FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3644, 534 aa 1>>>pF1KE3644 534 - 534 aa - 534 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9493+/-0.000435; mu= 20.7971+/- 0.027 mean_var=70.3665+/-13.753, 0's: 0 Z-trim(110.2): 41 B-trim: 51 in 3/51 Lambda= 0.152894 statistics sampled from 18451 (18483) to 18451 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.577), E-opt: 0.2 (0.217), width: 16 Scan time: 7.440 The best scores are: opt bits E(85289) NP_003896 (OMIM: 603385) NEDD8-activating enzyme E ( 534) 3511 784.2 0 NP_001273429 (OMIM: 603385) NEDD8-activating enzym ( 537) 3495 780.6 0 NP_001018169 (OMIM: 603385) NEDD8-activating enzym ( 528) 3407 761.2 0 XP_011521724 (OMIM: 603385) PREDICTED: NEDD8-activ ( 445) 2934 656.8 3.8e-188 XP_005256272 (OMIM: 603385) PREDICTED: NEDD8-activ ( 445) 2934 656.8 3.8e-188 NP_001018170 (OMIM: 603385) NEDD8-activating enzym ( 445) 2934 656.8 3.8e-188 NP_005491 (OMIM: 613294) SUMO-activating enzyme su ( 346) 334 83.2 1.4e-15 XP_006723026 (OMIM: 613294) PREDICTED: SUMO-activa ( 378) 334 83.3 1.5e-15 NP_001139186 (OMIM: 613294) SUMO-activating enzyme ( 266) 332 82.7 1.5e-15 XP_006723028 (OMIM: 613294) PREDICTED: SUMO-activa ( 281) 332 82.7 1.6e-15 NP_001139185 (OMIM: 613294) SUMO-activating enzyme ( 299) 332 82.7 1.7e-15 XP_016881624 (OMIM: 613294) PREDICTED: SUMO-activa ( 349) 332 82.8 1.9e-15 XP_016885270 (OMIM: 301830,314370) PREDICTED: ubiq (1058) 250 65.1 1.2e-09 XP_016885269 (OMIM: 301830,314370) PREDICTED: ubiq (1058) 250 65.1 1.2e-09 NP_695012 (OMIM: 301830,314370) ubiquitin-like mod (1058) 250 65.1 1.2e-09 NP_003325 (OMIM: 301830,314370) ubiquitin-like mod (1058) 250 65.1 1.2e-09 XP_005272706 (OMIM: 301830,314370) PREDICTED: ubiq (1064) 250 65.1 1.2e-09 XP_016885268 (OMIM: 301830,314370) PREDICTED: ubiq (1064) 250 65.1 1.2e-09 XP_011542256 (OMIM: 301830,314370) PREDICTED: ubiq (1072) 250 65.1 1.2e-09 XP_016885267 (OMIM: 301830,314370) PREDICTED: ubiq (1086) 250 65.1 1.2e-09 XP_016885266 (OMIM: 301830,314370) PREDICTED: ubiq (1109) 250 65.1 1.3e-09 XP_011532373 (OMIM: 191325) PREDICTED: ubiquitin-l ( 910) 223 59.1 6.7e-08 XP_011532372 (OMIM: 191325) PREDICTED: ubiquitin-l ( 960) 223 59.1 7e-08 XP_005265487 (OMIM: 191325) PREDICTED: ubiquitin-l ( 987) 223 59.1 7.2e-08 XP_006713384 (OMIM: 191325) PREDICTED: ubiquitin-l (1005) 223 59.1 7.3e-08 NP_003326 (OMIM: 191325) ubiquitin-like modifier-a (1012) 223 59.1 7.3e-08 XP_016863848 (OMIM: 611361) PREDICTED: ubiquitin-l (1009) 219 58.2 1.3e-07 NP_060697 (OMIM: 611361) ubiquitin-like modifier-a (1052) 219 58.3 1.4e-07 XP_016881625 (OMIM: 613294) PREDICTED: SUMO-activa ( 282) 189 51.2 5e-06 NP_005490 (OMIM: 613295) SUMO-activating enzyme su ( 640) 173 47.9 0.00011 NP_937838 (OMIM: 603172) NEDD8-activating enzyme E ( 449) 157 44.3 0.00095 NP_003959 (OMIM: 603172) NEDD8-activating enzyme E ( 463) 157 44.3 0.00098 >>NP_003896 (OMIM: 603385) NEDD8-activating enzyme E1 re (534 aa) initn: 3511 init1: 3511 opt: 3511 Z-score: 4185.6 bits: 784.2 E(85289): 0 Smith-Waterman score: 3511; 100.0% identity (100.0% similar) in 534 aa overlap (1-534:1-534) 10 20 30 40 50 60 pF1KE3 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTII 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 CRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 CRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNAL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 EDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 TPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 VAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 NEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVH 430 440 450 460 470 480 490 500 510 520 530 pF1KE3 EFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL 490 500 510 520 530 >>NP_001273429 (OMIM: 603385) NEDD8-activating enzyme E1 (537 aa) initn: 3171 init1: 3171 opt: 3495 Z-score: 4166.5 bits: 780.6 E(85289): 0 Smith-Waterman score: 3495; 99.4% identity (99.4% similar) in 537 aa overlap (1-534:1-537) 10 20 30 40 50 pF1KE3 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPG---IGSF ::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: NP_001 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGNVGIGSF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 TIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 SFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 NALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTY 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 KEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINI 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 TKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAV 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 GNHVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNHVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMD 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE3 NPDNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPDNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDD 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE3 YVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL 490 500 510 520 530 >>NP_001018169 (OMIM: 603385) NEDD8-activating enzyme E1 (528 aa) initn: 3403 init1: 3403 opt: 3407 Z-score: 4061.7 bits: 761.2 E(85289): 0 Smith-Waterman score: 3407; 98.7% identity (99.0% similar) in 525 aa overlap (10-534:4-528) 10 20 30 40 50 60 pF1KE3 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTII .: . ::::::::::::::::::::::::::::::::::::::::::: NP_001 MDAQQTKTNEARLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTII 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 DGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFF 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 CRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNAL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 EDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEK 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 EDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQ 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE3 TPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNH 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE3 VAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPD 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE3 NEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVH 420 430 440 450 460 470 490 500 510 520 530 pF1KE3 EFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL 480 490 500 510 520 >>XP_011521724 (OMIM: 603385) PREDICTED: NEDD8-activatin (445 aa) initn: 2934 init1: 2934 opt: 2934 Z-score: 3498.8 bits: 656.8 E(85289): 3.8e-188 Smith-Waterman score: 2934; 100.0% identity (100.0% similar) in 445 aa overlap (90-534:1-445) 60 70 80 90 100 110 pF1KE3 IDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSF :::::::::::::::::::::::::::::: XP_011 MEFLQELNSDVSGSFVEESPENLLDNDPSF 10 20 30 120 130 140 150 160 170 pF1KE3 FCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNA 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE3 LEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKE 100 110 120 130 140 150 240 250 260 270 280 290 pF1KE3 KEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITK 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE3 QTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGN 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE3 HVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNP 280 290 300 310 320 330 420 430 440 450 460 470 pF1KE3 DNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYV 340 350 360 370 380 390 480 490 500 510 520 530 pF1KE3 HEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL 400 410 420 430 440 >>XP_005256272 (OMIM: 603385) PREDICTED: NEDD8-activatin (445 aa) initn: 2934 init1: 2934 opt: 2934 Z-score: 3498.8 bits: 656.8 E(85289): 3.8e-188 Smith-Waterman score: 2934; 100.0% identity (100.0% similar) in 445 aa overlap (90-534:1-445) 60 70 80 90 100 110 pF1KE3 IDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSF :::::::::::::::::::::::::::::: XP_005 MEFLQELNSDVSGSFVEESPENLLDNDPSF 10 20 30 120 130 140 150 160 170 pF1KE3 FCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNA 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE3 LEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKE 100 110 120 130 140 150 240 250 260 270 280 290 pF1KE3 KEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITK 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE3 QTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGN 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE3 HVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNP 280 290 300 310 320 330 420 430 440 450 460 470 pF1KE3 DNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYV 340 350 360 370 380 390 480 490 500 510 520 530 pF1KE3 HEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL 400 410 420 430 440 >>NP_001018170 (OMIM: 603385) NEDD8-activating enzyme E1 (445 aa) initn: 2934 init1: 2934 opt: 2934 Z-score: 3498.8 bits: 656.8 E(85289): 3.8e-188 Smith-Waterman score: 2934; 100.0% identity (100.0% similar) in 445 aa overlap (90-534:1-445) 60 70 80 90 100 110 pF1KE3 IDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSF :::::::::::::::::::::::::::::: NP_001 MEFLQELNSDVSGSFVEESPENLLDNDPSF 10 20 30 120 130 140 150 160 170 pF1KE3 FCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNA 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE3 LEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKE 100 110 120 130 140 150 240 250 260 270 280 290 pF1KE3 KEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITK 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE3 QTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGN 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE3 HVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNP 280 290 300 310 320 330 420 430 440 450 460 470 pF1KE3 DNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYV 340 350 360 370 380 390 480 490 500 510 520 530 pF1KE3 HEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL 400 410 420 430 440 >>NP_005491 (OMIM: 613294) SUMO-activating enzyme subuni (346 aa) initn: 415 init1: 272 opt: 334 Z-score: 400.8 bits: 83.2 E(85289): 1.4e-15 Smith-Waterman score: 334; 25.7% identity (58.8% similar) in 311 aa overlap (12-317:18-316) 10 20 30 40 50 pF1KE3 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGI .::::.:::: ..:. :....: :.. . :.:: :::.: :. NP_005 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 GSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLD ..:..: .::. :: : .:... .:.:.:::::..: :.:: :. :. . :.. NP_005 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVD---VKVDTEDIEK 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 NDPSFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIES . ::: .: .: : ... ... .. ...: .. ..: :: . :: .: NP_005 KPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 HPDNALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSE-TNGRI . : . .. : ...: . : :: : . ..: :: ... . NP_005 KTKVAKVSQGVEDGPDTKRAKLDSSETT-MVKKKVVFCP---VKEALEVDWSSEKAKAAL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 PKTYKEKEDFRDLIRQGILKNENGAPED-EENFEEAIKNVNTALNTTQIPSSIEDIFNDD .: .. .. :.. :... . . ::. : .. : .:.. : :.. .: NP_005 KRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISP---DLLPED 240 250 260 270 280 290 300 310 320 330 340 pF1KE3 ---RCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREK :. ....: ... : . ..: NP_005 FVRYCF--SEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK 300 310 320 330 340 >>XP_006723026 (OMIM: 613294) PREDICTED: SUMO-activating (378 aa) initn: 383 init1: 272 opt: 334 Z-score: 400.3 bits: 83.3 E(85289): 1.5e-15 Smith-Waterman score: 334; 25.7% identity (58.8% similar) in 311 aa overlap (12-317:54-352) 10 20 30 40 pF1KE3 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATAT .::::.:::: ..:. :....: :.. . XP_006 LSGTGAEAGRAGAMVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGL 30 40 50 60 70 80 50 60 70 80 90 100 pF1KE3 GTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVS :.:: :::.: :. ..:..: .::. :: : .:... .:.:.:::::..: :.:: :. XP_006 GAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVD 90 100 110 120 130 140 110 120 130 140 150 160 pF1KE3 GSFVEESPENLLDNDPSFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGY :. . :.. . ::: .: .: : ... ... .. ...: .. ..: :: XP_006 ---VKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGY 150 160 170 180 190 200 170 180 190 200 210 220 pF1KE3 MRIIIKEHPVIESHPDNALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKY . :: .: . : . .. : ...: . : :: : . XP_006 TFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETT-MVKKKVVFCP---VKEAL 210 220 230 240 250 230 240 250 260 270 pF1KE3 LAQWYSE-TNGRIPKTYKEKEDFRDLIRQGILKNENGAPED-EENFEEAIKNVNTALNTT ..: :: ... . .: .. .. :.. :... . . ::. : .. : .:.. XP_006 EVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSL 260 270 280 290 300 310 280 290 300 310 320 330 pF1KE3 QIPSSIEDIFNDD---RCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADS : :.. .: :. ....: ... : . ..: XP_006 GISP---DLLPEDFVRYCF--SEMAPVCAVVGGILAQEIVKVLGCLRGLRPCLSGTLLTT 320 330 340 350 360 370 340 350 360 370 380 390 pF1KE3 GKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCR XP_006 TSSSSMA >>NP_001139186 (OMIM: 613294) SUMO-activating enzyme sub (266 aa) initn: 328 init1: 272 opt: 332 Z-score: 400.0 bits: 82.7 E(85289): 1.5e-15 Smith-Waterman score: 332; 30.6% identity (64.3% similar) in 196 aa overlap (12-207:18-210) 10 20 30 40 50 pF1KE3 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGI .::::.:::: ..:. :....: :.. . :.:: :::.: :. NP_001 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 GSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLD ..:..: .::. :: : .:... .:.:.:::::..: :.:: :. :. . :.. NP_001 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVD---VKVDTEDIEK 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 NDPSFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIES . ::: .: .: : ... ... .. ...: .. ..: :: . :: .: NP_001 KPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 HPDNALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIP . : . .. : ...: . ..:: NP_001 KTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 KTYKEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRC NP_001 SDYFLLQGTASPRWPQCVRWLEGFWHRKL 240 250 260 >>XP_006723028 (OMIM: 613294) PREDICTED: SUMO-activating (281 aa) initn: 328 init1: 272 opt: 332 Z-score: 399.6 bits: 82.7 E(85289): 1.6e-15 Smith-Waterman score: 332; 30.6% identity (64.3% similar) in 196 aa overlap (12-207:54-246) 10 20 30 40 pF1KE3 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATAT .::::.:::: ..:. :....: :.. . XP_006 LSGTGAEAGRAGAMVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGL 30 40 50 60 70 80 50 60 70 80 90 100 pF1KE3 GTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVS :.:: :::.: :. ..:..: .::. :: : .:... .:.:.:::::..: :.:: :. XP_006 GAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVD 90 100 110 120 130 140 110 120 130 140 150 160 pF1KE3 GSFVEESPENLLDNDPSFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGY :. . :.. . ::: .: .: : ... ... .. ...: .. ..: :: XP_006 ---VKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGY 150 160 170 180 190 200 170 180 190 200 210 220 pF1KE3 MRIIIKEHPVIESHPDNALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKY . :: .: . : . .. : ...: . ..:: XP_006 TFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDW 210 220 230 240 250 260 230 240 250 260 270 280 pF1KE3 LAQWYSETNGRIPKTYKEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQI XP_006 SSEKAKAALKRTTSDYFLLQA 270 280 534 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 03:05:45 2016 done: Mon Nov 7 03:05:46 2016 Total Scan time: 7.440 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]