FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6228, 260 aa 1>>>pF1KE6228 260 - 260 aa - 260 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1128+/-0.00034; mu= 15.5972+/- 0.021 mean_var=63.2657+/-12.504, 0's: 0 Z-trim(114.7): 28 B-trim: 0 in 0/54 Lambda= 0.161246 statistics sampled from 24681 (24707) to 24681 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.668), E-opt: 0.2 (0.29), width: 16 Scan time: 5.700 The best scores are: opt bits E(85289) NP_001035517 (OMIM: 138760,614033) hydroxyacylglut ( 260) 1757 417.2 1.5e-116 NP_005317 (OMIM: 138760,614033) hydroxyacylglutath ( 308) 1757 417.2 1.8e-116 XP_016878684 (OMIM: 138760,614033) PREDICTED: hydr ( 258) 1538 366.2 3.3e-101 XP_011520771 (OMIM: 138760,614033) PREDICTED: hydr ( 306) 1538 366.2 3.8e-101 NP_072094 (OMIM: 118800,609023) probable hydrolase ( 361) 647 159.0 1.1e-38 NP_056303 (OMIM: 118800,609023) probable hydrolase ( 385) 647 159.0 1.1e-38 NP_001273178 (OMIM: 138760,614033) hydroxyacylglut ( 236) 631 155.2 1e-37 XP_011520772 (OMIM: 138760,614033) PREDICTED: hydr ( 236) 631 155.2 1e-37 XP_016859261 (OMIM: 118800,609023) PREDICTED: prob ( 332) 430 108.5 1.6e-23 XP_016859260 (OMIM: 118800,609023) PREDICTED: prob ( 356) 430 108.5 1.7e-23 NP_055112 (OMIM: 602473,608451) persulfide dioxyge ( 254) 252 67.0 3.7e-11 XP_005258744 (OMIM: 602473,608451) PREDICTED: pers ( 227) 251 66.8 4e-11 NP_001307797 (OMIM: 602473,608451) persulfide diox ( 131) 147 42.4 0.00048 NP_001307798 (OMIM: 602473,608451) persulfide diox ( 156) 145 42.0 0.00077 >>NP_001035517 (OMIM: 138760,614033) hydroxyacylglutathi (260 aa) initn: 1757 init1: 1757 opt: 1757 Z-score: 2213.3 bits: 417.2 E(85289): 1.5e-116 Smith-Waterman score: 1757; 100.0% identity (100.0% similar) in 260 aa overlap (1-260:1-260) 10 20 30 40 50 60 pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 KPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 KFARHVEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KFARHVEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETD 190 200 210 220 230 240 250 260 pF1KE6 PVTTMRAVRREKDQFKMPRD :::::::::::::::::::: NP_001 PVTTMRAVRREKDQFKMPRD 250 260 >>NP_005317 (OMIM: 138760,614033) hydroxyacylglutathione (308 aa) initn: 1757 init1: 1757 opt: 1757 Z-score: 2212.2 bits: 417.2 E(85289): 1.8e-116 Smith-Waterman score: 1757; 100.0% identity (100.0% similar) in 260 aa overlap (1-260:49-308) 10 20 30 pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDP :::::::::::::::::::::::::::::: NP_005 ACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDP 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE6 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKIT 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE6 HLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTAD 140 150 160 170 180 190 160 170 180 190 200 210 pF1KE6 EMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEPT 200 210 220 230 240 250 220 230 240 250 260 pF1KE6 VPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREKDQFKMPRD :::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREKDQFKMPRD 260 270 280 290 300 >>XP_016878684 (OMIM: 138760,614033) PREDICTED: hydroxya (258 aa) initn: 1536 init1: 1536 opt: 1538 Z-score: 1938.0 bits: 366.2 E(85289): 3.3e-101 Smith-Waterman score: 1538; 95.0% identity (96.3% similar) in 241 aa overlap (1-241:1-241) 10 20 30 40 50 60 pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 KPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 KFARHVEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETD ::::::::::::::::::::::::::::::::::::::::::::::: . : .. XP_016 KFARHVEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVSGPGSSGGRGSAQ 190 200 210 220 230 240 250 260 pF1KE6 PVTTMRAVRREKDQFKMPRD : XP_016 PAARCWPPQGEDGAAARR 250 >>XP_011520771 (OMIM: 138760,614033) PREDICTED: hydroxya (306 aa) initn: 1536 init1: 1536 opt: 1538 Z-score: 1936.9 bits: 366.2 E(85289): 3.8e-101 Smith-Waterman score: 1538; 95.0% identity (96.3% similar) in 241 aa overlap (1-241:49-289) 10 20 30 pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDP :::::::::::::::::::::::::::::: XP_011 ACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDP 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE6 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKIT 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE6 HLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTAD 140 150 160 170 180 190 160 170 180 190 200 210 pF1KE6 EMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEPT 200 210 220 230 240 250 220 230 240 250 260 pF1KE6 VPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREKDQFKMPRD ::::::::::::::::: . : ..: XP_011 VPSTLAEEFTYNPFMRVSGPGSSGGRGSAQPAARCWPPQGEDGAAARR 260 270 280 290 300 >>NP_072094 (OMIM: 118800,609023) probable hydrolase PNK (361 aa) initn: 550 init1: 324 opt: 647 Z-score: 815.6 bits: 159.0 E(85289): 1.1e-38 Smith-Waterman score: 648; 40.6% identity (69.2% similar) in 266 aa overlap (1-256:95-359) 10 20 30 pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDP .:: .:.:.::: ::.:: ... :. ::: NP_072 GYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQLAVAVDP 70 80 90 100 110 120 40 50 60 70 80 pF1KE6 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGG-DDRIGALTHKI .:. : . .:.:: :...: ::.::::.:::. : . . .:::. .: : ::: . NP_072 SDPRAVQASIEKEGVTLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIPYLTHPL 130 140 150 160 170 180 90 100 110 120 130 140 pF1KE6 THLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTA : ....:: :... :::: ::.::. :... . : .:.:: ::..:::. .::.: NP_072 CHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYKGPSCLFSGDLLFLSGCGRTFEGNA 190 200 210 220 230 240 150 160 170 180 190 200 pF1KE6 DEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEP . : ..: ::: : :: .. ::::. .:: :: ::: : : ..:. :.... . NP_072 ETMLSSLDTVLG-LGDDTLLWPGHEYAEENLGFAGVVEPENLARERKMQWVQRQRLERKG 250 260 270 280 290 300 210 220 230 240 250 260 pF1KE6 TVPSTLAEEFTYNPFMRVREKTVQQH-------AGETDP--VTTMRAVRREKDQFKMPRD : ::::.:: .::::.:.. ..:. .:. : . .. .:: ::. : NP_072 TCPSTLGEERSYNPFLRTHCLALQEALGPGPGPTGDDDYSRAQLLEELRRLKDMHKSK 310 320 330 340 350 360 >>NP_056303 (OMIM: 118800,609023) probable hydrolase PNK (385 aa) initn: 550 init1: 324 opt: 647 Z-score: 815.2 bits: 159.0 E(85289): 1.1e-38 Smith-Waterman score: 648; 40.6% identity (69.2% similar) in 266 aa overlap (1-256:119-383) 10 20 30 pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDP .:: .:.:.::: ::.:: ... :. ::: NP_056 GYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQLAVAVDP 90 100 110 120 130 140 40 50 60 70 80 pF1KE6 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGG-DDRIGALTHKI .:. : . .:.:: :...: ::.::::.:::. : . . .:::. .: : ::: . NP_056 SDPRAVQASIEKEGVTLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIPYLTHPL 150 160 170 180 190 200 90 100 110 120 130 140 pF1KE6 THLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTA : ....:: :... :::: ::.::. :... . : .:.:: ::..:::. .::.: NP_056 CHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYKGPSCLFSGDLLFLSGCGRTFEGNA 210 220 230 240 250 260 150 160 170 180 190 200 pF1KE6 DEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEP . : ..: ::: : :: .. ::::. .:: :: ::: : : ..:. :.... . NP_056 ETMLSSLDTVLG-LGDDTLLWPGHEYAEENLGFAGVVEPENLARERKMQWVQRQRLERKG 270 280 290 300 310 320 210 220 230 240 250 260 pF1KE6 TVPSTLAEEFTYNPFMRVREKTVQQH-------AGETDP--VTTMRAVRREKDQFKMPRD : ::::.:: .::::.:.. ..:. .:. : . .. .:: ::. : NP_056 TCPSTLGEERSYNPFLRTHCLALQEALGPGPGPTGDDDYSRAQLLEELRRLKDMHKSK 330 340 350 360 370 380 >>NP_001273178 (OMIM: 138760,614033) hydroxyacylglutathi (236 aa) initn: 631 init1: 631 opt: 631 Z-score: 798.2 bits: 155.2 E(85289): 1e-37 Smith-Waterman score: 631; 100.0% identity (100.0% similar) in 97 aa overlap (1-97:49-145) 10 20 30 pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDP :::::::::::::::::::::::::::::: NP_001 ACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDP 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE6 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKIT 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE6 HLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTAD ::::::: NP_001 HLSTLQVTPCLWLAAGSSMKGLRMRCVKLCWRSWAGSPRTQESTVATSTPSTTSSLHATW 140 150 160 170 180 190 >>XP_011520772 (OMIM: 138760,614033) PREDICTED: hydroxya (236 aa) initn: 631 init1: 631 opt: 631 Z-score: 798.2 bits: 155.2 E(85289): 1e-37 Smith-Waterman score: 631; 100.0% identity (100.0% similar) in 97 aa overlap (1-97:49-145) 10 20 30 pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDP :::::::::::::::::::::::::::::: XP_011 ACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDP 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE6 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKIT 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE6 HLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTAD ::::::: XP_011 HLSTLQVTPCLWLAAGSSMKGLRMRCVKLCWRSWAGSPRTQESTVATSTPSTTSSLHATW 140 150 160 170 180 190 >>XP_016859261 (OMIM: 118800,609023) PREDICTED: probable (332 aa) initn: 587 init1: 246 opt: 430 Z-score: 543.3 bits: 108.5 E(85289): 1.6e-23 Smith-Waterman score: 522; 36.1% identity (61.7% similar) in 266 aa overlap (1-256:95-330) 10 20 30 pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDP .:: .:.:.::: ::.:: ... :. ::: XP_016 GYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQLAVAVDP 70 80 90 100 110 120 40 50 60 70 80 pF1KE6 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGG-DDRIGALTHKI .:. : . .:.:: :...: ::.::::.:::. : . . .:::. .: : ::: . XP_016 SDPRAVQASIEKEGVTLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIPYLTHPL 130 140 150 160 170 180 90 100 110 120 130 140 pF1KE6 THLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTA : ....:: :... :::: ::.::. :... . : .:.:: ::..::: XP_016 CHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYKGPSCLFSGDLLFLSGCG------- 190 200 210 220 230 150 160 170 180 190 200 pF1KE6 DEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEP :::. .:: :: ::: : : ..:. :.... . XP_016 -----------------------HEYAEENLGFAGVVEPENLARERKMQWVQRQRLERKG 240 250 260 270 210 220 230 240 250 260 pF1KE6 TVPSTLAEEFTYNPFMRVREKTVQQH-------AGETDP--VTTMRAVRREKDQFKMPRD : ::::.:: .::::.:.. ..:. .:. : . .. .:: ::. : XP_016 TCPSTLGEERSYNPFLRTHCLALQEALGPGPGPTGDDDYSRAQLLEELRRLKDMHKSK 280 290 300 310 320 330 >>XP_016859260 (OMIM: 118800,609023) PREDICTED: probable (356 aa) initn: 587 init1: 246 opt: 430 Z-score: 542.9 bits: 108.5 E(85289): 1.7e-23 Smith-Waterman score: 522; 36.1% identity (61.7% similar) in 266 aa overlap (1-256:119-354) 10 20 30 pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDP .:: .:.:.::: ::.:: ... :. ::: XP_016 GYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQLAVAVDP 90 100 110 120 130 140 40 50 60 70 80 pF1KE6 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGG-DDRIGALTHKI .:. : . .:.:: :...: ::.::::.:::. : . . .:::. .: : ::: . XP_016 SDPRAVQASIEKEGVTLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIPYLTHPL 150 160 170 180 190 200 90 100 110 120 130 140 pF1KE6 THLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTA : ....:: :... :::: ::.::. :... . : .:.:: ::..::: XP_016 CHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYKGPSCLFSGDLLFLSGCG------- 210 220 230 240 250 260 150 160 170 180 190 200 pF1KE6 DEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEP :::. .:: :: ::: : : ..:. :.... . XP_016 -----------------------HEYAEENLGFAGVVEPENLARERKMQWVQRQRLERKG 270 280 290 210 220 230 240 250 260 pF1KE6 TVPSTLAEEFTYNPFMRVREKTVQQH-------AGETDP--VTTMRAVRREKDQFKMPRD : ::::.:: .::::.:.. ..:. .:. : . .. .:: ::. : XP_016 TCPSTLGEERSYNPFLRTHCLALQEALGPGPGPTGDDDYSRAQLLEELRRLKDMHKSK 300 310 320 330 340 350 260 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:16:22 2016 done: Tue Nov 8 11:16:23 2016 Total Scan time: 5.700 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]