FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6945, 211 aa 1>>>pF1KB6945 211 - 211 aa - 211 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5550+/-0.000296; mu= 13.2858+/- 0.019 mean_var=74.3523+/-14.919, 0's: 0 Z-trim(118.7): 35 B-trim: 330 in 1/53 Lambda= 0.148740 statistics sampled from 31900 (31935) to 31900 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.745), E-opt: 0.2 (0.374), width: 16 Scan time: 5.960 The best scores are: opt bits E(85289) NP_001179 (OMIM: 600516) bcl-2 homologous antagoni ( 211) 1422 313.6 1.5e-85 XP_011513081 (OMIM: 600516) PREDICTED: bcl-2 homol ( 211) 1422 313.6 1.5e-85 XP_011513082 (OMIM: 600516) PREDICTED: bcl-2 homol ( 152) 1014 226.0 2.6e-59 NP_000648 (OMIM: 151430) apoptosis regulator Bcl-2 ( 205) 233 58.5 9.4e-09 NP_000624 (OMIM: 151430) apoptosis regulator Bcl-2 ( 239) 227 57.2 2.6e-08 XP_016881406 (OMIM: 151430) PREDICTED: apoptosis r ( 198) 219 55.4 7.3e-08 XP_011524437 (OMIM: 151430) PREDICTED: apoptosis r ( 224) 219 55.5 8.1e-08 NP_001309169 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 215 54.6 1.5e-07 XP_016883482 (OMIM: 600039) PREDICTED: bcl-2-like ( 233) 215 54.6 1.5e-07 XP_011527266 (OMIM: 600039) PREDICTED: bcl-2-like ( 233) 215 54.6 1.5e-07 NP_001304849 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 215 54.6 1.5e-07 NP_612815 (OMIM: 600039) bcl-2-like protein 1 isof ( 233) 215 54.6 1.5e-07 NP_001304848 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 215 54.6 1.5e-07 NP_001309171 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 215 54.6 1.5e-07 NP_001304850 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 215 54.6 1.5e-07 NP_001309168 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 215 54.6 1.5e-07 NP_001186768 (OMIM: 601931) bcl-2-like protein 2 [ ( 193) 210 53.5 2.7e-07 NP_004041 (OMIM: 601931) bcl-2-like protein 2 [Hom ( 193) 210 53.5 2.7e-07 NP_620116 (OMIM: 600040) apoptosis regulator BAX i ( 192) 206 52.6 4.9e-07 NP_004315 (OMIM: 600040) apoptosis regulator BAX i ( 218) 205 52.5 6.3e-07 XP_016882566 (OMIM: 600040) PREDICTED: apoptosis r ( 173) 202 51.8 8.2e-07 NP_620119 (OMIM: 600040) apoptosis regulator BAX i ( 179) 201 51.6 9.8e-07 NP_001278357 (OMIM: 600040) apoptosis regulator BA ( 221) 199 51.2 1.6e-06 NP_001278358 (OMIM: 600040) apoptosis regulator BA ( 181) 196 50.5 2.1e-06 NP_068779 (OMIM: 159552) induced myeloid leukemia ( 350) 196 50.6 3.6e-06 NP_001184249 (OMIM: 159552) induced myeloid leukem ( 197) 186 48.4 9.8e-06 NP_115904 (OMIM: 605404) bcl-2-related ovarian kil ( 212) 170 44.9 0.00011 XP_011509998 (OMIM: 605404) PREDICTED: bcl-2-relat ( 212) 170 44.9 0.00011 NP_001108207 (OMIM: 601056) bcl-2-related protein ( 163) 164 43.6 0.00022 NP_004040 (OMIM: 601056) bcl-2-related protein A1 ( 175) 164 43.6 0.00024 NP_001278360 (OMIM: 600040) apoptosis regulator BA ( 114) 156 41.8 0.00054 NP_620118 (OMIM: 600040) apoptosis regulator BAX i ( 143) 156 41.8 0.00065 NP_001278359 (OMIM: 600040) apoptosis regulator BA ( 140) 155 41.6 0.00075 XP_016860264 (OMIM: 605404) PREDICTED: bcl-2-relat ( 134) 148 40.1 0.002 XP_016860265 (OMIM: 605404) PREDICTED: bcl-2-relat ( 134) 148 40.1 0.002 >>NP_001179 (OMIM: 600516) bcl-2 homologous antagonist/k (211 aa) initn: 1422 init1: 1422 opt: 1422 Z-score: 1656.9 bits: 313.6 E(85289): 1.5e-85 Smith-Waterman score: 1422; 100.0% identity (100.0% similar) in 211 aa overlap (1-211:1-211) 10 20 30 40 50 60 pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 SGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAA 130 140 150 160 170 180 190 200 210 pF1KB6 LNLGNGPILNVLVVLGVVLLGQFVVRRFFKS ::::::::::::::::::::::::::::::: NP_001 LNLGNGPILNVLVVLGVVLLGQFVVRRFFKS 190 200 210 >>XP_011513081 (OMIM: 600516) PREDICTED: bcl-2 homologou (211 aa) initn: 1422 init1: 1422 opt: 1422 Z-score: 1656.9 bits: 313.6 E(85289): 1.5e-85 Smith-Waterman score: 1422; 100.0% identity (100.0% similar) in 211 aa overlap (1-211:1-211) 10 20 30 40 50 60 pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 SGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAA 130 140 150 160 170 180 190 200 210 pF1KB6 LNLGNGPILNVLVVLGVVLLGQFVVRRFFKS ::::::::::::::::::::::::::::::: XP_011 LNLGNGPILNVLVVLGVVLLGQFVVRRFFKS 190 200 210 >>XP_011513082 (OMIM: 600516) PREDICTED: bcl-2 homologou (152 aa) initn: 1014 init1: 1014 opt: 1014 Z-score: 1185.8 bits: 226.0 E(85289): 2.6e-59 Smith-Waterman score: 1014; 100.0% identity (100.0% similar) in 152 aa overlap (60-211:1-152) 30 40 50 60 70 80 pF1KB6 DTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRY :::::::::::::::::::::::::::::: XP_011 MVTLPLQPSSTMGQVGRQLAIIGDDINRRY 10 20 30 90 100 110 120 130 140 pF1KB6 DSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTG 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB6 FLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFF 100 110 120 130 140 150 210 pF1KB6 KS :: XP_011 KS >>NP_000648 (OMIM: 151430) apoptosis regulator Bcl-2 bet (205 aa) initn: 275 init1: 160 opt: 233 Z-score: 278.2 bits: 58.5 E(85289): 9.4e-09 Smith-Waterman score: 240; 30.5% identity (61.7% similar) in 141 aa overlap (53-181:60-199) 30 40 50 60 70 80 pF1KB6 SEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQ-PSSTMGQVGRQLAII :: :: : ::: :.. . .: :. . NP_000 WDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPV 30 40 50 60 70 80 90 100 110 120 130 pF1KB6 -----------GDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVA :::..::: .: : ..:. : .: :. .. ::..:.::::.:: NP_000 PPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVA 90 100 110 120 130 140 140 150 160 170 180 190 pF1KB6 LLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILN .. :: . .. .. .. .. ... ...... .: . :: . ::::.:: NP_000 FFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRH-LHTWIQDNGGWVGALGDVSLG 150 160 170 180 190 200 200 210 pF1KB6 VLVVLGVVLLGQFVVRRFFKS >>NP_000624 (OMIM: 151430) apoptosis regulator Bcl-2 alp (239 aa) initn: 262 init1: 160 opt: 227 Z-score: 270.2 bits: 57.2 E(85289): 2.6e-08 Smith-Waterman score: 234; 29.6% identity (59.9% similar) in 152 aa overlap (53-192:60-209) 30 40 50 60 70 80 pF1KB6 SEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQ-PSSTMGQVGRQLAII :: :: : ::: :.. . .: :. . NP_000 WDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPV 30 40 50 60 70 80 90 100 110 120 130 pF1KB6 -----------GDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVA :::..::: .: : ..:. : .: :. .. ::..:.::::.:: NP_000 PPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVA 90 100 110 120 130 140 140 150 160 170 180 190 pF1KB6 LLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILN .. :: . .. .. .. .. ... ...... .: . :: . ::: : ..: :: . NP_000 FFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRH-LHTWIQDNGGWDAFVEL-YGPSMR 150 160 170 180 190 200 200 210 pF1KB6 VLVVLGVVLLGQFVVRRFFKS : NP_000 PLFDFSWLSLKTLLSLALVGACITLGAYLGHK 210 220 230 >>XP_016881406 (OMIM: 151430) PREDICTED: apoptosis regul (198 aa) initn: 259 init1: 160 opt: 219 Z-score: 262.2 bits: 55.4 E(85289): 7.3e-08 Smith-Waterman score: 226; 29.0% identity (60.9% similar) in 138 aa overlap (53-178:60-196) 30 40 50 60 70 80 pF1KB6 SEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQ-PSSTMGQVGRQLAII :: :: : ::: :.. . .: :. . XP_016 WDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPV 30 40 50 60 70 80 90 100 110 120 130 pF1KB6 -----------GDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVA :::..::: .: : ..:. : .: :. .. ::..:.::::.:: XP_016 PPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVA 90 100 110 120 130 140 140 150 160 170 180 190 pF1KB6 LLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILN .. :: . .. .. .. .. ... ...... .: . :: . :::. XP_016 FFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRH-LHTWIQDNGGWLYM 150 160 170 180 190 200 210 pF1KB6 VLVVLGVVLLGQFVVRRFFKS >>XP_011524437 (OMIM: 151430) PREDICTED: apoptosis regul (224 aa) initn: 259 init1: 160 opt: 219 Z-score: 261.4 bits: 55.5 E(85289): 8.1e-08 Smith-Waterman score: 226; 29.5% identity (60.4% similar) in 139 aa overlap (53-179:60-197) 30 40 50 60 70 80 pF1KB6 SEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQ-PSSTMGQVGRQLAII :: :: : ::: :.. . .: :. . XP_011 WDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPV 30 40 50 60 70 80 90 100 110 120 130 pF1KB6 -----------GDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVA :::..::: .: : ..:. : .: :. .. ::..:.::::.:: XP_011 PPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVA 90 100 110 120 130 140 140 150 160 170 180 190 pF1KB6 LLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILN .. :: . .. .. .. .. ... ...... .: . :: . ::: : XP_011 FFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRH-LHTWIQDNGGWDALVLFAGLREFQ 150 160 170 180 190 200 200 210 pF1KB6 VLVVLGVVLLGQFVVRRFFKS XP_011 HGPGNYFLKRNLNAKF 210 220 >>NP_001309169 (OMIM: 600039) bcl-2-like protein 1 isofo (233 aa) initn: 236 init1: 169 opt: 215 Z-score: 256.5 bits: 54.6 E(85289): 1.5e-07 Smith-Waterman score: 227; 28.3% identity (62.5% similar) in 152 aa overlap (71-207:83-233) 50 60 70 80 90 100 pF1KB6 YRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHL :. : . : ::... :: :. . ..: NP_001 GNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQL 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB6 QPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVD . : .::. : .... ::..:.::::.::...:: : .. .. . ...... ... NP_001 HITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMAT 120 130 140 150 160 170 170 180 190 200 pF1KB6 FMLHHCIARWIAQRGGWVAALNL-GNGP--------------ILNVLVVLGVVLLGQFVV .. : . :: . ::: . ..: ::. .:. ..: ::::::.. NP_001 YLNDH-LEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFS 180 190 200 210 220 230 210 pF1KB6 RRFFKS :. NP_001 RK >>XP_016883482 (OMIM: 600039) PREDICTED: bcl-2-like prot (233 aa) initn: 236 init1: 169 opt: 215 Z-score: 256.5 bits: 54.6 E(85289): 1.5e-07 Smith-Waterman score: 227; 28.3% identity (62.5% similar) in 152 aa overlap (71-207:83-233) 50 60 70 80 90 100 pF1KB6 YRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHL :. : . : ::... :: :. . ..: XP_016 GNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQL 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB6 QPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVD . : .::. : .... ::..:.::::.::...:: : .. .. . ...... ... XP_016 HITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMAT 120 130 140 150 160 170 170 180 190 200 pF1KB6 FMLHHCIARWIAQRGGWVAALNL-GNGP--------------ILNVLVVLGVVLLGQFVV .. : . :: . ::: . ..: ::. .:. ..: ::::::.. XP_016 YLNDH-LEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFS 180 190 200 210 220 230 210 pF1KB6 RRFFKS :. XP_016 RK >>XP_011527266 (OMIM: 600039) PREDICTED: bcl-2-like prot (233 aa) initn: 236 init1: 169 opt: 215 Z-score: 256.5 bits: 54.6 E(85289): 1.5e-07 Smith-Waterman score: 227; 28.3% identity (62.5% similar) in 152 aa overlap (71-207:83-233) 50 60 70 80 90 100 pF1KB6 YRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHL :. : . : ::... :: :. . ..: XP_011 GNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQL 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB6 QPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVD . : .::. : .... ::..:.::::.::...:: : .. .. . ...... ... XP_011 HITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMAT 120 130 140 150 160 170 170 180 190 200 pF1KB6 FMLHHCIARWIAQRGGWVAALNL-GNGP--------------ILNVLVVLGVVLLGQFVV .. : . :: . ::: . ..: ::. .:. ..: ::::::.. XP_011 YLNDH-LEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFS 180 190 200 210 220 230 210 pF1KB6 RRFFKS :. XP_011 RK 211 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 02:26:41 2016 done: Mon Nov 7 02:26:42 2016 Total Scan time: 5.960 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]