FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1442, 255 aa 1>>>pF1KE1442 255 - 255 aa - 255 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.9841+/-0.000297; mu= 8.7160+/- 0.019 mean_var=156.8326+/-31.238, 0's: 0 Z-trim(122.9): 97 B-trim: 44 in 1/54 Lambda= 0.102413 statistics sampled from 41804 (41916) to 41804 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.816), E-opt: 0.2 (0.491), width: 16 Scan time: 5.240 The best scores are: opt bits E(85289) XP_011539688 (OMIM: 602250) PREDICTED: tumor necro ( 255) 1848 283.9 1.9e-76 NP_001552 (OMIM: 602250) tumor necrosis factor rec ( 255) 1848 283.9 1.9e-76 XP_006710681 (OMIM: 602250) PREDICTED: tumor necro ( 239) 1629 251.5 1e-66 XP_016866233 (OMIM: 605732) PREDICTED: tumor necro ( 444) 319 58.2 2.9e-08 NP_055267 (OMIM: 605732) tumor necrosis factor rec ( 655) 319 58.4 3.8e-08 NP_001265197 (OMIM: 174810,602080,603499,612301) t ( 602) 254 48.7 2.8e-05 NP_683700 (OMIM: 603905) tumor necrosis factor rec ( 234) 224 43.9 0.00031 NP_004186 (OMIM: 603905) tumor necrosis factor rec ( 241) 224 43.9 0.00032 XP_016858211 (OMIM: 603905) PREDICTED: tumor necro ( 347) 224 44.1 0.00041 NP_001233 (OMIM: 186711,615122) CD27 antigen precu ( 260) 210 41.9 0.0014 NP_001284534 (OMIM: 602746) tumor necrosis factor ( 184) 207 41.3 0.0015 XP_006711082 (OMIM: 602746) PREDICTED: tumor necro ( 197) 207 41.3 0.0016 XP_016875723 (OMIM: 186711,615122) PREDICTED: CD27 ( 358) 210 42.0 0.0018 XP_016875721 (OMIM: 186711,615122) PREDICTED: CD27 ( 405) 210 42.1 0.0019 NP_003811 (OMIM: 602746) tumor necrosis factor rec ( 283) 207 41.5 0.002 NP_001289682 (OMIM: 109535,606843) tumor necrosis ( 237) 204 41.0 0.0024 XP_016883624 (OMIM: 109535,606843) PREDICTED: tumo ( 323) 204 41.1 0.003 >>XP_011539688 (OMIM: 602250) PREDICTED: tumor necrosis (255 aa) initn: 1848 init1: 1848 opt: 1848 Z-score: 1493.3 bits: 283.9 E(85289): 1.9e-76 Smith-Waterman score: 1848; 100.0% identity (100.0% similar) in 255 aa overlap (1-255:1-255) 10 20 30 40 50 60 pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 CFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPARE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDG 190 200 210 220 230 240 250 pF1KE1 CSCRFPEEEEGGCEL ::::::::::::::: XP_011 CSCRFPEEEEGGCEL 250 >>NP_001552 (OMIM: 602250) tumor necrosis factor recepto (255 aa) initn: 1848 init1: 1848 opt: 1848 Z-score: 1493.3 bits: 283.9 E(85289): 1.9e-76 Smith-Waterman score: 1848; 100.0% identity (100.0% similar) in 255 aa overlap (1-255:1-255) 10 20 30 40 50 60 pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 CFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPARE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDG 190 200 210 220 230 240 250 pF1KE1 CSCRFPEEEEGGCEL ::::::::::::::: NP_001 CSCRFPEEEEGGCEL 250 >>XP_006710681 (OMIM: 602250) PREDICTED: tumor necrosis (239 aa) initn: 1629 init1: 1629 opt: 1629 Z-score: 1318.8 bits: 251.5 E(85289): 1e-66 Smith-Waterman score: 1629; 100.0% identity (100.0% similar) in 226 aa overlap (1-226:1-226) 10 20 30 40 50 60 pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 CFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPARE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDG :::::::::::::::::::::::::::::::::::::::::::::: XP_006 PGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQHGSSGDTFTILES 190 200 210 220 230 250 pF1KE1 CSCRFPEEEEGGCEL >>XP_016866233 (OMIM: 605732) PREDICTED: tumor necrosis (444 aa) initn: 227 init1: 64 opt: 319 Z-score: 269.3 bits: 58.2 E(85289): 2.9e-08 Smith-Waterman score: 325; 32.2% identity (54.6% similar) in 174 aa overlap (28-183:67-239) 10 20 30 40 50 pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTF----CDNNRNQICSPCPPNSF :..:::::. : :. ..:: :: ..: XP_016 STTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTF 40 50 60 70 80 90 60 70 80 90 100 110 pF1KE1 SS-AGGQRTCDICRQ-CKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQE . .: . : : : : . . :.. .. :: : ::. .: :. . : : XP_016 TRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMFQSNATCAP-HTVCPVGWG 100 110 120 130 140 150 120 130 140 150 160 pF1KE1 LTKKG-------CKDCCFGTFNDQKRGI--CRPWTNCSLDGKSVLVNGTKERDVVCGPSP . ::: ::.: :::.: .. :. .:.: .. :. :::: : ::: : XP_016 VRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLP 160 170 180 190 200 210 170 180 190 200 210 pF1KE1 A---DLSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKK . . ::. ... : : . : XP_016 SFSSSTSPSPGTAIFPRPEHMETHEVPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTV 220 230 240 250 260 270 >>NP_055267 (OMIM: 605732) tumor necrosis factor recepto (655 aa) initn: 227 init1: 64 opt: 319 Z-score: 267.1 bits: 58.4 E(85289): 3.8e-08 Smith-Waterman score: 325; 32.2% identity (54.6% similar) in 174 aa overlap (28-183:67-239) 10 20 30 40 50 pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTF----CDNNRNQICSPCPPNSF :..:::::. : :. ..:: :: ..: NP_055 STTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTF 40 50 60 70 80 90 60 70 80 90 100 110 pF1KE1 SS-AGGQRTCDICRQ-CKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQE . .: . : : : : . . :.. .. :: : ::. .: :. . : : NP_055 TRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMFQSNATCAP-HTVCPVGWG 100 110 120 130 140 150 120 130 140 150 160 pF1KE1 LTKKG-------CKDCCFGTFNDQKRGI--CRPWTNCSLDGKSVLVNGTKERDVVCGPSP . ::: ::.: :::.: .. :. .:.: .. :. :::: : ::: : NP_055 VRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLP 160 170 180 190 200 210 170 180 190 200 210 pF1KE1 A---DLSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKK . . ::. ... : : . : NP_055 SFSSSTSPSPGTAIFPRPEHMETHEVPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTV 220 230 240 250 260 270 >>NP_001265197 (OMIM: 174810,602080,603499,612301) tumor (602 aa) initn: 128 init1: 128 opt: 254 Z-score: 215.7 bits: 48.7 E(85289): 2.8e-05 Smith-Waterman score: 260; 25.6% identity (52.8% similar) in 246 aa overlap (28-254:47-269) 10 20 30 40 50 pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTF----CDNNRNQICSPCPPNSF :..: : . : .. ...: :: :. . NP_001 LCALLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKCTTTSDSVCLPCGPDEY 20 30 40 50 60 70 60 70 80 90 100 pF1KE1 -SSAGGQRTCDICRQCKG--VFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQD--CKQ .: . . : . . : .. . .::. .: :: :.: . : :... : NP_001 LDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYH-WSQDCECCRRNTECAP 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE1 GQELTKKGCKDCCFGTFND--QKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLS : : . :. :.: .. :::::::.. :: : .::.. :.:: NP_001 GL-----GAQHPCY--FSDAFSSTDKCRPWTNCTFLGKRVEHHGTEKSDAVC-------- 140 150 160 170 180 170 180 190 200 210 220 pF1KE1 PGASSVTPPAPAREPGHSPQI----ISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLY .::. :::.: . :.. . ..: ..:.::. ..: . . : .: . NP_001 --SSSL----PARKPPNEPHVYLPGLIILLLFASVALVAAIIFGVCYRKKGKALTANLWH 190 200 210 220 230 230 240 250 pF1KE1 IFKQPFMRPVQTTQEEDGCSCRFPEE----EEGGCEL ... : .. .: .: :: . ..:.:: NP_001 WINEACGR-LSGDKESSGDSCVSTHTANFGQQGACEGVLLLTLEEKTFPEDMCYPDQGGV 240 250 260 270 280 290 NP_001 CQGTCVGGGPYAQGEDARMLSLVSKTEIEEDSFRQMPTEDEYMDRPSQPTDQLLFLTEPG 300 310 320 330 340 350 >>NP_683700 (OMIM: 603905) tumor necrosis factor recepto (234 aa) initn: 263 init1: 149 opt: 224 Z-score: 197.0 bits: 43.9 E(85289): 0.00031 Smith-Waterman score: 270; 29.5% identity (50.2% similar) in 237 aa overlap (31-251:14-219) 10 20 30 40 50 pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQ--ICSP-CPPNSFSSAG : . .: . .: .: : :. . . NP_683 MAQHGAMGAFRALCGLALLCALSLGQRPTGGPGCGPGRLLLGT 10 20 30 40 60 70 80 90 100 110 pF1KE1 GQ--RTCDI--CRQCKGVFRTRKECSSTSNAECDCT-PGFHCLGAGCSMCEQD-CKQGQE : : : . : :. .:: :. .: :. : ::: :. :.. : :: NP_683 GTDARCCRVHTTRCCRDY--PGEECC--SEWDCMCVQPEFHCGDPCCTTCRHHPCPPGQG 50 60 70 80 90 120 130 140 150 160 pF1KE1 LTKKG-------CKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPAD . ..: : :: :::. ..: :.:::.:. : .. :.: ...:: NP_683 VQSQGKFSFGFQCIDCASGTFSGGHEGHCKPWTDCTQFGFLTVFPGNKTHNAVC------ 100 110 120 130 140 150 170 180 190 200 210 220 pF1KE1 LSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIF :: .::: :: .. .::... .::. : :. . . :: : . NP_683 -VPG----SPPA---EPLGWLTVV--LLAVAACVLLLTSAQLGLH---IWQLRKTQLLLE 160 170 180 190 200 230 240 250 pF1KE1 KQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL : . ::. ::.:::::.: NP_683 VPP--------STEDARSCQFPEEERGERSAEEKGRLGDLWV 210 220 230 >>NP_004186 (OMIM: 603905) tumor necrosis factor recepto (241 aa) initn: 259 init1: 145 opt: 224 Z-score: 196.9 bits: 43.9 E(85289): 0.00032 Smith-Waterman score: 275; 28.7% identity (51.9% similar) in 237 aa overlap (31-251:14-226) 10 20 30 40 50 pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQ--ICSP-CPPNSFSSAG : . .: . .: .: : :. . . NP_004 MAQHGAMGAFRALCGLALLCALSLGQRPTGGPGCGPGRLLLGT 10 20 30 40 60 70 80 90 100 110 pF1KE1 GQ--RTCDI--CRQCKGVFRTRKECSSTSNAECDCT-PGFHCLGAGCSMCEQD-CKQGQE : : : . : :. .:: :. .: :. : ::: :. :.. : :: NP_004 GTDARCCRVHTTRCCRDY--PGEECC--SEWDCMCVQPEFHCGDPCCTTCRHHPCPPGQG 50 60 70 80 90 120 130 140 150 160 pF1KE1 LTKKG-------CKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPAD . ..: : :: :::. ..: :.:::.:. : .. :.: ...:: NP_004 VQSQGKFSFGFQCIDCASGTFSGGHEGHCKPWTDCTQFGFLTVFPGNKTHNAVC------ 100 110 120 130 140 150 170 180 190 200 210 220 pF1KE1 LSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIF :: .::: :: .. .::... .::. : :. . . :.. .. NP_004 -VPG----SPPA---EPLGWLTVV--LLAVAACVLLLTSAQLGLH---IWQLRSQCMWPR 160 170 180 190 200 230 240 250 pF1KE1 KQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL . .. : . : :. ::.:::::.: NP_004 ETQLLLEVPPSTE-DARSCQFPEEERGERSAEEKGRLGDLWV 210 220 230 240 >>XP_016858211 (OMIM: 603905) PREDICTED: tumor necrosis (347 aa) initn: 230 init1: 149 opt: 224 Z-score: 194.8 bits: 44.1 E(85289): 0.00041 Smith-Waterman score: 233; 29.4% identity (51.0% similar) in 153 aa overlap (31-167:14-162) 10 20 30 40 50 pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQ--ICSP-CPPNSFSSAG : . .: . .: .: : :. . . XP_016 MAQHGAMGAFRALCGLALLCALSLGQRPTGGPGCGPGRLLLGT 10 20 30 40 60 70 80 90 100 110 pF1KE1 GQ--RTCDI--CRQCKGVFRTRKECSSTSNAECDCT-PGFHCLGAGCSMCEQD-CKQGQE : : : . : :. .:: :. .: :. : ::: :. :.. : :: XP_016 GTDARCCRVHTTRCCRD--YPGEECC--SEWDCMCVQPEFHCGDPCCTTCRHHPCPPGQG 50 60 70 80 90 120 130 140 150 160 pF1KE1 LTKKG-------CKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPAD . ..: : :: :::. ..: :.:::.:. : .. :.: ...:: :. XP_016 VQSQGKFSFGFQCIDCASGTFSGGHEGHCKPWTDCTQFGFLTVFPGNKTHNAVCVPGSPP 100 110 120 130 140 150 170 180 190 200 210 220 pF1KE1 LSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIF : XP_016 AEPLGWLTVVLLAVAACVLLLTSAQLGLHIWQLRSQCMWPRGLSQPGAGRWEHGCLLTVA 160 170 180 190 200 210 >>NP_001233 (OMIM: 186711,615122) CD27 antigen precursor (260 aa) initn: 138 init1: 83 opt: 210 Z-score: 185.3 bits: 41.9 E(85289): 0.0014 Smith-Waterman score: 210; 38.6% identity (61.4% similar) in 83 aa overlap (28-103:40-121) 10 20 30 40 50 pF1KE1 MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTF----CDNNRNQI-CSPCPPN- :. : ::: ::..:. :.:: :. NP_001 CVLGTLVGLSATPAPKSCPERHYWAQGKLCCQMCEPGTFLVKDCDQHRKAAQCDPCIPGV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 SFSSAGGQRT-CDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQ ::: : :. ::.:.. . .:. :. :.:::: : :..: :. :. NP_001 SFSPDHHTRPHCESCRHCNSGLLVRN-CTITANAECACRNGWQCRDKECTECDPLPNPSL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 ELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGAS NP_001 TARSSQALSPHPQPTHLPYVSEMLEARTAGHMQTLADFRQLPARTLSTHWPPQRSLCSSD 130 140 150 160 170 180 255 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 02:17:25 2016 done: Mon Nov 7 02:17:26 2016 Total Scan time: 5.240 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]