :: .::..::. ::. XP_011 QGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFED 100 110 120 130 140 150 250 pF1KE5 YPKFRKIIIPFLF ::: :: .:::.: XP_011 YPKSRKALIPFIF 160 >>XP_011531371 (OMIM: 264600,607306) PREDICTED: 3-oxo-5- (180 aa) initn: 625 init1: 608 opt: 646 Z-score: 808.3 bits: 156.7 E(85289): 2.8e-38 Smith-Waterman score: 648; 51.3% identity (74.3% similar) in 187 aa overlap (73-259:3-180) 50 60 70 80 90 100 pF1KE5 LPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIY :.. :: .: .: :. . . ..: XP_011 MTSQGMPR--TANHCQKLGTL------KTFVY 10 20 110 120 130 140 150 160 pF1KE5 PFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGM .: :: .:.: . . ::: :: ::. :: .:: : : : :: :: .: :.. :: XP_011 SLLNRG-RPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGM 30 40 50 60 70 80 170 180 190 200 210 220 pF1KE5 LINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFA ::::::.:::.:::::. .:.::.:::: ::..::..:::.:: :::::.::. . ::: XP_011 GINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFA 90 100 110 120 130 140 230 240 250 pF1KE5 FFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF ::..:::. :: .::..::. ::.::: :: .:::.: XP_011 FFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF 150 160 170 180 >>NP_612510 (OMIM: 610057,614020) very-long-chain enoyl- (308 aa) initn: 225 init1: 163 opt: 204 Z-score: 257.8 bits: 55.6 E(85289): 1.3e-07 Smith-Waterman score: 205; 28.7% identity (52.8% similar) in 178 aa overlap (94-259:137-308) 70 80 90 100 110 120 pF1KE5 LALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGK-PMPLLACTMAIM :: .: : :. : .. ::: . NP_612 FRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRN-----I 110 120 130 140 150 160 130 140 150 160 170 pF1KE5 FCTCNGYL-----QSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRK : .:. : .. :..: .:. . ....... .: :. ::.:: NP_612 FKNCTYYWGFAAWMAYYINH-PLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRP 170 180 190 200 210 220 180 190 200 210 220 230 pF1KE5 PGDTGYKIPRGG------LFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSG :. ::: :: :. :: :. : :.:. . . : :.. : .. NP_612 AGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTI 230 240 250 260 270 280 240 250 pF1KE5 RAKEHHEWYLRKFEEYPKFRKIIIPFLF :: .:. ::..:..:: .: :::::. NP_612 WAKGKHRSYLKEFRDYPPLRMPIIPFLL 290 300 >>NP_001308099 (OMIM: 610057,614020) very-long-chain eno (323 aa) initn: 225 init1: 163 opt: 204 Z-score: 257.4 bits: 55.6 E(85289): 1.3e-07 Smith-Waterman score: 205; 28.7% identity (52.8% similar) in 178 aa overlap (94-259:152-323) 70 80 90 100 110 120 pF1KE5 LALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGK-PMPLLACTMAIM :: .: : :. : .. ::: . NP_001 FRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRN-----I 130 140 150 160 170 130 140 150 160 170 pF1KE5 FCTCNGYL-----QSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRK : .:. : .. :..: .:. . ....... .: :. ::.:: NP_001 FKNCTYYWGFAAWMAYYINH-PLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRP 180 190 200 210 220 230 180 190 200 210 220 230 pF1KE5 PGDTGYKIPRGG------LFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSG :. ::: :: :. :: :. : :.:. . . : :.. : .. NP_001 AGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTI 240 250 260 270 280 290 240 250 pF1KE5 RAKEHHEWYLRKFEEYPKFRKIIIPFLF :: .:. ::..:..:: .: :::::. NP_001 WAKGKHRSYLKEFRDYPPLRMPIIPFLL 300 310 320 >>XP_011526744 (OMIM: 610057,614020) PREDICTED: very-lon (329 aa) initn: 225 init1: 163 opt: 204 Z-score: 257.3 bits: 55.6 E(85289): 1.4e-07 Smith-Waterman score: 205; 28.7% identity (52.8% similar) in 178 aa overlap (94-259:158-329) 70 80 90 100 110 120 pF1KE5 LALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGK-PMPLLACTMAIM :: .: : :. : .. ::: . XP_011 FRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRN-----I 130 140 150 160 170 180 130 140 150 160 170 pF1KE5 FCTCNGYL-----QSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRK : .:. : .. :..: .:. . ....... .: :. ::.:: XP_011 FKNCTYYWGFAAWMAYYINH-PLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRP 190 200 210 220 230 240 180 190 200 210 220 230 pF1KE5 PGDTGYKIPRGG------LFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSG :. ::: :: :. :: :. : :.:. . . : :.. : .. XP_011 AGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTI 250 260 270 280 290 300 240 250 pF1KE5 RAKEHHEWYLRKFEEYPKFRKIIIPFLF :: .:. ::..:..:: .: :::::. XP_011 WAKGKHRSYLKEFRDYPPLRMPIIPFLL 310 320 >>XP_006723008 (OMIM: 610057,614020) PREDICTED: very-lon (341 aa) initn: 225 init1: 163 opt: 204 Z-score: 257.1 bits: 55.6 E(85289): 1.4e-07 Smith-Waterman score: 205; 28.7% identity (52.8% similar) in 178 aa overlap (94-259:170-341) 70 80 90 100 110 120 pF1KE5 LALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGK-PMPLLACTMAIM :: .: : :. : .. ::: . XP_006 FRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRN-----I 140 150 160 170 180 190 130 140 150 160 170 pF1KE5 FCTCNGYL-----QSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRK : .:. : .. :..: .:. . ....... .: :. ::.:: XP_006 FKNCTYYWGFAAWMAYYINH-PLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRP 200 210 220 230 240 250 180 190 200 210 220 230 pF1KE5 PGDTGYKIPRGG------LFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSG :. ::: :: :. :: :. : :.:. . . : :.. : .. XP_006 AGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTI 260 270 280 290 300 310 240 250 pF1KE5 RAKEHHEWYLRKFEEYPKFRKIIIPFLF :: .:. ::..:..:: .: :::::. XP_006 WAKGKHRSYLKEFRDYPPLRMPIIPFLL 320 330 340 259 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 22:38:24 2016 done: Mon Nov 7 22:38:25 2016 Total Scan time: 5.380 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]