Result of FASTA (omim) for
pFN21AE0116
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0116, 390 aa
1>>>pF1KE0116 390 - 390 aa - 390 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.6580+/-0.000524; mu= -7.8907+/- 0.032
mean_var=387.9551+/-77.402, 0's: 0 Z-trim(117.1): 66 B-trim: 0 in 0/56
Lambda= 0.065115
statistics sampled from 28808 (28864) to 28808 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.688), E-opt: 0.2 (0.338), width: 16
Scan time: 9.400
The best scores are: opt bits E(85289)
NP_064512 (OMIM: 600087) tuftelin isoform 1 [Homo ( 390) 2501 249.3 1.1e-65
XP_016857712 (OMIM: 600087) PREDICTED: tuftelin is ( 371) 2353 235.4 1.7e-61
NP_001288246 (OMIM: 600087) tuftelin isoform 3 [Ho ( 409) 2353 235.4 1.8e-61
XP_016857713 (OMIM: 600087) PREDICTED: tuftelin is ( 346) 2198 220.8 3.9e-57
NP_001119809 (OMIM: 600087) tuftelin isoform 2 [Ho ( 365) 2198 220.8 4e-57
XP_011508263 (OMIM: 600087) PREDICTED: tuftelin is ( 331) 1991 201.3 2.7e-51
NP_001018110 (OMIM: 614071) myocardial zonula adhe ( 466) 375 49.7 1.7e-05
>>NP_064512 (OMIM: 600087) tuftelin isoform 1 [Homo sapi (390 aa)
initn: 2501 init1: 2501 opt: 2501 Z-score: 1299.9 bits: 249.3 E(85289): 1.1e-65
Smith-Waterman score: 2501; 100.0% identity (100.0% similar) in 390 aa overlap (1-390:1-390)
10 20 30 40 50 60
pF1KE0 MNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 MNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 HSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 HSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 SSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 SSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 AKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 AKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGME
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 TEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 TEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 KVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 KVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQ
310 320 330 340 350 360
370 380 390
pF1KE0 ARAKTENPGSIRISKPPSPKPMPVIRVVET
::::::::::::::::::::::::::::::
NP_064 ARAKTENPGSIRISKPPSPKPMPVIRVVET
370 380 390
>>XP_016857712 (OMIM: 600087) PREDICTED: tuftelin isofor (371 aa)
initn: 2353 init1: 2353 opt: 2353 Z-score: 1225.1 bits: 235.4 E(85289): 1.7e-61
Smith-Waterman score: 2353; 100.0% identity (100.0% similar) in 370 aa overlap (21-390:2-371)
10 20 30 40 50 60
pF1KE0 MNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAG
::::::::::::::::::::::::::::::::::::::::
XP_016 MGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAG
10 20 30 40
70 80 90 100 110 120
pF1KE0 HSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDI
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE0 SSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLL
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE0 AKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGME
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE0 TEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQR
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE0 KVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQ
290 300 310 320 330 340
370 380 390
pF1KE0 ARAKTENPGSIRISKPPSPKPMPVIRVVET
::::::::::::::::::::::::::::::
XP_016 ARAKTENPGSIRISKPPSPKPMPVIRVVET
350 360 370
>>NP_001288246 (OMIM: 600087) tuftelin isoform 3 [Homo s (409 aa)
initn: 2353 init1: 2353 opt: 2353 Z-score: 1224.5 bits: 235.4 E(85289): 1.8e-61
Smith-Waterman score: 2353; 100.0% identity (100.0% similar) in 370 aa overlap (21-390:40-409)
10 20 30 40 50
pF1KE0 MNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKT
::::::::::::::::::::::::::::::
NP_001 QLEKEECMQCVPCSPRTRVALLELYRAMCQGSVDILRLTLQGELTGDELEHIAQKAGRKT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 YAMVSSHSAGHSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YAMVSSHSAGHSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEAR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 NCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 SLRKTVQDLLAKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLRKTVQDLLAKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVG
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE0 ELQRRLLGMETEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELQRRLLGMETEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHH
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE0 LDDMLKSQQRKVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDDMLKSQQRKVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEK
310 320 330 340 350 360
360 370 380 390
pF1KE0 QISHGNFSTQARAKTENPGSIRISKPPSPKPMPVIRVVET
::::::::::::::::::::::::::::::::::::::::
NP_001 QISHGNFSTQARAKTENPGSIRISKPPSPKPMPVIRVVET
370 380 390 400
>>XP_016857713 (OMIM: 600087) PREDICTED: tuftelin isofor (346 aa)
initn: 2198 init1: 2198 opt: 2198 Z-score: 1146.7 bits: 220.8 E(85289): 3.9e-57
Smith-Waterman score: 2198; 100.0% identity (100.0% similar) in 345 aa overlap (46-390:2-346)
20 30 40 50 60 70
pF1KE0 EDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAGHSLASELVESHDGHE
::::::::::::::::::::::::::::::
XP_016 MAGRKTYAMVSSHSAGHSLASELVESHDGHE
10 20 30
80 90 100 110 120 130
pF1KE0 EIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQ
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE0 EIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLLAKLQEAKRQHQSDCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLLAKLQEAKRQHQSDCV
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE0 AFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGMETEHQALLAKVREGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGMETEHQALLAKVREGEV
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE0 ALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQRKVRQMIEQLQNSKAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQRKVRQMIEQLQNSKAV
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE0 IQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQARAKTENPGSIRISK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQARAKTENPGSIRISK
280 290 300 310 320 330
380 390
pF1KE0 PPSPKPMPVIRVVET
:::::::::::::::
XP_016 PPSPKPMPVIRVVET
340
>>NP_001119809 (OMIM: 600087) tuftelin isoform 2 [Homo s (365 aa)
initn: 2332 init1: 2198 opt: 2198 Z-score: 1146.5 bits: 220.8 E(85289): 4e-57
Smith-Waterman score: 2286; 93.6% identity (93.6% similar) in 390 aa overlap (1-390:1-365)
10 20 30 40 50 60
pF1KE0 MNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAG
:::::::::::::::::::: :::::::::::::::
NP_001 MNGTRNWCTLVDVHPEDQAA-------------------------AGRKTYAMVSSHSAG
10 20 30
70 80 90 100 110 120
pF1KE0 HSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDI
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE0 SSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE0 AKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGME
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE0 TEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQR
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE0 KVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQ
280 290 300 310 320 330
370 380 390
pF1KE0 ARAKTENPGSIRISKPPSPKPMPVIRVVET
::::::::::::::::::::::::::::::
NP_001 ARAKTENPGSIRISKPPSPKPMPVIRVVET
340 350 360
>>XP_011508263 (OMIM: 600087) PREDICTED: tuftelin isofor (331 aa)
initn: 2117 init1: 1983 opt: 1991 Z-score: 1041.9 bits: 201.3 E(85289): 2.7e-51
Smith-Waterman score: 2003; 84.9% identity (84.9% similar) in 390 aa overlap (1-390:1-331)
10 20 30 40 50 60
pF1KE0 MNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAG
::::::::::::::::::::
XP_011 MNGTRNWCTLVDVHPEDQAA----------------------------------------
10 20
70 80 90 100 110 120
pF1KE0 HSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDI
:::::::::::::::::::::::::::::::::::::::::
XP_011 -------------------VYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDI
30 40 50 60
130 140 150 160 170 180
pF1KE0 SSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLL
70 80 90 100 110 120
190 200 210 220 230 240
pF1KE0 AKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGME
130 140 150 160 170 180
250 260 270 280 290 300
pF1KE0 TEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQR
190 200 210 220 230 240
310 320 330 340 350 360
pF1KE0 KVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQ
250 260 270 280 290 300
370 380 390
pF1KE0 ARAKTENPGSIRISKPPSPKPMPVIRVVET
::::::::::::::::::::::::::::::
XP_011 ARAKTENPGSIRISKPPSPKPMPVIRVVET
310 320 330
>>NP_001018110 (OMIM: 614071) myocardial zonula adherens (466 aa)
initn: 450 init1: 240 opt: 375 Z-score: 219.6 bits: 49.7 E(85289): 1.7e-05
Smith-Waterman score: 383; 27.1% identity (58.0% similar) in 362 aa overlap (34-389:118-458)
10 20 30 40 50 60
pF1KE0 TRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAGHSL
. :: ... :: . : . ::. . :
NP_001 VVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGD-YDEMRQKIRQLTQELSVSHAQQEYL
90 100 110 120 130 140
70 80 90 100 110 120
pF1KE0 ASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSK
.. ...... . .... .. ..:.. .:.. .. : . :.. ::. : .:
NP_001 ENH-IQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDK
150 160 170 180 190 200
130 140 150 160 170 180
pF1KE0 LDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDV--ESLRKTVQDLLA
: .: : :: .: . : . : . : .: : .: ..
NP_001 L----------REKQRQLE----VAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEE
210 220 230 240 250
190 200 210 220 230 240
pF1KE0 KLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGMET
:::: .:.:... :. . . . :..: .: : .:.:. ..:::.: . ::
NP_001 KLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEK
260 270 280 290 300 310
250 260 270 280 290 300
pF1KE0 EHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQRK
:.. : .. : :. :. .. .: ...:. ::. :.:::.:.:::::.. ::.:
NP_001 ERHQLQLQLLEHET---EMSGELTD--SDKERYQQLEEASASLRERIRHLDDMVHCQQKK
320 330 340 350 360
310 320 330 340 350 360
pF1KE0 VRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQA
:.::.:.... : .:.:. : .: :::..::.:: :...:...: : : . . .
NP_001 VKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREI
370 380 390 400 410 420
370 380 390
pF1KE0 RAKTE----NPGSIRISKPPSPKPMPVIRVVET
. . . : : :: . : ::.:
NP_001 GVGCDLLPSQTGRTREIVMPSRNYTPYTRVLELTMKKTLT
430 440 450 460
390 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 02:24:06 2016 done: Fri Nov 4 02:24:07 2016
Total Scan time: 9.400 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]