FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9659, 222 aa 1>>>pF1KE9659 222 - 222 aa - 222 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0495+/-0.000365; mu= 7.2993+/- 0.023 mean_var=131.6675+/-26.865, 0's: 0 Z-trim(116.9): 18 B-trim: 385 in 1/53 Lambda= 0.111772 statistics sampled from 28348 (28366) to 28348 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.673), E-opt: 0.2 (0.333), width: 16 Scan time: 4.410 The best scores are: opt bits E(85289) NP_055268 (OMIM: 610893) charged multivesicular bo ( 222) 1379 233.1 2.9e-61 NP_940818 (OMIM: 610893) charged multivesicular bo ( 222) 1379 233.1 2.9e-61 XP_005258804 (OMIM: 610893) PREDICTED: charged mul ( 265) 1125 192.2 7.2e-49 XP_005258803 (OMIM: 610893) PREDICTED: charged mul ( 265) 1125 192.2 7.2e-49 NP_054762 (OMIM: 600795,609512,614696) charged mul ( 213) 427 79.5 4.6e-15 XP_011531878 (OMIM: 600795,609512,614696) PREDICTE ( 229) 408 76.5 4.1e-14 NP_001231573 (OMIM: 600795,609512,614696) charged ( 172) 346 66.4 3.3e-11 NP_057163 (OMIM: 610052) charged multivesicular bo ( 222) 308 60.4 2.8e-09 NP_065145 (OMIM: 606486) charged multivesicular bo ( 199) 296 58.4 1e-08 NP_002759 (OMIM: 164010,614961) charged multivesic ( 196) 258 52.3 6.9e-07 NP_001180446 (OMIM: 610052) charged multivesicular ( 182) 198 42.6 0.00053 NP_057494 (OMIM: 610900) charged multivesicular bo ( 219) 188 41.0 0.0019 NP_001005753 (OMIM: 610052) charged multivesicular ( 156) 175 38.8 0.0062 >>NP_055268 (OMIM: 610893) charged multivesicular body p (222 aa) initn: 1379 init1: 1379 opt: 1379 Z-score: 1220.8 bits: 233.1 E(85289): 2.9e-61 Smith-Waterman score: 1379; 100.0% identity (100.0% similar) in 222 aa overlap (1-222:1-222) 10 20 30 40 50 60 pF1KE9 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS 130 140 150 160 170 180 190 200 210 220 pF1KE9 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD :::::::::::::::::::::::::::::::::::::::::: NP_055 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD 190 200 210 220 >>NP_940818 (OMIM: 610893) charged multivesicular body p (222 aa) initn: 1379 init1: 1379 opt: 1379 Z-score: 1220.8 bits: 233.1 E(85289): 2.9e-61 Smith-Waterman score: 1379; 100.0% identity (100.0% similar) in 222 aa overlap (1-222:1-222) 10 20 30 40 50 60 pF1KE9 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS 130 140 150 160 170 180 190 200 210 220 pF1KE9 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD :::::::::::::::::::::::::::::::::::::::::: NP_940 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD 190 200 210 220 >>XP_005258804 (OMIM: 610893) PREDICTED: charged multive (265 aa) initn: 1206 init1: 1125 opt: 1125 Z-score: 998.4 bits: 192.2 E(85289): 7.2e-49 Smith-Waterman score: 1209; 82.7% identity (83.1% similar) in 254 aa overlap (1-211:1-254) 10 20 30 40 50 60 pF1KE9 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS 130 140 150 160 170 180 190 pF1KE9 -------------------------------------------NLPSTGGSLSVAAGGKK .:::::::::::::::: XP_005 SECSKSWTPFPTQGPATAPSPPFPCITPLRCLTPPAQTPTFSADLPSTGGSLSVAAGGKK 190 200 210 220 230 240 200 210 220 pF1KE9 AEAAASALADADADLEERLKNLRRD :::::::::::::: XP_005 AEAAASALADADADLEERLKNLRRD 250 260 >>XP_005258803 (OMIM: 610893) PREDICTED: charged multive (265 aa) initn: 1206 init1: 1125 opt: 1125 Z-score: 998.4 bits: 192.2 E(85289): 7.2e-49 Smith-Waterman score: 1209; 82.7% identity (83.1% similar) in 254 aa overlap (1-211:1-254) 10 20 30 40 50 60 pF1KE9 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS 130 140 150 160 170 180 190 pF1KE9 -------------------------------------------NLPSTGGSLSVAAGGKK .:::::::::::::::: XP_005 SECSKSWTPFPTQGPATAPSPPFPCITPLRCLTPPAQTPTFSADLPSTGGSLSVAAGGKK 190 200 210 220 230 240 200 210 220 pF1KE9 AEAAASALADADADLEERLKNLRRD :::::::::::::: XP_005 AEAAASALADADADLEERLKNLRRD 250 260 >>NP_054762 (OMIM: 600795,609512,614696) charged multive (213 aa) initn: 482 init1: 365 opt: 427 Z-score: 391.4 bits: 79.5 E(85289): 4.6e-15 Smith-Waterman score: 427; 33.3% identity (69.8% similar) in 222 aa overlap (1-222:1-213) 10 20 30 40 50 60 pF1KE9 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR : :: ..:: ........: : ..: . :.: :: :::.. .:::::: :. .: . NP_054 MASLF-KKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACK 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP ..::.::. :. . . ... ..: . ....:. .:: ::. ..:.: ..:... NP_054 VLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQ 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS . . :..:... :.: :::.::..:: . .:::::. .:.:::::.:. .. ... NP_054 KTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMA 120 130 140 150 160 170 190 200 210 220 pF1KE9 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD . ::.. :: :. .: :. : : ..:..:: : : NP_054 KAPSAARSLPSASTSK---ATIS-----DEEIERQLKALGVD 180 190 200 210 >>XP_011531878 (OMIM: 600795,609512,614696) PREDICTED: c (229 aa) initn: 482 init1: 365 opt: 408 Z-score: 374.4 bits: 76.5 E(85289): 4.1e-14 Smith-Waterman score: 408; 32.9% identity (70.0% similar) in 210 aa overlap (13-222:28-229) 10 20 30 40 pF1KE9 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIA .......: : ..: . :.: :: :::.. XP_011 MISAQRNHHLPDSSDSSTSAYRVARITDVIKEQNRELRGTQRAIIRDRAALEKQEKQLEL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 DIKKMAKQGQMDAVRIMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKG .:::::: :. .: ...::.::. :. . . ... ..: . ....:. .:: ::. XP_011 EIKKMAKIGNKEACKVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMST 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 VTKAMGTMNRQLKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVS ..:.: ..:... . . :..:... :.: :::.::..:: . .:::::. .:. XP_011 TAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVN 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 QVLDELGLSLTDELSNLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD :::::.:. .. .... ::.. :: :. .: :. : : ..:..:: : : XP_011 QVLDEIGIEISGKMAKAPSAARSLPSASTSK---ATIS-----DEEIERQLKALGVD 190 200 210 220 >>NP_001231573 (OMIM: 600795,609512,614696) charged mult (172 aa) initn: 371 init1: 336 opt: 346 Z-score: 322.1 bits: 66.4 E(85289): 3.3e-11 Smith-Waterman score: 346; 33.3% identity (70.1% similar) in 177 aa overlap (46-222:4-172) 20 30 40 50 60 70 pF1KE9 RQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVRIMAKDLVRTRRYVRK .:::::: :. .: ...::.::. :. . NP_001 MELEIKKMAKIGNKEACKVLAKQLVHLRKQKTR 10 20 30 80 90 100 110 120 130 pF1KE9 FVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLPQIQKIMMEFERQAEI . ... ..: . ....:. .:: ::. ..:.: ..:... . . :..:... NP_001 TFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMK 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE9 MDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGG :.: :::.::..:: . .:::::. .:.:::::.:. .. .... ::.. :: :. . NP_001 MEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTS 100 110 120 130 140 150 200 210 220 pF1KE9 KKAEAAASALADADADLEERLKNLRRD : :. : : ..:..:: : : NP_001 K---ATIS-----DEEIERQLKALGVD 160 170 >>NP_057163 (OMIM: 610052) charged multivesicular body p (222 aa) initn: 288 init1: 288 opt: 308 Z-score: 287.4 bits: 60.4 E(85289): 2.8e-09 Smith-Waterman score: 308; 27.4% identity (63.0% similar) in 219 aa overlap (4-212:3-220) 10 20 30 40 50 pF1KE9 MDLLFGR--RKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDA :::. .: :.::. . . . . :: .::. . .. .:.:. ..: ::.:: :. NP_057 MGLFGKTQEKPPKELVNEWSLKIRKEMRVVDRQIRDIQREEEKVKRSVKDAAKKGQKDV 10 20 30 40 50 60 70 80 90 100 110 pF1KE9 VRIMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLK ..::...:.:. : :. .:....: . ... . .: ... :..: .:. .: NP_057 CIVLAKEMIRSRKAVSKLYASKAHMNSVLMGMKNQLAVLRVAGSLQKSTEVMKAMQSLVK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 LPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDE-----LGL .:.:: : :. .. . :::..:.... .:: :::.. ....: : :: NP_057 IPEIQATMRELSKEMMKAGIIEEMLEDTFESMDDQEEMEEEAEMEIDRILFEITAGALGK 120 130 140 150 160 170 180 190 200 210 220 pF1KE9 S---LTDELSNLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD . .:: : . : :..... .. : : :. . : : NP_057 APSKVTDALPE-PEPPGAMAASEDEEEEEEALEAMQSRLATLRS 180 190 200 210 220 >>NP_065145 (OMIM: 606486) charged multivesicular body p (199 aa) initn: 342 init1: 287 opt: 296 Z-score: 277.7 bits: 58.4 E(85289): 1e-08 Smith-Waterman score: 299; 30.7% identity (66.3% similar) in 199 aa overlap (22-220:11-196) 10 20 30 40 50 60 pF1KE9 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR :. : .::.: .: . .:: : ::: ..:.:...: NP_065 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVAR 10 20 30 40 70 80 90 100 110 120 pF1KE9 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP : :.. .: . . .:. : : ..::. ..:: . ......: ::.:.: . . ..: NP_065 IHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLE 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE9 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS .:. .: .::.: : .:.. ..:.:..... ... : ..... :: ::.:. :: NP_065 KISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMEL- 110 120 130 140 150 160 190 200 210 220 pF1KE9 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD :. : . ::.. ..::: : .: .:: :: NP_065 --PQ-GQTGSVGT------SVASAEQD---ELSQRLARLRDQV 170 180 190 >>NP_002759 (OMIM: 164010,614961) charged multivesicular (196 aa) initn: 215 init1: 199 opt: 258 Z-score: 244.6 bits: 52.3 E(85289): 6.9e-07 Smith-Waterman score: 260; 26.1% identity (61.8% similar) in 199 aa overlap (22-220:8-195) 10 20 30 40 50 60 pF1KE9 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR :. . ..:.. .: : . : : .:: : ... .: NP_002 MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALLQKNVECAR 10 20 30 40 70 80 90 100 110 120 pF1KE9 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP ..:.. .: . ... : . ..::. :.:: . ..... : ::::. . : NP_002 VYAENAIRKKNEGVNWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSTMDLQ 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE9 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS .....: .::.:.. .:.. .:.:....: .:. :... :. .: :: . :.:: NP_002 KVSSVMDRFEQQVQNLDVHTSVMEDSMSSATTLTTPQEQVDSLIMQIAEENGLEVLDQLS 110 120 130 140 150 160 190 200 210 220 pF1KE9 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD .:: : .: . .:. .. : .: .:: :: NP_002 QLPE----------GASAVGESSVRSQED-QLSRRLAALRN 170 180 190 222 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 18:54:21 2016 done: Mon Nov 7 18:54:22 2016 Total Scan time: 4.410 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]